ANK1 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description ankyrin 1, erythrocytic|Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008] (NCBI Entrez Gene Database, 286)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_ANK1
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Genes

74 co-expressed genes for ANK1 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ACSL6 acyl-CoA synthetase long-chain family member 6
AHSP alpha hemoglobin stabilizing protein
ALAD aminolevulinate dehydratase
ALAS2 5'-aminolevulinate synthase 2
ANK1 ankyrin 1, erythrocytic
BLVRB biliverdin reductase B
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSG basigin (Ok blood group)
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CDC27 cell division cycle 27
CLIC2 chloride intracellular channel 2
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CTSE cathepsin E
DCAF11 DDB1 and CUL4 associated factor 11
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
EPB42 erythrocyte membrane protein band 4.2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FBXO7 F-box protein 7
FECH ferrochelatase
FOXO3 forkhead box O3
GATA1 GATA binding protein 1 (globin transcription factor 1)
GCLM glutamate-cysteine ligase, modifier subunit
GLRX5 glutaredoxin 5
GYPA glycophorin A (MNS blood group)
GYPB glycophorin B (MNS blood group)
GYPC glycophorin C (Gerbich blood group)
GYPE glycophorin E (MNS blood group)
H1F0 H1 histone family, member 0
HBD hemoglobin, delta
HBQ1 hemoglobin, theta 1
HEBP1 heme binding protein 1
HIST1H4C histone cluster 1, H4c
HMBS hydroxymethylbilane synthase
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
KAT2B K(lysine) acetyltransferase 2B
KEL Kell blood group, metallo-endopeptidase
KLF1 Kruppel-like factor 1 (erythroid)
MAP2K3 mitogen-activated protein kinase kinase 3
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MINPP1 multiple inositol-polyphosphate phosphatase 1
MPP1 membrane protein, palmitoylated 1, 55kDa
NARF nuclear prelamin A recognition factor
NFE2 nuclear factor, erythroid 2
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
OSBP2 oxysterol binding protein 2
PPOX protoporphyrinogen oxidase
PRDX2 peroxiredoxin 2
RAD23A RAD23 homolog A (S. cerevisiae)
RANBP10 RAN binding protein 10
RHAG Rh-associated glycoprotein
RHCE Rh blood group, CcEe antigens
RHD Rh blood group, D antigen
RNF123 ring finger protein 123
SELENBP1 selenium binding protein 1
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPTA1 spectrin, alpha, erythrocytic 1
SPTB spectrin, beta, erythrocytic
TAL1 T-cell acute lymphocytic leukemia 1
TFDP1 transcription factor Dp-1
TMCC2 transmembrane and coiled-coil domain family 2
TRAK2 trafficking protein, kinesin binding 2
TRIM10 tripartite motif containing 10
TSPAN5 tetraspanin 5
TSPO2 translocator protein 2
UBAC1 UBA domain containing 1
UROD uroporphyrinogen decarboxylase
XK X-linked Kx blood group
XPO7 exportin 7