AP1G1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description adaptor-related protein complex 1, gamma 1 subunit|Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 164)
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Genes

317 genes differentially expressed following the AP1G1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
UPK3B uroplakin 3B 2.85879
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 2.85879
C8ORF48 chromosome 8 open reading frame 48 2.85879
SLC25A45 solute carrier family 25, member 45 2.85879
LMO1 LIM domain only 1 (rhombotin 1) 2.85879
PTH2 parathyroid hormone 2 2.85879
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.85879
XCL1 chemokine (C motif) ligand 1 2.85879
ASB17 ankyrin repeat and SOCS box containing 17 2.85879
ASB12 ankyrin repeat and SOCS box containing 12 2.85879
PKD1L1 polycystic kidney disease 1 like 1 2.85879
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 2.85879
AKR1C2 aldo-keto reductase family 1, member C2 2.85879
CST11 cystatin 11 2.85879
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 2.85879
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.85879
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 2.85879
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.85879
SACK1A scaffolding CK1 anchoring protein A 2.85879
SLC26A9 solute carrier family 26 (anion exchanger), member 9 2.85879
OR52A5 olfactory receptor, family 52, subfamily A, member 5 2.85879
IL22RA2 interleukin 22 receptor, alpha 2 2.85879
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.85879
FAM86B2 family with sequence similarity 86, member B2 2.85879
GYPB glycophorin B (MNS blood group) 2.85879
ATOH8 atonal homolog 8 (Drosophila) 2.85879
HMX3 H6 family homeobox 3 2.85879
C2ORF78 chromosome 2 open reading frame 78 2.85879
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 2.85879
TDO2 tryptophan 2,3-dioxygenase 2.85879
FAM161B family with sequence similarity 161, member B 2.85879
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 2.85879
PODN podocan 2.85879
SPDEF SAM pointed domain containing ETS transcription factor 2.85879
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.85879
PLK5 polo-like kinase 5 2.85879
CBY1 chibby homolog 1 (Drosophila) 2.85879
GIMAP4 GTPase, IMAP family member 4 2.85879
GIMAP8 GTPase, IMAP family member 8 2.85879
LYNX1 Ly6/neurotoxin 1 2.85879
FBLN7 fibulin 7 2.85879
C11ORF87 chromosome 11 open reading frame 87 2.85879
GSG1 germ cell associated 1 2.85879
PCDHB8 protocadherin beta 8 2.85879
TDRD1 tudor domain containing 1 2.85879
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 2.85879
HOXB3 homeobox B3 2.85879
SPDYE6 speedy/RINGO cell cycle regulator family member E6 2.85879
LRTM3 leucine rich repeat transmembrane protein 3 2.85879
RAB6D RAB6D, member RAS oncogene family 2.85879
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 2.85879
GIPC3 GIPC PDZ domain containing family, member 3 2.85879
MGAT4D MGAT4 family, member D 2.85879
FMOD fibromodulin 2.85879
MLN motilin 2.85879
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.85879
MYZAP myocardial zonula adherens protein 2.85879
C10ORF53 chromosome 10 open reading frame 53 2.85879
DEPP1 DEPP autophagy regulator 1 2.85879
TBXT T-box transcription factor T 2.85879
CBLIF cobalamin binding intrinsic factor 2.85879
C1ORF232 chromosome 1 open reading frame 230 2.85879
LOC124906010 uncharacterized LOC124906010 2.85879
H4C11 H4 clustered histone 11 2.85879
C20ORF204 chromosome 20 open reading frame 204 2.85879
SMIM31 small integral membrane protein 31 2.85879
NFILZ NFIL3 like basic leucine zipper 2.85879
GARIN1A golgi associated RAB2 interactor 1A 2.85879
ELOA2 elongin A2 2.85879
CCDC187 coiled-coil domain containing 187 2.85879
RASD1 RAS, dexamethasone-induced 1 2.85879
GPBP1L1 GC-rich promoter binding protein 1-like 1 2.85879
KHDC1L KH homology domain containing 1-like 2.85879
ERRFI1 ERBB receptor feedback inhibitor 1 2.85879
TLR7 toll-like receptor 7 2.85879
S1PR5 sphingosine-1-phosphate receptor 5 2.85879
SCRT2 scratch family zinc finger 2 2.85879
SCRT1 scratch family zinc finger 1 2.85879
ULBP1 UL16 binding protein 1 2.85879
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.85879
IRF8 interferon regulatory factor 8 2.85879
ACTL8 actin-like 8 2.85879
SLC45A2 solute carrier family 45, member 2 2.85879
ESR1 estrogen receptor 1 2.85879
C1QTNF1 C1q and tumor necrosis factor related protein 1 2.85879
C11ORF21 chromosome 11 open reading frame 21 2.85879
ZNF705A zinc finger protein 705A 2.85879
C15ORF62 chromosome 15 open reading frame 62 2.85879
CLEC6A C-type lectin domain family 6, member A 2.85879
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.85879
TAS1R1 taste receptor, type 1, member 1 2.85879
SAMD11 sterile alpha motif domain containing 11 2.85879
PLB1 phospholipase B1 2.85879
PRR18 proline rich 18 2.85879
RS1 retinoschisin 1 2.85879
CSTA cystatin A (stefin A) 2.85879
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 2.85879
CGB2 chorionic gonadotropin, beta polypeptide 2 2.85879
PCDHGA2 protocadherin gamma subfamily A, 2 2.85879
BAHCC1 BAH domain and coiled-coil containing 1 2.85879
MUC13 mucin 13, cell surface associated 2.85879
ALOXE3 arachidonate lipoxygenase 3 2.85879
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 2.85879
SIAH3 siah E3 ubiquitin protein ligase family member 3 2.85879
COL6A5 collagen, type VI, alpha 5 2.85879
CLEC4C C-type lectin domain family 4, member C 2.85879
TEKT5 tektin 5 2.85879
FATE1 fetal and adult testis expressed 1 2.85879
KLHL6 kelch-like family member 6 2.85879
S100A14 S100 calcium binding protein A14 2.85879
CXCR6 chemokine (C-X-C motif) receptor 6 2.85879
WFDC1 WAP four-disulfide core domain 1 2.85879
GOLGA6B golgin A6 family, member B 2.85879
HOXD1 homeobox D1 2.85879
AKNAD1 AKNA domain containing 1 2.85879
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.85879
KLK6 kallikrein-related peptidase 6 2.85879
CTXN2 cortexin 2 2.85879
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2.85879
ABLIM3 actin binding LIM protein family, member 3 2.85879
OTP orthopedia homeobox 2.85879
CCNA1 cyclin A1 2.85879
OPALIN oligodendrocytic myelin paranodal and inner loop protein 2.85879
WNT4 wingless-type MMTV integration site family, member 4 2.85879
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 2.85879
GOLGA8H golgin A8 family, member H 2.85879
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.85879
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 2.85879
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 2.85879
TCAP titin-cap 2.85879
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.85879
DMRT1 doublesex and mab-3 related transcription factor 1 2.85879
PRSS37 protease, serine, 37 2.85879
SDS serine dehydratase 2.85879
TMEM31 transmembrane protein 31 2.85879
INSM1 insulinoma-associated 1 2.85879
GPR68 G protein-coupled receptor 68 2.85879
IDI2 isopentenyl-diphosphate delta isomerase 2 2.85879
HAND2 heart and neural crest derivatives expressed 2 2.85879
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 2.85879
CCL25 chemokine (C-C motif) ligand 25 2.85879
CETP cholesteryl ester transfer protein, plasma 2.85879
TMEM86B transmembrane protein 86B 2.85879
TMEM132D transmembrane protein 132D 2.85879
FZD1 frizzled class receptor 1 2.85879
PALMD palmdelphin 2.85879
ACOX2 acyl-CoA oxidase 2, branched chain 2.85879
NPAS4 neuronal PAS domain protein 4 2.85879
DYTN dystrotelin 2.85879
ADGRF1 adhesion G protein-coupled receptor F1 2.85879
ACKR2 atypical chemokine receptor 2 2.85879
EREG epiregulin 2.85879
AGBL4 ATP/GTP binding protein-like 4 2.85879
NPR3 natriuretic peptide receptor 3 2.85879
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 2.85879
NRGN neurogranin (protein kinase C substrate, RC3) 2.85879
NLRP3 NLR family, pyrin domain containing 3 2.85879
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.85879
CT55 cancer/testis antigen 55 2.85879
ERICH4 glutamate-rich 4 2.85879
PMP2 peripheral myelin protein 2 2.85879
PRSS57 protease, serine, 57 2.85879
MMP12 matrix metallopeptidase 12 2.85879
CEL carboxyl ester lipase 2.84784
ZNF284 zinc finger protein 284 2.74938
TMEM17 transmembrane protein 17 2.74938
ANPEP alanyl (membrane) aminopeptidase 2.74938
PCDHGB6 protocadherin gamma subfamily B, 6 2.74938
IMPACT impact RWD domain protein 2.70739
RPL13 ribosomal protein L13 2.70495
TIMCC TIM double twin CX3C motif chaperone 2.69352
COPE coatomer protein complex, subunit epsilon 2.6803
GOLGB1 golgin B1 2.66385
MRAS muscle RAS oncogene homolog 2.6508
RPL38 ribosomal protein L38 2.59418
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 2.59331
C2CD2 C2 calcium-dependent domain containing 2 2.58638
THOC2 THO complex 2 2.58104
RPS14 ribosomal protein S14 2.5197
H4C1 H4 clustered histone 1 2.50802
GREP1 glycine rich extracellular protein 1 2.50667
PNMA8B PNMA family member 8B 2.50667
ING3 inhibitor of growth family, member 3 2.49479
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.44726
FBXO22 F-box protein 22 2.44337
VAV3 vav 3 guanine nucleotide exchange factor 2.42181
RPL28 ribosomal protein L28 2.38712
CACNB1 calcium channel, voltage-dependent, beta 1 subunit 2.34541
RWDD1 RWD domain containing 1 2.32612
ARRB1 arrestin, beta 1 2.32052
ZNF175 zinc finger protein 175 2.31121
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 2.29974
ANKRD52 ankyrin repeat domain 52 2.29786
KIF15 kinesin family member 15 2.28807
PRIM2 primase, DNA, polypeptide 2 (58kDa) 2.26854
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) 2.26208
RSL1D1 ribosomal L1 domain containing 1 2.24111
DOCK3 dedicator of cytokinesis 3 2.22219
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) 2.22089
TTC17 tetratricopeptide repeat domain 17 2.21143
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) 2.20668
PEG10 paternally expressed 10 2.20668
ZNF626 zinc finger protein 626 2.20467
PLD1 phospholipase D1, phosphatidylcholine-specific 2.20148
ZNF808 zinc finger protein 808 2.12991
NBR1 neighbor of BRCA1 gene 1 2.12062
BST2 bone marrow stromal cell antigen 2 2.11838
BEST2 bestrophin 2 2.10719
PHF3 PHD finger protein 3 2.09608
COG2 component of oligomeric golgi complex 2 2.06307
ZNF75A zinc finger protein 75a 2.05688
CC2D2A coiled-coil and C2 domain containing 2A 2.05688
VBP1 von Hippel-Lindau binding protein 1 2.05688
SFMBT2 Scm-like with four mbt domains 2 2.0564
ITPKB inositol-trisphosphate 3-kinase B 2.05542
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 2.03819
GRTP1 growth hormone regulated TBC protein 1 2.03068
MPST mercaptopyruvate sulfurtransferase 2.0273
CASP8AP2 caspase 8 associated protein 2 2.01372
ACOX1 acyl-CoA oxidase 1, palmitoyl 2.01363
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) 2.01363
PDZD2 PDZ domain containing 2 2.01363
EXO1 exonuclease 1 2.01298
DYNC2I2 dynein 2 intermediate chain 2 2.00941
HAUS4 HAUS augmin-like complex, subunit 4 2.00757

decreased expression

Symbol Name Standardized Value
PDE1A phosphodiesterase 1A, calmodulin-dependent -2.85879
AURKB aurora kinase B -2.85879
ZNF70 zinc finger protein 70 -2.85879
SLFNL1 schlafen-like 1 -2.85879
CXCL3 chemokine (C-X-C motif) ligand 3 -2.85879
FKBP2 FK506 binding protein 2, 13kDa -2.85879
HPS3 Hermansky-Pudlak syndrome 3 -2.85879
AVIL advillin -2.85879
LXN latexin -2.85879
H4C2 H4 clustered histone 2 -2.85879
TWIST2 twist family bHLH transcription factor 2 -2.85879
INTS14 integrator complex subunit 14 -2.82916
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -2.79263
DPPA3 developmental pluripotency associated 3 -2.70495
LRRC63 leucine rich repeat containing 63 -2.70495
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) -2.70495
TMC8 transmembrane channel-like 8 -2.70495
MYL7 myosin, light chain 7, regulatory -2.70495
RAMACL RNA guanine-7 methyltransferase activating subunit like -2.70495
HES2 hes family bHLH transcription factor 2 -2.70495
LBP lipopolysaccharide binding protein -2.70495
DEGS2 delta(4)-desaturase, sphingolipid 2 -2.70495
CFAP141 cilia and flagella associated protein 141 -2.70495
CLBA1 clathrin binding box of aftiphilin containing 1 -2.70495
UNC5CL unc-5 homolog C (C. elegans)-like -2.70495
RSPH14 radial spoke head 14 homolog (Chlamydomonas) -2.70495
CALCA calcitonin-related polypeptide alpha -2.70495
ZBTB16 zinc finger and BTB domain containing 16 -2.70495
LGALS7B lectin, galactoside-binding, soluble, 7B -2.70495
PCDHA6 protocadherin alpha 6 -2.70495
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -2.70495
RUNDC3B RUN domain containing 3B -2.70495
WNK4 WNK lysine deficient protein kinase 4 -2.70495
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 -2.70495
STYK1 serine/threonine/tyrosine kinase 1 -2.70495
LCT lactase -2.70495
PRSS51 protease, serine, 51 -2.70495
CD247 CD247 molecule -2.70495
AZIN2 antizyme inhibitor 2 -2.70495
KCNK10 potassium channel, two pore domain subfamily K, member 10 -2.70495
CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5 -2.70495
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 -2.70495
ARL2BP ADP-ribosylation factor-like 2 binding protein -2.59781
SPDYE18 speedy/RINGO cell cycle regulator family member E18 -2.58209
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -2.50667
DPYSL3 dihydropyrimidinase-like 3 -2.49402
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -2.46318
MMP9 matrix metallopeptidase 9 -2.46318
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog -2.46082
C2ORF69 chromosome 2 open reading frame 69 -2.43265
MCRIP1 MAPK regulated corepressor interacting protein 1 -2.35744
LIMCH1 LIM and calponin homology domains 1 -2.33372
PKN2 protein kinase N2 -2.29779
BCAR3 breast cancer anti-estrogen resistance 3 -2.29339
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 -2.29339
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 -2.29047
SAP25 Sin3A-associated protein, 25kDa -2.29047
LHCGR luteinizing hormone/choriogonadotropin receptor -2.28682
NBAS neuroblastoma amplified sequence -2.27741
CTTNBP2 cortactin binding protein 2 -2.27462
DALRD3 DALR anticodon binding domain containing 3 -2.24111
TRAPPC14 trafficking protein particle complex subunit 14 -2.2374
MED14 mediator complex subunit 14 -2.23595
COPG1 coatomer protein complex, subunit gamma 1 -2.21079
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1 -2.20812
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.20668
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.17898
VARS2 valyl-tRNA synthetase 2, mitochondrial -2.17898
BCCIP BRCA2 and CDKN1A interacting protein -2.17507
NICOL1 NELL2 interacting cell ontogeny regulator 1 -2.16116
TMEM121B transmembrane protein 121B -2.12444
CRHR2 corticotropin releasing hormone receptor 2 -2.12444
GAL galanin/GMAP prepropeptide -2.12444
MBOAT2 membrane bound O-acyltransferase domain containing 2 -2.09477
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D -2.09477
SETMAR SET domain and mariner transposase fusion gene -2.07684
RIPOR2 RHO family interacting cell polarization regulator 2 -2.07446
PAMR1 peptidase domain containing associated with muscle regeneration 1 -2.0681
BRD7 bromodomain containing 7 -2.06652
CLEC2L C-type lectin domain family 2, member L -2.06307
PNMA6A paraneoplastic Ma antigen family member 6A -2.06307
GSTM2 glutathione S-transferase mu 2 (muscle) -2.06307
ZNF593 zinc finger protein 593 -2.05688
METRN meteorin, glial cell differentiation regulator -2.0564
LRTM1 leucine-rich repeats and transmembrane domains 1 -2.0564
NTAQ1 N-terminal glutamine amidase 1 -2.05517
KIAA1217 KIAA1217 -2.05517
PSAP prosaposin -2.05201
LMBRD1 LMBR1 domain containing 1 -2.0321
KLF3 Kruppel-like factor 3 (basic) -2.0321
TCF15 transcription factor 15 (basic helix-loop-helix) -2.0273
DAZL deleted in azoospermia-like -2.0273