| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | apoptotic peptidase activating factor 1|This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 317) |
| External Link | https://ncbi.nlm.nih.gov/gene/317 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the APAF1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NES | nestin | 0.0148882 |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein | 0.0142778 |
| FCGBP | Fc fragment of IgG binding protein | 0.0139941 |
| MAP7 | microtubule-associated protein 7 | 0.0136297 |
| CHGB | chromogranin B | 0.0133367 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0128741 |
| RBM34 | RNA binding motif protein 34 | 0.0126996 |
| PODXL | podocalyxin-like | 0.0126882 |
| AUTS2 | autism susceptibility candidate 2 | 0.0119924 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.0115749 |
| TCTA | T-cell leukemia translocation altered | 0.0115104 |
| ABLIM1 | actin binding LIM protein 1 | 0.0114727 |
| PDZK1IP1 | PDZK1 interacting protein 1 | 0.0113538 |
| DLK1 | delta-like 1 homolog (Drosophila) | 0.0111866 |
| CRABP1 | cellular retinoic acid binding protein 1 | 0.0109868 |
| PTHLH | parathyroid hormone-like hormone | 0.0102623 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0100379 |
| ASS1 | argininosuccinate synthase 1 | 0.0097194 |
| MSN | moesin | 0.00970852 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.00970781 |
| XPO7 | exportin 7 | 0.00968187 |
| LAMP3 | lysosomal-associated membrane protein 3 | 0.00964831 |
| BHLHE41 | basic helix-loop-helix family, member e41 | 0.00957257 |
| NDNF | neuron-derived neurotrophic factor | 0.00955149 |
| TMEM176B | transmembrane protein 176B | 0.0095098 |
| TUBB2B | tubulin, beta 2B class IIb | 0.00949755 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.00944964 |
| RET | ret proto-oncogene | 0.00935868 |
| COG7 | component of oligomeric golgi complex 7 | 0.00927379 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.00916032 |
| C1QA | complement component 1, q subcomponent, A chain | 0.00913515 |
| PRUNE2 | prune homolog 2 (Drosophila) | 0.0091115 |
| PDGFD | platelet derived growth factor D | 0.0090928 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.00899325 |
| MYOF | myoferlin | 0.00896964 |
| SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | 0.00896862 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.00896069 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | 0.00889759 |
| EGR2 | early growth response 2 | 0.00887626 |
| KLF6 | Kruppel-like factor 6 | 0.0088163 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | 0.00879312 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | 0.00878977 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | 0.00873766 |
| ANK2 | ankyrin 2, neuronal | 0.00860081 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | 0.0085497 |
| CRYAB | crystallin, alpha B | 0.00852663 |
| CTSZ | cathepsin Z | 0.00847605 |
| RGS5 | regulator of G-protein signaling 5 | 0.0084707 |
| ANOS1 | anosmin 1 | 0.00846427 |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta | 0.00846321 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.00844168 |
| GAL | galanin/GMAP prepropeptide | 0.00840524 |
| NEBL | nebulette | 0.00839208 |
| SNX7 | sorting nexin 7 | 0.0083683 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.00836514 |
| TFF1 | trefoil factor 1 | 0.00831956 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | 0.00830303 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00829064 |
| CH25H | cholesterol 25-hydroxylase | 0.00828282 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.00821095 |
| C1QB | complement component 1, q subcomponent, B chain | 0.00818428 |
| TPBG | trophoblast glycoprotein | 0.00817881 |
| AIM2 | absent in melanoma 2 | 0.00817713 |
| CX3CL1 | chemokine (C-X3-C motif) ligand 1 | 0.00807906 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.00801892 |
| BMP2 | bone morphogenetic protein 2 | 0.00799623 |
| FNBP1 | formin binding protein 1 | 0.00799246 |
| EGR1 | early growth response 1 | 0.00795581 |
| IL13RA2 | interleukin 13 receptor, alpha 2 | 0.00789245 |
| GOLM1 | golgi membrane protein 1 | 0.00787134 |
| SETBP1 | SET binding protein 1 | 0.00786315 |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 0.00770493 |
| TNNC1 | troponin C type 1 (slow) | 0.00769786 |
| FABP7 | fatty acid binding protein 7, brain | 0.0075359 |
| MEN1 | multiple endocrine neoplasia I | 0.00751925 |
| TLE4 | transducin-like enhancer of split 4 | 0.00746275 |
| TUBB3 | tubulin, beta 3 class III | 0.0074475 |
| ACTB | actin, beta | 0.00736037 |
| TOX | thymocyte selection-associated high mobility group box | 0.00735697 |
| KBTBD11 | kelch repeat and BTB (POZ) domain containing 11 | 0.00733091 |
| FBP1 | fructose-1,6-bisphosphatase 1 | 0.00732458 |
| AOC1 | amine oxidase, copper containing 1 | 0.0072834 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.00723263 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.00723055 |
| PADI2 | peptidyl arginine deiminase, type II | 0.00722516 |
| GSDME | gasdermin E | 0.00722214 |
| MMP12 | matrix metallopeptidase 12 | 0.00720575 |
| AQP1 | aquaporin 1 (Colton blood group) | 0.00720076 |
| IMPDH2 | IMP (inosine 5'-monophosphate) dehydrogenase 2 | 0.00719742 |
| INSM1 | insulinoma-associated 1 | 0.00719636 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.00718323 |
| SIRT3 | sirtuin 3 | 0.007165 |
| PGBD5 | piggyBac transposable element derived 5 | 0.00713484 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.00704502 |
| A2M | alpha-2-macroglobulin | 0.00704065 |
| PTN | pleiotrophin | 0.00703901 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.0069803 |
| CHEK1 | checkpoint kinase 1 | 0.00696524 |
| PTGER4 | prostaglandin E receptor 4 (subtype EP4) | 0.00689402 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.00688858 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | 0.00688391 |
| TAOK3 | TAO kinase 3 | 0.00688243 |
| GALNT6 | polypeptide N-acetylgalactosaminyltransferase 6 | 0.00686271 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.00685771 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0068536 |
| CADM1 | cell adhesion molecule 1 | 0.00681177 |
| P2RX4 | purinergic receptor P2X, ligand gated ion channel, 4 | 0.00680633 |
| NKX2-1 | NK2 homeobox 1 | 0.00678138 |
| CAVIN1 | caveolae associated protein 1 | 0.00676268 |
| INSR | insulin receptor | 0.00676147 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 0.00675845 |
| AHCYL1 | adenosylhomocysteinase-like 1 | 0.00674266 |
| PRL | prolactin | 0.00673769 |
| SOBP | sine oculis binding protein homolog (Drosophila) | 0.00669635 |
| MGP | matrix Gla protein | 0.00667333 |
| KLK10 | kallikrein-related peptidase 10 | 0.00667142 |
| NFASC | neurofascin | 0.00665679 |
| MYBPC1 | myosin binding protein C, slow type | 0.00665376 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | 0.00664553 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.00662792 |
| COPA | coatomer protein complex, subunit alpha | 0.00662086 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | 0.00660107 |
| NRCAM | neuronal cell adhesion molecule | 0.00657582 |
| NDRG1 | N-myc downstream regulated 1 | 0.00656826 |
| EDN3 | endothelin 3 | 0.00656615 |
| SFRP1 | secreted frizzled-related protein 1 | 0.00654483 |
| DST | dystonin | 0.00654352 |
| IL32 | interleukin 32 | 0.00653262 |
| HSPA8 | heat shock 70kDa protein 8 | 0.00651576 |
| SULT1C2 | sulfotransferase family, cytosolic, 1C, member 2 | 0.00651335 |
| CTSC | cathepsin C | 0.00647916 |
| TUBB4B | tubulin, beta 4B class IVb | 0.00646233 |
| CBX1 | chromobox homolog 1 | 0.00646079 |
| PABPC4 | poly(A) binding protein, cytoplasmic 4 (inducible form) | 0.00638838 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.00636196 |
| HIP1 | huntingtin interacting protein 1 | 0.0063501 |
| FNDC3B | fibronectin type III domain containing 3B | 0.00634917 |
| IFI44L | interferon-induced protein 44-like | 0.0063467 |
| FAM189A2 | family with sequence similarity 189, member A2 | 0.00634662 |
| IPW | imprinted in Prader-Willi syndrome (non-protein coding) | 0.00633478 |
| SNCAIP | synuclein, alpha interacting protein | 0.00630908 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | 0.00630175 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) | 0.00629762 |
| MSX1 | msh homeobox 1 | 0.00627925 |
| NLGN4X | neuroligin 4, X-linked | 0.00626705 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.00624791 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | 0.00622482 |
| PAEP | progestagen-associated endometrial protein | 0.00622267 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.00621435 |
| TRIM36 | tripartite motif containing 36 | 0.00620891 |
| HOXA5 | homeobox A5 | 0.00619422 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 0.00619385 |
| PLCE1 | phospholipase C, epsilon 1 | 0.00617561 |
| GAB2 | GRB2-associated binding protein 2 | 0.00615964 |
| MGLL | monoglyceride lipase | 0.00615163 |
| IRAK1 | interleukin-1 receptor-associated kinase 1 | 0.00614278 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0061265 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0061233 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0061001 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.00609191 |
| ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) | 0.00607536 |
| LAPTM5 | lysosomal protein transmembrane 5 | 0.00606983 |
| CDC20 | cell division cycle 20 | 0.00605976 |
| NEFM | neurofilament, medium polypeptide | 0.00605505 |
| GRK5 | G protein-coupled receptor kinase 5 | 0.0060288 |
| VLDLR | very low density lipoprotein receptor | 0.0060137 |
| TACC1 | transforming, acidic coiled-coil containing protein 1 | 0.00598351 |
| DIXDC1 | DIX domain containing 1 | 0.00595573 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | 0.00594738 |
| TFF3 | trefoil factor 3 (intestinal) | 0.00594717 |
| PLAT | plasminogen activator, tissue | 0.0059449 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.00594319 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | 0.00593351 |
| TNPO3 | transportin 3 | 0.00593274 |
| SLC26A3 | solute carrier family 26 (anion exchanger), member 3 | 0.0059111 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.00588948 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 | 0.00588899 |
| CD93 | CD93 molecule | 0.00588468 |
| VSIG4 | V-set and immunoglobulin domain containing 4 | 0.00587951 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.00587422 |
| NEFH | neurofilament, heavy polypeptide | 0.00586437 |
| LIMA1 | LIM domain and actin binding 1 | 0.00585392 |
| CLDN8 | claudin 8 | 0.00584529 |
| VWF | von Willebrand factor | 0.00583695 |
| STMN2 | stathmin 2 | 0.00583336 |
| PAM | peptidylglycine alpha-amidating monooxygenase | 0.0058166 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.00581069 |
| ITPKB | inositol-trisphosphate 3-kinase B | 0.00580904 |
| PNMA2 | paraneoplastic Ma antigen 2 | 0.00578395 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | 0.00577504 |
| CCN2 | cellular communication network factor 2 | 0.00577219 |
| FBLN5 | fibulin 5 | 0.00575926 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0057585 |
| FMO1 | flavin containing monooxygenase 1 | 0.00573074 |
| TRPM3 | transient receptor potential cation channel, subfamily M, member 3 | 0.0057008 |
| MMP10 | matrix metallopeptidase 10 | 0.00569635 |
| CCDC86 | coiled-coil domain containing 86 | 0.0056553 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.00563657 |
| VPS72 | vacuolar protein sorting 72 homolog (S. cerevisiae) | 0.00563467 |
| OGN | osteoglycin | 0.00560779 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.00560672 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.00560401 |
| SLC27A6 | solute carrier family 27 (fatty acid transporter), member 6 | 0.00557837 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0055752 |
| SLN | sarcolipin | 0.0055592 |
| EXOC5 | exocyst complex component 5 | 0.00554998 |
| MED1 | mediator complex subunit 1 | 0.00554991 |
| GPM6B | glycoprotein M6B | 0.0055452 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | 0.0055299 |
| HSPB8 | heat shock 22kDa protein 8 | 0.00552752 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | 0.00552239 |
| CGA | glycoprotein hormones, alpha polypeptide | 0.00552181 |
| CDH3 | cadherin 3, type 1, P-cadherin (placental) | 0.00551829 |
| MEG3 | maternally expressed 3 (non-protein coding) | 0.00551826 |
| RASIP1 | Ras interacting protein 1 | 0.00551364 |
| FTO | fat mass and obesity associated | 0.00550988 |
| RRAGD | Ras-related GTP binding D | 0.00550415 |
| BBOX1 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | 0.00549192 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.00549019 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.00547499 |
| NDRG4 | NDRG family member 4 | 0.00545355 |
| ACTA1 | actin, alpha 1, skeletal muscle | 0.00545162 |
| ZNF426 | zinc finger protein 426 | 0.0054391 |
| KRT14 | keratin 14, type I | 0.0054265 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | 0.00542284 |
| MATN2 | matrilin 2 | 0.00542063 |
| TRAF3IP2 | TRAF3 interacting protein 2 | 0.00542046 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 0.00541869 |
| LAIR1 | leukocyte-associated immunoglobulin-like receptor 1 | 0.00541087 |
| RBPMS | RNA binding protein with multiple splicing | 0.00540485 |
| REEP1 | receptor accessory protein 1 | 0.00540467 |
| DENND1B | DENN/MADD domain containing 1B | 0.00540339 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.00539248 |
| DKK2 | dickkopf WNT signaling pathway inhibitor 2 | 0.00534877 |
| TRIM29 | tripartite motif containing 29 | 0.00534478 |
| CPM | carboxypeptidase M | 0.00534452 |
| FERMT1 | fermitin family member 1 | 0.00534376 |
| TMEM176A | transmembrane protein 176A | 0.00533993 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.00533852 |
| IER2 | immediate early response 2 | 0.00533086 |
| RIMS3 | regulating synaptic membrane exocytosis 3 | 0.00532391 |
| CYB5R2 | cytochrome b5 reductase 2 | 0.00531656 |
| SMCO4 | single-pass membrane protein with coiled-coil domains 4 | 0.00531496 |
| MMP3 | matrix metallopeptidase 3 | 0.00531325 |
| RGCC | regulator of cell cycle | 0.0053116 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.00531034 |
| RUSC1 | RUN and SH3 domain containing 1 | 0.00527894 |
| CA4 | carbonic anhydrase IV | 0.00527861 |
| MID1 | midline 1 | 0.00526907 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.0130408 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | -0.0118693 |
| F5 | coagulation factor V (proaccelerin, labile factor) | -0.0105721 |
| CRIP2 | cysteine-rich protein 2 | -0.0100696 |
| TM7SF2 | transmembrane 7 superfamily member 2 | -0.00985865 |
| SLC38A2 | solute carrier family 38, member 2 | -0.00983284 |
| FGG | fibrinogen gamma chain | -0.00953376 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.00948977 |
| RPA3 | replication protein A3, 14kDa | -0.00945078 |
| FGB | fibrinogen beta chain | -0.00911491 |
| MMD | monocyte to macrophage differentiation-associated | -0.00908298 |
| SCAND1 | SCAN domain containing 1 | -0.00904077 |
| RAB5IF | RAB5 interacting factor | -0.00898066 |
| CSTA | cystatin A (stefin A) | -0.00889393 |
| PHTF2 | putative homeodomain transcription factor 2 | -0.00883902 |
| CNIH1 | cornichon family AMPA receptor auxiliary protein 1 | -0.00883652 |
| UGT2B15 | UDP glucuronosyltransferase 2 family, polypeptide B15 | -0.00876227 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -0.00875924 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.00872009 |
| FGFR3 | fibroblast growth factor receptor 3 | -0.00858092 |
| TSPAN13 | tetraspanin 13 | -0.00848107 |
| NPY1R | neuropeptide Y receptor Y1 | -0.00843093 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | -0.00838237 |
| ARG1 | arginase 1 | -0.00826469 |
| THBS1 | thrombospondin 1 | -0.00817615 |
| CLDN1 | claudin 1 | -0.00813265 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.008092 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) | -0.00808941 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | -0.00806157 |
| SAR1B | secretion associated, Ras related GTPase 1B | -0.00801831 |
| CYP4F3 | cytochrome P450, family 4, subfamily F, polypeptide 3 | -0.00798631 |
| HP | haptoglobin | -0.00796161 |
| ZBTB18 | zinc finger and BTB domain containing 18 | -0.00793628 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.00788353 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.00785356 |
| TSPYL5 | TSPY-like 5 | -0.00785337 |
| TMEM134 | transmembrane protein 134 | -0.00775872 |
| LEF1 | lymphoid enhancer-binding factor 1 | -0.0077384 |
| DCXR | dicarbonyl/L-xylulose reductase | -0.00771785 |
| RAMP1 | receptor (G protein-coupled) activity modifying protein 1 | -0.00763789 |
| VCAM1 | vascular cell adhesion molecule 1 | -0.00759092 |
| WTAP | Wilms tumor 1 associated protein | -0.00758724 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | -0.00756355 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | -0.00755697 |
| METTL7A | methyltransferase like 7A | -0.00754505 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | -0.00750471 |
| TM4SF4 | transmembrane 4 L six family member 4 | -0.00748315 |
| CST3 | cystatin C | -0.00743309 |
| TOB1 | transducer of ERBB2, 1 | -0.00739006 |
| ADIRF | adipogenesis regulatory factor | -0.00738869 |
| FGL1 | fibrinogen-like 1 | -0.00731294 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.00730496 |
| DCK | deoxycytidine kinase | -0.00725508 |
| PCP4 | Purkinje cell protein 4 | -0.00724734 |
| UGT2B28 | UDP glucuronosyltransferase 2 family, polypeptide B28 | -0.00714988 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.00710331 |
| G0S2 | G0/G1 switch 2 | -0.00710059 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | -0.00709953 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.00709914 |
| GGH | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | -0.00708074 |
| S100P | S100 calcium binding protein P | -0.00704972 |
| ITIH3 | inter-alpha-trypsin inhibitor heavy chain 3 | -0.00704514 |
| AHR | aryl hydrocarbon receptor | -0.00701782 |
| SLC27A5 | solute carrier family 27 (fatty acid transporter), member 5 | -0.00700447 |
| SNAP23 | synaptosomal-associated protein, 23kDa | -0.00699735 |
| KRT10 | keratin 10, type I | -0.00699432 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0069902 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | -0.00697923 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | -0.00695936 |
| METRN | meteorin, glial cell differentiation regulator | -0.00694583 |
| AHSG | alpha-2-HS-glycoprotein | -0.00694071 |
| TMEM14B | transmembrane protein 14B | -0.00693182 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | -0.00693058 |
| PLEKHF2 | pleckstrin homology domain containing, family F (with FYVE domain) member 2 | -0.00692741 |
| CTBS | chitobiase, di-N-acetyl- | -0.00689914 |
| GPX2 | glutathione peroxidase 2 | -0.0068882 |
| LEPR | leptin receptor | -0.00688732 |
| APOC1 | apolipoprotein C-I | -0.00687381 |
| HBD | hemoglobin, delta | -0.00685759 |
| IL1R1 | interleukin 1 receptor, type I | -0.00684759 |
| AADAC | arylacetamide deacetylase | -0.00681402 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | -0.00681204 |
| GOLT1B | golgi transport 1B | -0.00681048 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.00680625 |
| TMEM106B | transmembrane protein 106B | -0.00675146 |
| KLRB1 | killer cell lectin-like receptor subfamily B, member 1 | -0.00670255 |
| ATF1 | activating transcription factor 1 | -0.0066992 |
| CRISP3 | cysteine-rich secretory protein 3 | -0.00669372 |
| EIF5A | eukaryotic translation initiation factor 5A | -0.00668232 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.00667304 |
| DYNLT1 | dynein, light chain, Tctex-type 1 | -0.00666689 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.00665305 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.00662777 |
| TSNAX | translin-associated factor X | -0.00661848 |
| DEFA4 | defensin, alpha 4, corticostatin | -0.00660737 |
| STK10 | serine/threonine kinase 10 | -0.00660684 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | -0.00660303 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | -0.00659445 |
| NXT1 | nuclear transport factor 2-like export factor 1 | -0.00658845 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | -0.00656184 |
| PTGER3 | prostaglandin E receptor 3 (subtype EP3) | -0.00654723 |
| CSK | c-src tyrosine kinase | -0.00653525 |
| ASGR2 | asialoglycoprotein receptor 2 | -0.00653017 |
| LCN2 | lipocalin 2 | -0.00650717 |
| CYP2E1 | cytochrome P450, family 2, subfamily E, polypeptide 1 | -0.00649831 |
| IL6ST | interleukin 6 signal transducer | -0.00645159 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | -0.00644047 |
| CP | ceruloplasmin (ferroxidase) | -0.00643496 |
| RWDD1 | RWD domain containing 1 | -0.00643143 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | -0.00640901 |
| TMEM50B | transmembrane protein 50B | -0.00638726 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | -0.00638378 |
| MSMB | microseminoprotein, beta- | -0.00636372 |
| LSR | lipolysis stimulated lipoprotein receptor | -0.00633684 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.00633021 |
| METTL5 | methyltransferase like 5 | -0.00631059 |
| NMU | neuromedin U | -0.00631024 |
| SDS | serine dehydratase | -0.00629958 |
| RPL39L | ribosomal protein L39-like | -0.00629637 |
| FCN1 | ficolin (collagen/fibrinogen domain containing) 1 | -0.00626574 |
| FAM162A | family with sequence similarity 162, member A | -0.00625066 |
| QPCT | glutaminyl-peptide cyclotransferase | -0.00624274 |
| COMT | catechol-O-methyltransferase | -0.00622978 |
| RPS27L | ribosomal protein S27-like | -0.00619726 |
| ASPN | asporin | -0.00619327 |
| ETNK1 | ethanolamine kinase 1 | -0.00618335 |
| TXNDC9 | thioredoxin domain containing 9 | -0.00615502 |
| ALG5 | ALG5, dolichyl-phosphate beta-glucosyltransferase | -0.0061535 |
| MLF1 | myeloid leukemia factor 1 | -0.00615309 |
| TSPAN6 | tetraspanin 6 | -0.00614306 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 | -0.00613592 |
| GSTO1 | glutathione S-transferase omega 1 | -0.00613104 |
| MOK | MOK protein kinase | -0.00610006 |
| EAPP | E2F-associated phosphoprotein | -0.00608242 |
| RDH11 | retinol dehydrogenase 11 (all-trans/9-cis/11-cis) | -0.00606713 |
| FGA | fibrinogen alpha chain | -0.0060576 |
| AQP9 | aquaporin 9 | -0.00605101 |
| FADS1 | fatty acid desaturase 1 | -0.00605011 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.00603621 |
| TMEM126B | transmembrane protein 126B | -0.00603233 |
| LTBP2 | latent transforming growth factor beta binding protein 2 | -0.00602392 |
| ATP13A3 | ATPase type 13A3 | -0.0060023 |
| GET1 | guided entry of tail-anchored proteins factor 1 | -0.00600054 |
| CD46 | CD46 molecule, complement regulatory protein | -0.00599297 |
| CD52 | CD52 molecule | -0.00597418 |
| BID | BH3 interacting domain death agonist | -0.0059718 |
| MPC2 | mitochondrial pyruvate carrier 2 | -0.00596802 |
| PSMA6 | proteasome (prosome, macropain) subunit, alpha type, 6 | -0.00596495 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.00594277 |
| S100A4 | S100 calcium binding protein A4 | -0.00593951 |
| PRKCB | protein kinase C, beta | -0.00592462 |
| GTF3A | general transcription factor IIIA | -0.00590331 |
| ACP3 | acid phosphatase 3 | -0.00588621 |
| TP53TG1 | TP53 target 1 (non-protein coding) | -0.00588081 |
| MOB4 | MOB family member 4, phocein | -0.0058573 |
| FN1 | fibronectin 1 | -0.00585456 |
| BAMBI | BMP and activin membrane-bound inhibitor | -0.00585189 |
| SNRPG | small nuclear ribonucleoprotein polypeptide G | -0.00585159 |
| LYZ | lysozyme | -0.00584842 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.00583741 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -0.00582758 |
| THAP12 | THAP domain containing 12 | -0.00581065 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.00580879 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | -0.00577474 |
| CCL19 | chemokine (C-C motif) ligand 19 | -0.00577282 |
| CHP1 | calcineurin-like EF-hand protein 1 | -0.00577249 |
| THBS2 | thrombospondin 2 | -0.00576548 |
| CTSH | cathepsin H | -0.00574553 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.00574321 |
| ATG4B | autophagy related 4B, cysteine peptidase | -0.00572347 |
| C12ORF29 | chromosome 12 open reading frame 29 | -0.00572283 |
| TESC | tescalcin | -0.00568357 |
| CPB2 | carboxypeptidase B2 (plasma) | -0.00566921 |
| ADH1A | alcohol dehydrogenase 1A (class I), alpha polypeptide | -0.00564607 |
| FZD6 | frizzled class receptor 6 | -0.00561391 |
| CNPY3 | canopy FGF signaling regulator 3 | -0.00561157 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.00560075 |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 | -0.00558081 |
| CPS1 | carbamoyl-phosphate synthase 1, mitochondrial | -0.00557787 |
| HRASLS | HRAS-like suppressor | -0.00556347 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | -0.00555765 |
| ITIH1 | inter-alpha-trypsin inhibitor heavy chain 1 | -0.00554937 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.00554685 |
| CMC2 | C-x(9)-C motif containing 2 | -0.00554345 |
| ANXA4 | annexin A4 | -0.00551187 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | -0.00550877 |
| FCER1A | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | -0.00550254 |
| CAPN1 | calpain 1, (mu/I) large subunit | -0.00549535 |
| EMP3 | epithelial membrane protein 3 | -0.00548632 |
| SLC38A4 | solute carrier family 38, member 4 | -0.00548184 |
| BCHE | butyrylcholinesterase | -0.00548173 |
| ICAM2 | intercellular adhesion molecule 2 | -0.00548097 |
| PON1 | paraoxonase 1 | -0.00547496 |
| NOTCH2NL | notch 2 N-terminal like | -0.00547354 |
| TMEM165 | transmembrane protein 165 | -0.00546542 |
| DSE | dermatan sulfate epimerase | -0.00546464 |
| F12 | coagulation factor XII (Hageman factor) | -0.00546175 |
| SERF2 | small EDRK-rich factor 2 | -0.00545813 |
| PSCA | prostate stem cell antigen | -0.00545574 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.00545124 |
| COCH | cochlin | -0.00544179 |
| CRP | C-reactive protein, pentraxin-related | -0.00543124 |
| VCAN | versican | -0.00542177 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.00540229 |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) | -0.00538881 |
| LPAR6 | lysophosphatidic acid receptor 6 | -0.00538745 |
| DGKA | diacylglycerol kinase, alpha 80kDa | -0.0053762 |
| SLC25A14 | solute carrier family 25 (mitochondrial carrier, brain), member 14 | -0.00536294 |
| ORM1 | orosomucoid 1 | -0.00535355 |
| LOXL1 | lysyl oxidase-like 1 | -0.00535099 |
| PNN | pinin, desmosome associated protein | -0.0053426 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.00534237 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.00533967 |
| SERPINA7 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 | -0.00533451 |
| SOCS2 | suppressor of cytokine signaling 2 | -0.0053212 |
| SEC24A | SEC24 family member A | -0.0052886 |
| EPHB6 | EPH receptor B6 | -0.00528498 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | -0.00528208 |
| RORA | RAR-related orphan receptor A | -0.0052786 |
| SRP54 | signal recognition particle 54kDa | -0.00527497 |
| CROCCP2 | ciliary rootlet coiled-coil, rootletin pseudogene 2 | -0.00526992 |
| RCN2 | reticulocalbin 2, EF-hand calcium binding domain | -0.00525921 |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | -0.00525597 |
| CLGN | calmegin | -0.00525 |
| ANKRD46 | ankyrin repeat domain 46 | -0.00524829 |
| SAA4 | serum amyloid A4, constitutive | -0.00523916 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.00522682 |
| PTK2B | protein tyrosine kinase 2 beta | -0.00521852 |
| PTGES | prostaglandin E synthase | -0.00520884 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.00520679 |
| MIOS | missing oocyte, meiosis regulator, homolog (Drosophila) | -0.00520572 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -0.00520536 |
| TPSAB1 | tryptase alpha/beta 1 | -0.00519994 |
| C6ORF48 | chromosome 6 open reading frame 48 | -0.00519868 |
| SKIV2L | superkiller viralicidic activity 2-like (S. cerevisiae) | -0.00519616 |
| HSD11B1 | hydroxysteroid (11-beta) dehydrogenase 1 | -0.00518977 |
| PERP | PERP, TP53 apoptosis effector | -0.0051795 |
| CHPT1 | choline phosphotransferase 1 | -0.00517134 |
| PF4 | platelet factor 4 | -0.00516557 |
| NDUFB5 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa | -0.00516006 |
| HAUS3 | HAUS augmin-like complex, subunit 3 | -0.00515842 |
| DIMT1 | DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) | -0.0051577 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.00515225 |
| GNPTAB | N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits | -0.00514565 |
| ATG2A | autophagy related 2A | -0.00511359 |
| CYB5A | cytochrome b5 type A (microsomal) | -0.00511262 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -0.00508539 |
| DGKZ | diacylglycerol kinase, zeta | -0.00507322 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | -0.00506945 |
| SEPHS2 | selenophosphate synthetase 2 | -0.00506044 |
