APAF1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description apoptotic peptidase activating factor 1|This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 317)
External Link http://www.ncbi.nlm.nih.gov/gene/317
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Genes

30 interacting proteins for APAF1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
APIP APAF1 interacting protein
AVEN apoptosis, caspase activation inhibitor
BCL2L1 BCL2-like 1
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CYC1 cytochrome c-1
CYCS cytochrome c, somatic
DIABLO diablo, IAP-binding mitochondrial protein
ELAVL1 ELAV like RNA binding protein 1
FAS Fas cell surface death receptor
FEM1B fem-1 homolog b (C. elegans)
HIP1 huntingtin interacting protein 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1B heat shock 70kDa protein 1B
HSPA4 heat shock 70kDa protein 4
NLRP1 NLR family, pyrin domain containing 1
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
TOP1 topoisomerase (DNA) I
TRIAP1 TP53 regulated inhibitor of apoptosis 1
UBC ubiquitin C
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon