APBA2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description amyloid beta (A4) precursor protein-binding, family A, member 2|The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 321)
External Link http://www.ncbi.nlm.nih.gov/gene/321
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Genes

48 interacting proteins for APBA2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
APP amyloid beta (A4) precursor protein
ATAD3B ATPase family, AAA domain containing 3B
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CLSTN1 calsyntenin 1
CLSTN3 calsyntenin 3
ECI2 enoyl-CoA delta isomerase 2
EIF3C eukaryotic translation initiation factor 3, subunit C
EIF3E eukaryotic translation initiation factor 3, subunit E
FECH ferrochelatase
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
LRP1 low density lipoprotein receptor-related protein 1
LRP2 low density lipoprotein receptor-related protein 2
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LRRC59 leucine rich repeat containing 59
MAP7D1 MAP7 domain containing 1
MAPK6 mitogen-activated protein kinase 6
MYO1A myosin IA
MYO1C myosin IC
N4BP3 NEDD4 binding protein 3
NECAB3 N-terminal EF-hand calcium binding protein 3
NEURL4 neuralized E3 ubiquitin protein ligase 4
NUP153 nucleoporin 153kDa
PLEC plectin
PLEKHA7 pleckstrin homology domain containing, family A member 7
PLK1 polo-like kinase 1
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
PSEN2 presenilin 2
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
RAD17 RAD17 homolog (S. pombe)
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RGPD6 RANBP2-like and GRIP domain containing 6
STXBP1 syntaxin binding protein 1
SUN2 Sad1 and UNC84 domain containing 2
SYTL4 synaptotagmin-like 4
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
USP20 ubiquitin specific peptidase 20
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
ZNF770 zinc finger protein 770