APC Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description adenomatous polyposis coli|This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 324)
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Genes

346 genes differentially expressed following the APC gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
AKR1C3 aldo-keto reductase family 1, member C3 2.42987
PSD4 pleckstrin and Sec7 domain containing 4 2.42987
AMPD1 adenosine monophosphate deaminase 1 2.42987
SCRT2 scratch family zinc finger 2 2.42987
CIITA class II, major histocompatibility complex, transactivator 2.42987
ZMYND12 zinc finger, MYND-type containing 12 2.42987
NLRP7 NLR family, pyrin domain containing 7 2.42987
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 2.42987
TCL1B T-cell leukemia/lymphoma 1B 2.42987
CILP2 cartilage intermediate layer protein 2 2.42987
SLC31A2 solute carrier family 31 (copper transporter), member 2 2.42987
MYPN myopalladin 2.42987
TMEM179 transmembrane protein 179 2.42987
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.42987
NXPH4 neurexophilin 4 2.42987
HLF hepatic leukemia factor 2.42987
IL4I1 interleukin 4 induced 1 2.42987
H3C13 H3 clustered histone 13 2.42987
MYO1A myosin IA 2.42987
ADGRD2 adhesion G protein-coupled receptor D2 2.42987
TLE6 transducin-like enhancer of split 6 2.42987
AKAP3 A kinase (PRKA) anchor protein 3 2.42987
CNTN2 contactin 2 (axonal) 2.42987
FAM178B family with sequence similarity 178, member B 2.42987
KLK4 kallikrein-related peptidase 4 2.42987
HCRTR2 hypocretin (orexin) receptor 2 2.42987
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 2.42987
SH2D2A SH2 domain containing 2A 2.37365
OR52A5 olfactory receptor, family 52, subfamily A, member 5 2.26958
REG4 regenerating islet-derived family, member 4 2.26958
SLC26A7 solute carrier family 26 (anion exchanger), member 7 2.26958
CD1D CD1d molecule 2.26958
PCDHA7 protocadherin alpha 7 2.26958
ERAS ES cell expressed Ras 2.26958
CST11 cystatin 11 2.26958
COL20A1 collagen, type XX, alpha 1 2.26958
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 2.26958
PGLYRP2 peptidoglycan recognition protein 2 2.26958
PCDHA2 protocadherin alpha 2 2.26958
TSSK4 testis-specific serine kinase 4 2.26958
SLC46A2 solute carrier family 46, member 2 2.26958
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 2.26958
CD160 CD160 molecule 2.26958
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.26958
GIMAP4 GTPase, IMAP family member 4 2.26958
SFTPD surfactant protein D 2.26958
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.26958
C3ORF22 chromosome 3 open reading frame 22 2.26958
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 2.26958
USP53 ubiquitin specific peptidase 53 2.26958
C9ORF152 chromosome 9 open reading frame 152 2.26958
FSCN2 fascin actin-bundling protein 2, retinal 2.26958
ZNF324B zinc finger protein 324B 2.26958
GPR20 G protein-coupled receptor 20 2.26958
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 2.26958
SNX9 sorting nexin 9 2.26958
PKP1 plakophilin 1 2.26958
CASP4 caspase 4, apoptosis-related cysteine peptidase 2.26958
UMOD uromodulin 2.26958
MTTP microsomal triglyceride transfer protein 2.26958
CSMD3 CUB and Sushi multiple domains 3 2.26958
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 2.26958
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.26958
LBP lipopolysaccharide binding protein 2.26958
FAM86B2 family with sequence similarity 86, member B2 2.26958
FABP12 fatty acid binding protein 12 2.26958
LOC124909439 uncharacterized LOC124909439 2.26958
HBG1 hemoglobin, gamma A 2.26958
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 2.26958
GBP4 guanylate binding protein 4 2.26958
CAPN9 calpain 9 2.26958
PNLIPRP1 pancreatic lipase-related protein 1 2.26958
KRT86 keratin 86, type II 2.26958
TMPRSS4 transmembrane protease, serine 4 2.26958
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 2.26958
NEBL nebulette 2.26958
USP42 ubiquitin specific peptidase 42 2.26958
BDKRB2 bradykinin receptor B2 2.26958
MYOCOS myocilin opposite strand 2.26958
DNAI7 dynein axonemal intermediate chain 7 2.26958
SPMIP10 sperm microtubule inner protein 10 2.26958
HSFX4 heat shock transcription factor family, X-linked member 4 2.26958
SMIM47 small integral membrane protein 47 2.26958
STRIT1 small transmembrane regulator of ion transport 1 2.26958
REELD1 reeler domain containing 1 2.26958
CTXND1 cortexin domain containing 1 2.26958
IQCN IQ motif containing N 2.26958
ODAPH odontogenesis associated phosphoprotein 2.26958
TAFA1 TAFA chemokine like family member 1 2.26958
VXN vexin 2.26958
CCDC198 coiled-coil domain containing 198 2.26958
SPATA22 spermatogenesis associated 22 2.26958
TINAG tubulointerstitial nephritis antigen 2.26958
PRRT4 proline-rich transmembrane protein 4 2.26958
SLC45A2 solute carrier family 45, member 2 2.26958
GOLGA7B golgin A7 family, member B 2.26958
CXCL16 chemokine (C-X-C motif) ligand 16 2.26958
SUMO4 small ubiquitin-like modifier 4 2.26958
TMEM235 transmembrane protein 235 2.26958
ANXA13 annexin A13 2.26958
SP140 SP140 nuclear body protein 2.26958
ZBTB16 zinc finger and BTB domain containing 16 2.26958
MAGEB1 melanoma antigen family B1 2.26958
MAGEB3 melanoma antigen family B3 2.26958
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 2.26958
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 2.26958
ACE2 angiotensin I converting enzyme 2 2.26958
ZNF684 zinc finger protein 684 2.26958
PXDC1 PX domain containing 1 2.26958
WNT9B wingless-type MMTV integration site family, member 9B 2.26958
NPIPB8 nuclear pore complex interacting protein family, member B8 2.26958
PNPLA1 patatin-like phospholipase domain containing 1 2.26958
LRRC71 leucine rich repeat containing 71 2.26958
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 2.26958
BLNK B-cell linker 2.26958
RBM44 RNA binding motif protein 44 2.26958
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.26958
GDA guanine deaminase 2.26958
ZNF541 zinc finger protein 541 2.26958
PSKH2 protein serine kinase H2 2.26958
SNX31 sorting nexin 31 2.26958
EMP1 epithelial membrane protein 1 2.26958
DRD5 dopamine receptor D5 2.26958
C2CD4D C2 calcium-dependent domain containing 4D 2.26958
BAHCC1 BAH domain and coiled-coil containing 1 2.26958
MCCD1 mitochondrial coiled-coil domain 1 2.26958
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 2.26958
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.26958
IL11 interleukin 11 2.26958
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.26958
CALHM1 calcium homeostasis modulator 1 2.26958
GOLGA6B golgin A6 family, member B 2.26958
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 2.26958
TNR tenascin R 2.26958
DAPK2 death-associated protein kinase 2 2.26958
BTNL8 butyrophilin-like 8 2.26958
C11ORF91 chromosome 11 open reading frame 91 2.26958
SMIM24 small integral membrane protein 24 2.26958
CDHR4 cadherin-related family member 4 2.26958
EMX2 empty spiracles homeobox 2 2.26958
RNASE11 ribonuclease, RNase A family, 11 (non-active) 2.26958
TBC1D10C TBC1 domain family, member 10C 2.26958
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2.26958
SIAH3 siah E3 ubiquitin protein ligase family member 3 2.26958
CCNI2 cyclin I family, member 2 2.26958
RIN1 Ras and Rab interactor 1 2.26958
HDDC3 HD domain containing 3 2.26958
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 2.26958
ADCY4 adenylate cyclase 4 2.26958
HPGDS hematopoietic prostaglandin D synthase 2.26958
ADAM18 ADAM metallopeptidase domain 18 2.26958
CCDC78 coiled-coil domain containing 78 2.26958
CCDC70 coiled-coil domain containing 70 2.26958
MZB1 marginal zone B and B1 cell-specific protein 2.26958
QRFP pyroglutamylated RFamide peptide 2.26958
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 2.26958
SDR42E2 short chain dehydrogenase/reductase family 42E, member 2 2.26958
RNF128 ring finger protein 128, E3 ubiquitin protein ligase 2.26958
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.26958
ASTL astacin-like metallo-endopeptidase (M12 family) 2.26958
TRAPPC2 trafficking protein particle complex 2 2.26958
PRR35 proline rich 35 2.26958
PIP prolactin-induced protein 2.26958
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 2.26958
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.26958
KLHDC8A kelch domain containing 8A 2.26958
DLX2 distal-less homeobox 2 2.26958
CFI complement factor I 2.26958
PLAU plasminogen activator, urokinase 2.26958
MIXL1 Mix paired-like homeobox 2.26958
NNMT nicotinamide N-methyltransferase 2.26958
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 2.26958
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 2.26958
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.26958
SPHK1 sphingosine kinase 1 2.26958
ZNF662 zinc finger protein 662 2.26958
RSPH1 radial spoke head 1 homolog (Chlamydomonas) 2.26958
VSX1 visual system homeobox 1 2.26958
AOC1 amine oxidase, copper containing 1 2.26958
ANXA8 annexin A8 2.26958
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 2.26958
FXYD3 FXYD domain containing ion transport regulator 3 2.26958
EBI3 Epstein-Barr virus induced 3 2.26958
BCL2L10 BCL2-like 10 (apoptosis facilitator) 2.26958
NPC1L1 NPC1-like 1 2.26958
LOXL2 lysyl oxidase-like 2 2.26958
ZNF804A zinc finger protein 804A 2.26958
ACRBP acrosin binding protein 2.26958
CHRDL2 chordin-like 2 2.26958
MYOZ2 myozenin 2 2.26958
VTCN1 V-set domain containing T cell activation inhibitor 1 2.26958
SPRN shadow of prion protein homolog (zebrafish) 2.26958
TCF21 transcription factor 21 2.26958
TSPAN32 tetraspanin 32 2.26958
ATOH7 atonal homolog 7 (Drosophila) 2.26958
ICMT isoprenylcysteine carboxyl methyltransferase 2.26958
OMP olfactory marker protein 2.26958
KEL Kell blood group, metallo-endopeptidase 2.26958
APOD apolipoprotein D 2.26958
C22ORF15 chromosome 22 open reading frame 15 2.26958
EDIL3 EGF-like repeats and discoidin I-like domains 3 2.26958
PRSS53 protease, serine, 53 2.26958
CD177 CD177 molecule 2.26958
POTEI POTE ankyrin domain family, member I 2.26958
AMER3 APC membrane recruitment protein 3 2.26958
EPX eosinophil peroxidase 2.26958
WDFY4 WDFY family member 4 2.26958
RAB40A RAB40A, member RAS oncogene family 2.26958
SEMG1 semenogelin I 2.26958
GFI1B growth factor independent 1B transcription repressor 2.26958
COG5 component of oligomeric golgi complex 5 2.26666
ABHD1 abhydrolase domain containing 1 2.25869
KIFC2 kinesin family member C2 2.25869
SSH1 slingshot protein phosphatase 1 2.2356
FAM91A1 family with sequence similarity 91, member A1 2.2356
PCDHGA6 protocadherin gamma subfamily A, 6 2.23496
KIF1C kinesin family member 1C 2.23423
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 2.2059
RBAK RB-associated KRAB zinc finger 2.18952
GPRIN1 G protein regulated inducer of neurite outgrowth 1 2.16195
FSTL5 follistatin-like 5 2.13008
ABHD14B abhydrolase domain containing 14B 2.11805
TMEM134 transmembrane protein 134 2.11236
LDB1 LIM domain binding 1 2.0881
KRABD5 KRAB domain containing 5 2.08559
RAB5B RAB5B, member RAS oncogene family 2.07669
PDLIM1 PDZ and LIM domain 1 2.05806
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 2.05694
CRIP2 cysteine-rich protein 2 2.05694
TCEAL4 transcription elongation factor A (SII)-like 4 2.05079
PIMREG PICALM interacting mitotic regulator 2.05079
EPB41L5 erythrocyte membrane protein band 4.1 like 5 2.0455
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like 2.02281
ZNF564 zinc finger protein 564 2.02222

decreased expression

Symbol Name Standardized Value
TRPM6 transient receptor potential cation channel, subfamily M, member 6 -2.42987
BTBD18 BTB (POZ) domain containing 18 -2.42987
ARMCX6 armadillo repeat containing, X-linked 6 -2.42987
APOM apolipoprotein M -2.42987
COQ6 coenzyme Q6 monooxygenase -2.42987
WNT2B wingless-type MMTV integration site family, member 2B -2.42987
HLA-DRA major histocompatibility complex, class II, DR alpha -2.42987
BZW2 basic leucine zipper and W2 domains 2 -2.42987
FHOD1 formin homology 2 domain containing 1 -2.42987
RIDA reactive intermediate imine deaminase A homolog -2.42987
PCSK2 proprotein convertase subtilisin/kexin type 2 -2.42987
CNRIP1 cannabinoid receptor interacting protein 1 -2.42987
PBDC1 polysaccharide biosynthesis domain containing 1 -2.37365
VAMP8 vesicle-associated membrane protein 8 -2.26958
MFAP4 microfibrillar-associated protein 4 -2.26958
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 -2.26958
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 -2.26958
ZNF239 zinc finger protein 239 -2.26958
DRP2 dystrophin related protein 2 -2.26958
TP53INP2 tumor protein p53 inducible nuclear protein 2 -2.26958
TMC1 transmembrane channel-like 1 -2.26958
C19ORF38 chromosome 19 open reading frame 38 -2.26958
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 -2.26958
OSGIN1 oxidative stress induced growth inhibitor 1 -2.26958
OR6A2 olfactory receptor, family 6, subfamily A, member 2 -2.26958
PKN1 protein kinase N1 -2.26958
TNS4 tensin 4 -2.26958
EFNA4 ephrin-A4 -2.26958
ESRRB estrogen-related receptor beta -2.26958
DPYD dihydropyrimidine dehydrogenase -2.26958
FOXI3 forkhead box I3 -2.26958
GHRHR growth hormone releasing hormone receptor -2.26958
ERRFI1 ERBB receptor feedback inhibitor 1 -2.26958
GPATCH1 G patch domain containing 1 -2.26958
COMMD7 COMM domain containing 7 -2.26958
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) -2.26958
PEX1 peroxisomal biogenesis factor 1 -2.26958
ELAVL3 ELAV like neuron-specific RNA binding protein 3 -2.26958
CES3 carboxylesterase 3 -2.26958
LOX lysyl oxidase -2.26958
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma -2.26958
RENBP renin binding protein -2.26958
SCG3 secretogranin III -2.26958
SCN2A sodium channel, voltage gated, type II alpha subunit -2.26958
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 -2.26958
PDE4C phosphodiesterase 4C, cAMP-specific -2.26958
UPB1 ureidopropionase, beta -2.26958
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like -2.26958
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -2.26958
ADAP2 ArfGAP with dual PH domains 2 -2.26958
NOS2 nitric oxide synthase 2, inducible -2.26958
IFI16 interferon, gamma-inducible protein 16 -2.26958
OAZ3 ornithine decarboxylase antizyme 3 -2.26958
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 -2.26958
GHDC GH3 domain containing -2.26958
DNAH17 dynein, axonemal, heavy chain 17 -2.26958
C11ORF98 chromosome 11 open reading frame 98 -2.26958
RNFT1 ring finger protein, transmembrane 1 -2.26958
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 -2.26958
MUC16 mucin 16, cell surface associated -2.26958
FBXL22 F-box and leucine-rich repeat protein 22 -2.26958
MAOB monoamine oxidase B -2.26958
SMIM10 small integral membrane protein 10 -2.26958
PLAC8 placenta-specific 8 -2.26958
MOG myelin oligodendrocyte glycoprotein -2.26958
QPCT glutaminyl-peptide cyclotransferase -2.26958
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.26958
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -2.26958
AGBL3 ATP/GTP binding protein-like 3 -2.26958
TNS2 tensin 2 -2.26958
SSPN sarcospan -2.26958
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 -2.26958
NOLC1 nucleolar and coiled-body phosphoprotein 1 -2.26958
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 -2.26958
HRC histidine rich calcium binding protein -2.26958
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) -2.26654
SPOUT1 SPOUT domain containing methyltransferase 1 -2.26149
GRB14 growth factor receptor-bound protein 14 -2.2356
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 -2.22402
EDRF1 erythroid differentiation regulatory factor 1 -2.22085
GDAP2 ganglioside induced differentiation associated protein 2 -2.20622
LYSET lysosomal enzyme trafficking factor -2.2059
RNF114 ring finger protein 114 -2.2059
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) -2.18812
ZNF70 zinc finger protein 70 -2.17925
MGARP mitochondria-localized glutamic acid-rich protein -2.17925
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5 -2.17925
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 -2.17925
OSGEP O-sialoglycoprotein endopeptidase -2.17235
REEP2 receptor accessory protein 2 -2.17171
CCDC50 coiled-coil domain containing 50 -2.16678
TMEM167A transmembrane protein 167A -2.12383
SPG11 spastic paraplegia 11 (autosomal recessive) -2.12364
WRNIP1 Werner helicase interacting protein 1 -2.11805
NTN4 netrin 4 -2.11752
MZT2B mitotic spindle organizing protein 2B -2.11236
CHAC2 ChaC, cation transport regulator homolog 2 (E. coli) -2.10136
PANK4 pantothenate kinase 4 -2.09259
RUNX2 runt-related transcription factor 2 -2.08847
EMC7 ER membrane protein complex subunit 7 -2.08078
CFAP96 cilia and flagella associated protein 96 -2.08078
SNAI3 snail family zinc finger 3 -2.05694
KIAA0586 KIAA0586 -2.05253
ASGR1 asialoglycoprotein receptor 1 -2.05079
CHMP2A charged multivesicular body protein 2A -2.05079
NKAPD1 NKAP domain containing 1 -2.05079
SAMM50 SAMM50 sorting and assembly machinery component -2.05079
TUBB4A tubulin, beta 4A class IVa -2.04735
SLTM SAFB-like, transcription modulator -2.04402
MGAT4C MGAT4 family, member C -2.03652
SLC26A11 solute carrier family 26 (anion exchanger), member 11 -2.01566
RAB28 RAB28, member RAS oncogene family -2.01428