APC Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description adenomatous polyposis coli|This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 324)
External Link http://www.ncbi.nlm.nih.gov/gene/324
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147 interacting proteins for hub protein APC from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ACTN1 actinin, alpha 1
ADGRL1 adhesion G protein-coupled receptor L1
AGFG1 ArfGAP with FG repeats 1
ANKRD17 ankyrin repeat domain 17
ANXA7 annexin A7
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APC adenomatous polyposis coli
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
AXIN1 axin 1
AXIN2 axin 2
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
BUB3 BUB3 mitotic checkpoint protein
C4A complement component 4A (Rodgers blood group)
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CDC20 cell division cycle 20
CDK2 cyclin-dependent kinase 2
CGNL1 cingulin-like 1
CKAP5 cytoskeleton associated protein 5
COG4 component of oligomeric golgi complex 4
COG5 component of oligomeric golgi complex 5
CREBBP CREB binding protein
CSNK1A1 casein kinase 1, alpha 1
CSNK1A1L casein kinase 1, alpha 1-like
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CSNK1G1 casein kinase 1, gamma 1
CSNK1G2 casein kinase 1, gamma 2
CSNK1G3 casein kinase 1, gamma 3
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2B casein kinase 2, beta polypeptide
CTBP1 C-terminal binding protein 1
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNNBIP1 catenin, beta interacting protein 1
CYTH2 cytohesin 2
DDB1 damage-specific DNA binding protein 1, 127kDa
DLG3 discs, large homolog 3 (Drosophila)
DLG4 discs, large homolog 4 (Drosophila)
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DST dystonin
DVL1 dishevelled segment polarity protein 1
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
EPAS1 endothelial PAS domain protein 1
ERBB2IP erbb2 interacting protein
EXPH5 exophilin 5
FAM214A family with sequence similarity 214, member A
FBXO30 F-box protein 30
FHOD1 formin homology 2 domain containing 1
FLNA filamin A, alpha
GIGYF2 GRB10 interacting GYF protein 2
GOLGA2 golgin A2
GSK3B glycogen synthase kinase 3 beta
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HNRNPM heterogeneous nuclear ribonucleoprotein M
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IGHA1 immunoglobulin heavy constant alpha 1
ING5 inhibitor of growth family, member 5
IQGAP1 IQ motif containing GTPase activating protein 1
JUP junction plakoglobin
KIAA1328 KIAA1328
KIF5B kinesin family member 5B
KIFAP3 kinesin-associated protein 3
KRT1 keratin 1, type II
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KRT9 keratin 9, type I
LAMA3 laminin, alpha 3
LAMA4 laminin, alpha 4
MACF1 microtubule-actin crosslinking factor 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MBD5 methyl-CpG binding domain protein 5
MCM3AP minichromosome maintenance complex component 3 associated protein
MCM5 minichromosome maintenance complex component 5
MT-ND4 NADH dehydrogenase, subunit 4 (complex I)
MUC1 mucin 1, cell surface associated
MYH10 myosin, heavy chain 10, non-muscle
MYH11 myosin, heavy chain 11, smooth muscle
MYO6 myosin VI
NAV1 neuron navigator 1
NAV2 neuron navigator 2
NAV3 neuron navigator 3
NCKAP5 NCK-associated protein 5
NCKAP5L NCK-associated protein 5-like
NEB nebulin
NOSTRIN nitric oxide synthase trafficking
NUP153 nucleoporin 153kDa
NUP214 nucleoporin 214kDa
NUP54 nucleoporin 54kDa
NUP98 nucleoporin 98kDa
NUPL1 nucleoporin like 1
NUPL2 nucleoporin like 2
PNISR PNN-interacting serine/arginine-rich protein
POM121 POM121 transmembrane nucleoporin
POM121C POM121 transmembrane nucleoporin C
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCB protein kinase C, beta
PRKG1 protein kinase, cGMP-dependent, type I
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PTK2 protein tyrosine kinase 2
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RANBP2 RAN binding protein 2
RANBP9 RAN binding protein 9
RBM4B RNA binding motif protein 4B
RP1 retinitis pigmentosa 1 (autosomal dominant)
RPS27 ribosomal protein S27
SCRIB scribbled planar cell polarity protein
SEC23A Sec23 homolog A (S. cerevisiae)
SEC31A SEC31 homolog A (S. cerevisiae)
SETDB1 SET domain, bifurcated 1
SFN stratifin
SIAH1 siah E3 ubiquitin protein ligase 1
SMC3 structural maintenance of chromosomes 3
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like
SPTBN1 spectrin, beta, non-erythrocytic 1
SPTBN2 spectrin, beta, non-erythrocytic 2
SYNE1 spectrin repeat containing, nuclear envelope 1
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TBL1X transducin (beta)-like 1X-linked
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TBL1Y transducin (beta)-like 1, Y-linked
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
TPR translocated promoter region, nuclear basket protein
TRIM21 tripartite motif containing 21
TRIM28 tripartite motif containing 28
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
UBC ubiquitin C
XPO1 exportin 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNF106 zinc finger protein 106