| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/11705608 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in APD668 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 1.47 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 1.23 |
| AOC1 | amine oxidase, copper containing 1 | 1.15 |
| B3GNTL1 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 | 0.97 |
| TNKS2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | 0.95 |
| CEP290 | centrosomal protein 290kDa | 0.87 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | 0.85 |
| MAP1A | microtubule-associated protein 1A | 0.82 |
| TSC22D4 | TSC22 domain family, member 4 | 0.8 |
| ZNF724 | zinc finger protein 724 | 0.77 |
| RNF146 | ring finger protein 146 | 0.72 |
| ABHD2 | abhydrolase domain containing 2 | 0.69 |
| C5ORF30 | chromosome 5 open reading frame 30 | 0.66 |
| NRP1 | neuropilin 1 | 0.62 |
| KLHL5 | kelch-like family member 5 | 0.54 |
| KIAA0556 | KIAA0556 | 0.5 |
| FBXO31 | F-box protein 31 | 0.49 |
| TRABD | TraB domain containing | 0.49 |
| KBTBD8 | kelch repeat and BTB (POZ) domain containing 8 | 0.48 |
| STC2 | stanniocalcin 2 | 0.48 |
| ATMIN | ATM interactor | 0.47 |
| PLEKHM1 | pleckstrin homology domain containing, family M (with RUN domain) member 1 | 0.47 |
| ZNF771 | zinc finger protein 771 | 0.47 |
| EREG | epiregulin | 0.46 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.46 |
| ZNF776 | zinc finger protein 776 | 0.45 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.45 |
| ZNF777 | zinc finger protein 777 | 0.45 |
| EGR1 | early growth response 1 | 0.44 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | 0.44 |
| RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing | 0.42 |
| PLEKHG4 | pleckstrin homology domain containing, family G (with RhoGef domain) member 4 | 0.42 |
| TRIM14 | tripartite motif containing 14 | 0.42 |
| R3HDM2 | R3H domain containing 2 | 0.42 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.41 |
| XYLB | xylulokinase homolog (H. influenzae) | 0.41 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.41 |
| TTC39B | tetratricopeptide repeat domain 39B | 0.41 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 0.41 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.41 |
| NIBAN1 | niban apoptosis regulator 1 | 0.41 |
| PIAS3 | protein inhibitor of activated STAT, 3 | 0.4 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.4 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 0.4 |
| ADGRA3 | adhesion G protein-coupled receptor A3 | 0.39 |
| GOLGA4 | golgin A4 | 0.39 |
| IKZF5 | IKAROS family zinc finger 5 (Pegasus) | 0.39 |
| IFT54 | intraflagellar transport 54 | 0.38 |
| PRR14L | proline rich 14-like | 0.38 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 0.38 |
| NBEAL1 | neurobeachin-like 1 | 0.38 |
| CCDC71L | coiled-coil domain containing 71-like | 0.38 |
| C8ORF37 | chromosome 8 open reading frame 37 | 0.38 |
| GPT2 | glutamic pyruvate transaminase (alanine aminotransferase) 2 | 0.37 |
| TULP4 | tubby like protein 4 | 0.37 |
| CASC3 | cancer susceptibility candidate 3 | 0.37 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.37 |
| HMGN4 | high mobility group nucleosomal binding domain 4 | 0.37 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.37 |
| ZMAT5 | zinc finger, matrin-type 5 | 0.36 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.36 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.36 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.36 |
| SYNE4 | spectrin repeat containing, nuclear envelope family member 4 | 0.36 |
| CLOCK | clock circadian regulator | 0.35 |
| GPATCH4 | G patch domain containing 4 | 0.35 |
| CD3EAP | CD3e molecule, epsilon associated protein | 0.35 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.35 |
| CCDC85B | coiled-coil domain containing 85B | 0.35 |
| ASNSD1 | asparagine synthetase domain containing 1 | 0.35 |
| ZNF646 | zinc finger protein 646 | 0.35 |
| BPTF | bromodomain PHD finger transcription factor | 0.35 |
| SPRTN | SprT-like N-terminal domain | 0.35 |
| EEF2KMT | eukaryotic elongation factor 2 lysine methyltransferase | 0.35 |
| ANKRD44 | ankyrin repeat domain 44 | 0.35 |
| TIPE1 | TNF alpha induced protein 8 like 1 | 0.34 |
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | 0.34 |
| ZNF749 | zinc finger protein 749 | 0.34 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.34 |
| EVI5L | ecotropic viral integration site 5-like | 0.33 |
| HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | 0.33 |
| RNF166 | ring finger protein 166 | 0.33 |
| ACY1 | aminoacylase 1 | 0.33 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.33 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.33 |
| SNRNP35 | small nuclear ribonucleoprotein 35kDa (U11/U12) | 0.33 |
| MYH15 | myosin, heavy chain 15 | 0.33 |
| KMT5A | lysine methyltransferase 5A | 0.32 |
| E4F1 | E4F transcription factor 1 | 0.32 |
| FCHSD1 | FCH and double SH3 domains 1 | 0.32 |
| ANKRD20A4 | ankyrin repeat domain 20 family, member A4 | 0.32 |
| TUBE1 | tubulin, epsilon 1 | 0.32 |
| TFCP2L1 | transcription factor CP2-like 1 | 0.32 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.31 |
| GLT8D1 | glycosyltransferase 8 domain containing 1 | 0.31 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.31 |
| DENND4A | DENN/MADD domain containing 4A | 0.31 |
| AMPD1 | adenosine monophosphate deaminase 1 | 0.31 |
| LMO4 | LIM domain only 4 | 0.31 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 0.31 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ALS2CL | ALS2 C-terminal like | -1.76 |
| SBSN | suprabasin | -1.17 |
| COL17A1 | collagen, type XVII, alpha 1 | -1.1 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | -0.91 |
| ZNF654 | zinc finger protein 654 | -0.75 |
| TGDS | TDP-glucose 4,6-dehydratase | -0.72 |
| PDE5A | phosphodiesterase 5A, cGMP-specific | -0.7 |
| SGSH | N-sulfoglucosamine sulfohydrolase | -0.69 |
| SCYL3 | SCY1-like 3 (S. cerevisiae) | -0.66 |
| ZNF28 | zinc finger protein 28 | -0.62 |
| CRYM | crystallin, mu | -0.62 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.6 |
| DHFR | dihydrofolate reductase | -0.58 |
| ZBED1 | zinc finger, BED-type containing 1 | -0.58 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -0.54 |
| NOVA1 | neuro-oncological ventral antigen 1 | -0.53 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | -0.52 |
| BDH2 | 3-hydroxybutyrate dehydrogenase, type 2 | -0.5 |
| ATF6 | activating transcription factor 6 | -0.49 |
| TCP11L2 | t-complex 11, testis-specific-like 2 | -0.49 |
| ABHD4 | abhydrolase domain containing 4 | -0.48 |
| ACBD5 | acyl-CoA binding domain containing 5 | -0.48 |
| SEPTIN5 | septin 5 | -0.47 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.47 |
| FBXO46 | F-box protein 46 | -0.42 |
| PSEN2 | presenilin 2 | -0.42 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.42 |
| HOXB4 | homeobox B4 | -0.41 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.4 |
| DGAT1 | diacylglycerol O-acyltransferase 1 | -0.4 |
| GBA | glucosidase, beta, acid | -0.4 |
| SYTL4 | synaptotagmin-like 4 | -0.39 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.39 |
| PARD6G | par-6 family cell polarity regulator gamma | -0.38 |
| CDK2AP1 | cyclin-dependent kinase 2 associated protein 1 | -0.38 |
| C12ORF60 | chromosome 12 open reading frame 60 | -0.37 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | -0.37 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.36 |
| CUTA | cutA divalent cation tolerance homolog (E. coli) | -0.36 |
| TMEM59 | transmembrane protein 59 | -0.36 |
| TMEM129 | transmembrane protein 129, E3 ubiquitin protein ligase | -0.35 |
| CPLANE1 | ciliogenesis and planar polarity effector complex subunit 1 | -0.35 |
| PXYLP1 | 2-phosphoxylose phosphatase 1 | -0.35 |
| SCD5 | stearoyl-CoA desaturase 5 | -0.35 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | -0.34 |
| B3GNT3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | -0.34 |
| NARF | nuclear prelamin A recognition factor | -0.34 |
| RAB24 | RAB24, member RAS oncogene family | -0.33 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | -0.33 |
| YAP1 | Yes-associated protein 1 | -0.33 |
| CCND3 | cyclin D3 | -0.33 |
| MKRN3 | makorin ring finger protein 3 | -0.33 |
| CASTOR2 | cytosolic arginine sensor for mTORC1 subunit 2 | -0.33 |
| VIM | vimentin | -0.33 |
| FBXO17 | F-box protein 17 | -0.33 |
| ANGPTL4 | angiopoietin-like 4 | -0.32 |
| FAM122B | family with sequence similarity 122B | -0.32 |
| FAM102A | family with sequence similarity 102, member A | -0.32 |
| RASSF7 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 | -0.32 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.32 |
| OTUB2 | OTU deubiquitinase, ubiquitin aldehyde binding 2 | -0.32 |
| HOXB7 | homeobox B7 | -0.31 |
| DGCR2 | DiGeorge syndrome critical region gene 2 | -0.31 |
| COL13A1 | collagen, type XIII, alpha 1 | -0.31 |
| TMEM184A | transmembrane protein 184A | -0.31 |
| SP110 | SP110 nuclear body protein | -0.3 |
| RETREG3 | reticulophagy regulator family member 3 | -0.29 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.29 |
| METTL22 | methyltransferase like 22 | -0.29 |
| TRAF4 | TNF receptor-associated factor 4 | -0.29 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.28 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.28 |
| LMBRD1 | LMBR1 domain containing 1 | -0.28 |
| LRRC49 | leucine rich repeat containing 49 | -0.28 |
| RAC3 | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) | -0.28 |
| DCLRE1A | DNA cross-link repair 1A | -0.28 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | -0.28 |
| ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | -0.28 |
| FEM1A | fem-1 homolog a (C. elegans) | -0.27 |
| FAM89A | family with sequence similarity 89, member A | -0.27 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.27 |
| PCMTD2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | -0.26 |
| XBP1 | X-box binding protein 1 | -0.26 |
| CDCA3 | cell division cycle associated 3 | -0.26 |
| CCDC82 | coiled-coil domain containing 82 | -0.26 |
| DES | desmin | -0.26 |
| TTYH3 | tweety family member 3 | -0.26 |
| F2R | coagulation factor II (thrombin) receptor | -0.25 |
| VSIR | V-set immunoregulatory receptor | -0.25 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.25 |
| PPP2R2D | protein phosphatase 2, regulatory subunit B, delta | -0.25 |
| ALKBH6 | alkB, alkylation repair homolog 6 (E. coli) | -0.24 |
| TEAD2 | TEA domain family member 2 | -0.24 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | -0.24 |
| PCBD2 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 | -0.24 |
| LYSMD2 | LysM, putative peptidoglycan-binding, domain containing 2 | -0.24 |
| CLN8 | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) | -0.24 |
| NMRAL1 | NmrA-like family domain containing 1 | -0.24 |
| ARRB1 | arrestin, beta 1 | -0.24 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.24 |
