APEX1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description APEX nuclease (multifunctional DNA repair enzyme) 1|Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 328)
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Genes

348 genes differentially expressed following the APEX1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CFHR5 complement factor H-related 5 3.46298
TBX18 T-box 18 3.46298
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 3.46298
AZGP1 alpha-2-glycoprotein 1, zinc-binding 3.46298
AFM afamin 3.46298
GJB3 gap junction protein, beta 3, 31kDa 3.46298
FFAR4 free fatty acid receptor 4 3.46298
HBA1 hemoglobin, alpha 1 3.46298
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 3.46298
SUSD2 sushi domain containing 2 3.46298
TRPV3 transient receptor potential cation channel, subfamily V, member 3 3.46298
TM4SF20 transmembrane 4 L six family member 20 3.46298
ZNF467 zinc finger protein 467 3.46298
PCDHB4 protocadherin beta 4 3.46298
HLF hepatic leukemia factor 3.46298
AGTR1 angiotensin II receptor, type 1 3.46298
CARD18 caspase recruitment domain family, member 18 3.46298
HPCAL4 hippocalcin like 4 3.46298
SLC46A3 solute carrier family 46, member 3 3.46298
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 3.46298
NANOS3 nanos homolog 3 (Drosophila) 3.46298
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 3.46298
NXPH4 neurexophilin 4 3.46298
CELA3A chymotrypsin-like elastase family, member 3A 3.46298
GADL1 glutamate decarboxylase-like 1 3.46298
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 3.46298
ZNF556 zinc finger protein 556 3.46298
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) 3.46298
SKOR2 SKI family transcriptional corepressor 2 3.46298
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 3.46298
OIT3 oncoprotein induced transcript 3 3.46298
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 3.46298
BTBD19 BTB (POZ) domain containing 19 3.46298
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 3.46298
GRM6 glutamate receptor, metabotropic 6 3.46298
HIGD1C HIG1 hypoxia inducible domain family, member 1C 3.46298
FXYD3 FXYD domain containing ion transport regulator 3 3.46298
BMP2 bone morphogenetic protein 2 3.46298
MPL MPL proto-oncogene, thrombopoietin receptor 3.46298
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 3.46298
TDRD9 tudor domain containing 9 3.46298
GMFG glia maturation factor, gamma 3.46298
LRRC10B leucine rich repeat containing 10B 3.46298
OXCT2 3-oxoacid CoA transferase 2 3.46298
ZNF324B zinc finger protein 324B 3.46298
DLX4 distal-less homeobox 4 3.46298
TCP11 t-complex 11, testis-specific 3.46298
GMNC geminin coiled-coil domain containing 3.46298
SHE Src homology 2 domain containing E 3.46298
HIPK4 homeodomain interacting protein kinase 4 3.46298
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 3.46298
SBK3 SH3 domain binding kinase family, member 3 3.46298
SPMIP11 sperm microtubule inner protein 11 3.46298
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 3.46298
DNAAF1 dynein, axonemal, assembly factor 1 3.46298
KRT86 keratin 86, type II 3.46298
PLCZ1 phospholipase C, zeta 1 3.46298
SMLR1 small leucine-rich protein 1 3.46298
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 3.46298
FAM228A family with sequence similarity 228, member A 3.46298
PRDM7 PR domain containing 7 3.46298
POU2F3 POU class 2 homeobox 3 3.46298
CSF1 colony stimulating factor 1 (macrophage) 3.46298
GBP6 guanylate binding protein family, member 6 3.46298
PCDHGA9 protocadherin gamma subfamily A, 9 3.46298
STYXL2 serine/threonine/tyrosine interacting like 2 3.46298
CIMAP1D CIMAP1 family member D 3.46298
LOC122526780 uncharacterized LOC122526780 3.46298
H4C14 H4 clustered histone 14 3.46298
TMEM225B transmembrane protein 225B 3.46298
INSYN2B inhibitory synaptic factor family member 2B 3.46298
TERB1 telomere repeat binding bouquet formation protein 1 3.46298
CFAP100 cilia and flagella associated protein 100 3.46298
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 3.46298
DNAI7 dynein axonemal intermediate chain 7 3.46298
PMIS2 PMIS2 transmembrane protein 3.46298
NOXA1 NADPH oxidase activator 1 3.46298
ZAR1L zygote arrest 1-like 3.46298
PGA3 pepsinogen 3, group I (pepsinogen A) 3.46298
SCN10A sodium channel, voltage gated, type X alpha subunit 3.46298
AMBP alpha-1-microglobulin/bikunin precursor 3.46298
ERVFRD-1 endogenous retrovirus group FRD, member 1 3.46298
NXPE4 neurexophilin and PC-esterase domain family, member 4 3.46298
PTPRH protein tyrosine phosphatase, receptor type, H 3.46298
ACTL8 actin-like 8 3.46298
SPDYE6 speedy/RINGO cell cycle regulator family member E6 3.46298
ZNF99 zinc finger protein 99 3.46298
SLC22A14 solute carrier family 22, member 14 3.46298
ACR acrosin 3.46298
CALCA calcitonin-related polypeptide alpha 3.46298
CKM creatine kinase, muscle 3.46298
MEOX2 mesenchyme homeobox 2 3.46298
C7 complement component 7 3.46298
SBSN suprabasin 3.46298
C6ORF118 chromosome 6 open reading frame 118 3.46298
FAM186A family with sequence similarity 186, member A 3.46298
RNF113B ring finger protein 113B 3.46298
BHLHA9 basic helix-loop-helix family, member a9 3.46298
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 3.46298
CXCL14 chemokine (C-X-C motif) ligand 14 3.46298
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 3.46298
CD79A CD79a molecule, immunoglobulin-associated alpha 3.46298
HNF4A hepatocyte nuclear factor 4, alpha 3.46298
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 3.46298
TMEM150B transmembrane protein 150B 3.46298
PDCD1 programmed cell death 1 3.46298
LMOD3 leiomodin 3 (fetal) 3.46298
SLFN12L schlafen family member 12-like 3.46298
ACSM4 acyl-CoA synthetase medium-chain family member 4 3.46298
NTSR1 neurotensin receptor 1 (high affinity) 3.46298
SFRP5 secreted frizzled-related protein 5 3.46298
ZNF843 zinc finger protein 843 3.46298
EDN3 endothelin 3 3.46298
TULP2 tubby like protein 2 3.46298
LPAR5 lysophosphatidic acid receptor 5 3.46298
NUTM2F NUT family member 2F 3.46298
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) 3.46298
MMP7 matrix metallopeptidase 7 3.46298
FGR FGR proto-oncogene, Src family tyrosine kinase 3.46298
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 3.46298
FIBIN fin bud initiation factor homolog (zebrafish) 3.46298
NUPR1 nuclear protein, transcriptional regulator, 1 3.46298
JSRP1 junctional sarcoplasmic reticulum protein 1 3.46298
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 3.46298
CBX8 chromobox homolog 8 3.46298
BTNL9 butyrophilin-like 9 3.46298
SNTA1 syntrophin, alpha 1 3.46298
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 3.46298
EFCAB9 EF-hand calcium binding domain 9 3.46298
EBLN1 endogenous Bornavirus-like nucleoprotein 1 3.46298
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 3.46298
TRIM50 tripartite motif containing 50 3.46298
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 3.46298
POU2AF1 POU class 2 associating factor 1 3.46298
PCDHGA2 protocadherin gamma subfamily A, 2 3.46298
KCNK7 potassium channel, two pore domain subfamily K, member 7 3.46298
LRRC46 leucine rich repeat containing 46 3.46298
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 3.46298
TF transferrin 3.46298
AMN amnion associated transmembrane protein 3.46298
ERVV-2 endogenous retrovirus group V, member 2 3.46298
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 3.46298
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 3.46298
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 3.46298
TRAF3IP3 TRAF3 interacting protein 3 3.46298
GBX1 gastrulation brain homeobox 1 3.46298
MMP19 matrix metallopeptidase 19 3.46298
AHSG alpha-2-HS-glycoprotein 3.46298
ZBTB7C zinc finger and BTB domain containing 7C 3.46298
ICAM1 intercellular adhesion molecule 1 3.46298
NEUROD2 neuronal differentiation 2 3.46298
C22ORF31 chromosome 22 open reading frame 31 3.46298
NRGN neurogranin (protein kinase C substrate, RC3) 3.46298
BTG4 B-cell translocation gene 4 3.46298
NLRP14 NLR family, pyrin domain containing 14 3.46298
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 3.46298
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 3.46298
ADAM20 ADAM metallopeptidase domain 20 3.46298
C10ORF90 chromosome 10 open reading frame 90 3.46298
NNMT nicotinamide N-methyltransferase 3.46298
FCRLB Fc receptor-like B 3.46298
GRAP2 GRB2-related adaptor protein 2 3.46298
TICAM1 toll-like receptor adaptor molecule 1 3.46298
SLC51B solute carrier family 51, beta subunit 3.46298
SCNN1D sodium channel, non voltage gated 1 delta subunit 3.46298
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 3.46298
DMRT1 doublesex and mab-3 related transcription factor 1 3.46298
TEX36 testis expressed 36 3.46298
GPR61 G protein-coupled receptor 61 3.46298
ATP10B ATPase, class V, type 10B 3.46298
SH2D1B SH2 domain containing 1B 3.46298
TGM2 transglutaminase 2 3.46298
UBXN10 UBX domain protein 10 3.46298
CARMIL3 capping protein regulator and myosin 1 linker 3 3.37617
SCN3B sodium channel, voltage gated, type III beta subunit 3.33473
CAMTA2 calmodulin binding transcription activator 2 3.24416
CXXC4 CXXC finger protein 4 3.24416
BRD8 bromodomain containing 8 2.61642
PSAT1 phosphoserine aminotransferase 1 2.59628
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.57233
SMC6 structural maintenance of chromosomes 6 2.51823
TIMM23B translocase of inner mitochondrial membrane 23 homolog B (yeast) 2.51781
CTSO cathepsin O 2.5042
KLHL32 kelch-like family member 32 2.5042
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 2.5042
DNAH6 dynein, axonemal, heavy chain 6 2.5042
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 2.5042
TRO trophinin 2.4651
RIMS2 regulating synaptic membrane exocytosis 2 2.4651
TRAFD1 TRAF-type zinc finger domain containing 1 2.4651
TARBP1 TAR (HIV-1) RNA binding protein 1 2.4254
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa 2.39326
TMEM64 transmembrane protein 64 2.38815
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 2.38815
BRAF B-Raf proto-oncogene, serine/threonine kinase 2.38739
RABGAP1 RAB GTPase activating protein 1 2.38739
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 2.3786
NUP62 nucleoporin 62kDa 2.3523
ACSF3 acyl-CoA synthetase family member 3 2.34852
PPP4R3A protein phosphatase 4 regulatory subunit 3A 2.34442
COA8 cytochrome c oxidase assembly factor 8 2.30972
LARS1 leucyl-tRNA synthetase 1 2.307
UMPS uridine monophosphate synthetase 2.28833
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 2.28585
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 2.28439
MAP2K1 mitogen-activated protein kinase kinase 1 2.28439
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 2.25761
RBM45 RNA binding motif protein 45 2.25557
RNF13 ring finger protein 13 2.24105
IL12RB2 interleukin 12 receptor, beta 2 2.2351
SLC41A3 solute carrier family 41, member 3 2.22582
DEMA1 DPM1 ER membrane anchor 1 2.21304
DTWD1 DTW domain containing 1 2.20286
RPL31 ribosomal protein L31 2.1898
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 2.17887
TCF7 transcription factor 7 (T-cell specific, HMG-box) 2.17887
ZC3H10 zinc finger CCCH-type containing 10 2.17887
MRPS33 mitochondrial ribosomal protein S33 2.17887
EGR1 early growth response 1 2.17887
TTC28 tetratricopeptide repeat domain 28 2.17775
NTF3 neurotrophin 3 2.15879
SERHL2 serine hydrolase-like 2 2.15879
SRP54 signal recognition particle 54kDa 2.14858
SRBD1 S1 RNA binding domain 1 2.14841
SESN2 sestrin 2 2.14841
IKZF4 IKAROS family zinc finger 4 (Eos) 2.14424
RAB5B RAB5B, member RAS oncogene family 2.14148
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 2.13667
FNTB farnesyltransferase, CAAX box, beta 2.13508
MASTL microtubule associated serine/threonine kinase-like 2.12887
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 2.12619
TRIM56 tripartite motif containing 56 2.11527
SGO1 shugoshin 1 2.11363
ZNF761 zinc finger protein 761 2.09293
TMEM41B transmembrane protein 41B 2.09244
ZNF121 zinc finger protein 121 2.0866
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 2.08472
CDC40 cell division cycle 40 2.08371
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 2.07622
POLR2G polymerase (RNA) II (DNA directed) polypeptide G 2.07128
CHAF1A chromatin assembly factor 1, subunit A (p150) 2.06777
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.05248
GCHFR GTP cyclohydrolase I feedback regulator 2.05248
TCEAL7 transcription elongation factor A (SII)-like 7 2.0448
FAM229B family with sequence similarity 229, member B 2.04331
ATP10D ATPase, class V, type 10D 2.00969

decreased expression

Symbol Name Standardized Value
MROH8 maestro heat-like repeat family member 8 -3.46298
CNGA4 cyclic nucleotide gated channel alpha 4 -3.46298
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -3.46298
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 -3.46298
CCK cholecystokinin -3.46298
SMG8 SMG8 nonsense mediated mRNA decay factor -3.46298
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 -3.46298
CCM2L cerebral cavernous malformation 2-like -3.46298
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -3.46298
INPP1 inositol polyphosphate-1-phosphatase -3.46298
TEDC1 tubulin epsilon and delta complex 1 -3.46298
CCDC163 CCDC163 homolog -3.46298
ZFP36L1 ZFP36 ring finger protein-like 1 -3.46298
CATSPER4 cation channel, sperm associated 4 -3.46298
ARID5B AT rich interactive domain 5B (MRF1-like) -3.44485
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta -3.2541
RPN2 ribophorin II -3.18414
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 -3.14736
SH2D4B SH2 domain containing 4B -3.06455
CALR3 calreticulin 3 -3.06455
PRB2 proline-rich protein BstNI subfamily 2 -3.06455
MMRN2 multimerin 2 -3.06455
FDXACB1 ferredoxin-fold anticodon binding domain containing 1 -3.06455
SPATA16 spermatogenesis associated 16 -3.06455
CFAP74 cilia and flagella associated protein 74 -3.06455
OVCH1 ovochymase 1 -3.06455
GOLGA8H golgin A8 family, member H -3.06455
CCDC121 coiled-coil domain containing 121 -3.06455
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) -3.06455
GPR183 G protein-coupled receptor 183 -3.06455
ASB12 ankyrin repeat and SOCS box containing 12 -3.06455
TRAM1L1 translocation associated membrane protein 1-like 1 -3.06455
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) -3.06455
FBP2 fructose-1,6-bisphosphatase 2 -3.06455
MAMLD1 mastermind-like domain containing 1 -3.06455
KLF9 Kruppel-like factor 9 -3.06455
PNPLA1 patatin-like phospholipase domain containing 1 -3.06455
C2CD4B C2 calcium-dependent domain containing 4B -3.06455
KISS1 KiSS-1 metastasis-suppressor -3.06455
GPER1 G protein-coupled estrogen receptor 1 -3.06455
REP15 RAB15 effector protein -3.06455
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) -2.99825
LOC102723564 uncharacterized LOC102723564 -2.9232
YIPF1 Yip1 domain family, member 1 -2.90234
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like -2.90123
CRYBB1 crystallin, beta B1 -2.84229
MRE11 MRE11 homolog, double strand break repair nuclease -2.82663
PEX13 peroxisomal biogenesis factor 13 -2.78567
METTL8 methyltransferase like 8 -2.71591
RANGAP1 Ran GTPase activating protein 1 -2.70178
ARPP19 cAMP-regulated phosphoprotein, 19kDa -2.68943
ARHGAP22 Rho GTPase activating protein 22 -2.64696
PGAP3 post-GPI attachment to proteins 3 -2.5142
ANAPC15 anaphase promoting complex subunit 15 -2.49115
SRP72 signal recognition particle 72kDa -2.4651
NR1D1 nuclear receptor subfamily 1, group D, member 1 -2.4254
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide -2.4254
PATL2 protein associated with topoisomerase II homolog 2 (yeast) -2.4254
GLYATL2 glycine-N-acyltransferase-like 2 -2.40535
PTPRG protein tyrosine phosphatase, receptor type, G -2.40283
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.38815
LRRC7 leucine rich repeat containing 7 -2.38739
CACNB3 calcium channel, voltage-dependent, beta 3 subunit -2.38739
FOXL2 forkhead box L2 -2.38739
ESR2 estrogen receptor 2 (ER beta) -2.38343
DICER1 dicer 1, ribonuclease type III -2.38343
LYSET lysosomal enzyme trafficking factor -2.32642
XPR1 xenotropic and polytropic retrovirus receptor 1 -2.30972
SAMHD1 SAM domain and HD domain 1 -2.28833
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B -2.27416
AARD alanine and arginine rich domain containing protein -2.26654
CXCL6 chemokine (C-X-C motif) ligand 6 -2.26654
DIRAS1 DIRAS family, GTP-binding RAS-like 1 -2.2592
RIN3 Ras and Rab interactor 3 -2.2592
SLC35A4 solute carrier family 35, member A4 -2.25761
TMEM205 transmembrane protein 205 -2.24424
KATNIP katanin interacting protein -2.24105
AK1 adenylate kinase 1 -2.23992
ZC3H12A zinc finger CCCH-type containing 12A -2.17887
CRYL1 crystallin, lambda 1 -2.17887
GRHL1 grainyhead-like 1 (Drosophila) -2.17887
GDAP1L1 ganglioside induced differentiation associated protein 1-like 1 -2.17887
PDZD7 PDZ domain containing 7 -2.14565
SERF1B small EDRK-rich factor 1B (centromeric) -2.14565
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 -2.12619
FBN2 fibrillin 2 -2.12542
BPHL biphenyl hydrolase-like (serine hydrolase) -2.1134
LMBRD1 LMBR1 domain containing 1 -2.09389
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 -2.0933
CDK1 cyclin-dependent kinase 1 -2.0933
RPAP1 RNA polymerase II associated protein 1 -2.09293
MED10 mediator complex subunit 10 -2.09293
PTPRT protein tyrosine phosphatase, receptor type, T -2.09244
TAMM41 TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae) -2.08734
ZCRB1 zinc finger CCHC-type and RNA binding motif 1 -2.0866
ITGB8 integrin, beta 8 -2.05248
BRD9 bromodomain containing 9 -2.04331
APH1B APH1B gamma secretase subunit -2.01886
AKTIP AKT interacting protein -2.01839
SPG11 spastic paraplegia 11 (autosomal recessive) -2.00772
CNMD chondromodulin -2.00772
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 -2.00025