APEX1 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description APEX nuclease (multifunctional DNA repair enzyme) 1|Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 328)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GCM_APEX1
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Genes

187 co-expressed genes for APEX1 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ACTG1 actin gamma 1
ANAPC5 anaphase promoting complex subunit 5
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARMCX6 armadillo repeat containing, X-linked 6
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
ATP5F1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP5L ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G
BCLAF1 BCL2-associated transcription factor 1
BLMH bleomycin hydrolase
BTF3 basic transcription factor 3
C14ORF166 chromosome 14 open reading frame 166
CAPRIN1 cell cycle associated protein 1
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1
CBFB core-binding factor, beta subunit
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CCT7 chaperonin containing TCP1, subunit 7 (eta)
CDC123 cell division cycle 123
CFL1 cofilin 1 (non-muscle)
CHD1L chromodomain helicase DNA binding protein 1-like
CLIC1 chloride intracellular channel 1
COMMD3 COMM domain containing 3
COPS5 COP9 signalosome subunit 5
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CSNK2B casein kinase 2, beta polypeptide
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DHPS deoxyhypusine synthase
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DKC1 dyskeratosis congenita 1, dyskerin
DUT deoxyuridine triphosphatase
EED embryonic ectoderm development
EEF1B2 eukaryotic translation elongation factor 1 beta 2
EEF1G eukaryotic translation elongation factor 1 gamma
EEF2 eukaryotic translation elongation factor 2
EIF3A eukaryotic translation initiation factor 3, subunit A
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3L eukaryotic translation initiation factor 3, subunit L
EIF4A1 eukaryotic translation initiation factor 4A1
EIF4B eukaryotic translation initiation factor 4B
ERH enhancer of rudimentary homolog (Drosophila)
ESD esterase D
EXOSC8 exosome component 8
FBL fibrillarin
FUS FUS RNA binding protein
FXR1 fragile X mental retardation, autosomal homolog 1
GDI2 GDP dissociation inhibitor 2
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GRSF1 G-rich RNA sequence binding factor 1
H2AFV H2A histone family, member V
H2AFZ H2A histone family, member Z
H3F3A H3 histone, family 3A
HDAC1 histone deacetylase 1
HINT1 histidine triad nucleotide binding protein 1
HMGB1 high mobility group box 1
HMGN1 high mobility group nucleosome binding domain 1
HMGN2 high mobility group nucleosomal binding domain 2
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPM heterogeneous nuclear ribonucleoprotein M
HNRNPR heterogeneous nuclear ribonucleoprotein R
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HPRT1 hypoxanthine phosphoribosyltransferase 1
IK IK cytokine, down-regulator of HLA II
ILF2 interleukin enhancer binding factor 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
LMNB2 lamin B2
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MRPL16 mitochondrial ribosomal protein L16
MRPL9 mitochondrial ribosomal protein L9
MTF2 metal response element binding transcription factor 2
NACA nascent polypeptide-associated complex alpha subunit
NAP1L1 nucleosome assembly protein 1-like 1
NASP nuclear autoantigenic sperm protein (histone-binding)
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
NOL11 nucleolar protein 11
NOLC1 nucleolar and coiled-body phosphoprotein 1
NONO non-POU domain containing, octamer-binding
NOP14 NOP14 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NUCLEOLIN nucleolin multifunctional protein
NUP43 nucleoporin 43kDa
PABPN1 poly(A) binding protein, nuclear 1
PCBP1 poly(rC) binding protein 1
PCBP2 poly(rC) binding protein 2
PDS5A PDS5 cohesin associated factor A
PES1 pescadillo ribosomal biogenesis factor 1
PFN1 profilin 1
PNN pinin, desmosome associated protein
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POLG polymerase (DNA directed), gamma
POLR2G polymerase (RNA) II (DNA directed) polypeptide G
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPIH peptidylprolyl isomerase H (cyclophilin H)
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PRMT1 protein arginine methyltransferase 1
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PTBP1 polypyrimidine tract binding protein 1
PTMA prothymosin, alpha
PWP1 PWP1 homolog (S. cerevisiae)
QARS glutaminyl-tRNA synthetase
RAD21 RAD21 homolog (S. pombe)
RBMX RNA binding motif protein, X-linked
RHOA ras homolog family member A
RPL10A ribosomal protein L10a
RPL14 ribosomal protein L14
RPL17 ribosomal protein L17
RPL18 ribosomal protein L18
RPL19 ribosomal protein L19
RPL21 ribosomal protein L21
RPL27 ribosomal protein L27
RPL29 ribosomal protein L29
RPL4 ribosomal protein L4
RPL6 ribosomal protein L6
RPL7 ribosomal protein L7
RPS19 ribosomal protein S19
RPS23 ribosomal protein S23
RPS24 ribosomal protein S24
RPS5 ribosomal protein S5
RPS7 ribosomal protein S7
RPS8 ribosomal protein S8
SERBP1 SERPINE1 mRNA binding protein 1
SET SET nuclear proto-oncogene
SF3B3 splicing factor 3b, subunit 3, 130kDa
SFPQ splicing factor proline/glutamine-rich
SLBP stem-loop binding protein
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC7A5P1 solute carrier family 7 (amino acid transporter light chain, L system), member 5 pseudogene 1
SNRPA small nuclear ribonucleoprotein polypeptide A
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa
SNRPE small nuclear ribonucleoprotein polypeptide E
SNRPF small nuclear ribonucleoprotein polypeptide F
SRP72 signal recognition particle 72kDa
SRSF1 serine/arginine-rich splicing factor 1
SRSF10 serine/arginine-rich splicing factor 10
SRSF2 serine/arginine-rich splicing factor 2
SRSF3 serine/arginine-rich splicing factor 3
SRSF4 serine/arginine-rich splicing factor 4
SRSF7 serine/arginine-rich splicing factor 7
SRSF9 serine/arginine-rich splicing factor 9
SSB Sjogren syndrome antigen B (autoantigen La)
SUMO2 small ubiquitin-like modifier 2
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
SUZ12 SUZ12 polycomb repressive complex 2 subunit
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TARDBP TAR DNA binding protein
TCERG1 transcription elongation regulator 1
TCP1 t-complex 1
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
TOPBP1 topoisomerase (DNA) II binding protein 1
TRA2B transformer 2 beta homolog (Drosophila)
TRIM28 tripartite motif containing 28
U2AF1 U2 small nuclear RNA auxiliary factor 1
U2SURP U2 snRNP-associated SURP domain containing
USP1 ubiquitin specific peptidase 1
WDR41 WD repeat domain 41
WDR46 WD repeat domain 46
XPO1 exportin 1
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNF22 zinc finger protein 22
ZNHIT3 zinc finger, HIT-type containing 3