APH1A Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description APH1A gamma secretase subunit|This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 51107)
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Genes

343 genes differentially expressed following the APH1A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SCGB3A1 secretoglobin, family 3A, member 1 3.46543
THRSP thyroid hormone responsive 3.46543
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 3.46543
OR13C4 olfactory receptor, family 13, subfamily C, member 4 3.46543
MS4A14 membrane-spanning 4-domains, subfamily A, member 14 3.46543
TNS4 tensin 4 3.46543
LCN12 lipocalin 12 3.46543
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 3.46543
CPB1 carboxypeptidase B1 (tissue) 3.46543
TMEM89 transmembrane protein 89 3.46543
ADGB androglobin 3.46543
PECAM1 platelet/endothelial cell adhesion molecule 1 3.46543
CAMP cathelicidin antimicrobial peptide 3.46543
PDIA2 protein disulfide isomerase family A, member 2 3.46543
PCDHGB3 protocadherin gamma subfamily B, 3 3.46543
EPB42 erythrocyte membrane protein band 4.2 3.46543
SKOR2 SKI family transcriptional corepressor 2 3.46543
GJB5 gap junction protein, beta 5, 31.1kDa 3.46543
PAX3 paired box 3 3.46543
XCL1 chemokine (C motif) ligand 1 3.46543
SLC30A2 solute carrier family 30 (zinc transporter), member 2 3.46543
SOWAHB sosondowah ankyrin repeat domain family member B 3.46543
COPZ2 coatomer protein complex, subunit zeta 2 3.46543
ADAT3 adenosine deaminase, tRNA-specific 3 3.46543
DEFB123 defensin, beta 123 3.46543
TAS2R42 taste receptor, type 2, member 42 3.46543
ANXA1 annexin A1 3.46543
PF4V1 platelet factor 4 variant 1 3.46543
GREM1 gremlin 1, DAN family BMP antagonist 3.46543
TGM7 transglutaminase 7 3.46543
TGM4 transglutaminase 4 3.46543
ADRA1B adrenoceptor alpha 1B 3.46543
TEX38 testis expressed 38 3.46543
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 3.46543
MMRN1 multimerin 1 3.46543
LONRF3 LON peptidase N-terminal domain and ring finger 3 3.46543
S100A1 S100 calcium binding protein A1 3.46543
MMP20 matrix metallopeptidase 20 3.46543
LOC102724877 uncharacterized LOC102724877 3.46543
STAP1 signal transducing adaptor family member 1 3.46543
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 3.46543
PCDHGA11 protocadherin gamma subfamily A, 11 3.46543
DHRS9 dehydrogenase/reductase (SDR family) member 9 3.46543
TSSK1B testis-specific serine kinase 1B 3.46543
PTPN7 protein tyrosine phosphatase, non-receptor type 7 3.46543
CIMIP4 ciliary microtubule inner protein 4 3.46543
TLE7 TLE family member 7 3.46543
GBP6 guanylate binding protein family, member 6 3.46543
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 3.46543
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.46543
OTOR otoraplin 3.46543
FMOD fibromodulin 3.46543
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.46543
MAGIX MAGI family member, X-linked 3.46543
NDP Norrie disease (pseudoglioma) 3.46543
MYOCOS myocilin opposite strand 3.46543
TMEM270 transmembrane protein 270 3.46543
PRR20G proline rich 20G 3.46543
TBC1D3I TBC1 domain family member 3I 3.46543
WASH8P WAS protein family homolog 8, pseudogene 3.46543
LOC124903372 uncharacterized LOC124903372 3.46543
SMIM31 small integral membrane protein 31 3.46543
ACP4 acid phosphatase 4 3.46543
STPG3 sperm-tail PG-rich repeat containing 3 3.46543
CFAP107 cilia and flagella associated protein 107 3.46543
H2AC1 H2A clustered histone 1 3.46543
HNF1A HNF1 homeobox A 3.46543
IL16 interleukin 16 3.46543
SBSN suprabasin 3.46543
SBK3 SH3 domain binding kinase family, member 3 3.46543
SIX3 SIX homeobox 3 3.46543
INHBC inhibin, beta C 3.46543
XAF1 XIAP associated factor 1 3.46543
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 3.46543
GNLY granulysin 3.46543
ENTHD1 ENTH domain containing 1 3.46543
IL22RA2 interleukin 22 receptor, alpha 2 3.46543
PRICKLE4 prickle homolog 4 (Drosophila) 3.46543
HABP2 hyaluronan binding protein 2 3.46543
FABP9 fatty acid binding protein 9, testis 3.46543
PIWIL3 piwi-like RNA-mediated gene silencing 3 3.46543
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G 3.46543
TFEC transcription factor EC 3.46543
ADGRG1 adhesion G protein-coupled receptor G1 3.46543
C10ORF67 chromosome 10 open reading frame 67 3.46543
CCR6 chemokine (C-C motif) receptor 6 3.46543
TEX101 testis expressed 101 3.46543
PCDHB11 protocadherin beta 11 3.46543
LIPF lipase, gastric 3.46543
CX3CL1 chemokine (C-X3-C motif) ligand 1 3.46543
THTPA thiamine triphosphatase 3.46543
MAB21L2 mab-21-like 2 (C. elegans) 3.46543
POU2AF1 POU class 2 associating factor 1 3.46543
FIBIN fin bud initiation factor homolog (zebrafish) 3.46543
TTC9B tetratricopeptide repeat domain 9B 3.46543
PCDHGA3 protocadherin gamma subfamily A, 3 3.46543
LMOD2 leiomodin 2 (cardiac) 3.46543
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 3.46543
HRCT1 histidine rich carboxyl terminus 1 3.46543
CLEC4E C-type lectin domain family 4, member E 3.46543
CPA2 carboxypeptidase A2 (pancreatic) 3.46543
MUCL1 mucin-like 1 3.46543
HHATL hedgehog acyltransferase-like 3.46543
CXCR6 chemokine (C-X-C motif) receptor 6 3.46543
CYSLTR1 cysteinyl leukotriene receptor 1 3.46543
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 3.46543
C2ORF66 chromosome 2 open reading frame 66 3.46543
KLF1 Kruppel-like factor 1 (erythroid) 3.46543
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 3.46543
SPO11 SPO11 meiotic protein covalently bound to DSB 3.46543
PDZRN4 PDZ domain containing ring finger 4 3.46543
SST somatostatin 3.46543
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 3.46543
IL27 interleukin 27 3.46543
OTP orthopedia homeobox 3.46543
CLEC18A C-type lectin domain family 18, member A 3.46543
C22ORF31 chromosome 22 open reading frame 31 3.46543
DRC7 dynein regulatory complex subunit 7 3.46543
MB myoglobin 3.46543
OR52N1 olfactory receptor, family 52, subfamily N, member 1 3.46543
GPR149 G protein-coupled receptor 149 3.46543
RGS4 regulator of G-protein signaling 4 3.46543
IZUMO1R IZUMO1 receptor, JUNO 3.46543
UTS2B urotensin 2B 3.46543
ROPN1 rhophilin associated tail protein 1 3.46543
FGR FGR proto-oncogene, Src family tyrosine kinase 3.46543
TPPP2 tubulin polymerization-promoting protein family member 2 3.46543
CLEC9A C-type lectin domain family 9, member A 3.46543
SCNN1B sodium channel, non voltage gated 1 beta subunit 3.46543
GSTA2 glutathione S-transferase alpha 2 3.46543
DLX1 distal-less homeobox 1 3.46543
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.46543
EBF2 early B-cell factor 2 3.46543
FBXO39 F-box protein 39 3.46543
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 3.46543
CCL27 chemokine (C-C motif) ligand 27 3.46543
PRRX1 paired related homeobox 1 3.46543
NXNL1 nucleoredoxin-like 1 3.46543
MC5R melanocortin 5 receptor 3.46543
TMIGD3 transmembrane and immunoglobulin domain containing 3 3.46543
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 3.46543
SHOX2 short stature homeobox 2 3.46543
GIMAP2 GTPase, IMAP family member 2 3.46543
ADGRA1 adhesion G protein-coupled receptor A1 3.46543
UBQLNL ubiquilin-like 3.46543
GRAPL GRB2-related adaptor protein-like 3.46543
ENDOU endonuclease, polyU-specific 3.46543
GPBAR1 G protein-coupled bile acid receptor 1 3.46543
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 3.46543
POU3F3 POU class 3 homeobox 3 3.46543
SMIM22 small integral membrane protein 22 3.46543
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 3.46543
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 3.46065
SLC35D3 solute carrier family 35, member D3 3.46065
NAAA N-acylethanolamine acid amidase 3.0513
ADCY9 adenylate cyclase 9 3.00125
RGS11 regulator of G-protein signaling 11 2.93395
RPL3L ribosomal protein L3-like 2.93395
SCFD1 sec1 family domain containing 1 2.84511
CHURC1 churchill domain containing 1 2.82754
RGS16 regulator of G-protein signaling 16 2.82313
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 2.7457
SEC31B SEC31 homolog B (S. cerevisiae) 2.7457
MATR3 matrin 3 2.70663
PRRC2B proline-rich coiled-coil 2B 2.65768
CDCA4 cell division cycle associated 4 2.65411
BEAN1 brain expressed, associated with NEDD4, 1 2.63637
ATXN2L ataxin 2-like 2.54804
ATP11A ATPase, class VI, type 11A 2.49324
CMSS1 cms1 ribosomal small subunit homolog (yeast) 2.49261
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 2.48008
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 2.45342
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 2.45342
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 2.45342
PTGER4 prostaglandin E receptor 4 (subtype EP4) 2.45342
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 2.42037
NLE1 notchless homolog 1 (Drosophila) 2.40374
CROCC ciliary rootlet coiled-coil, rootletin 2.38011
CLIP1 CAP-GLY domain containing linker protein 1 2.37401
SUMF2 sulfatase modifying factor 2 2.37248
ATXN1 ataxin 1 2.37234
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 2.34545
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 2.34066
TNRC6A trinucleotide repeat containing 6A 2.33552
F2RL1 coagulation factor II (thrombin) receptor-like 1 2.33504
BRD9 bromodomain containing 9 2.32291
LEP leptin 2.32016
TLR7 toll-like receptor 7 2.32016
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 2.31196
BAHCC1 BAH domain and coiled-coil containing 1 2.31196
GSTZ1 glutathione S-transferase zeta 1 2.28045
TAOK3 TAO kinase 3 2.27677
SH3BP1 SH3-domain binding protein 1 2.26761
ARTN artemin 2.26018
FTO fat mass and obesity associated 2.23493
CXCL2 chemokine (C-X-C motif) ligand 2 2.22978
ERAP1 endoplasmic reticulum aminopeptidase 1 2.19392
ZNF385B zinc finger protein 385B 2.18472
ARHGAP19 Rho GTPase activating protein 19 2.17434
ANKAR ankyrin and armadillo repeat containing 2.15656
SATL1 spermidine/spermine N1-acetyl transferase-like 1 2.15584
GDI1 GDP dissociation inhibitor 1 2.12885
TNNT2 troponin T type 2 (cardiac) 2.107
TAS2R4 taste receptor, type 2, member 4 2.1052
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 2.08763
PKD2 polycystic kidney disease 2 (autosomal dominant) 2.087
NCALD neurocalcin delta 2.08466
SH3KBP1 SH3-domain kinase binding protein 1 2.08399
RAB23 RAB23, member RAS oncogene family 2.07282
COL4A5 collagen, type IV, alpha 5 2.06497
ASPN asporin 2.06497
CHPF chondroitin polymerizing factor 2.05088
MYBBP1A MYB binding protein (P160) 1a 2.05088
ATL2 atlastin GTPase 2 2.03201
LYSET lysosomal enzyme trafficking factor 2.03201
AGFG2 ArfGAP with FG repeats 2 2.02466

decreased expression

Symbol Name Standardized Value
MUC6 mucin 6, oligomeric mucus/gel-forming -3.46543
SNX17 sorting nexin 17 -3.46543
LY6G5B lymphocyte antigen 6 complex, locus G5B -3.46543
SYTL4 synaptotagmin-like 4 -3.46543
PSORS1C1 psoriasis susceptibility 1 candidate 1 -3.46543
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 -3.46543
OR51M1 olfactory receptor, family 51, subfamily M, member 1 -3.46543
MYPN myopalladin -3.46543
ARHGAP23 Rho GTPase activating protein 23 -3.46543
FXYD3 FXYD domain containing ion transport regulator 3 -3.46543
TMEM79 transmembrane protein 79 -3.46543
DRC5 dynein regulatory complex subunit 5 -3.46543
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit -3.46543
LURAP1L leucine rich adaptor protein 1-like -3.46543
RGPD3 RANBP2-like and GRIP domain containing 3 -3.46543
CCDC17 coiled-coil domain containing 17 -3.46543
HIPK4 homeodomain interacting protein kinase 4 -3.46543
LRRC61 leucine rich repeat containing 61 -3.46543
BRICD5 BRICHOS domain containing 5 -3.46543
SLC22A25 solute carrier family 22, member 25 -3.46543
GPX2 glutathione peroxidase 2 -3.46543
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein -3.46543
SFR1 SWI5-dependent recombination repair 1 -3.46543
CES4A carboxylesterase 4A -3.46543
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 -3.46543
FNDC8 fibronectin type III domain containing 8 -3.46543
PENK proenkephalin -3.46543
EPPIN epididymal peptidase inhibitor -3.46543
TBX1 T-box 1 -3.46543
PLA2G2C phospholipase A2, group IIC -3.46543
SIDT1 SID1 transmembrane family, member 1 -3.46543
NOTCH2NLB notch 2 N-terminal like B -3.46543
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q -3.44323
POLR2G polymerase (RNA) II (DNA directed) polypeptide G -3.40418
ICOSLG inducible T-cell co-stimulator ligand -3.3987
ADAM21 ADAM metallopeptidase domain 21 -3.3987
RNPEP arginyl aminopeptidase (aminopeptidase B) -3.01674
CACNG5 calcium channel, voltage-dependent, gamma subunit 5 -3.00125
APH1A APH1A gamma secretase subunit -2.94786
ZBTB12 zinc finger and BTB domain containing 12 -2.88875
REL v-rel avian reticuloendotheliosis viral oncogene homolog -2.86239
CR1L complement component (3b/4b) receptor 1-like -2.85605
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -2.85605
LAMA4 laminin, alpha 4 -2.84864
RPL21 ribosomal protein L21 -2.84702
VDAC1 voltage-dependent anion channel 1 -2.76161
HELZ helicase with zinc finger -2.7124
IGFBP3 insulin-like growth factor binding protein 3 -2.70976
MTA2 metastasis associated 1 family, member 2 -2.70076
H3C1 H3 clustered histone 1 -2.6781
SETD2 SET domain containing 2 -2.64311
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -2.57765
CDC37 cell division cycle 37 -2.55359
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa -2.53708
ARHGAP21 Rho GTPase activating protein 21 -2.53708
TXNRD1 thioredoxin reductase 1 -2.51347
ATP9B ATPase, class II, type 9B -2.49324
LRRN2 leucine rich repeat neuronal 2 -2.45342
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 -2.44515
TENT5D terminal nucleotidyltransferase 5D -2.42037
GNG8 guanine nucleotide binding protein (G protein), gamma 8 -2.42037
CCHCR1 coiled-coil alpha-helical rod protein 1 -2.42037
ZCRB1 zinc finger CCHC-type and RNA binding motif 1 -2.40892
F5 coagulation factor V (proaccelerin, labile factor) -2.38345
DNAAF19 dynein axonemal assembly factor 19 -2.38345
CD27 CD27 molecule -2.38345
PLK5 polo-like kinase 5 -2.38345
FNBP4 formin binding protein 4 -2.38229
ADRA2A adrenoceptor alpha 2A -2.37248
ERVV-2 endogenous retrovirus group V, member 2 -2.37248
KCNK13 potassium channel, two pore domain subfamily K, member 13 -2.37248
SYCP3 synaptonemal complex protein 3 -2.37248
ZNF704 zinc finger protein 704 -2.3644
SPATA16 spermatogenesis associated 16 -2.36178
PTPRB protein tyrosine phosphatase, receptor type, B -2.34483
ZNF222 zinc finger protein 222 -2.34483
SYT5 synaptotagmin V -2.34483
MKX mohawk homeobox -2.34182
CAPRIN2 caprin family member 2 -2.326
RHOV ras homolog family member V -2.31315
ZDHHC11B zinc finger, DHHC-type containing 11B -2.31315
MTG2 mitochondrial ribosome-associated GTPase 2 -2.25155
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 -2.24872
MTPAP mitochondrial poly(A) polymerase -2.24642
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 -2.24599
OR2A42 olfactory receptor, family 2, subfamily A, member 42 -2.24599
TUBA1C tubulin, alpha 1c -2.23099
CBARP CACN subunit beta associated regulatory protein -2.21317
STMN1 stathmin 1 -2.212
THYN1 thymocyte nuclear protein 1 -2.212
HK2 hexokinase 2 -2.20559
PHB1 prohibitin 1 -2.20139
PHF5A PHD finger protein 5A -2.19201
SCAMP3 secretory carrier membrane protein 3 -2.18472
RGS7BP regulator of G-protein signaling 7 binding protein -2.18472
TRIP4 thyroid hormone receptor interactor 4 -2.18472
PTAFR platelet-activating factor receptor -2.17747
MRPL2 mitochondrial ribosomal protein L2 -2.16913
MCF2 MCF.2 cell line derived transforming sequence -2.15656
LHX6 LIM homeobox 6 -2.15584
GHRL ghrelin/obestatin prepropeptide -2.14779
ING2 inhibitor of growth family, member 2 -2.14347
PLEKHA7 pleckstrin homology domain containing, family A member 7 -2.14108
CDK5RAP1 CDK5 regulatory subunit associated protein 1 -2.13069
TIMM29 translocase of inner mitochondrial membrane 29 -2.12222
RPL3 ribosomal protein L3 -2.12222
CELA2B chymotrypsin-like elastase family, member 2B -2.1161
BSPRY B-box and SPRY domain containing -2.1161
TRAM1L1 translocation associated membrane protein 1-like 1 -2.11405
F12 coagulation factor XII (Hageman factor) -2.10629
NIT1 nitrilase 1 -2.09474
PCGF3 polycomb group ring finger 3 -2.09024
RARS1 arginyl-tRNA synthetase 1 -2.08997
AOPEP aminopeptidase O (putative) -2.08859
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae) -2.08763
GSTM2 glutathione S-transferase mu 2 (muscle) -2.08579
SFT2D3 SFT2 domain containing 3 -2.08399
RTN4IP1 reticulon 4 interacting protein 1 -2.07928
TRAPPC6B trafficking protein particle complex 6B -2.05088
PDCD6IP programmed cell death 6 interacting protein -2.05088
AFF4 AF4/FMR2 family, member 4 -2.04875
KIRREL2 kin of IRRE like 2 (Drosophila) -2.03201
METTL18 methyltransferase like 18 -2.03201
OLFM1 olfactomedin 1 -2.03201
DPF3 D4, zinc and double PHD fingers, family 3 -2.03201
MROH6 maestro heat-like repeat family member 6 -2.03201
USP35 ubiquitin specific peptidase 35 -2.02466