APH1A Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description APH1A gamma secretase subunit|This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 51107)
External Link http://www.ncbi.nlm.nih.gov/gene/51107
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43 interacting proteins for APH1A from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
ATF4 activating transcription factor 4
BHLHE40 basic helix-loop-helix family, member e40
CREB3 cAMP responsive element binding protein 3
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DLL1 delta-like 1 (Drosophila)
DTX1 deltex 1, E3 ubiquitin ligase
DTX2 deltex 2, E3 ubiquitin ligase
DTX4 deltex 4, E3 ubiquitin ligase
ELAVL1 ELAV like RNA binding protein 1
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
EPHB4 EPH receptor B4
EPHB6 EPH receptor B6
ERBB4 erb-b2 receptor tyrosine kinase 4
ERLIN2 ER lipid raft associated 2
GLP1R glucagon-like peptide 1 receptor
GPATCH8 G patch domain containing 8
HES1 hes family bHLH transcription factor 1
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HNF4A hepatocyte nuclear factor 4, alpha
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
KLF11 Kruppel-like factor 11
NCSTN nicastrin
NGF nerve growth factor (beta polypeptide)
NGFR nerve growth factor receptor
NOTCH1 notch 1
NOTCH2 notch 2
NOTCH3 notch 3
NOTCH4 notch 4
PSEN1 presenilin 1
PSEN2 presenilin 2
PSENEN presenilin enhancer gamma secretase subunit
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
SDC3 syndecan 3
SORT1 sortilin 1
THPO thrombopoietin
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
UBC ubiquitin C
ZNF274 zinc finger protein 274