APOA1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description apolipoprotein A-I|This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 335)
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Genes

352 genes differentially expressed following the APOA1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
VIT vitrin 2.81109
MAP3K7CL MAP3K7 C-terminal like 2.81109
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.81109
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.81109
FBXL8 F-box and leucine-rich repeat protein 8 2.81109
ADGRE3 adhesion G protein-coupled receptor E3 2.81109
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.81109
LRRTM4 leucine rich repeat transmembrane neuronal 4 2.81109
SLC16A11 solute carrier family 16, member 11 2.81109
PRICKLE4 prickle homolog 4 (Drosophila) 2.81109
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 2.81109
PGAM4 phosphoglycerate mutase family member 4 2.81109
ELF4 E74-like factor 4 (ets domain transcription factor) 2.81109
TARP TCR gamma alternate reading frame protein 2.81109
PCDHA3 protocadherin alpha 3 2.81109
TMEM229A transmembrane protein 229A 2.81109
LIPM lipase, family member M 2.81109
RLBP1 retinaldehyde binding protein 1 2.81109
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.81109
ZRANB1 zinc finger, RAN-binding domain containing 1 2.81109
FAM3D family with sequence similarity 3, member D 2.81109
TBX21 T-box 21 2.81109
PDILT protein disulfide isomerase-like, testis expressed 2.81109
HNF4A hepatocyte nuclear factor 4, alpha 2.81109
SRL sarcalumenin 2.81109
TRIM15 tripartite motif containing 15 2.81109
FGL2 fibrinogen-like 2 2.81109
SPNS2 spinster homolog 2 (Drosophila) 2.81109
RGPD1 RANBP2-like and GRIP domain containing 1 2.81109
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.81109
TTLL2 tubulin tyrosine ligase-like family member 2 2.81109
FABP12 fatty acid binding protein 12 2.81109
C8ORF74 chromosome 8 open reading frame 74 2.81109
S100A2 S100 calcium binding protein A2 2.81109
NPIPA3 nuclear pore complex interacting protein family, member A3 2.81109
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 2.81109
MUC20 mucin 20, cell surface associated 2.81109
CRYGN crystallin, gamma N 2.81109
UBA7 ubiquitin-like modifier activating enzyme 7 2.81109
TMEM217 transmembrane protein 217 2.81109
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.81109
SLC35G5 solute carrier family 35, member G5 2.81109
OSGIN1 oxidative stress induced growth inhibitor 1 2.81109
ERN2 endoplasmic reticulum to nucleus signaling 2 2.81109
OR10A2 olfactory receptor, family 10, subfamily A, member 2 2.81109
TMEM191C transmembrane protein 191C 2.81109
PTH2 parathyroid hormone 2 2.81109
OPRL1 opiate receptor-like 1 2.81109
FAM86B2 family with sequence similarity 86, member B2 2.81109
SPINT3 serine peptidase inhibitor, Kunitz type, 3 2.81109
GBP1 guanylate binding protein 1, interferon-inducible 2.81109
TAS2R13 taste receptor, type 2, member 13 2.81109
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.81109
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.81109
MUCL3 mucin like 3 2.81109
CHCT1 CHD1 helical C-terminal domain containing 1 2.81109
NDUFAF8 NADH:ubiquinone oxidoreductase complex assembly factor 8 2.81109
H2BC3 H2B clustered histone 3 2.81109
BNIP5 BCL2 interacting protein 5 2.81109
HJV hemojuvelin BMP co-receptor 2.81109
MINAR1 membrane integral NOTCH2 associated receptor 1 2.81109
LORICRIN loricrin cornified envelope precursor protein 2.81109
LOC122539214 Zinc finger protein LOC122539214 2.81109
OTOF otoferlin 2.81109
CD300LF CD300 molecule-like family member f 2.81109
RAMACL RNA guanine-7 methyltransferase activating subunit like 2.81109
INSYN1 inhibitory synaptic factor 1 2.81109
SPATA31G1 SPATA31 subfamily G member 1 2.81109
OR1R1 olfactory receptor family 1 subfamily R member 1 2.81109
SPMIP9 sperm microtubule inner protein 9 2.81109
TEKTL1 tektin like 1 2.81109
LY6S lymphocyte antigen 6 family member S 2.81109
TEX53 testis expressed 53 2.81109
SMIM32 small integral membrane protein 32 2.81109
LITAFD LITAF domain containing 2.81109
FAM240C family with sequence similarity 240 member C 2.81109
FAM237A family with sequence similarity 237 member A 2.81109
REELD1 reeler domain containing 1 2.81109
UBN2 ubinuclein 2 2.81109
VN1R1 vomeronasal 1 receptor 1 2.81109
MYOT myotilin 2.81109
C1QL2 complement component 1, q subcomponent-like 2 2.81109
SH3TC2 SH3 domain and tetratricopeptide repeats 2 2.81109
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.81109
NPNT nephronectin 2.81109
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.81109
CXCL16 chemokine (C-X-C motif) ligand 16 2.81109
SLC22A25 solute carrier family 22, member 25 2.81109
CD48 CD48 molecule 2.81109
DAO D-amino-acid oxidase 2.81109
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 2.81109
EXOC3L1 exocyst complex component 3-like 1 2.81109
CCR3 chemokine (C-C motif) receptor 3 2.81109
RD3 retinal degeneration 3 2.81109
MLN motilin 2.81109
MUSTN1 musculoskeletal, embryonic nuclear protein 1 2.81109
PROC protein C (inactivator of coagulation factors Va and VIIIa) 2.81109
MYEOV myeloma overexpressed 2.81109
FAM228A family with sequence similarity 228, member A 2.81109
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 2.81109
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 2.81109
METTL4 methyltransferase like 4 2.81109
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.81109
S100G S100 calcium binding protein G 2.81109
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 2.81109
CETP cholesteryl ester transfer protein, plasma 2.81109
PLA2G4E phospholipase A2, group IVE 2.81109
DES desmin 2.81109
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.81109
FNDC9 fibronectin type III domain containing 9 2.81109
C1ORF185 chromosome 1 open reading frame 185 2.81109
CCDC70 coiled-coil domain containing 70 2.81109
EFCAB3 EF-hand calcium binding domain 3 2.81109
ARR3 arrestin 3, retinal (X-arrestin) 2.81109
CTAGE9 CTAGE family, member 9 2.81109
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) 2.81109
PLA2G4D phospholipase A2, group IVD (cytosolic) 2.81109
PTGDR prostaglandin D2 receptor (DP) 2.81109
ITPKA inositol-trisphosphate 3-kinase A 2.81109
AQP1 aquaporin 1 (Colton blood group) 2.81109
FGF16 fibroblast growth factor 16 2.81109
ZPBP zona pellucida binding protein 2.81109
STARD10 StAR-related lipid transfer (START) domain containing 10 2.81109
VTCN1 V-set domain containing T cell activation inhibitor 1 2.81109
POTEI POTE ankyrin domain family, member I 2.81109
TEX29 testis expressed 29 2.81109
EOMES eomesodermin 2.81109
C9ORF50 chromosome 9 open reading frame 50 2.81109
ETV3L ets variant 3-like 2.81109
REST RE1-silencing transcription factor 2.81109
FAIM2 Fas apoptotic inhibitory molecule 2 2.81109
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 2.81109
DEFB135 defensin, beta 135 2.81109
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2.81109
SIGLEC15 sialic acid binding Ig-like lectin 15 2.81109
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.81109
VAV1 vav 1 guanine nucleotide exchange factor 2.81109
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.81109
SLC38A8 solute carrier family 38, member 8 2.81109
QRFP pyroglutamylated RFamide peptide 2.81109
SLCO2B1 solute carrier organic anion transporter family, member 2B1 2.81109
UTS2R urotensin 2 receptor 2.81109
KLHL41 kelch-like family member 41 2.81109
ADAM12 ADAM metallopeptidase domain 12 2.81109
CTRB1 chymotrypsinogen B1 2.81109
TTC9B tetratricopeptide repeat domain 9B 2.81109
CRHR1 corticotropin releasing hormone receptor 1 2.81109
PLA2G2C phospholipase A2, group IIC 2.81109
GPR142 G protein-coupled receptor 142 2.81109
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.81109
KLK4 kallikrein-related peptidase 4 2.81109
HK3 hexokinase 3 (white cell) 2.81109
CD28 CD28 molecule 2.81109
SLC39A12 solute carrier family 39 (zinc transporter), member 12 2.81109
NPPC natriuretic peptide C 2.81109
SPINT4 serine peptidase inhibitor, Kunitz type 4 2.81109
FGF9 fibroblast growth factor 9 2.81109
FAM161B family with sequence similarity 161, member B 2.81109
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 2.81109
MZB1 marginal zone B and B1 cell-specific protein 2.81109
OR52N2 olfactory receptor, family 52, subfamily N, member 2 2.81109
BTBD16 BTB (POZ) domain containing 16 2.81109
RBP4 retinol binding protein 4, plasma 2.81109
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2 2.81109
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.81109
UPK1B uroplakin 1B 2.81109
GALR3 galanin receptor 3 2.81109
SPX spexin hormone 2.81109
ETV2 ets variant 2 2.81109
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.81109
OIT3 oncoprotein induced transcript 3 2.81109
THEMIS thymocyte selection associated 2.81109
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.81109
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.81109
NFE2 nuclear factor, erythroid 2 2.81109
OR51I2 olfactory receptor, family 51, subfamily I, member 2 2.81109
GPRC5A G protein-coupled receptor, class C, group 5, member A 2.81109
FRMPD1 FERM and PDZ domain containing 1 2.81109
GOLGA8H golgin A8 family, member H 2.81109
SPNS3 spinster homolog 3 (Drosophila) 2.81109
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.81109
TMPRSS13 transmembrane protease, serine 13 2.81109
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.81109
GP5 glycoprotein V (platelet) 2.81109
EVI2A ecotropic viral integration site 2A 2.81109
GRAP2 GRB2-related adaptor protein 2 2.81109
ELMO2 engulfment and cell motility 2 2.80868
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 2.77026
MESD mesoderm development LRP chaperone 2.7637
SEC61B Sec61 beta subunit 2.73129
ZNF200 zinc finger protein 200 2.704
REC114 REC114 meiotic recombination protein 2.68324
C20ORF203 chromosome 20 open reading frame 203 2.68324
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa 2.68324
TTLL1 tubulin tyrosine ligase-like family member 1 2.68324
SERTM1 serine-rich and transmembrane domain containing 1 2.59212
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 2.59212
BMP8B bone morphogenetic protein 8b 2.59012
OLFML2A olfactomedin-like 2A 2.57883
NELFE negative elongation factor complex member E 2.49508
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 2.49508
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 2.47047
PELO pelota homolog (Drosophila) 2.40576
NRDC nardilysin convertase 2.37957
UBL3 ubiquitin-like 3 2.33497
H1-5 H1.5 linker histone, cluster member 2.31399
C14ORF132 chromosome 14 open reading frame 132 2.31335
RUFY3 RUN and FYVE domain containing 3 2.3031
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 2.29792
TMCO1 transmembrane and coiled-coil domains 1 2.29115
PEDS1 plasmanylethanolamine desaturase 1 2.2519
RAE1 ribonucleic acid export 1 2.24663
HKDC1 hexokinase domain containing 1 2.23238
AMOTL1 angiomotin like 1 2.21054
KIAA1549 KIAA1549 2.18123
RPL35 ribosomal protein L35 2.17695
CRB2 crumbs family member 2 2.16118
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 2.13924
USP45 ubiquitin specific peptidase 45 2.13502
ZDHHC5 zinc finger, DHHC-type containing 5 2.09824
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 2.09187
GUCD1 guanylyl cyclase domain containing 1 2.08459
HNRNPK heterogeneous nuclear ribonucleoprotein K 2.06684
CTNNA2 catenin (cadherin-associated protein), alpha 2 2.05929
CLSPN claspin 2.05929
RABL2B RAB, member of RAS oncogene family-like 2B 2.05905
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 2.05905
MAML1 mastermind-like 1 (Drosophila) 2.05905
TMEM218 transmembrane protein 218 2.05905
LSM10 LSM10, U7 small nuclear RNA associated 2.05168
TMEM167B transmembrane protein 167B 2.04
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 2.03966
TUBE1 tubulin, epsilon 1 2.03728
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 2.03347
SFR1 SWI5-dependent recombination repair 1 2.03201
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 2.02869
RBM39 RNA binding motif protein 39 2.02869
ACTN2 actinin, alpha 2 2.02869
MEX3D mex-3 RNA binding family member D 2.02179
POLR1H RNA polymerase I subunit H 2.01648
PPP6R3 protein phosphatase 6, regulatory subunit 3 2.01637
USP31 ubiquitin specific peptidase 31 2.00747
ACER3 alkaline ceramidase 3 2.00747
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 2.00685
ZBTB9 zinc finger and BTB domain containing 9 2.0061

decreased expression

Symbol Name Standardized Value
PVRIG poliovirus receptor related immunoglobulin domain containing -2.81109
IRF8 interferon regulatory factor 8 -2.81109
IL32 interleukin 32 -2.81109
TEX38 testis expressed 38 -2.81109
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 -2.81109
BBS5 Bardet-Biedl syndrome 5 -2.81109
FGF18 fibroblast growth factor 18 -2.81109
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -2.81109
BRDT bromodomain, testis-specific -2.81109
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 -2.81109
CDC20B cell division cycle 20B -2.81109
HCRT hypocretin (orexin) neuropeptide precursor -2.81109
TNN tenascin N -2.81109
VPREB3 pre-B lymphocyte 3 -2.81109
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 -2.81109
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 -2.81109
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 -2.81109
COL8A1 collagen, type VIII, alpha 1 -2.81109
H2BC8 H2B clustered histone 8 -2.81109
HCRTR2 hypocretin (orexin) receptor 2 -2.81109
TDRD1 tudor domain containing 1 -2.81109
ARRDC2 arrestin domain containing 2 -2.81109
PDZK1 PDZ domain containing 1 -2.81109
GNRHR gonadotropin-releasing hormone receptor -2.81109
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -2.81109
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 -2.81109
CFAP57 cilia and flagella associated protein 57 -2.81109
ULK1 unc-51 like autophagy activating kinase 1 -2.81109
DGCR6 DiGeorge syndrome critical region gene 6 -2.81109
PLEKHD1 pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 -2.81109
ALKAL1 ALK and LTK ligand 1 -2.81109
DUSP9 dual specificity phosphatase 9 -2.81109
ZMYM6 zinc finger, MYM-type 6 -2.81109
ITGA11 integrin, alpha 11 -2.81109
IGSF23 immunoglobulin superfamily, member 23 -2.81109
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 -2.81109
H3C13 H3 clustered histone 13 -2.81109
PATL2 protein associated with topoisomerase II homolog 2 (yeast) -2.81109
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -2.81109
IL18 interleukin 18 -2.81109
FRYL FRY-like -2.81109
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) -2.81109
WIF1 WNT inhibitory factor 1 -2.78017
ST7 suppression of tumorigenicity 7 -2.77026
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2 -2.74441
LIN7C lin-7 homolog C (C. elegans) -2.73901
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -2.73081
SMIM18 small integral membrane protein 18 -2.70887
SNORC secondary ossification center associated regulator of chondrocyte maturation -2.69744
GTF2A1 general transcription factor IIA, 1, 19/37kDa -2.63783
DAZAP1 DAZ associated protein 1 -2.63404
GATD3 glutamine amidotransferase class 1 domain containing 3 -2.60894
ERRFI1 ERBB receptor feedback inhibitor 1 -2.59714
PHLDA2 pleckstrin homology-like domain, family A, member 2 -2.56498
STARD8 StAR-related lipid transfer (START) domain containing 8 -2.55697
UNC50 unc-50 homolog (C. elegans) -2.54833
ZNF232 zinc finger protein 232 -2.53446
LRRC20 leucine rich repeat containing 20 -2.52497
CCDC172 coiled-coil domain containing 172 -2.49913
ZNF324 zinc finger protein 324 -2.49508
IAPP islet amyloid polypeptide -2.49508
SAXO1 stabilizer of axonemal microtubules 1 -2.4664
DTNA dystrobrevin, alpha -2.45794
WDR33 WD repeat domain 33 -2.43486
HIPK3 homeodomain interacting protein kinase 3 -2.41419
WDR4 WD repeat domain 4 -2.40087
LPCAT3 lysophosphatidylcholine acyltransferase 3 -2.35318
RTN3 reticulon 3 -2.35305
DAP death-associated protein -2.34787
SARM1 sterile alpha and TIR motif containing 1 -2.3223
HENMT1 HEN1 methyltransferase homolog 1 (Arabidopsis) -2.24585
LAS1L LAS1-like (S. cerevisiae) -2.22555
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -2.21501
MICALL1 MICAL-like 1 -2.20262
PAQR4 progestin and adipoQ receptor family member IV -2.20172
EFNA1 ephrin-A1 -2.19438
NALCN sodium leak channel, non selective -2.19438
IFT38 intraflagellar transport 38 -2.16652
OTUD5 OTU deubiquitinase 5 -2.16118
RPS13 ribosomal protein S13 -2.16118
ADAP2 ArfGAP with dual PH domains 2 -2.15581
EFCAB11 EF-hand calcium binding domain 11 -2.15581
ETAA1 Ewing tumor-associated antigen 1 -2.15581
ADCY6 adenylate cyclase 6 -2.1433
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like -2.13931
CCDC150 coiled-coil domain containing 150 -2.13931
LRRC27 leucine rich repeat containing 27 -2.13502
TRPM3 transient receptor potential cation channel, subfamily M, member 3 -2.13216
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 -2.11053
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C -2.09824
BCAR3 breast cancer anti-estrogen resistance 3 -2.08742
ADGRL3 adhesion G protein-coupled receptor L3 -2.08672
RPL41 ribosomal protein L41 -2.08216
TNNT2 troponin T type 2 (cardiac) -2.06684
ACSL4 acyl-CoA synthetase long-chain family member 4 -2.05905
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 -2.05841
AGER advanced glycosylation end product-specific receptor -2.03966
FBXO32 F-box protein 32 -2.03966
ZDHHC21 zinc finger, DHHC-type containing 21 -2.03265
NHLH2 nescient helix loop helix 2 -2.02869
MAPT microtubule-associated protein tau -2.02869
MOB3C MOB kinase activator 3C -2.02869
ABHD14B abhydrolase domain containing 14B -2.02869
RPS12 ribosomal protein S12 -2.02869
FANCD2OS FANCD2 opposite strand -2.02869
CDK15 cyclin-dependent kinase 15 -2.02869
WDR3 WD repeat domain 3 -2.00747