APOBEC3G Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G|This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein encoded by this gene has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 60489)
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Genes

320 genes differentially expressed following the APOBEC3G gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLFN14 schlafen family member 14 3.89653
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like 3.89653
ECEL1 endothelin converting enzyme-like 1 3.89653
PCDHGB3 protocadherin gamma subfamily B, 3 3.89653
MICALL2 MICAL-like 2 3.89653
APLN apelin 3.89653
FOXR1 forkhead box R1 3.89653
PAX8 paired box 8 3.89653
SLC15A5 solute carrier family 15, member 5 3.89653
GDNF glial cell derived neurotrophic factor 3.89653
PGBDF plakoglobin binding and degradation factor 3.89653
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 3.89653
PDILT protein disulfide isomerase-like, testis expressed 3.89653
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 3.89653
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 3.89653
COL20A1 collagen, type XX, alpha 1 3.89653
ZACN zinc activated ligand-gated ion channel 3.89653
SELPLG selectin P ligand 3.89653
GOT1L1 glutamic-oxaloacetic transaminase 1-like 1 3.89653
ADGRE3 adhesion G protein-coupled receptor E3 3.89653
MGAM2 maltase-glucoamylase 2 (putative) 3.89653
ASB17 ankyrin repeat and SOCS box containing 17 3.89653
ADAD2 adenosine deaminase domain containing 2 3.89653
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 3.89653
TMEM132C transmembrane protein 132C 3.89653
EPHB3 EPH receptor B3 3.89653
STAP1 signal transducing adaptor family member 1 3.89653
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 3.89653
TLDC2 TBC/LysM-associated domain containing 2 3.89653
PRSS21 protease, serine, 21 (testisin) 3.89653
CYSRT1 cysteine-rich tail protein 1 3.89653
HRG histidine-rich glycoprotein 3.89653
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.89653
GRP gastrin-releasing peptide 3.89653
SLC39A4 solute carrier family 39 (zinc transporter), member 4 3.89653
OCM2 oncomodulin 2 3.89653
PSCA prostate stem cell antigen 3.89653
NEUROG3 neurogenin 3 3.89653
MAGED4 melanoma antigen family D4 3.89653
S100A1 S100 calcium binding protein A1 3.89653
MUC20 mucin 20, cell surface associated 3.89653
ATOH1 atonal homolog 1 (Drosophila) 3.89653
VCX variable charge, X-linked 3.89653
RHOJ ras homolog family member J 3.89653
AGA-DT AGA divergent transcript 3.89653
ZNF524 zinc finger protein 524 3.89653
CD300LF CD300 molecule-like family member f 3.89653
CCER2 coiled-coil glutamate-rich protein 2 3.89653
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 3.89653
ZG16 zymogen granule protein 16 3.89653
PLN phospholamban 3.89653
DNAAF1 dynein, axonemal, assembly factor 1 3.89653
SRGN serglycin 3.89653
SMPX small muscle protein, X-linked 3.89653
MCHR2 melanin-concentrating hormone receptor 2 3.89653
PCDHGA9 protocadherin gamma subfamily A, 9 3.89653
CIMAP1D CIMAP1 family member D 3.89653
SMIM35 small integral membrane protein 35 3.89653
SMIM31 small integral membrane protein 31 3.89653
GSG1L2 GSG1 like 2 3.89653
H2AP H2A.P histone 3.89653
TRAPPC14 trafficking protein particle complex subunit 14 3.89653
DERPC DERPC proline and glycine rich nuclear protein 3.89653
SEPTIN14 septin 14 3.89653
CES4A carboxylesterase 4A 3.89653
ASB4 ankyrin repeat and SOCS box containing 4 3.89653
OR8G5 olfactory receptor, family 8, subfamily G, member 5 3.89653
TLR8 toll-like receptor 8 3.89653
F8A2 coagulation factor VIII-associated 2 3.89653
LOC124905976 uncharacterized LOC124905976 3.89653
OR11A1 olfactory receptor, family 11, subfamily A, member 1 3.89653
CBLN3 cerebellin 3 precursor 3.89653
TRIM67 tripartite motif containing 67 3.89653
C4ORF17 chromosome 4 open reading frame 17 3.89653
KLHL30 kelch-like family member 30 3.89653
PCDHA7 protocadherin alpha 7 3.89653
AWAT2 acyl-CoA wax alcohol acyltransferase 2 3.89653
PRR18 proline rich 18 3.89653
VSIG8 V-set and immunoglobulin domain containing 8 3.89653
GATA2 GATA binding protein 2 3.89653
KL klotho 3.89653
ACE2 angiotensin I converting enzyme 2 3.89653
NPIPB8 nuclear pore complex interacting protein family, member B8 3.89653
C9 complement component 9 3.89653
NR0B1 nuclear receptor subfamily 0, group B, member 1 3.89653
S100G S100 calcium binding protein G 3.89653
EXOC3L1 exocyst complex component 3-like 1 3.89653
FOXD2 forkhead box D2 3.89653
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 3.89653
TTC16 tetratricopeptide repeat domain 16 3.89653
GFI1B growth factor independent 1B transcription repressor 3.89653
PCDHGB4 protocadherin gamma subfamily B, 4 3.89653
C8G complement component 8, gamma polypeptide 3.89653
LY96 lymphocyte antigen 96 3.89653
TF transferrin 3.89653
DMRT2 doublesex and mab-3 related transcription factor 2 3.89653
TBPL2 TATA box binding protein like 2 3.89653
HSPB9 heat shock protein, alpha-crystallin-related, B9 3.89653
FOSB FBJ murine osteosarcoma viral oncogene homolog B 3.89653
TMEM31 transmembrane protein 31 3.89653
IL12A interleukin 12A 3.89653
FIGLA folliculogenesis specific basic helix-loop-helix 3.89653
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 3.89653
PTGDR prostaglandin D2 receptor (DP) 3.89653
WDFY4 WDFY family member 4 3.89653
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 3.89653
CHI3L2 chitinase 3-like 2 3.89653
GPR61 G protein-coupled receptor 61 3.89653
SPATA4 spermatogenesis associated 4 3.89653
CLEC4G C-type lectin domain family 4, member G 3.89653
FBP2 fructose-1,6-bisphosphatase 2 3.89653
CYS1 cystin 1 3.89653
ADAM7 ADAM metallopeptidase domain 7 3.89653
POU2AF1 POU class 2 associating factor 1 3.89653
WFDC8 WAP four-disulfide core domain 8 3.89653
TBXA2R thromboxane A2 receptor 3.89653
C22ORF42 chromosome 22 open reading frame 42 3.89653
MKRN3 makorin ring finger protein 3 3.89653
KLF2 Kruppel-like factor 2 3.89653
S100Z S100 calcium binding protein Z 3.89653
ETNPPL ethanolamine-phosphate phospho-lyase 3.89653
HCLS1 hematopoietic cell-specific Lyn substrate 1 3.89653
CCL15 chemokine (C-C motif) ligand 15 3.89653
GPR12 G protein-coupled receptor 12 3.89653
C9ORF50 chromosome 9 open reading frame 50 3.89653
CD37 CD37 molecule 3.89653
RNF224 ring finger protein 224 3.89653
LAMB3 laminin, beta 3 3.89653
LMX1A LIM homeobox transcription factor 1, alpha 3.89653
IL33 interleukin 33 3.89653
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 3.89653
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 3.89653
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 3.89653
TSKS testis-specific serine kinase substrate 3.89653
TMEM45B transmembrane protein 45B 3.89653
PPP1R27 protein phosphatase 1, regulatory subunit 27 3.89653
ALLC allantoicase 3.89653
TGM7 transglutaminase 7 3.89653
FKBP1C FK506 binding protein 1C 3.89653
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 3.89653
PITX2 paired-like homeodomain 2 3.89653
NPAS4 neuronal PAS domain protein 4 3.89653
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 3.89653
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 3.89653
CTSS cathepsin S 3.89653
PLGLB2 plasminogen-like B2 3.89653
POU4F1 POU class 4 homeobox 1 3.89653
SP100 SP100 nuclear antigen 3.89653
QRFP pyroglutamylated RFamide peptide 3.89653
GSC2 goosecoid homeobox 2 3.89653
RASA4 RAS p21 protein activator 4 3.89653
LIMS3 LIM and senescent cell antigen-like domains 3 3.89653
POTEF POTE ankyrin domain family, member F 3.89653
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 3.89653
DAND5 DAN domain family member 5, BMP antagonist 3.89653
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 3.89653
ARSA arylsulfatase A 3.83728
LYG1 lysozyme G-like 1 3.47796
MAP2K3 mitogen-activated protein kinase kinase 3 3.26952
SAFB scaffold attachment factor B 3.26527
CFAP77 cilia and flagella associated protein 77 3.18416
C1QL1 complement component 1, q subcomponent-like 1 2.99765
ZNF677 zinc finger protein 677 2.96899
RPA4 replication protein A4, 30kDa 2.95533
CDHR4 cadherin-related family member 4 2.95533
SLC33A2 solute carrier family 33 member 2 2.88227
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 2.85702
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.80351
BRWD3 bromodomain and WD repeat domain containing 3 2.7422
SLC30A7 solute carrier family 30 (zinc transporter), member 7 2.73759
PYGM phosphorylase, glycogen, muscle 2.70679
SF3B2 splicing factor 3b, subunit 2, 145kDa 2.65773
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 2.6011
HEATR4 HEAT repeat containing 4 2.57759
IL7 interleukin 7 2.56113
EID2 EP300 interacting inhibitor of differentiation 2 2.55421
HAPLN2 hyaluronan and proteoglycan link protein 2 2.53066
PDCD1LG2 programmed cell death 1 ligand 2 2.53066
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 2.51018
LRRC39 leucine rich repeat containing 39 2.50783
STX19 syntaxin 19 2.50783
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) 2.50783
POM121C POM121 transmembrane nucleoporin C 2.44259
MMP28 matrix metallopeptidase 28 2.43928
CREB1 cAMP responsive element binding protein 1 2.41932
OSCAR osteoclast associated, immunoglobulin-like receptor 2.39164
TPH1 tryptophan hydroxylase 1 2.38724
TMEM70 transmembrane protein 70 2.36747
ANKRD16 ankyrin repeat domain 16 2.36374
FLOT2 flotillin 2 2.34494
TRIM39 tripartite motif containing 39 2.33551
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 2.2966
NSUN6 NOP2/Sun domain family, member 6 2.26932
RTF2 replication termination factor 2 2.25657
SMIM10L2A small integral membrane protein 10 like 2A 2.25308
GBA2 glucosidase, beta (bile acid) 2 2.24557
SAMD15 sterile alpha motif domain containing 15 2.23895
SCTR secretin receptor 2.23895
SYNJ1 synaptojanin 1 2.23895
HTRA2 HtrA serine peptidase 2 2.23126
HIST1H2BI histone cluster 1, H2bi 2.18798
ZNF138 zinc finger protein 138 2.15193
GTPBP1 GTP binding protein 1 2.13532
ZNF621 zinc finger protein 621 2.13227
ZBED8L ZBED8 like 2.1181
PROSER1 proline and serine rich 1 2.06643
PRRC2C proline-rich coiled-coil 2C 2.04423
SERGEF secretion regulating guanine nucleotide exchange factor 2.03807
BAZ1B bromodomain adjacent to zinc finger domain, 1B 2.01476
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 2.01476
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 2.0016

decreased expression

Symbol Name Standardized Value
SLC67A1 solute carrier family 67 member 1 -3.89653
IQCJ IQ motif containing J -3.89653
C12ORF42 chromosome 12 open reading frame 42 -3.89653
MMRN2 multimerin 2 -3.89653
NPNT nephronectin -3.89653
CLPSL1 colipase-like 1 -3.89653
PLEKHD1 pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 -3.89653
TMT1B thiol methyltransferase 1B -3.89653
HIPK4 homeodomain interacting protein kinase 4 -3.72686
TMEM150B transmembrane protein 150B -3.72686
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 -3.72686
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -3.72686
PLGLB1 plasminogen-like B1 -3.72686
MT1M metallothionein 1M -3.72686
ANXA9 annexin A9 -3.72686
S100A2 S100 calcium binding protein A2 -3.72686
TMEM82 transmembrane protein 82 -3.72686
CSMD3 CUB and Sushi multiple domains 3 -3.72686
ANKRD42-DT ANKRD42 divergent transcript -3.72686
GBP4 guanylate binding protein 4 -3.72686
C6ORF118 chromosome 6 open reading frame 118 -3.72686
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 -3.72686
OVOL3 ovo-like zinc finger 3 -3.72686
GDA guanine deaminase -3.72686
CD96 CD96 molecule -3.72686
TXLNB taxilin beta -3.72686
EGFL6 EGF-like-domain, multiple 6 -3.72686
SLC16A6 solute carrier family 16, member 6 -3.72686
NACA2 nascent polypeptide-associated complex alpha subunit 2 -3.72686
GAGE10 G antigen 10 -3.72686
PDZRN4 PDZ domain containing ring finger 4 -3.72686
TMEM255A transmembrane protein 255A -3.72686
CRYBB2 crystallin, beta B2 -3.72686
IL21R interleukin 21 receptor -3.72686
KLF1 Kruppel-like factor 1 (erythroid) -3.72686
AKAP11 A kinase (PRKA) anchor protein 11 -3.70786
GLE1 GLE1 RNA export mediator -3.64906
MSH2 mutS homolog 2 -3.64906
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) -3.61893
ADAM32 ADAM metallopeptidase domain 32 -3.61893
RNF128 ring finger protein 128, E3 ubiquitin protein ligase -3.61893
TBX6 T-box 6 -3.61893
TLCD4 TLC domain containing 4 -3.61893
STARD13 StAR-related lipid transfer (START) domain containing 13 -3.52682
MTOR mechanistic target of rapamycin (serine/threonine kinase) -3.52335
SKAP1 src kinase associated phosphoprotein 1 -3.39557
BCL2 B-cell CLL/lymphoma 2 -3.38545
HS1BP3 HCLS1 binding protein 3 -3.09791
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) -3.07487
SSRP1 structure specific recognition protein 1 -3.04864
BCDIN3D BCDIN3 domain containing -2.92075
C22ORF15 chromosome 22 open reading frame 15 -2.90831
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.89395
MTERF2 mitochondrial transcription termination factor 2 -2.85298
NEURL1 neuralized E3 ubiquitin protein ligase 1 -2.833
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -2.80977
COMMD1 copper metabolism (Murr1) domain containing 1 -2.76283
TMEM231 transmembrane protein 231 -2.63454
TRABD2A TraB domain containing 2A -2.59621
PRRT2 proline-rich transmembrane protein 2 -2.57741
MTMR7 myotubularin related protein 7 -2.49497
RXRA retinoid X receptor, alpha -2.48829
MAGEE1 melanoma antigen family E1 -2.48091
SNX31 sorting nexin 31 -2.4774
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) -2.4774
RABIF RAB interacting factor -2.41921
FGF12 fibroblast growth factor 12 -2.38976
DGKA diacylglycerol kinase, alpha 80kDa -2.33551
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 -2.33551
VAMP5 vesicle-associated membrane protein 5 -2.32949
PGBD4 piggyBac transposable element derived 4 -2.28804
PGBD2 piggyBac transposable element derived 2 -2.25095
ZSWIM1 zinc finger, SWIM-type containing 1 -2.24883
DXO decapping exoribonuclease -2.23895
OPN1SW opsin 1 (cone pigments), short-wave-sensitive -2.23895
ADGRD1 adhesion G protein-coupled receptor D1 -2.23895
GLRB glycine receptor, beta -2.23895
CKAP5 cytoskeleton associated protein 5 -2.2245
COL27A1 collagen, type XXVII, alpha 1 -2.20748
EEA1 early endosome antigen 1 -2.19223
C5ORF63 chromosome 5 open reading frame 63 -2.18991
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 -2.18983
SCN3B sodium channel, voltage gated, type III beta subunit -2.18983
PCDHGA1 protocadherin gamma subfamily A, 1 -2.18798
PALM2AKAP2 PALM2 and AKAP2 fusion -2.17629
ATOSA atos homolog A -2.17164
NIN ninein (GSK3B interacting protein) -2.17048
CTNNA3 catenin (cadherin-associated protein), alpha 3 -2.17048
RAVER1 ribonucleoprotein, PTB-binding 1 -2.17048
HPS5 Hermansky-Pudlak syndrome 5 -2.17048
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.15635
KBTBD7 kelch repeat and BTB (POZ) domain containing 7 -2.15559
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 -2.13532
ZNF217 zinc finger protein 217 -2.13227
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase -2.11374
KIF1B kinesin family member 1B -2.10782
STX8 syntaxin 8 -2.10503
NEK3 NIMA-related kinase 3 -2.07926
BKGD beta-keto-L-gulonate decarboxylase -2.07463
CMC2 C-x(9)-C motif containing 2 -2.06861
PAPPA2 pappalysin 2 -2.05762
TTI2 TELO2 interacting protein 2 -2.05741
UPRT uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) -2.04754
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -2.03803
ETFA electron-transfer-flavoprotein, alpha polypeptide -2.03535
PPIF peptidylprolyl isomerase F -2.02296
DYNLRB1 dynein, light chain, roadblock-type 1 -2.01029
COPS4 COP9 signalosome subunit 4 -2.01014
KIAA0586 KIAA0586 -2.00881