APP Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description amyloid beta (A4) precursor protein|This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014] (NCBI Entrez Gene Database, 351)
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Genes

331 genes differentially expressed following the APP gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TMPRSS11F transmembrane protease, serine 11F 2.63123
PLIN4 perilipin 4 2.63123
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 2.63123
CD160 CD160 molecule 2.63123
GLYAT glycine-N-acyltransferase 2.63123
PKD1L1 polycystic kidney disease 1 like 1 2.63123
UPB1 ureidopropionase, beta 2.63123
PEAR1 platelet endothelial aggregation receptor 1 2.63123
IL5RA interleukin 5 receptor, alpha 2.63123
SLC25A41 solute carrier family 25, member 41 2.63123
CCL5 chemokine (C-C motif) ligand 5 2.63123
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 2.63123
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 2.63123
CD274 CD274 molecule 2.63123
LY86 lymphocyte antigen 86 2.63123
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 2.63123
USP26 ubiquitin specific peptidase 26 2.63123
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 2.63123
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 2.63123
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.63123
ADGRE1 adhesion G protein-coupled receptor E1 2.63123
SCN2B sodium channel, voltage gated, type II beta subunit 2.63123
ALOX15 arachidonate 15-lipoxygenase 2.63123
FOXR1 forkhead box R1 2.63123
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.63123
HBB hemoglobin, beta 2.63123
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 2.63123
BFSP2 beaded filament structural protein 2, phakinin 2.63123
ACOT12 acyl-CoA thioesterase 12 2.63123
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 2.63123
GALR3 galanin receptor 3 2.63123
C2ORF78 chromosome 2 open reading frame 78 2.63123
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.63123
SPACA5 sperm acrosome associated 5 2.63123
MYL4 myosin, light chain 4, alkali; atrial, embryonic 2.63123
MUC20 mucin 20, cell surface associated 2.63123
HBZ hemoglobin, zeta 2.63123
DSG3 desmoglein 3 2.63123
XCL2 chemokine (C motif) ligand 2 2.63123
SLC30A2 solute carrier family 30 (zinc transporter), member 2 2.63123
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2.63123
ADAD2 adenosine deaminase domain containing 2 2.63123
GIMAP8 GTPase, IMAP family member 8 2.63123
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.63123
C1ORF141 chromosome 1 open reading frame 141 2.63123
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.63123
WNT8B wingless-type MMTV integration site family, member 8B 2.63123
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 2.63123
SIX6 SIX homeobox 6 2.63123
LY6S lymphocyte antigen 6 family member S 2.63123
CLDN14 claudin 14 2.63123
VN1R1 vomeronasal 1 receptor 1 2.63123
ZG16 zymogen granule protein 16 2.63123
PKD2L1 polycystic kidney disease 2-like 1 2.63123
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.63123
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 2.63123
WDR64 WD repeat domain 64 2.63123
ASB4 ankyrin repeat and SOCS box containing 4 2.63123
MIOX myo-inositol oxygenase 2.63123
DOK2 docking protein 2, 56kDa 2.63123
BEND2 BEN domain containing 2 2.63123
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 2.63123
GREP1 glycine rich extracellular protein 1 2.63123
CFAP90 cilia and flagella associated protein 90 2.63123
MYMK myomaker, myoblast fusion factor 2.63123
CCDC188 coiled-coil domain containing 188 2.63123
GARIN6 golgi associated RAB2 interactor family member 6 2.63123
ODAPH odontogenesis associated phosphoprotein 2.63123
CGB3 chorionic gonadotropin subunit beta 3 2.63123
CRAMP1 cramped chromatin regulator homolog 1 2.63123
HAO2 hydroxyacid oxidase 2 (long chain) 2.63123
YIPF7 Yip1 domain family, member 7 2.63123
TSPAN8 tetraspanin 8 2.63123
PRDM7 PR domain containing 7 2.63123
OVOL3 ovo-like zinc finger 3 2.63123
IL4 interleukin 4 2.63123
IL6 interleukin 6 2.63123
CBLN3 cerebellin 3 precursor 2.63123
LGALS7B lectin, galactoside-binding, soluble, 7B 2.63123
IL12RB1 interleukin 12 receptor, beta 1 2.63123
LIPC lipase, hepatic 2.63123
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 2.63123
SLC22A10 solute carrier family 22, member 10 2.63123
PDILT protein disulfide isomerase-like, testis expressed 2.63123
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 2.63123
KLRF2 killer cell lectin-like receptor subfamily F, member 2 2.63123
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) 2.63123
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 2.63123
FAM107A family with sequence similarity 107, member A 2.63123
IL16 interleukin 16 2.63123
PRG4 proteoglycan 4 2.63123
STARD6 StAR-related lipid transfer (START) domain containing 6 2.63123
OOSP1 oocyte secreted protein 1, pseudogene 2.63123
GTSF1 gametocyte specific factor 1 2.63123
C6ORF118 chromosome 6 open reading frame 118 2.63123
OR2L5 olfactory receptor, family 2, subfamily L, member 5 2.63123
PLVAP plasmalemma vesicle associated protein 2.63123
TBC1D26 TBC1 domain family, member 26 2.63123
MR1 major histocompatibility complex, class I-related 2.63123
NOG noggin 2.63123
CST1 cystatin SN 2.63123
EBLN1 endogenous Bornavirus-like nucleoprotein 1 2.63123
PIH1D2 PIH1 domain containing 2 2.63123
THTPA thiamine triphosphatase 2.63123
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.63123
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 2.63123
KLHL41 kelch-like family member 41 2.63123
SOWAHA sosondowah ankyrin repeat domain family member A 2.63123
RSAD2 radical S-adenosyl methionine domain containing 2 2.63123
CSF3R colony stimulating factor 3 receptor (granulocyte) 2.63123
TSPAN32 tetraspanin 32 2.63123
PMP2 peripheral myelin protein 2 2.63123
MORC1 MORC family CW-type zinc finger 1 2.63123
CABP7 calcium binding protein 7 2.63123
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 2.63123
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.63123
GFI1B growth factor independent 1B transcription repressor 2.63123
KCNK3 potassium channel, two pore domain subfamily K, member 3 2.63123
IL21R interleukin 21 receptor 2.63123
BPIFB2 BPI fold containing family B, member 2 2.63123
XIRP2 xin actin binding repeat containing 2 2.63123
GPR61 G protein-coupled receptor 61 2.63123
PENK proenkephalin 2.63123
MOG myelin oligodendrocyte glycoprotein 2.63123
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 2.63123
PCDH20 protocadherin 20 2.63123
PPP1R27 protein phosphatase 1, regulatory subunit 27 2.63123
GOLGA8K golgin A8 family, member K 2.63123
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 2.63123
SCNN1B sodium channel, non voltage gated 1 beta subunit 2.63123
RBM20 RNA binding motif protein 20 2.63123
WFDC1 WAP four-disulfide core domain 1 2.63123
TDRD10 tudor domain containing 10 2.63123
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.63123
ODF1 outer dense fiber of sperm tails 1 2.63123
TMEM138 transmembrane protein 138 2.63123
MCCD1 mitochondrial coiled-coil domain 1 2.63123
SAMD7 sterile alpha motif domain containing 7 2.63123
CRYBA1 crystallin, beta A1 2.63123
TF transferrin 2.63123
CPEB1 cytoplasmic polyadenylation element binding protein 1 2.63123
ANKRD33 ankyrin repeat domain 33 2.63123
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.63123
ERAP2 endoplasmic reticulum aminopeptidase 2 2.63123
CCDC83 coiled-coil domain containing 83 2.63123
SLC51B solute carrier family 51, beta subunit 2.63123
GRAPL GRB2-related adaptor protein-like 2.63123
CIB4 calcium and integrin binding family member 4 2.63123
AGBL4 ATP/GTP binding protein-like 4 2.63123
ADAM29 ADAM metallopeptidase domain 29 2.63123
CDYL2 chromodomain protein, Y-like 2 2.63123
PCDHGA12 protocadherin gamma subfamily A, 12 2.63123
KRTAP12-1 keratin associated protein 12-1 2.63123
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 2.63123
TRPM1 transient receptor potential cation channel, subfamily M, member 1 2.63123
GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2.63123
RHOJ ras homolog family member J 2.63123
IRX4 iroquois homeobox 4 2.63123
GCM1 glial cells missing homolog 1 (Drosophila) 2.63123
POU3F2 POU class 3 homeobox 2 2.63123
NEUROD1 neuronal differentiation 1 2.63123
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.63123
USP34 ubiquitin specific peptidase 34 2.63123
TXNDC17 thioredoxin domain containing 17 2.63123
PXT1 peroxisomal, testis specific 1 2.63123
ZNF141 zinc finger protein 141 2.61463
LRP12 low density lipoprotein receptor-related protein 12 2.612
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 2.59754
PRUNE1 prune exopolyphosphatase 1 2.5542
CNBP CCHC-type zinc finger, nucleic acid binding protein 2.55053
PCDHGB2 protocadherin gamma subfamily B, 2 2.55053
H2BC12 H2B clustered histone 12 2.55053
L1CAM L1 cell adhesion molecule 2.55053
GLRA1 glycine receptor, alpha 1 2.55053
FILIP1L filamin A interacting protein 1-like 2.55053
AGPS alkylglycerone phosphate synthase 2.54538
OR2A14 olfactory receptor, family 2, subfamily A, member 14 2.4948
MKNK2 MAP kinase interacting serine/threonine kinase 2 2.4911
H2AC4 H2A clustered histone 4 2.48028
FGFRL1 fibroblast growth factor receptor-like 1 2.46741
PRORP protein only RNase P catalytic subunit 2.45355
SHISA8 shisa family member 8 2.44392
SPMIP11 sperm microtubule inner protein 11 2.44324
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 2.43791
PIGM phosphatidylinositol glycan anchor biosynthesis, class M 2.43188
BOD1 biorientation of chromosomes in cell division 1 2.37817
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 2.36799
PLPPR1 phospholipid phosphatase related 1 2.3583
GJA9 gap junction protein, alpha 9, 59kDa 2.35461
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 2.35461
LEP leptin 2.34287
CCNE2 cyclin E2 2.33085
CCDC81 coiled-coil domain containing 81 2.32477
BAG3 BCL2-associated athanogene 3 2.30468
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 2.28364
PLXDC1 plexin domain containing 1 2.27106
EFCC1 EF-hand and coiled-coil domain containing 1 2.26862
SCO1 SCO1 cytochrome c oxidase assembly protein 2.24987
UBE2W ubiquitin-conjugating enzyme E2W (putative) 2.24352
AMOTL1 angiomotin like 1 2.21342
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 2.20545
DRC9 dynein regulatory complex subunit 9 2.19514
MYH9 myosin, heavy chain 9, non-muscle 2.19497
CSNK1G1 casein kinase 1, gamma 1 2.19321
ZFP62 ZFP62 zinc finger protein 2.18939
TOX4 TOX high mobility group box family member 4 2.16051
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 2.15381
KIF17 kinesin family member 17 2.15347
MVP major vault protein 2.15077
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2.14499
SMIM18 small integral membrane protein 18 2.12263
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 2.11992
MED13L mediator complex subunit 13-like 2.11872
RNF217 ring finger protein 217 2.11136
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 2.11136
TLCD1 TLC domain containing 1 2.09887
DEF6 differentially expressed in FDCP 6 homolog (mouse) 2.09118
CUL5 cullin 5 2.07816
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 2.06818
SLC39A1 solute carrier family 39 (zinc transporter), member 1 2.04412
C16ORF96 chromosome 16 open reading frame 96 2.03747
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 2.03277
MTLN mitoregulin 2.0297
LHFPL5 lipoma HMGIC fusion partner-like 5 2.02624
TMPRSS5 transmembrane protease, serine 5 2.01177
ZNF613 zinc finger protein 613 2.01177
TMEM196 transmembrane protein 196 2.00737
STARD9 StAR-related lipid transfer (START) domain containing 9 2.00737
FAM184A family with sequence similarity 184, member A 2.00685

decreased expression

Symbol Name Standardized Value
APP amyloid beta (A4) precursor protein -3.78734
EHD2 EH-domain containing 2 -2.63123
SMIM47 small integral membrane protein 47 -2.63123
TRIM73 tripartite motif containing 73 -2.63123
NGF nerve growth factor (beta polypeptide) -2.63123
C9ORF72 chromosome 9 open reading frame 72 -2.63123
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -2.63123
MBTPS1 membrane-bound transcription factor peptidase, site 1 -2.63123
TCF24 transcription factor 24 -2.63123
SCRG1 stimulator of chondrogenesis 1 -2.63123
NECAB1 N-terminal EF-hand calcium binding protein 1 -2.63123
BAHCC1 BAH domain and coiled-coil containing 1 -2.63123
DAZAP1 DAZ associated protein 1 -2.63092
VRK3 vaccinia related kinase 3 -2.60013
ATAD2B ATPase family, AAA domain containing 2B -2.59754
PTRH1 peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae) -2.59456
ING4 inhibitor of growth family, member 4 -2.58552
C6ORF58 chromosome 6 open reading frame 58 -2.55053
CHRND cholinergic receptor, nicotinic, delta (muscle) -2.55053
CIMIP2B ciliary microtubule inner protein 2B -2.55053
RGPD3 RANBP2-like and GRIP domain containing 3 -2.55053
GNRHR gonadotropin-releasing hormone receptor -2.55053
LRRC63 leucine rich repeat containing 63 -2.55053
IL2RB interleukin 2 receptor, beta -2.55053
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2 -2.55053
XDH xanthine dehydrogenase -2.55053
ZEB2 zinc finger E-box binding homeobox 2 -2.55053
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 -2.55053
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -2.55053
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 -2.55053
ZNF816 zinc finger protein 816 -2.55053
COL19A1 collagen, type XIX, alpha 1 -2.55053
NOXO1 NADPH oxidase organizer 1 -2.55053
NOTO notochord homeobox -2.55053
VEGFD vascular endothelial growth factor D -2.55053
BLTP1 bridge-like lipid transfer protein family member 1 -2.55053
MORN5 MORN repeat containing 5 -2.55053
CFAP276 cilia and flagella associated protein 276 -2.55053
SLA Src-like-adaptor -2.55053
ZNF7 zinc finger protein 7 -2.55053
PLCZ1 phospholipase C, zeta 1 -2.55053
KLK4 kallikrein-related peptidase 4 -2.55053
RUNX3 runt-related transcription factor 3 -2.55053
OCM oncomodulin -2.55053
RIPPLY2 ripply transcriptional repressor 2 -2.55053
ALOX15B arachidonate 15-lipoxygenase, type B -2.55053
CARMIL3 capping protein regulator and myosin 1 linker 3 -2.55053
ACADL acyl-CoA dehydrogenase, long chain -2.55053
LKAAEAR1 LKAAEAR motif containing 1 -2.55053
GDF6 growth differentiation factor 6 -2.55053
AZU1 azurocidin 1 -2.55053
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 -2.55053
NELL1 NEL-like 1 (chicken) -2.55053
FANCB Fanconi anemia, complementation group B -2.52674
CRB3 crumbs family member 3 -2.52674
ECI2 enoyl-CoA delta isomerase 2 -2.52389
LY6G5B lymphocyte antigen 6 complex, locus G5B -2.51026
WDR54 WD repeat domain 54 -2.44392
TMEM230 transmembrane protein 230 -2.42204
CERS3 ceramide synthase 3 -2.41307
AOAH acyloxyacyl hydrolase (neutrophil) -2.40887
C6ORF141 chromosome 6 open reading frame 141 -2.32315
PRKCG protein kinase C, gamma -2.32303
MYO18A myosin XVIIIA -2.28364
TPX2 TPX2, microtubule-associated -2.2787
PRRC2A proline-rich coiled-coil 2A -2.27106
NLRX1 NLR family member X1 -2.26862
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 -2.26577
GPALPP1 GPALPP motifs containing 1 -2.26289
COPS6 COP9 signalosome subunit 6 -2.22601
AIF1 allograft inflammatory factor 1 -2.22601
NOD2 nucleotide-binding oligomerization domain containing 2 -2.21342
IFI16 interferon, gamma-inducible protein 16 -2.21342
ACER3 alkaline ceramidase 3 -2.20392
LIPI lipase, member I -2.20241
SLC25A38 solute carrier family 25, member 38 -2.19514
ZNF408 zinc finger protein 408 -2.19497
MBIP MAP3K12 binding inhibitory protein 1 -2.17299
ZNF593 zinc finger protein 593 -2.16394
SLC35A4 solute carrier family 35, member A4 -2.15381
SPTBN4 spectrin, beta, non-erythrocytic 4 -2.14499
SP140L SP140 nuclear body protein-like -2.12685
NUTM1 NUT midline carcinoma, family member 1 -2.10685
IAPP islet amyloid polypeptide -2.10685
DDR2 discoidin domain receptor tyrosine kinase 2 -2.10685
CCDC68 coiled-coil domain containing 68 -2.10685
FDXR ferredoxin reductase -2.10685
C1ORF56 chromosome 1 open reading frame 56 -2.10685
RXRB retinoid X receptor, beta -2.09889
ATXN2L ataxin 2-like -2.08288
PIWIL2 piwi-like RNA-mediated gene silencing 2 -2.07816
LEAP2 liver expressed antimicrobial peptide 2 -2.04998
OLFM3 olfactomedin 3 -2.04998
WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules -2.04768
SYF2 SYF2 pre-mRNA-splicing factor -2.04374
TULP1 tubby like protein 1 -2.04214
MICOS10 mitochondrial contact site and cristae organizing system subunit 10 -2.04038
TSPAN18 tetraspanin 18 -2.0298
POLN polymerase (DNA directed) nu -2.01331
STEAP1B STEAP family member 1B -2.00737
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -2.00617
MITD1 MIT, microtubule interacting and transport, domain containing 1 -2.00092