APP Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description amyloid beta (A4) precursor protein|This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014] (NCBI Entrez Gene Database, 351)
External Link http://www.ncbi.nlm.nih.gov/gene/351
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Genes

187 interacting proteins for hub protein APP from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACHE acetylcholinesterase (Yt blood group)
ACTB actin, beta
ADAM17 ADAM metallopeptidase domain 17
AGRN agrin
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
APLP1 amyloid beta (A4) precursor-like protein 1
APLP2 amyloid beta (A4) precursor-like protein 2
APOA1 apolipoprotein A-I
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
BACE1 beta-site APP-cleaving enzyme 1
BACE2 beta-site APP-cleaving enzyme 2
BCAP31 B-cell receptor-associated protein 31
BGN biglycan
BLMH bleomycin hydrolase
CALR calreticulin
CALU calumenin
CANX calnexin
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CBFB core-binding factor, beta subunit
CDK1 cyclin-dependent kinase 1
CDK5 cyclin-dependent kinase 5
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CLSTN1 calsyntenin 1
CLSTN3 calsyntenin 3
CLU clusterin
CNTN1 contactin 1
CNTN3 contactin 3 (plasmacytoma associated)
CNTN4 contactin 4
COL1A2 collagen, type I, alpha 2
COL25A1 collagen, type XXV, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CPE carboxypeptidase E
CRYAB crystallin, alpha B
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CST3 cystatin C
CTRB1 chymotrypsinogen B1
CTSD cathepsin D
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DNAH1 dynein, axonemal, heavy chain 1
DNM1 dynamin 1
EPB41 erythrocyte membrane protein band 4.1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERP44 endoplasmic reticulum protein 44
F12 coagulation factor XII (Hageman factor)
F9 coagulation factor IX
FBLN1 fibulin 1
FLOT1 flotillin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FYN FYN proto-oncogene, Src family tyrosine kinase
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GANAB glucosidase, alpha; neutral AB
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
GFAP glial fibrillary acidic protein
GPC1 glypican 1
GRB2 growth factor receptor-bound protein 2
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GSN gelsolin
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HMOX2 heme oxygenase 2
HOMER2 homer scaffolding protein 2
HOMER3 homer scaffolding protein 3
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPG2 heparan sulfate proteoglycan 2
HTRA2 HtrA serine peptidase 2
HYOU1 hypoxia up-regulated 1
IDE insulin-degrading enzyme
INSR insulin receptor
ITM2A integral membrane protein 2A
ITM2B integral membrane protein 2B
JUN jun proto-oncogene
KAT5 K(lysine) acetyltransferase 5
KLC1 kinesin light chain 1
KLK6 kallikrein-related peptidase 6
KNG1 kininogen 1
LAMA1 laminin, alpha 1
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LINGO1 leucine rich repeat and Ig domain containing 1
LRP1 low density lipoprotein receptor-related protein 1
LRP1B low density lipoprotein receptor-related protein 1B
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK10 mitogen-activated protein kinase 10
MAPK8 mitogen-activated protein kinase 8
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MAPK9 mitogen-activated protein kinase 9
MAPT microtubule-associated protein tau
MAT1A methionine adenosyltransferase I, alpha
MBP myelin basic protein
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MYH9 myosin, heavy chain 9, non-muscle
NAE1 NEDD8 activating enzyme E1 subunit 1
NCAM1 neural cell adhesion molecule 1
NCSTN nicastrin
NECAB3 N-terminal EF-hand calcium binding protein 3
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEFL neurofilament, light polypeptide
NF1 neurofibromin 1
NFASC neurofascin
NGFR nerve growth factor receptor
NID1 nidogen 1
NSF N-ethylmaleimide-sensitive factor
NUMB numb homolog (Drosophila)
NUMBL numb homolog (Drosophila)-like
OAT ornithine aminotransferase
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PDIA3 protein disulfide isomerase family A, member 3
PDIA6 protein disulfide isomerase family A, member 6
PGAM1 phosphoglycerate mutase 1 (brain)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PITRM1 pitrilysin metallopeptidase 1
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPID peptidylprolyl isomerase D
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2
PRNP prion protein
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PSEN1 presenilin 1
PSEN2 presenilin 2
RAB11A RAB11A, member RAS oncogene family
RAP1A RAP1A, member of RAS oncogene family
RCN2 reticulocalbin 2, EF-hand calcium binding domain
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SET SET nuclear proto-oncogene
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNCB synuclein, beta
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
STX12 syntaxin 12
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
THY1 Thy-1 cell surface antigen
TM2D1 TM2 domain containing 1
TMCC2 transmembrane and coiled-coil domain family 2
TNC tenascin C
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TP53BP2 tumor protein p53 binding protein 2
TTR transthyretin
TUBB tubulin, beta class I
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta