| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | amyloid beta (A4) precursor protein|This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014] (NCBI Entrez Gene Database, 351) |
| External Link | https://ncbi.nlm.nih.gov/gene/351 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the APP gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CADM1 | cell adhesion molecule 1 | 0.00718566 |
| GPX3 | glutathione peroxidase 3 | 0.00646518 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | 0.00625846 |
| COQ8A | coenzyme Q8A | 0.00584775 |
| PCOLCE2 | procollagen C-endopeptidase enhancer 2 | 0.0057674 |
| ARG2 | arginase 2 | 0.00569142 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.00559373 |
| ANOS1 | anosmin 1 | 0.00555937 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.00551091 |
| ASPN | asporin | 0.00546974 |
| CFH | complement factor H | 0.00538646 |
| SPARCL1 | SPARC-like 1 (hevin) | 0.00522661 |
| FXYD6 | FXYD domain containing ion transport regulator 6 | 0.00514408 |
| MECOM | MDS1 and EVI1 complex locus | 0.00504634 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.00500951 |
| C1S | complement component 1, s subcomponent | 0.00500435 |
| TGM2 | transglutaminase 2 | 0.00499353 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.00497848 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.00496042 |
| MYBPC1 | myosin binding protein C, slow type | 0.00495187 |
| C10ORF10 | chromosome 10 open reading frame 10 | 0.00475607 |
| SNRPB | small nuclear ribonucleoprotein polypeptides B and B1 | 0.00475425 |
| MSX1 | msh homeobox 1 | 0.00474731 |
| TRIM2 | tripartite motif containing 2 | 0.00471252 |
| FABP7 | fatty acid binding protein 7, brain | 0.00467889 |
| SNX10 | sorting nexin 10 | 0.00467857 |
| GNAS | GNAS complex locus | 0.00467599 |
| C3 | complement component 3 | 0.00461691 |
| PGC | progastricsin (pepsinogen C) | 0.00459594 |
| ADRB2 | adrenoceptor beta 2, surface | 0.00453929 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.0045004 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 0.00446463 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0044065 |
| MAOB | monoamine oxidase B | 0.00435507 |
| KIF14 | kinesin family member 14 | 0.00433609 |
| IRS2 | insulin receptor substrate 2 | 0.00433037 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | 0.00432754 |
| APOC2 | apolipoprotein C-II | 0.00432243 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | 0.00430085 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | 0.00427343 |
| FGF13 | fibroblast growth factor 13 | 0.00425862 |
| FKBP5 | FK506 binding protein 5 | 0.00422577 |
| MGST2 | microsomal glutathione S-transferase 2 | 0.00422271 |
| SFTPB | surfactant protein B | 0.00420946 |
| IMPDH2 | IMP (inosine 5'-monophosphate) dehydrogenase 2 | 0.00416259 |
| TESC | tescalcin | 0.00408779 |
| SFTPA2 | surfactant protein A2 | 0.00403573 |
| ZBTB16 | zinc finger and BTB domain containing 16 | 0.00402953 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | 0.00402558 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 0.00400982 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 0.00400821 |
| PCNA | proliferating cell nuclear antigen | 0.00400803 |
| UXT | ubiquitously-expressed, prefoldin-like chaperone | 0.00398394 |
| LEPR | leptin receptor | 0.00395591 |
| FGG | fibrinogen gamma chain | 0.00395555 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | 0.0039441 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.00394242 |
| XPO7 | exportin 7 | 0.00393001 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | 0.00390689 |
| GLUL | glutamate-ammonia ligase | 0.00389575 |
| CST3 | cystatin C | 0.00387852 |
| CP | ceruloplasmin (ferroxidase) | 0.00387737 |
| TMEM204 | transmembrane protein 204 | 0.0038426 |
| CCP110 | centriolar coiled coil protein 110kDa | 0.00384072 |
| CSTA | cystatin A (stefin A) | 0.00379263 |
| PLN | phospholamban | 0.00378746 |
| DMAC2L | distal membrane arm assembly component 2 like | 0.00378588 |
| LAPTM5 | lysosomal protein transmembrane 5 | 0.00377337 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | 0.00376712 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | 0.00376363 |
| C4BPA | complement component 4 binding protein, alpha | 0.00375873 |
| SORBS1 | sorbin and SH3 domain containing 1 | 0.00374314 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | 0.00372359 |
| LUM | lumican | 0.00371171 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | 0.00370993 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.00369341 |
| FGFR3 | fibroblast growth factor receptor 3 | 0.00369261 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | 0.00368909 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.00367719 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.00367648 |
| CPB2 | carboxypeptidase B2 (plasma) | 0.00366475 |
| PRR4 | proline rich 4 (lacrimal) | 0.00366431 |
| NME4 | NME/NM23 nucleoside diphosphate kinase 4 | 0.00365467 |
| RRAGD | Ras-related GTP binding D | 0.00364712 |
| RPL14 | ribosomal protein L14 | 0.00364336 |
| RFC5 | replication factor C (activator 1) 5, 36.5kDa | 0.00364043 |
| RAB4A | RAB4A, member RAS oncogene family | 0.00363045 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 0.00362112 |
| SPON1 | spondin 1, extracellular matrix protein | 0.00360945 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | 0.00359954 |
| ADGRF5 | adhesion G protein-coupled receptor F5 | 0.00359775 |
| ACKR1 | atypical chemokine receptor 1 (Duffy blood group) | 0.00359358 |
| PLLP | plasmolipin | 0.00357563 |
| ZNF652 | zinc finger protein 652 | 0.00355894 |
| S100B | S100 calcium binding protein B | 0.00354077 |
| MPPED2 | metallophosphoesterase domain containing 2 | 0.00353963 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.0035373 |
| OLFM1 | olfactomedin 1 | 0.00352754 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.00352257 |
| FAM216A | family with sequence similarity 216, member A | 0.00352208 |
| PALLD | palladin, cytoskeletal associated protein | 0.00351024 |
| MARCO | macrophage receptor with collagenous structure | 0.00350822 |
| MSMB | microseminoprotein, beta- | 0.00350564 |
| EIF3D | eukaryotic translation initiation factor 3, subunit D | 0.00349894 |
| CLDN5 | claudin 5 | 0.0034918 |
| LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 | 0.00347792 |
| GSTA4 | glutathione S-transferase alpha 4 | 0.00346812 |
| POLR1D | polymerase (RNA) I polypeptide D, 16kDa | 0.00346729 |
| NDFIP1 | Nedd4 family interacting protein 1 | 0.00346618 |
| ESD | esterase D | 0.00346381 |
| SST | somatostatin | 0.00345874 |
| FGA | fibrinogen alpha chain | 0.00344636 |
| ANKRD28 | ankyrin repeat domain 28 | 0.00343602 |
| RDX | radixin | 0.0034346 |
| NSG1 | neuron specific gene family member 1 | 0.0034311 |
| FHL1 | four and a half LIM domains 1 | 0.00342777 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | 0.00342777 |
| KRT13 | keratin 13, type I | 0.00342521 |
| PSRC1 | proline/serine-rich coiled-coil 1 | 0.00342123 |
| TSPAN7 | tetraspanin 7 | 0.00342077 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | 0.00341318 |
| TAGLN2 | transgelin 2 | 0.00339438 |
| H1-0 | H1.0 linker histone | 0.00339161 |
| EDNRB | endothelin receptor type B | 0.00337468 |
| KRT6A | keratin 6A, type II | 0.00337237 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 0.00336975 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 0.00336549 |
| HNMT | histamine N-methyltransferase | 0.00336399 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.00336157 |
| CDO1 | cysteine dioxygenase type 1 | 0.00336132 |
| AKAP8 | A kinase (PRKA) anchor protein 8 | 0.00336072 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.00335372 |
| AOC3 | amine oxidase, copper containing 3 | 0.00335086 |
| ACTB | actin, beta | 0.00334955 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.00334931 |
| GNPTAB | N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits | 0.00334297 |
| VPS72 | vacuolar protein sorting 72 homolog (S. cerevisiae) | 0.00334193 |
| MPZL2 | myelin protein zero-like 2 | 0.00334063 |
| TATDN2 | TatD DNase domain containing 2 | 0.00333147 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.00331226 |
| MFNG | MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 0.00328959 |
| C3ORF14 | chromosome 3 open reading frame 14 | 0.00326943 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.00326453 |
| RELN | reelin | 0.00321403 |
| ERGIC3 | ERGIC and golgi 3 | 0.00320575 |
| BANF1 | barrier to autointegration factor 1 | 0.00320196 |
| PRDX2 | peroxiredoxin 2 | 0.00319939 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | 0.00318073 |
| TMEM100 | transmembrane protein 100 | 0.0031772 |
| PDGFRL | platelet-derived growth factor receptor-like | 0.00317354 |
| NCAPD3 | non-SMC condensin II complex, subunit D3 | 0.0031716 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | 0.0031628 |
| ARL5A | ADP-ribosylation factor-like 5A | 0.00314901 |
| SOBP | sine oculis binding protein homolog (Drosophila) | 0.00314861 |
| CAPNS1 | calpain, small subunit 1 | 0.00314826 |
| AADAC | arylacetamide deacetylase | 0.00314537 |
| SFTPD | surfactant protein D | 0.00314313 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.00314053 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 0.00313885 |
| TNS1 | tensin 1 | 0.00313517 |
| GPC3 | glypican 3 | 0.00311864 |
| ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | 0.00311771 |
| SRSF6 | serine/arginine-rich splicing factor 6 | 0.00311342 |
| ALG8 | ALG8, alpha-1,3-glucosyltransferase | 0.0031132 |
| SOX11 | SRY (sex determining region Y)-box 11 | 0.00310049 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | 0.00309268 |
| C1R | complement component 1, r subcomponent | 0.00308561 |
| CDH5 | cadherin 5, type 2 (vascular endothelium) | 0.00308528 |
| PWP1 | PWP1 homolog (S. cerevisiae) | 0.00307812 |
| GTF3A | general transcription factor IIIA | 0.00307648 |
| PMF1 | polyamine-modulated factor 1 | 0.0030732 |
| ADIPOR2 | adiponectin receptor 2 | 0.00306654 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | 0.00306289 |
| PDE3B | phosphodiesterase 3B, cGMP-inhibited | 0.00304379 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.00303694 |
| IFRD2 | interferon-related developmental regulator 2 | 0.00303543 |
| SERINC5 | serine incorporator 5 | 0.00303399 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.00303233 |
| BPIFA1 | BPI fold containing family A, member 1 | 0.00303084 |
| ORC1 | origin recognition complex, subunit 1 | 0.0030279 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.00302513 |
| ALDH9A1 | aldehyde dehydrogenase 9 family, member A1 | 0.00301514 |
| PRELP | proline/arginine-rich end leucine-rich repeat protein | 0.00300564 |
| RNF130 | ring finger protein 130 | 0.002998 |
| MT1E | metallothionein 1E | 0.00299238 |
| PPL | periplakin | 0.00299093 |
| EMP2 | epithelial membrane protein 2 | 0.00299079 |
| UBAP2L | ubiquitin associated protein 2-like | 0.00298667 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.00298412 |
| NCOA4 | nuclear receptor coactivator 4 | 0.00297855 |
| PRMT1 | protein arginine methyltransferase 1 | 0.00297598 |
| CD99 | CD99 molecule | 0.00297511 |
| CCT3 | chaperonin containing TCP1, subunit 3 (gamma) | 0.0029747 |
| C1QA | complement component 1, q subcomponent, A chain | 0.00296697 |
| FMO5 | flavin containing monooxygenase 5 | 0.00296321 |
| PON3 | paraoxonase 3 | 0.00296211 |
| NPTX2 | neuronal pentraxin II | 0.00295587 |
| CLDN10 | claudin 10 | 0.00295286 |
| MYH11 | myosin, heavy chain 11, smooth muscle | 0.00294396 |
| HMBS | hydroxymethylbilane synthase | 0.00294157 |
| SNRPE | small nuclear ribonucleoprotein polypeptide E | 0.00293573 |
| GSN | gelsolin | 0.00292149 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | 0.00292106 |
| ATP5G2 | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) | 0.00291582 |
| DERA | deoxyribose-phosphate aldolase (putative) | 0.00290486 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.00290187 |
| TSC22D1 | TSC22 domain family, member 1 | 0.00290142 |
| GYG2 | glycogenin 2 | 0.00289606 |
| SNX11 | sorting nexin 11 | 0.00288665 |
| CCNG1 | cyclin G1 | 0.00288274 |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | 0.00288105 |
| FOXO1 | forkhead box O1 | 0.0028761 |
| TM4SF4 | transmembrane 4 L six family member 4 | 0.00287043 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.00285926 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | 0.00284795 |
| KLHDC3 | kelch domain containing 3 | 0.00283789 |
| COL21A1 | collagen, type XXI, alpha 1 | 0.00283533 |
| APOB | apolipoprotein B | 0.00283297 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.00283142 |
| MLF2 | myeloid leukemia factor 2 | 0.00282654 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.00282144 |
| MKNK1 | MAP kinase interacting serine/threonine kinase 1 | 0.00281993 |
| UQCRC1 | ubiquinol-cytochrome c reductase core protein I | 0.00281655 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.00280829 |
| MRPS18B | mitochondrial ribosomal protein S18B | 0.00280783 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.00280305 |
| ASF1A | anti-silencing function 1A histone chaperone | 0.00280256 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | 0.00279814 |
| SSX1 | synovial sarcoma, X breakpoint 1 | 0.00279592 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.00279188 |
| GPR87 | G protein-coupled receptor 87 | 0.0027911 |
| APOH | apolipoprotein H (beta-2-glycoprotein I) | 0.00278526 |
| RNPS1 | RNA binding protein S1, serine-rich domain | 0.0027843 |
| PGD | phosphogluconate dehydrogenase | 0.00278285 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | 0.00277602 |
| RHOA | ras homolog family member A | 0.00277205 |
| MALL | mal, T-cell differentiation protein-like | 0.00276746 |
| CFD | complement factor D (adipsin) | 0.00275 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | 0.00274278 |
| CCK | cholecystokinin | 0.00274182 |
| NEK7 | NIMA-related kinase 7 | 0.00273876 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | 0.00273727 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 | 0.00273576 |
| STATH | statherin | 0.00272883 |
| IL27RA | interleukin 27 receptor, alpha | 0.00272818 |
| GPD1L | glycerol-3-phosphate dehydrogenase 1-like | 0.0027273 |
| CDCA3 | cell division cycle associated 3 | 0.002726 |
| CLU | clusterin | 0.00272412 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric | 0.0027231 |
| ACP3 | acid phosphatase 3 | 0.00272066 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VAV3 | vav 3 guanine nucleotide exchange factor | -0.00867247 |
| MX1 | MX dynamin-like GTPase 1 | -0.0082651 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | -0.00811596 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | -0.00783566 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | -0.00767141 |
| CAST | calpastatin | -0.00748055 |
| APP | amyloid beta (A4) precursor protein | -0.00741351 |
| VEGFA | vascular endothelial growth factor A | -0.00735856 |
| CA12 | carbonic anhydrase XII | -0.00710075 |
| ADD3 | adducin 3 (gamma) | -0.0069849 |
| XIC | X chromosome inactivation center | -0.00665905 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | -0.00633224 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.00617511 |
| TUBB6 | tubulin, beta 6 class V | -0.00614202 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0061149 |
| PITX3 | paired-like homeodomain 3 | -0.00584046 |
| POSTN | periostin, osteoblast specific factor | -0.0057935 |
| HTRA1 | HtrA serine peptidase 1 | -0.00569695 |
| PLAAT3 | phospholipase A and acyltransferase 3 | -0.00559168 |
| CLC | Charcot-Leyden crystal galectin | -0.00549337 |
| FBN2 | fibrillin 2 | -0.00548867 |
| PTK2B | protein tyrosine kinase 2 beta | -0.00544751 |
| GBP1 | guanylate binding protein 1, interferon-inducible | -0.00534157 |
| CTBP2 | C-terminal binding protein 2 | -0.00533014 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.00530172 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | -0.0051589 |
| AREG | amphiregulin | -0.00512066 |
| LAMB1 | laminin, beta 1 | -0.00510866 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.00508511 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | -0.00505834 |
| RGS4 | regulator of G-protein signaling 4 | -0.00501009 |
| KRT20 | keratin 20, type I | -0.0049921 |
| H1-2 | H1.2 linker histone, cluster member | -0.00498904 |
| AOC1 | amine oxidase, copper containing 1 | -0.00493251 |
| ZNF91 | zinc finger protein 91 | -0.00487781 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | -0.00485819 |
| MYO6 | myosin VI | -0.0048421 |
| MAP7 | microtubule-associated protein 7 | -0.00483586 |
| BLNK | B-cell linker | -0.00479561 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | -0.00478277 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.00473425 |
| KRT19 | keratin 19, type I | -0.00473296 |
| PXDC1 | PX domain containing 1 | -0.00469663 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.00466962 |
| ITM2C | integral membrane protein 2C | -0.00466024 |
| GLDC | glycine dehydrogenase (decarboxylating) | -0.00464825 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.00464529 |
| SYNE3 | spectrin repeat containing, nuclear envelope family member 3 | -0.00460085 |
| KLF4 | Kruppel-like factor 4 (gut) | -0.00459679 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0045794 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.00454831 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.00447912 |
| CHERP | calcium homeostasis endoplasmic reticulum protein | -0.00444477 |
| STC2 | stanniocalcin 2 | -0.00442529 |
| IRF7 | interferon regulatory factor 7 | -0.00441294 |
| AHNAK | AHNAK nucleoprotein | -0.00439831 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.00439397 |
| RND3 | Rho family GTPase 3 | -0.00439322 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.00438582 |
| TSPAN1 | tetraspanin 1 | -0.00432618 |
| MUC2 | mucin 2, oligomeric mucus/gel-forming | -0.00431516 |
| HIST1H2BD | histone cluster 1, H2bd | -0.00431485 |
| HIST1H2AC | histone cluster 1, H2ac | -0.00422361 |
| DPEP1 | dipeptidase 1 (renal) | -0.00420384 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0041998 |
| SDC4 | syndecan 4 | -0.00417995 |
| IRF1 | interferon regulatory factor 1 | -0.00417136 |
| PLBD1 | phospholipase B domain containing 1 | -0.00416006 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.00415434 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.00414583 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | -0.00414134 |
| LMNA | lamin A/C | -0.00413491 |
| NVL | nuclear VCP-like | -0.00412742 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | -0.00411227 |
| TSPAN12 | tetraspanin 12 | -0.0040896 |
| CLIC3 | chloride intracellular channel 3 | -0.00407298 |
| NEBL | nebulette | -0.00403789 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | -0.00402471 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | -0.00399974 |
| FCGBP | Fc fragment of IgG binding protein | -0.00398877 |
| TNIK | TRAF2 and NCK interacting kinase | -0.00397391 |
| ATF3 | activating transcription factor 3 | -0.00397291 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.00396632 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | -0.00395544 |
| ZSCAN18 | zinc finger and SCAN domain containing 18 | -0.00394172 |
| CLCA1 | chloride channel accessory 1 | -0.00393856 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | -0.00391412 |
| HEPH | hephaestin | -0.00389082 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.00387854 |
| TWSG1 | twisted gastrulation BMP signaling modulator 1 | -0.00384332 |
| DKFZP586I1420 | uncharacterized protein DKFZp586I1420 | -0.0038412 |
| PRUNE2 | prune homolog 2 (Drosophila) | -0.00382484 |
| TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | -0.00380867 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0038083 |
| TRIM22 | tripartite motif containing 22 | -0.00380449 |
| CLEC2B | C-type lectin domain family 2, member B | -0.00380351 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.00378153 |
| FSCN1 | fascin actin-bundling protein 1 | -0.00375885 |
| USP25 | ubiquitin specific peptidase 25 | -0.0037381 |
| TPSAB1 | tryptase alpha/beta 1 | -0.00369257 |
| PLXNB2 | plexin B2 | -0.00366819 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | -0.00365845 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | -0.00365617 |
| LY75 | lymphocyte antigen 75 | -0.00365486 |
| BANK1 | B-cell scaffold protein with ankyrin repeats 1 | -0.00364968 |
| RAB21 | RAB21, member RAS oncogene family | -0.00364729 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.00364668 |
| HSPA13 | heat shock protein 70kDa family, member 13 | -0.00364633 |
| TUBB2A | tubulin, beta 2A class IIa | -0.00364312 |
| GATAD2A | GATA zinc finger domain containing 2A | -0.00363712 |
| DUSP8 | dual specificity phosphatase 8 | -0.0036256 |
| LEFTY1 | left-right determination factor 1 | -0.00361843 |
| NPR3 | natriuretic peptide receptor 3 | -0.0036005 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | -0.00359511 |
| SRGN | serglycin | -0.00359183 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.00358726 |
| DACH1 | dachshund family transcription factor 1 | -0.00358692 |
| HOXB2 | homeobox B2 | -0.00357846 |
| CERS6 | ceramide synthase 6 | -0.00355636 |
| TPBG | trophoblast glycoprotein | -0.00354897 |
| CPA3 | carboxypeptidase A3 (mast cell) | -0.00353761 |
| HSPA2 | heat shock 70kDa protein 2 | -0.00352774 |
| S100P | S100 calcium binding protein P | -0.00351126 |
| FAR2 | fatty acyl CoA reductase 2 | -0.00350795 |
| MICAL1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | -0.00350717 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.00350314 |
| EREG | epiregulin | -0.0034991 |
| IFI44L | interferon-induced protein 44-like | -0.00349713 |
| ITGA4 | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | -0.00347935 |
| IFI44 | interferon-induced protein 44 | -0.00347734 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.00347056 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.00346474 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 | -0.00345947 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.00345784 |
| PTGER2 | prostaglandin E receptor 2 (subtype EP2), 53kDa | -0.00345572 |
| MXRA5 | matrix-remodelling associated 5 | -0.00343544 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.00343237 |
| LRRC17 | leucine rich repeat containing 17 | -0.00342288 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.00341995 |
| IPO13 | importin 13 | -0.00341381 |
| MLF1 | myeloid leukemia factor 1 | -0.00341202 |
| STK38 | serine/threonine kinase 38 | -0.00339785 |
| SMC6 | structural maintenance of chromosomes 6 | -0.00339098 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | -0.0033895 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0033822 |
| PLK2 | polo-like kinase 2 | -0.00337624 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | -0.00336951 |
| ANXA6 | annexin A6 | -0.00336848 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.00336841 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | -0.00336478 |
| TFF3 | trefoil factor 3 (intestinal) | -0.0033635 |
| CCNE1 | cyclin E1 | -0.00335842 |
| AUTS2 | autism susceptibility candidate 2 | -0.00335253 |
| PEG10 | paternally expressed 10 | -0.00335136 |
| OGA | O-GlcNAcase | -0.0033453 |
| PHF1 | PHD finger protein 1 | -0.00332895 |
| SPINK4 | serine peptidase inhibitor, Kazal type 4 | -0.00332162 |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | -0.00331149 |
| BAMBI | BMP and activin membrane-bound inhibitor | -0.00330966 |
| THY1 | Thy-1 cell surface antigen | -0.00330909 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | -0.00330771 |
| BCL3 | B-cell CLL/lymphoma 3 | -0.00329767 |
| ANKRD12 | ankyrin repeat domain 12 | -0.00329097 |
| CRAT | carnitine O-acetyltransferase | -0.00328249 |
| TMEM50B | transmembrane protein 50B | -0.00327515 |
| RRAGA | Ras-related GTP binding A | -0.00326656 |
| PWP2 | PWP2 periodic tryptophan protein homolog (yeast) | -0.00326515 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) | -0.00326243 |
| FEM1C | fem-1 homolog c (C. elegans) | -0.00325874 |
| CEBPG | CCAAT/enhancer binding protein (C/EBP), gamma | -0.00325745 |
| MS4A1 | membrane-spanning 4-domains, subfamily A, member 1 | -0.00324615 |
| BTF3P11 | basic transcription factor 3 pseudogene 11 | -0.00323236 |
| HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) | -0.00322711 |
| ICA1 | islet cell autoantigen 1, 69kDa | -0.00322008 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | -0.00321814 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.00321274 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.00320907 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.00320867 |
| CEACAM7 | carcinoembryonic antigen-related cell adhesion molecule 7 | -0.00320682 |
| GSTM3 | glutathione S-transferase mu 3 (brain) | -0.00320268 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | -0.00320135 |
| MFAP2 | microfibrillar-associated protein 2 | -0.00318663 |
| KLF10 | Kruppel-like factor 10 | -0.00317885 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | -0.00316593 |
| SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1 | -0.00315142 |
| PLAT | plasminogen activator, tissue | -0.00314456 |
| NRIP3 | nuclear receptor interacting protein 3 | -0.00313244 |
| GPR183 | G protein-coupled receptor 183 | -0.00311243 |
| PPBP | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | -0.00310885 |
| CCNA2 | cyclin A2 | -0.00310149 |
| SPDEF | SAM pointed domain containing ETS transcription factor | -0.00310059 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | -0.00309843 |
| TUFT1 | tuftelin 1 | -0.0030984 |
| CRYBG1 | crystallin beta-gamma domain containing 1 | -0.00307054 |
| TFF1 | trefoil factor 1 | -0.00306336 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.00306232 |
| PDZK1IP1 | PDZK1 interacting protein 1 | -0.00305115 |
| AMOTL2 | angiomotin like 2 | -0.00304501 |
| PON2 | paraoxonase 2 | -0.003044 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.00304333 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.0030318 |
| ANXA4 | annexin A4 | -0.0030206 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.00301954 |
| NBPF10 | neuroblastoma breakpoint family, member 10 | -0.00301731 |
| NPY1R | neuropeptide Y receptor Y1 | -0.00301424 |
| PF4 | platelet factor 4 | -0.00300988 |
| PRPF4 | pre-mRNA processing factor 4 | -0.00300845 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.00300656 |
| NID2 | nidogen 2 (osteonidogen) | -0.00300318 |
| SCO2 | SCO2 cytochrome c oxidase assembly protein | -0.00300111 |
| CENPE | centromere protein E, 312kDa | -0.00299931 |
| MEX3D | mex-3 RNA binding family member D | -0.00299039 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.00298599 |
| THBS1 | thrombospondin 1 | -0.00298102 |
| CA2 | carbonic anhydrase II | -0.00298091 |
| KIF13B | kinesin family member 13B | -0.00297233 |
| PAN2 | PAN2 poly(A) specific ribonuclease subunit | -0.00296814 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | -0.00296799 |
| HDAC9 | histone deacetylase 9 | -0.00296729 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | -0.00296716 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | -0.00296608 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.00296508 |
| CCNG2 | cyclin G2 | -0.0029626 |
| PBLD | phenazine biosynthesis-like protein domain containing | -0.00296019 |
| KCTD12 | potassium channel tetramerization domain containing 12 | -0.00295921 |
| TOB1 | transducer of ERBB2, 1 | -0.00295768 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | -0.00294573 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | -0.00294019 |
| MOK | MOK protein kinase | -0.00293207 |
| KLF6 | Kruppel-like factor 6 | -0.00292824 |
| BTG3 | BTG family, member 3 | -0.00292774 |
| AHR | aryl hydrocarbon receptor | -0.0029238 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | -0.00291886 |
| EHD4 | EH-domain containing 4 | -0.00290488 |
| FMO1 | flavin containing monooxygenase 1 | -0.00290456 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.00289213 |
| BIN1 | bridging integrator 1 | -0.00289084 |
| ANO3 | anoctamin 3 | -0.00288803 |
| ALDH8A1 | aldehyde dehydrogenase 8 family, member A1 | -0.00288734 |
| ZC3H12A | zinc finger CCCH-type containing 12A | -0.0028858 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.002883 |
| SLC12A8 | solute carrier family 12, member 8 | -0.00287676 |
| CDCA4 | cell division cycle associated 4 | -0.00287373 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -0.00286975 |
| EZR | ezrin | -0.00286806 |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase | -0.00286183 |
| CTSK | cathepsin K | -0.00285011 |
| GOLIM4 | golgi integral membrane protein 4 | -0.00284689 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 | -0.002846 |
