APPL1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1|The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 26060)
External Link http://www.ncbi.nlm.nih.gov/gene/26060
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Genes

134 interacting proteins for APPL1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTL6A actin-like 6A
ACTN2 actinin, alpha 2
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
ANKRD11 ankyrin repeat domain 11
ANKRD12 ankyrin repeat domain 12
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
AR androgen receptor
ARID4B AT rich interactive domain 4B (RBP1-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BIN1 bridging integrator 1
BRMS1 breast cancer metastasis suppressor 1
C11ORF30 chromosome 11 open reading frame 30
C1QTNF9 C1q and tumor necrosis factor related protein 9
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CCT7 chaperonin containing TCP1, subunit 7 (eta)
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDYL chromodomain protein, Y-like
CHD3 chromodomain helicase DNA binding protein 3
CHD4 chromodomain helicase DNA binding protein 4
CLUH clustered mitochondria (cluA/CLU1) homolog
CMTM4 CKLF-like MARVEL transmembrane domain containing 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTNBP2 cortactin binding protein 2
DACT1 dishevelled-binding antagonist of beta-catenin 1
DCC DCC netrin 1 receptor
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNM2 dynamin 2
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1
DPYSL5 dihydropyrimidinase-like 5
DST dystonin
DTNA dystrobrevin, alpha
DYSF dysferlin
EEA1 early endosome antigen 1
EGFR epidermal growth factor receptor
ELAVL1 ELAV like RNA binding protein 1
ELMSAN1 ELM2 and Myb/SANT-like domain containing 1
FSHR follicle stimulating hormone receptor
GATAD2A GATA zinc finger domain containing 2A
GATAD2B GATA zinc finger domain containing 2B
GPC3 glypican 3
GPS2 G protein pathway suppressor 2
GSE1 Gse1 coiled-coil protein
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HDAC5 histone deacetylase 5
HDIP1 HDAC and MIER1 interacting protein 1
HMG20A high mobility group 20A
HMG20B high mobility group 20B
HSPB1 heat shock 27kDa protein 1
IPO5 importin 5
KDM1A lysine (K)-specific demethylase 1A
KIAA1468 KIAA1468
KPNA1 karyopherin alpha 1 (importin alpha 5)
KXD1 KxDL motif containing 1
LRP2 low density lipoprotein receptor-related protein 2
LUC7L LUC7-like (S. cerevisiae)
MAX MYC associated factor X
MBD2 methyl-CpG binding domain protein 2
MBD3 methyl-CpG binding domain protein 3
MEF2C myocyte enhancer factor 2C
MIER1 mesoderm induction early response 1, transcriptional regulator
MTA1 metastasis associated 1
MTA2 metastasis associated 1 family, member 2
MTA3 metastasis associated 1 family, member 3
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic
NARS asparaginyl-tRNA synthetase
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
OCRL oculocerebrorenal syndrome of Lowe
PHB prohibitin
PHF21A PHD finger protein 21A
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
RAB21 RAB21, member RAS oncogene family
RAB22A RAB22A, member RAS oncogene family
RAB5A RAB5A, member RAS oncogene family
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RBBP4 retinoblastoma binding protein 4
RBBP7 retinoblastoma binding protein 7
RBSN rabenosyn, RAB effector
RCOR1 REST corepressor 1
RCOR2 REST corepressor 2
RCOR3 REST corepressor 3
RREB1 ras responsive element binding protein 1
RUVBL2 RuvB-like AAA ATPase 2
RXRB retinoid X receptor, beta
SAP130 Sin3A-associated protein, 130kDa
SFN stratifin
SIN3A SIN3 transcription regulator family member A
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1)
SPG20 spastic paraplegia 20 (Troyer syndrome)
SRRM2 serine/arginine repetitive matrix 2
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)
SYNE2 spectrin repeat containing, nuclear envelope 2
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TBL1X transducin (beta)-like 1X-linked
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCP1 t-complex 1
TRAF2 TNF receptor-associated factor 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TTC4 tetratricopeptide repeat domain 4
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum)
UBC ubiquitin C
VCP valosin containing protein
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae)
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZMYM2 zinc finger, MYM-type 2
ZNF217 zinc finger protein 217