| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | APTO-253 perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the APTO-253_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0863518 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.085868 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0797705 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0685316 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0578064 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0576142 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0572678 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0555737 |
| POTEF | POTE ankyrin domain family, member F | 0.0482216 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0474287 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0469901 |
| CALR | calreticulin | 0.0428356 |
| MAP1B | microtubule-associated protein 1B | 0.0426951 |
| PRELID2 | PRELI domain containing 2 | 0.0356396 |
| HDAC9 | histone deacetylase 9 | 0.0350537 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0343401 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0324642 |
| LDHA | lactate dehydrogenase A | 0.0314187 |
| DST | dystonin | 0.03089 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0308206 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0307795 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0294246 |
| KIFAP3 | kinesin-associated protein 3 | 0.0279395 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0271583 |
| SP100 | SP100 nuclear antigen | 0.0256695 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0253837 |
| CD44 | CD44 molecule (Indian blood group) | 0.0253032 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0252012 |
| TPM3 | tropomyosin 3 | 0.0240483 |
| VEGFC | vascular endothelial growth factor C | 0.0240024 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.023822 |
| NEK7 | NIMA-related kinase 7 | 0.0238098 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0237822 |
| TLE4 | transducin-like enhancer of split 4 | 0.0236636 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0234995 |
| VCL | vinculin | 0.0221058 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0217821 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.0217453 |
| LMNA | lamin A/C | 0.0216062 |
| SON | SON DNA binding protein | 0.021292 |
| MT1X | metallothionein 1X | 0.0211197 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0208548 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0205759 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0204163 |
| TXNRD1 | thioredoxin reductase 1 | 0.0202631 |
| FBN1 | fibrillin 1 | 0.0202323 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0200439 |
| PFN1 | profilin 1 | 0.0192593 |
| ENO1 | enolase 1, (alpha) | 0.0188637 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | 0.0183832 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0183095 |
| MB21D2 | Mab-21 domain containing 2 | 0.0182871 |
| RUNX1 | runt-related transcription factor 1 | 0.0182596 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0182409 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0180829 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.017905 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.017574 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0174005 |
| TENM3 | teneurin transmembrane protein 3 | 0.0173229 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0173162 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0171732 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0168119 |
| MSN | moesin | 0.0160748 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0159836 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0155936 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.015533 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0153462 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0152619 |
| INSIG2 | insulin induced gene 2 | 0.0151465 |
| DIAPH3 | diaphanous-related formin 3 | 0.0150529 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0150255 |
| MEIS2 | Meis homeobox 2 | 0.0148458 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0145481 |
| MMP12 | matrix metallopeptidase 12 | 0.0145153 |
| CLU | clusterin | 0.0143105 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0141804 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | 0.0140167 |
| OR51B5 | olfactory receptor, family 51, subfamily B, member 5 | 0.013876 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0138555 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | 0.0137874 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0137159 |
| SUCNR1 | succinate receptor 1 | 0.0135876 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0134448 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0133952 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.013373 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0132317 |
| PCDH7 | protocadherin 7 | 0.0130443 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0130442 |
| XKR6 | XK, Kell blood group complex subunit-related family, member 6 | 0.0126975 |
| HELZ | helicase with zinc finger | 0.0125575 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0124898 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.012429 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0124072 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0123492 |
| BSG | basigin (Ok blood group) | 0.0123419 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0123373 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0122843 |
| RRM2 | ribonucleotide reductase M2 | 0.0122332 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | 0.0121961 |
| CXXC5 | CXXC finger protein 5 | 0.012162 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.248233 |
| PODXL | podocalyxin-like | -0.144101 |
| CDH13 | cadherin 13 | -0.129229 |
| PLAT | plasminogen activator, tissue | -0.108821 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0934258 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0783673 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0697557 |
| CSTB | cystatin B (stefin B) | -0.0642185 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0504571 |
| LOXL2 | lysyl oxidase-like 2 | -0.0488926 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0483897 |
| THBS2 | thrombospondin 2 | -0.047973 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0479454 |
| HLA-B | major histocompatibility complex, class I, B | -0.0478355 |
| NAV1 | neuron navigator 1 | -0.0471236 |
| AHNAK | AHNAK nucleoprotein | -0.0453821 |
| CCND1 | cyclin D1 | -0.0444597 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0438673 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0425881 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0394654 |
| COL5A1 | collagen, type V, alpha 1 | -0.0376917 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0369684 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0368008 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0352588 |
| RPL37A | ribosomal protein L37a | -0.0349656 |
| FN1 | fibronectin 1 | -0.0336563 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0333997 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.0332066 |
| RPS6 | ribosomal protein S6 | -0.0315956 |
| RPL35A | ribosomal protein L35a | -0.0315005 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0302762 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0300797 |
| PRSS23 | protease, serine, 23 | -0.0298587 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0284745 |
| SEPTIN9 | septin 9 | -0.028407 |
| KRT81 | keratin 81, type II | -0.0282019 |
| CAVIN1 | caveolae associated protein 1 | -0.0281415 |
| FLNB | filamin B, beta | -0.0278466 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0271302 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0270736 |
| RPLP2 | ribosomal protein, large, P2 | -0.0270344 |
| RPL31 | ribosomal protein L31 | -0.0254743 |
| RPS27A | ribosomal protein S27a | -0.0252716 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0252701 |
| EGFR | epidermal growth factor receptor | -0.0251755 |
| S100A6 | S100 calcium binding protein A6 | -0.0248597 |
| RPS8 | ribosomal protein S8 | -0.0248253 |
| CTSB | cathepsin B | -0.0242733 |
| EFNA5 | ephrin-A5 | -0.0242224 |
| MT2A | metallothionein 2A | -0.0239603 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0237562 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0235079 |
| SLFN5 | schlafen family member 5 | -0.0234522 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | -0.0233096 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0231553 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0219853 |
| ZNF217 | zinc finger protein 217 | -0.0219147 |
| S100A11 | S100 calcium binding protein A11 | -0.0213949 |
| RPL37 | ribosomal protein L37 | -0.0213918 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0213412 |
| FTL | ferritin, light polypeptide | -0.020983 |
| RPL12 | ribosomal protein L12 | -0.0201703 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0200648 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0198676 |
| TNS3 | tensin 3 | -0.0198387 |
| NDRG1 | N-myc downstream regulated 1 | -0.0198006 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.0197549 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0196357 |
| RASA3 | RAS p21 protein activator 3 | -0.0196258 |
| RTN4 | reticulon 4 | -0.0196126 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | -0.0192895 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0192763 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | -0.0190737 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0190465 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0190422 |
| RPS3 | ribosomal protein S3 | -0.0190003 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0189505 |
| RPS13 | ribosomal protein S13 | -0.0185833 |
| NIBAN1 | niban apoptosis regulator 1 | -0.0184735 |
| CYTH3 | cytohesin 3 | -0.0183786 |
| RAI14 | retinoic acid induced 14 | -0.0180557 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0179325 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0179134 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0178102 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.0176503 |
| RPL38 | ribosomal protein L38 | -0.0175721 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0175628 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0174775 |
| RACK1 | receptor for activated C kinase 1 | -0.0174469 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0173422 |
| PLXNA2 | plexin A2 | -0.0171964 |
| FAM107B | family with sequence similarity 107, member B | -0.0171166 |
| RPL23 | ribosomal protein L23 | -0.0171056 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0170904 |
| GLIS3 | GLIS family zinc finger 3 | -0.0170546 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0170215 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0170193 |
| RPS11 | ribosomal protein S11 | -0.0169053 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0168759 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0167831 |
