| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | APTO-253 perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the APTO-253_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.25929 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.12985 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0922471 |
| MKI67 | marker of proliferation Ki-67 | 0.0839647 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0810319 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0711692 |
| CENPF | centromere protein F, 350/400kDa | 0.0658277 |
| TXNRD1 | thioredoxin reductase 1 | 0.0640202 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0580339 |
| TPI1 | triosephosphate isomerase 1 | 0.0541325 |
| ANXA1 | annexin A1 | 0.0506913 |
| CALR | calreticulin | 0.049586 |
| PTMA | prothymosin, alpha | 0.0493018 |
| CANX | calnexin | 0.0445505 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0426499 |
| RRM2 | ribonucleotide reductase M2 | 0.0423244 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0390961 |
| XPO1 | exportin 1 | 0.0387753 |
| H1-0 | H1.0 linker histone | 0.038452 |
| HDAC9 | histone deacetylase 9 | 0.0380548 |
| TPX2 | TPX2, microtubule-associated | 0.037427 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0370807 |
| DIAPH3 | diaphanous-related formin 3 | 0.0362968 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0360707 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0357734 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0350212 |
| WWOX | WW domain containing oxidoreductase | 0.0342155 |
| CBX3 | chromobox homolog 3 | 0.0335941 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0333754 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0330775 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0330629 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0324013 |
| CENPE | centromere protein E, 312kDa | 0.0303491 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.029976 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0298345 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0295263 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0292661 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0290116 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0285681 |
| YAP1 | Yes-associated protein 1 | 0.0280987 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0279354 |
| DEK | DEK proto-oncogene | 0.027926 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0279155 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0277206 |
| TUBA1B | tubulin, alpha 1b | 0.0274055 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0270726 |
| FTL | ferritin, light polypeptide | 0.0267593 |
| PFN1 | profilin 1 | 0.0264029 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0258055 |
| KIF4A | kinesin family member 4A | 0.0254514 |
| NLGN1 | neuroligin 1 | 0.0248304 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0245514 |
| STMN1 | stathmin 1 | 0.024476 |
| TPR | translocated promoter region, nuclear basket protein | 0.0231631 |
| MED13L | mediator complex subunit 13-like | 0.0231329 |
| ENO1 | enolase 1, (alpha) | 0.0227658 |
| LDHA | lactate dehydrogenase A | 0.0225989 |
| HMGA2 | high mobility group AT-hook 2 | 0.0224963 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 0.0224565 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0223968 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0223473 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0222161 |
| YBX3 | Y box binding protein 3 | 0.0220331 |
| NDC80 | NDC80 kinetochore complex component | 0.0218805 |
| KIF5B | kinesin family member 5B | 0.0217844 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0213085 |
| CIP2A | cellular inhibitor of PP2A | 0.0213071 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0209078 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0207011 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0206908 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0205108 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0204727 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | 0.0203149 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0200326 |
| TPM3 | tropomyosin 3 | 0.0198628 |
| ANLN | anillin, actin binding protein | 0.0198485 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0193703 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0193476 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0192167 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0191379 |
| CCDC88A | coiled-coil domain containing 88A | 0.0189417 |
| CLTC | clathrin, heavy chain (Hc) | 0.0189374 |
| SGO2 | shugoshin 2 | 0.0188879 |
| HMGB1 | high mobility group box 1 | 0.0187767 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0186943 |
| ECT2 | epithelial cell transforming 2 | 0.0185979 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.0184086 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0183367 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0183362 |
| STAG2 | stromal antigen 2 | 0.0182865 |
| FUS | FUS RNA binding protein | 0.0182647 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | 0.0182209 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0180711 |
| LDHB | lactate dehydrogenase B | 0.0179896 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0178825 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | 0.0178777 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0178137 |
| ADIPOR2 | adiponectin receptor 2 | 0.0176996 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0175761 |
| HMGB2 | high mobility group box 2 | 0.0174324 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.143592 |
| AREG | amphiregulin | -0.101501 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0607002 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0597437 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0579655 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0504742 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0500886 |
| RPS12 | ribosomal protein S12 | -0.0485158 |
| RPL37A | ribosomal protein L37a | -0.0438597 |
| RASAL2 | RAS protein activator like 2 | -0.043224 |
| RPS13 | ribosomal protein S13 | -0.0409844 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0387076 |
| RPS29 | ribosomal protein S29 | -0.0381183 |
| EHBP1 | EH domain binding protein 1 | -0.0380328 |
| RPS6 | ribosomal protein S6 | -0.0379555 |
| BCHE | butyrylcholinesterase | -0.0373429 |
| RPL11 | ribosomal protein L11 | -0.0353704 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0343327 |
| RPL31 | ribosomal protein L31 | -0.0340362 |
| PCDH7 | protocadherin 7 | -0.034006 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.033293 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0327262 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0326278 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0321504 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.031578 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0307191 |
| RPL26 | ribosomal protein L26 | -0.0306798 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0299964 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0299706 |
| FBXO11 | F-box protein 11 | -0.0299699 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0297605 |
| IPO7 | importin 7 | -0.0296948 |
| RPL37 | ribosomal protein L37 | -0.0293657 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | -0.0290331 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0277455 |
| RPL35A | ribosomal protein L35a | -0.0276448 |
| RPS27A | ribosomal protein S27a | -0.0272253 |
| TMSB10 | thymosin beta 10 | -0.0269864 |
| SBF2 | SET binding factor 2 | -0.0267902 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0263161 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0255127 |
| CCN2 | cellular communication network factor 2 | -0.0254848 |
| NEBL | nebulette | -0.025407 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0230175 |
| RPS23 | ribosomal protein S23 | -0.0227109 |
| NABP1 | nucleic acid binding protein 1 | -0.0223166 |
| RPS16 | ribosomal protein S16 | -0.0221537 |
| RPS20 | ribosomal protein S20 | -0.0211949 |
| MMP12 | matrix metallopeptidase 12 | -0.0211629 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0207695 |
| RPS3 | ribosomal protein S3 | -0.0205717 |
| PRR16 | proline rich 16 | -0.0205437 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.020421 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | -0.0202271 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0199554 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0197842 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0193876 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.0193813 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.019082 |
| RPS17 | ribosomal protein S17 | -0.0189004 |
| RPS25 | ribosomal protein S25 | -0.0188239 |
| CMIP | c-Maf inducing protein | -0.018806 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0187827 |
| SLC25A3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | -0.018746 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | -0.0184419 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0184398 |
| MTAP | methylthioadenosine phosphorylase | -0.018429 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0183807 |
| RPL38 | ribosomal protein L38 | -0.01825 |
| ASPH | aspartate beta-hydroxylase | -0.0179313 |
| MCL1 | myeloid cell leukemia 1 | -0.0178681 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0177013 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0176307 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0175393 |
| NAV3 | neuron navigator 3 | -0.017379 |
| RPL3 | ribosomal protein L3 | -0.016798 |
| TBC1D32 | TBC1 domain family, member 32 | -0.0160282 |
| RPL7A | ribosomal protein L7a | -0.0156319 |
| DENND5A | DENN/MADD domain containing 5A | -0.0156166 |
| RPS11 | ribosomal protein S11 | -0.0155684 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0155097 |
| RHBDD1 | rhomboid domain containing 1 | -0.015503 |
| YEATS2 | YEATS domain containing 2 | -0.0155026 |
| RIMKLB | ribosomal modification protein rimK-like family member B | -0.015291 |
| EIF4B | eukaryotic translation initiation factor 4B | -0.0152726 |
| RPL28 | ribosomal protein L28 | -0.0151692 |
| LMO7 | LIM domain 7 | -0.0151364 |
| MTPN | myotrophin | -0.0149325 |
| FSTL5 | follistatin-like 5 | -0.0148407 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -0.0146424 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0144086 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0143864 |
| ATF4 | activating transcription factor 4 | -0.0143429 |
| RASA2 | RAS p21 protein activator 2 | -0.0143277 |
| RPL15 | ribosomal protein L15 | -0.0143258 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0142934 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.0141733 |
| MEMO1 | mediator of cell motility 1 | -0.0141705 |
| CLDN1 | claudin 1 | -0.0140041 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0138674 |
