APTO-253_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the APTO-253_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.167211
FTH1 ferritin, heavy polypeptide 1 0.155297
IGFBP3 insulin-like growth factor binding protein 3 0.122692
VIM vimentin 0.121246
TMSB10 thymosin beta 10 0.0968473
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0945103
B2M beta-2-microglobulin 0.0878459
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0849751
CP ceruloplasmin (ferroxidase) 0.0774466
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0631481
RPS8 ribosomal protein S8 0.0575887
HLA-B major histocompatibility complex, class I, B 0.057029
RPL35A ribosomal protein L35a 0.05364
RPS4X ribosomal protein S4, X-linked 0.0535263
RPL34 ribosomal protein L34 0.0526254
RPS6 ribosomal protein S6 0.0521253
HSPB1 heat shock 27kDa protein 1 0.051831
RPL23 ribosomal protein L23 0.0499012
EIF1 eukaryotic translation initiation factor 1 0.0455158
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 0.0431759
EEF2 eukaryotic translation elongation factor 2 0.0425904
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0419887
RND3 Rho family GTPase 3 0.0416388
ZFP36L1 ZFP36 ring finger protein-like 1 0.0408851
GLIS3 GLIS family zinc finger 3 0.0397945
ASPH aspartate beta-hydroxylase 0.0383773
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0376209
RPL12 ribosomal protein L12 0.0374947
RPS19 ribosomal protein S19 0.0372793
GDF15 growth differentiation factor 15 0.0370369
PFN1 profilin 1 0.0367944
RPL8 ribosomal protein L8 0.0366346
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0365226
MGST1 microsomal glutathione S-transferase 1 0.0356051
TPT1 tumor protein, translationally-controlled 1 0.035473
RAI14 retinoic acid induced 14 0.035285
CXCL8 chemokine (C-X-C motif) ligand 8 0.0351886
RPLP1 ribosomal protein, large, P1 0.0350267
RPLP2 ribosomal protein, large, P2 0.0347432
IFI16 interferon, gamma-inducible protein 16 0.0341472
RPLP0 ribosomal protein, large, P0 0.034139
IFITM3 interferon induced transmembrane protein 3 0.0337515
HLA-A major histocompatibility complex, class I, A 0.0332868
MT2A metallothionein 2A 0.0325239
S100A9 S100 calcium binding protein A9 0.0317673
OSMR oncostatin M receptor 0.0317504
RPL30 ribosomal protein L30 0.03094
CA12 carbonic anhydrase XII 0.0309377
RPL35 ribosomal protein L35 0.0308919
RPL26 ribosomal protein L26 0.0308301
HMGB1 high mobility group box 1 0.0307774
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0304301
S100A10 S100 calcium binding protein A10 0.0303466
RPS13 ribosomal protein S13 0.0303394
TFPI2 tissue factor pathway inhibitor 2 0.0295641
RACK1 receptor for activated C kinase 1 0.029489
S100A6 S100 calcium binding protein A6 0.0282966
RPL31 ribosomal protein L31 0.0279735
KPNB1 karyopherin (importin) beta 1 0.0279714
TXNRD1 thioredoxin reductase 1 0.0277324
RPL28 ribosomal protein L28 0.0276637
IFI6 interferon, alpha-inducible protein 6 0.0275938
PBX1 pre-B-cell leukemia homeobox 1 0.0275901
GPC5 glypican 5 0.0268345
NRP1 neuropilin 1 0.0263884
EIF4A1 eukaryotic translation initiation factor 4A1 0.0259072
ENO1 enolase 1, (alpha) 0.0253694
PALLD palladin, cytoskeletal associated protein 0.0252758
CALD1 caldesmon 1 0.0249606
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0249005
MYADM myeloid-associated differentiation marker 0.0247658
S100A11 S100 calcium binding protein A11 0.0239337
RPS17 ribosomal protein S17 0.0238242
VCAM1 vascular cell adhesion molecule 1 0.0237809
RPS27 ribosomal protein S27 0.0229252
RPS24 ribosomal protein S24 0.0229142
UBC ubiquitin C 0.0228942
RPL36 ribosomal protein L36 0.0228195
RPL32 ribosomal protein L32 0.0226491
RPL19 ribosomal protein L19 0.0225949
TKT transketolase 0.022531
PTMA prothymosin, alpha 0.0224143
RPS14 ribosomal protein S14 0.0219104
LIMA1 LIM domain and actin binding 1 0.0218143
RPS23 ribosomal protein S23 0.0218079
EIF5B eukaryotic translation initiation factor 5B 0.0214315
CD63 CD63 molecule 0.0211599
IFITM1 interferon induced transmembrane protein 1 0.0208462
RPL36A ribosomal protein L36a 0.0207318
RPS5 ribosomal protein S5 0.0207251
HLA-C major histocompatibility complex, class I, C 0.0204965
IFI27 interferon, alpha-inducible protein 27 0.0201727
RSL1D1 ribosomal L1 domain containing 1 0.0200721
LDHA lactate dehydrogenase A 0.019953
PLIN2 perilipin 2 0.0198552
SOD1 superoxide dismutase 1, soluble 0.0197158
TMED9 transmembrane emp24 protein transport domain containing 9 0.0196685
LOC102724023 ES1 protein homolog, mitochondrial 0.0196413
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0195896
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0195683

decreased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor -0.138101
NAV2 neuron navigator 2 -0.124761
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0945806
FNDC3B fibronectin type III domain containing 3B -0.094093
MYH9 myosin, heavy chain 9, non-muscle -0.0881316
SPAG9 sperm associated antigen 9 -0.0857614
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0841401
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0837016
NAMPT nicotinamide phosphoribosyltransferase -0.0731777
GPC6 glypican 6 -0.0714443
FMNL2 formin-like 2 -0.0662953
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0657468
NRIP1 nuclear receptor interacting protein 1 -0.0613158
MSN moesin -0.0594395
FRMD4A FERM domain containing 4A -0.0582643
RUNX1 runt-related transcription factor 1 -0.0581585
EXT1 exostosin glycosyltransferase 1 -0.0560775
PAX8 paired box 8 -0.0551435
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0527341
ANKRD33B ankyrin repeat domain 33B -0.0520556
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0456463
CADM1 cell adhesion molecule 1 -0.0455682
CLTC clathrin, heavy chain (Hc) -0.0447971
ECPAS Ecm29 proteasome adaptor and scaffold -0.0436399
CDK6 cyclin-dependent kinase 6 -0.0430866
XPO1 exportin 1 -0.0425928
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0423768
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0415155
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0413921
APP amyloid beta (A4) precursor protein -0.0412667
RBM39 RNA binding motif protein 39 -0.0408061
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.040718
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0406104
RNF220 ring finger protein 220 -0.0402757
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0398998
ANKRD11 ankyrin repeat domain 11 -0.039541
KMT2E lysine (K)-specific methyltransferase 2E -0.039358
SBF2 SET binding factor 2 -0.0393073
NDRG1 N-myc downstream regulated 1 -0.0390379
TPST1 tyrosylprotein sulfotransferase 1 -0.0385069
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.038472
SOD2 superoxide dismutase 2, mitochondrial -0.0383421
TTC28 tetratricopeptide repeat domain 28 -0.0375197
ZFAND3 zinc finger, AN1-type domain 3 -0.0372274
ANLN anillin, actin binding protein -0.036758
RPS2 ribosomal protein S2 -0.0366827
PDE4D phosphodiesterase 4D, cAMP-specific -0.0362165
UBQLN1 ubiquilin 1 -0.0358893
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0358833
KMT2C lysine (K)-specific methyltransferase 2C -0.0352497
PTK2 protein tyrosine kinase 2 -0.0350839
ARHGAP26 Rho GTPase activating protein 26 -0.0349689
OSBPL3 oxysterol binding protein-like 3 -0.0346604
SUCO SUN domain containing ossification factor -0.0343646
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0342945
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.03399
NUP98 nucleoporin 98kDa -0.0332513
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0331487
FAF1 Fas (TNFRSF6) associated factor 1 -0.033029
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0330173
ZFC3H1 zinc finger, C3H1-type containing -0.0330108
GRB10 growth factor receptor-bound protein 10 -0.0327133
DDIT4 DNA-damage-inducible transcript 4 -0.0325104
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.032372
DIAPH3 diaphanous-related formin 3 -0.0322765
MACF1 microtubule-actin crosslinking factor 1 -0.0321676
COG6 component of oligomeric golgi complex 6 -0.0320289
COG5 component of oligomeric golgi complex 5 -0.0320129
BIRC6 baculoviral IAP repeat containing 6 -0.0320103
KDM6A lysine (K)-specific demethylase 6A -0.031395
UBAP2 ubiquitin associated protein 2 -0.0313401
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0309886
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0307774
ANKRD17 ankyrin repeat domain 17 -0.0307579
USP34 ubiquitin specific peptidase 34 -0.0305549
NCKAP1 NCK-associated protein 1 -0.0304802
MYO10 myosin X -0.0300202
WAC WW domain containing adaptor with coiled-coil -0.0300149
SLC35F3 solute carrier family 35, member F3 -0.0299082
SRPK2 SRSF protein kinase 2 -0.0297217
SSH2 slingshot protein phosphatase 2 -0.0296673
SDCBP syndecan binding protein (syntenin) -0.0295398
ZC3H11A zinc finger CCCH-type containing 11A -0.0293641
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0289744
GOLGA3 golgin A3 -0.0289284
ANXA5 annexin A5 -0.0288089
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -0.0287772
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0287415
SMAD3 SMAD family member 3 -0.0285683
WNK1 WNK lysine deficient protein kinase 1 -0.0284354
AHNAK AHNAK nucleoprotein -0.0284132
LOXL2 lysyl oxidase-like 2 -0.0283178
WDR43 WD repeat domain 43 -0.028288
RAB1A RAB1A, member RAS oncogene family -0.028208
JAK1 Janus kinase 1 -0.0281689
SP3 Sp3 transcription factor -0.02816
PUM2 pumilio RNA-binding family member 2 -0.0280018
TPM3 tropomyosin 3 -0.0279398
IARS1 isoleucyl-tRNA synthetase 1 -0.0278358
DST dystonin -0.027593