| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | APTO-253 perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the APTO-253_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.118583 |
| PDE10A | phosphodiesterase 10A | 0.0900204 |
| EFNA5 | ephrin-A5 | 0.0753884 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0648914 |
| KYNU | kynureninase | 0.048827 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0466291 |
| SMAD3 | SMAD family member 3 | 0.0447624 |
| CMIP | c-Maf inducing protein | 0.0379271 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0371464 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0370807 |
| OSMR | oncostatin M receptor | 0.035257 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0314048 |
| MCL1 | myeloid cell leukemia 1 | 0.0306442 |
| EGFR | epidermal growth factor receptor | 0.0283983 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0279215 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0279043 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0270865 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0265602 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.0261965 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0246185 |
| SMYD3 | SET and MYND domain containing 3 | 0.0243289 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0241314 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0234238 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0233419 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0231718 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0228512 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0221384 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0209587 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0207046 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0203436 |
| GLIS3 | GLIS family zinc finger 3 | 0.0187374 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0184947 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0182859 |
| TGM2 | transglutaminase 2 | 0.0182341 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0178414 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0178093 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.017723 |
| ANO6 | anoctamin 6 | 0.0174627 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0174254 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0171909 |
| FAT1 | FAT atypical cadherin 1 | 0.0168627 |
| GRAMD1B | GRAM domain containing 1B | 0.0164157 |
| CYFIP1 | cytoplasmic FMR1 interacting protein 1 | 0.0162343 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.016003 |
| TDRD7 | tudor domain containing 7 | 0.0159055 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0153867 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0153321 |
| ETNK1 | ethanolamine kinase 1 | 0.0153303 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0151172 |
| MYO9A | myosin IXA | 0.0147528 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0147389 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0145574 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.0144364 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0143053 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0141608 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0141502 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0141307 |
| WWOX | WW domain containing oxidoreductase | 0.0140168 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0135986 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | 0.0135888 |
| RAD51B | RAD51 paralog B | 0.0135786 |
| BMP6 | bone morphogenetic protein 6 | 0.0135514 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0134403 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0132832 |
| RIGI | RNA sensor RIG-I | 0.0131517 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0131453 |
| PLSCR1 | phospholipid scramblase 1 | 0.0129596 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0128883 |
| SETX | senataxin | 0.0128444 |
| RUNX1 | runt-related transcription factor 1 | 0.0128403 |
| GPATCH2L | G patch domain containing 2-like | 0.0128345 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | 0.012824 |
| TUT7 | terminal uridylyl transferase 7 | 0.0128174 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0127737 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0127222 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0127179 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0126464 |
| MAMLD1 | mastermind-like domain containing 1 | 0.0125424 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0125025 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0124673 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.012435 |
| DST | dystonin | 0.0123853 |
| EXOC6B | exocyst complex component 6B | 0.012338 |
| SGMS1 | sphingomyelin synthase 1 | 0.0123236 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0123086 |
| PLEC | plectin | 0.0120812 |
| MYO1E | myosin IE | 0.012063 |
| LAMC2 | laminin, gamma 2 | 0.0119568 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0119459 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0118575 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0116915 |
| HDAC8 | histone deacetylase 8 | 0.0116647 |
| CLTC | clathrin, heavy chain (Hc) | 0.011612 |
| KIAA1217 | KIAA1217 | 0.0116002 |
| JAG1 | jagged 1 | 0.0115402 |
| HMGA2 | high mobility group AT-hook 2 | 0.0114331 |
| VCL | vinculin | 0.0111686 |
| TRIM25 | tripartite motif containing 25 | 0.0110956 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0110913 |
| JMJD1C | jumonji domain containing 1C | 0.0110815 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | -0.194458 |
| TMSB10 | thymosin beta 10 | -0.187884 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.161674 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.14297 |
| PTMA | prothymosin, alpha | -0.137927 |
| MT2A | metallothionein 2A | -0.119039 |
| VIM | vimentin | -0.110177 |
| RPS6 | ribosomal protein S6 | -0.108495 |
| RPS19 | ribosomal protein S19 | -0.105599 |
| USP3 | ubiquitin specific peptidase 3 | -0.0942081 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.08386 |
| MT1X | metallothionein 1X | -0.0827049 |
| ACTG1 | actin gamma 1 | -0.0786992 |
| RPLP1 | ribosomal protein, large, P1 | -0.0774685 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0746529 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0702451 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.064142 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0601886 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0601781 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.059749 |
| GOLGA4 | golgin A4 | -0.058887 |
| RPL23 | ribosomal protein L23 | -0.0549894 |
| HELZ | helicase with zinc finger | -0.054907 |
| SPAG9 | sperm associated antigen 9 | -0.0544267 |
| S100A10 | S100 calcium binding protein A10 | -0.053132 |
| PFN1 | profilin 1 | -0.0529707 |
| RPL19 | ribosomal protein L19 | -0.0518679 |
| RPS8 | ribosomal protein S8 | -0.0506646 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0497138 |
| KRT81 | keratin 81, type II | -0.049501 |
| RPL12 | ribosomal protein L12 | -0.0491135 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0489527 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0481016 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0480479 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0475958 |
| RPS24 | ribosomal protein S24 | -0.046107 |
| TKT | transketolase | -0.0460136 |
| S100A6 | S100 calcium binding protein A6 | -0.0455525 |
| RPL35A | ribosomal protein L35a | -0.0454207 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0451631 |
| RPS16 | ribosomal protein S16 | -0.0451114 |
| CANX | calnexin | -0.0441707 |
| NDRG1 | N-myc downstream regulated 1 | -0.0436694 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0434093 |
| PGK1 | phosphoglycerate kinase 1 | -0.0426391 |
| RPLP0 | ribosomal protein, large, P0 | -0.0421605 |
| VDAC1 | voltage-dependent anion channel 1 | -0.041916 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0417908 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0407458 |
| WDR45B | WD repeat domain 45B | -0.0400063 |
| RPS3 | ribosomal protein S3 | -0.0389583 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0377749 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0374344 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0370615 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0368469 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0364752 |
| RPL26 | ribosomal protein L26 | -0.0363365 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0355269 |
| RPS27A | ribosomal protein S27a | -0.0353653 |
| RPL8 | ribosomal protein L8 | -0.0351557 |
| RPS13 | ribosomal protein S13 | -0.0348708 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0345427 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0344116 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0339582 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0329936 |
| UBC | ubiquitin C | -0.0327596 |
| FMNL2 | formin-like 2 | -0.0327146 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0325721 |
| PKM | pyruvate kinase, muscle | -0.0323052 |
| NUP58 | nucleoporin 58 | -0.0318688 |
| SEPTIN7 | septin 7 | -0.0314154 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0313281 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0313112 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0310829 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.03062 |
| RPS5 | ribosomal protein S5 | -0.0306109 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0303366 |
| HMGA1 | high mobility group AT-hook 1 | -0.0300679 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0297844 |
| RPL31 | ribosomal protein L31 | -0.0297285 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0296305 |
| RPL28 | ribosomal protein L28 | -0.0291886 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0290962 |
| FBL | fibrillarin | -0.0283625 |
| RPLP2 | ribosomal protein, large, P2 | -0.0283192 |
| TPI1 | triosephosphate isomerase 1 | -0.0281323 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0279639 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0278762 |
| LMNA | lamin A/C | -0.0278084 |
| RPS11 | ribosomal protein S11 | -0.0277374 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0276042 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0276041 |
| ADM | adrenomedullin | -0.0275764 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0275556 |
| RPL37A | ribosomal protein L37a | -0.0274903 |
| RPL32 | ribosomal protein L32 | -0.0272985 |
| KLF6 | Kruppel-like factor 6 | -0.0272977 |
| POTEF | POTE ankyrin domain family, member F | -0.0272894 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0271076 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0269914 |
