| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | APTO-253 perturbation in AsPC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the APTO-253_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.333487 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.182525 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | 0.131444 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0950755 |
| TMSB10 | thymosin beta 10 | 0.0865982 |
| TXNIP | thioredoxin interacting protein | 0.0846143 |
| EZR | ezrin | 0.0811067 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.076914 |
| FLNB | filamin B, beta | 0.0707935 |
| PTMA | prothymosin, alpha | 0.0696073 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0691573 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | 0.06337 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0599273 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0594542 |
| GOLGA4 | golgin A4 | 0.0592519 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0570991 |
| DSG2 | desmoglein 2 | 0.0531935 |
| MYOF | myoferlin | 0.05283 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | 0.0517064 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0500409 |
| CALU | calumenin | 0.0499251 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0474497 |
| TPM3 | tropomyosin 3 | 0.0470635 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0468946 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0467749 |
| SGMS2 | sphingomyelin synthase 2 | 0.0454638 |
| RRBP1 | ribosome binding protein 1 | 0.0453252 |
| VIM | vimentin | 0.0449947 |
| LMTK2 | lemur tyrosine kinase 2 | 0.0449762 |
| EMP1 | epithelial membrane protein 1 | 0.0436672 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0414961 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0411707 |
| NOP58 | NOP58 ribonucleoprotein | 0.0407716 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0391011 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0390875 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0384723 |
| WWC1 | WW and C2 domain containing 1 | 0.0383957 |
| PGK1 | phosphoglycerate kinase 1 | 0.0381514 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0379362 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0379087 |
| RAB10 | RAB10, member RAS oncogene family | 0.0378944 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0371875 |
| EFNA5 | ephrin-A5 | 0.0363433 |
| S100A10 | S100 calcium binding protein A10 | 0.0362062 |
| CAB39 | calcium binding protein 39 | 0.0360016 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0347458 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0325834 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.0319554 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0313007 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0312594 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0311564 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0311082 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0310646 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0309378 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0308212 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0307546 |
| MED13L | mediator complex subunit 13-like | 0.0302126 |
| CD2AP | CD2-associated protein | 0.0297057 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0293929 |
| IKBIP | IKBKB interacting protein | 0.0293562 |
| OSMR | oncostatin M receptor | 0.0291977 |
| SRP54 | signal recognition particle 54kDa | 0.0290487 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0284372 |
| SACK1A | scaffolding CK1 anchoring protein A | 0.0280611 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0279947 |
| MTDH | metadherin | 0.0279261 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0278111 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0277798 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0277736 |
| FTL | ferritin, light polypeptide | 0.0277073 |
| RPL8 | ribosomal protein L8 | 0.0275936 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0272524 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0272349 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 0.0267123 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0266348 |
| BCL2L1 | BCL2-like 1 | 0.0262458 |
| PROSER2 | proline and serine rich 2 | 0.0260645 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.026016 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0259007 |
| RPS2 | ribosomal protein S2 | 0.0258621 |
| CLINT1 | clathrin interactor 1 | 0.0256185 |
| RLF | rearranged L-myc fusion | 0.02487 |
| PMM2 | phosphomannomutase 2 | 0.0248211 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0248109 |
| SLMAP | sarcolemma associated protein | 0.0247042 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0246842 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0246651 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0245027 |
| TNPO3 | transportin 3 | 0.0243468 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0242398 |
| MATR3 | matrin 3 | 0.0240955 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0238724 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0233786 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0230586 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.023009 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0229551 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0228669 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.022779 |
| SEPTIN7 | septin 7 | 0.0227166 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.0226045 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.142393 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | -0.0822821 |
| CLMP | CXADR-like membrane protein | -0.0805154 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0760714 |
| EGFR | epidermal growth factor receptor | -0.0711277 |
| INTS6 | integrator complex subunit 6 | -0.0651702 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0645781 |
| LAMA4 | laminin, alpha 4 | -0.0638931 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0595976 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0585578 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0501986 |
| LAMC2 | laminin, gamma 2 | -0.0498607 |
| XYLT1 | xylosyltransferase I | -0.0493867 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0490309 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0482316 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0482089 |
| LAMB3 | laminin, beta 3 | -0.0476608 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0464708 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0462228 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0458513 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0441887 |
| NABP1 | nucleic acid binding protein 1 | -0.0435081 |
| DIAPH2 | diaphanous-related formin 2 | -0.0423053 |
| UPP1 | uridine phosphorylase 1 | -0.041949 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0401189 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0398548 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0389155 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0388505 |
| FMNL2 | formin-like 2 | -0.038731 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | -0.0385959 |
| MCL1 | myeloid cell leukemia 1 | -0.0375351 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0373642 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0371359 |
| PLEC | plectin | -0.0369791 |
| MXD1 | MAX dimerization protein 1 | -0.0368775 |
| LMO7 | LIM domain 7 | -0.0362566 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0361043 |
| ASPH | aspartate beta-hydroxylase | -0.0360482 |
| KLK10 | kallikrein-related peptidase 10 | -0.0355296 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.035432 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0347173 |
| FERMT1 | fermitin family member 1 | -0.0344125 |
| BMP6 | bone morphogenetic protein 6 | -0.0339787 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.0334548 |
| STC1 | stanniocalcin 1 | -0.0334542 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0328761 |
| MMP1 | matrix metallopeptidase 1 | -0.0328142 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.032682 |
| BMERB1 | bMERB domain containing 1 | -0.0323798 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0320954 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0320908 |
| GRB10 | growth factor receptor-bound protein 10 | -0.03175 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0315815 |
| ERI2 | ERI1 exoribonuclease family member 2 | -0.0313699 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | -0.0311352 |
| ATXN1 | ataxin 1 | -0.0310543 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0306667 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.030344 |
| SKAP2 | src kinase associated phosphoprotein 2 | -0.0300441 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0300082 |
| MYO5B | myosin VB | -0.0299406 |
| EGR1 | early growth response 1 | -0.0296577 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0284474 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0283691 |
| HDAC9 | histone deacetylase 9 | -0.0278443 |
| AHNAK | AHNAK nucleoprotein | -0.0274813 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0274371 |
| ADAM32 | ADAM metallopeptidase domain 32 | -0.0272083 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.0271163 |
| PPP1R1C | protein phosphatase 1, regulatory (inhibitor) subunit 1C | -0.0270551 |
| RPS29 | ribosomal protein S29 | -0.0267724 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.026593 |
| USP53 | ubiquitin specific peptidase 53 | -0.0265104 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0264258 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0262317 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0260397 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | -0.0250073 |
| ZNF83 | zinc finger protein 83 | -0.024987 |
| AREG | amphiregulin | -0.0248663 |
| TGFA | transforming growth factor, alpha | -0.0248656 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0247489 |
| HOMER1 | homer scaffolding protein 1 | -0.0246107 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | -0.0244604 |
| CDK13 | cyclin-dependent kinase 13 | -0.0243404 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.024145 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0240615 |
| PRSS3 | protease, serine, 3 | -0.0239832 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0237752 |
| AADAC | arylacetamide deacetylase | -0.0237468 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0235657 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0233783 |
| DENND2C | DENN/MADD domain containing 2C | -0.0233707 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.0233115 |
| KPNA7 | karyopherin alpha 7 (importin alpha 8) | -0.0231575 |
| EXOC6B | exocyst complex component 6B | -0.0230011 |
| HMGA2 | high mobility group AT-hook 2 | -0.0228984 |
| MUC17 | mucin 17, cell surface associated | -0.0228778 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0224828 |
| PCF11 | PCF11 cleavage and polyadenylation factor subunit | -0.0223305 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0219135 |
