APTO-253_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the APTO-253_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 0.402949
RPL19 ribosomal protein L19 0.226165
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.180795
MT2A metallothionein 2A 0.151597
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.144873
FTH1 ferritin, heavy polypeptide 1 0.120731
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.103785
TMSB10 thymosin beta 10 0.097958
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0752351
ASPH aspartate beta-hydroxylase 0.0746282
S100A9 S100 calcium binding protein A9 0.0711335
S100A8 S100 calcium binding protein A8 0.0640427
SMYD3 SET and MYND domain containing 3 0.0623753
LOC102724023 ES1 protein homolog, mitochondrial 0.0609366
CDK12 cyclin-dependent kinase 12 0.0605772
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0594311
ERBB2 erb-b2 receptor tyrosine kinase 2 0.0572474
RPS19 ribosomal protein S19 0.0572405
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.0569121
RIMS2 regulating synaptic membrane exocytosis 2 0.0540462
AREG amphiregulin 0.0504308
ANKRD12 ankyrin repeat domain 12 0.0497414
FBXL20 F-box and leucine-rich repeat protein 20 0.0493317
RPLP1 ribosomal protein, large, P1 0.048341
PRRC2C proline-rich coiled-coil 2C 0.0473942
ADARB1 adenosine deaminase, RNA-specific, B1 0.0469907
ANKRD36C ankyrin repeat domain 36C 0.0460568
TPT1 tumor protein, translationally-controlled 1 0.0455511
TXNRD1 thioredoxin reductase 1 0.0431525
ENO1 enolase 1, (alpha) 0.0422828
RPL35A ribosomal protein L35a 0.0407143
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0406906
PTPRK protein tyrosine phosphatase, receptor type, K 0.0396117
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0389393
S100A7 S100 calcium binding protein A7 0.0386565
FNDC3A fibronectin type III domain containing 3A 0.038528
RPLP0 ribosomal protein, large, P0 0.0384831
SRCIN1 SRC kinase signaling inhibitor 1 0.0381158
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0379754
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0377031
LOC112694756 uncharaterized LOC112694756 0.0373458
EEF2 eukaryotic translation elongation factor 2 0.0373131
RPS29 ribosomal protein S29 0.0371553
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0370474
MYL12B myosin, light chain 12B, regulatory 0.037021
RPS3 ribosomal protein S3 0.036665
SYTL2 synaptotagmin-like 2 0.0364522
LASP1 LIM and SH3 protein 1 0.0364033
CCNI cyclin I 0.0351593
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 0.0344018
RPL37 ribosomal protein L37 0.0342877
ATXN1 ataxin 1 0.0339748
HLA-B major histocompatibility complex, class I, B 0.0331292
IFI6 interferon, alpha-inducible protein 6 0.0323218
RPL35 ribosomal protein L35 0.0322819
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0314621
RPL12 ribosomal protein L12 0.031174
S100A14 S100 calcium binding protein A14 0.0311373
NTN4 netrin 4 0.0311044
ANXA2 annexin A2 0.0309443
RPL36 ribosomal protein L36 0.0304394
PFDN4 prefoldin subunit 4 0.030158
CEMIP cell migration inducing protein, hyaluronan binding 0.0301187
SLC38A1 solute carrier family 38, member 1 0.0295476
THSD4 thrombospondin, type I, domain containing 4 0.0294723
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0293072
LMNA lamin A/C 0.0287863
RPL8 ribosomal protein L8 0.0286102
OSMR oncostatin M receptor 0.0282723
FGB fibrinogen beta chain 0.0282192
GLCCI1 glucocorticoid induced 1 0.0276228
BPTF bromodomain PHD finger transcription factor 0.0273194
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0272721
HLA-C major histocompatibility complex, class I, C 0.0271496
GNAS GNAS complex locus 0.0269145
INTS6 integrator complex subunit 6 0.0265894
DYNLRB1 dynein, light chain, roadblock-type 1 0.0265423
ACTG1 actin gamma 1 0.0265119
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.0264684
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0263349
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 0.0262298
RPL32 ribosomal protein L32 0.0260643
S100P S100 calcium binding protein P 0.0257276
IFIH1 interferon induced with helicase C domain 1 0.0255719
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0255707
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0255296
TRPS1 trichorhinophalangeal syndrome I 0.0251032
TPI1 triosephosphate isomerase 1 0.0251018
EIF5B eukaryotic translation initiation factor 5B 0.0249463
CBX3 chromobox homolog 3 0.0249063
PFN1 profilin 1 0.0247258
ADGRG6 adhesion G protein-coupled receptor G6 0.0246101
MIEN1 migration and invasion enhancer 1 0.0245995
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0245305
NF1 neurofibromin 1 0.0244812
NCOA7 nuclear receptor coactivator 7 0.0243037
SERINC3 serine incorporator 3 0.0240724
RPL5 ribosomal protein L5 0.0237949
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0234793
KLF6 Kruppel-like factor 6 0.0234009

decreased expression

Symbol Name Standardized Value
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.129781
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0694777
ACACA acetyl-CoA carboxylase alpha -0.0527114
TMEM123 transmembrane protein 123 -0.0519945
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0519407
CLTC clathrin, heavy chain (Hc) -0.0507832
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0495092
ZMYND8 zinc finger, MYND-type containing 8 -0.0436944
NAMPT nicotinamide phosphoribosyltransferase -0.0405609
IGFBP5 insulin-like growth factor binding protein 5 -0.0387965
GRB10 growth factor receptor-bound protein 10 -0.0349617
NCOA3 nuclear receptor coactivator 3 -0.0311036
VCL vinculin -0.0289776
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0285624
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0283808
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0282462
SRPK1 SRSF protein kinase 1 -0.0282216
PRLR prolactin receptor -0.0273305
ITCH itchy E3 ubiquitin protein ligase -0.0272055
DSTN destrin (actin depolymerizing factor) -0.0265467
ZC3H11A zinc finger CCCH-type containing 11A -0.0262155
SREBF2 sterol regulatory element binding transcription factor 2 -0.0259885
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0259181
ECT2 epithelial cell transforming 2 -0.0256841
FDPS farnesyl diphosphate synthase -0.0249884
ELOVL5 ELOVL fatty acid elongase 5 -0.0249208
MYH9 myosin, heavy chain 9, non-muscle -0.0246996
MTSS1 metastasis suppressor 1 -0.0246753
TSC22D2 TSC22 domain family, member 2 -0.0246038
DTNA dystrobrevin, alpha -0.0244945
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0242381
CANX calnexin -0.0237371
PDLIM5 PDZ and LIM domain 5 -0.0235869
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -0.0233046
MACF1 microtubule-actin crosslinking factor 1 -0.0231253
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0230931
JMJD1C jumonji domain containing 1C -0.02301
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0228864
TOM1L1 target of myb1 (chicken)-like 1 -0.0228796
DENND5A DENN/MADD domain containing 5A -0.0226474
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0226058
PBX1 pre-B-cell leukemia homeobox 1 -0.0225952
MYO10 myosin X -0.02242
KDM7A lysine (K)-specific demethylase 7A -0.0223754
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0217936
TOP6BL TOP6B like initiator of meiotic double strand breaks -0.0217346
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0212462
SPAG9 sperm associated antigen 9 -0.021077
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0209542
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B -0.0205144
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 -0.0204754
BIRC3 baculoviral IAP repeat containing 3 -0.0203505
RESF1 retroelement silencing factor 1 -0.0201673
BZW1 basic leucine zipper and W2 domains 1 -0.0201577
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0197572
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0195565
GOLGA4 golgin A4 -0.0192031
ANLN anillin, actin binding protein -0.0191428
ZNF292 zinc finger protein 292 -0.0191177
YEATS2 YEATS domain containing 2 -0.0190655
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0188637
KDM3A lysine (K)-specific demethylase 3A -0.0187375
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0186063
IPO7 importin 7 -0.0184507
MYO6 myosin VI -0.0181829
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) -0.0180086
TPM4 tropomyosin 4 -0.0177361
POLD3 polymerase (DNA-directed), delta 3, accessory subunit -0.0177258
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 -0.0175599
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0173984
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0173846
SEC23A Sec23 homolog A (S. cerevisiae) -0.0172906
TCEA2 transcription elongation factor A (SII), 2 -0.0172574
ADAM17 ADAM metallopeptidase domain 17 -0.0166913
NDRG1 N-myc downstream regulated 1 -0.0165255
VEGFA vascular endothelial growth factor A -0.0162329
WWC1 WW and C2 domain containing 1 -0.016168
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0160555
MARCHF6 membrane associated ring-CH-type finger 6 -0.0160161
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0159208
PTPN2 protein tyrosine phosphatase, non-receptor type 2 -0.0158973
SQSTM1 sequestosome 1 -0.0158444
HOOK2 hook microtubule-tethering protein 2 -0.0156637
CFB complement factor B -0.0156549
SUCO SUN domain containing ossification factor -0.0156435
PANK3 pantothenate kinase 3 -0.0156364
PDIA5 protein disulfide isomerase family A, member 5 -0.0155918
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0153044
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0152802
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.0151749
KIF16B kinesin family member 16B -0.015173
MSMO1 methylsterol monooxygenase 1 -0.0151241
RREB1 ras responsive element binding protein 1 -0.015033
HELZ helicase with zinc finger -0.0149356
TARS1 threonyl-tRNA synthetase 1 -0.0149115
GSK3B glycogen synthase kinase 3 beta -0.014901
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.014827
ZFC3H1 zinc finger, C3H1-type containing -0.0148015
SEC31A SEC31 homolog A (S. cerevisiae) -0.0147447
CD24 CD24 molecule -0.0147396