APTO-253_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the APTO-253_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERBB4 erb-b2 receptor tyrosine kinase 4 0.198134
TENM3 teneurin transmembrane protein 3 0.157184
SLIT2 slit homolog 2 (Drosophila) 0.113005
COL5A2 collagen, type V, alpha 2 0.107334
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.100612
RAD51B RAD51 paralog B 0.084567
TOX thymocyte selection-associated high mobility group box 0.0794566
SOX5 SRY (sex determining region Y)-box 5 0.0766199
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0755879
CADM2 cell adhesion molecule 2 0.0726286
ADGRG6 adhesion G protein-coupled receptor G6 0.0685081
ZNF608 zinc finger protein 608 0.0680787
CDH18 cadherin 18, type 2 0.060664
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0590379
CELF2 CUGBP, Elav-like family member 2 0.0560599
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0557934
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0503744
NEBL nebulette 0.0499846
NFIA nuclear factor I/A 0.0491197
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0488147
RIGI RNA sensor RIG-I 0.0426343
DST dystonin 0.0383998
GRID2 glutamate receptor, ionotropic, delta 2 0.0361836
SHROOM3 shroom family member 3 0.0361751
NPAS3 neuronal PAS domain protein 3 0.0357395
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0346875
BNC2 basonuclin 2 0.0343631
MLIP muscular LMNA-interacting protein 0.0317404
SMYD3 SET and MYND domain containing 3 0.0298322
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0292872
MCTP1 multiple C2 domains, transmembrane 1 0.0281213
TTC28 tetratricopeptide repeat domain 28 0.0278097
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0275622
WLS wntless Wnt ligand secretion mediator 0.0265687
JMJD1C jumonji domain containing 1C 0.026204
FBXL7 F-box and leucine-rich repeat protein 7 0.0261141
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0257751
BCAS3 breast carcinoma amplified sequence 3 0.0256055
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0240514
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0235427
NBEA neurobeachin 0.0232345
ATP11A ATPase, class VI, type 11A 0.0227389
CEP112 centrosomal protein 112kDa 0.0224625
ARB2A ARB2 cotranscriptional regulator A 0.0208702
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0207018
CARD18 caspase recruitment domain family, member 18 0.020412
EXT1 exostosin glycosyltransferase 1 0.0201688
EFNA5 ephrin-A5 0.0201134
VEGFC vascular endothelial growth factor C 0.0197323
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0195639
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0194107
SIK3 SIK family kinase 3 0.019065
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0182837
DCDC2 doublecortin domain containing 2 0.0181999
NALF1 NALCN channel auxiliary factor 1 0.0180408
EXOC4 exocyst complex component 4 0.0179424
VMP1 vacuole membrane protein 1 0.0178763
BABAM2 BRISC and BRCA1 A complex member 2 0.0176502
OSBPL10 oxysterol binding protein-like 10 0.0175264
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0173326
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0172096
H1-0 H1.0 linker histone 0.0163582
TBC1D5 TBC1 domain family, member 5 0.0161173
TRIP12 thyroid hormone receptor interactor 12 0.0160624
FER fer (fps/fes related) tyrosine kinase 0.0158924
RPL3 ribosomal protein L3 0.0158433
NRG1 neuregulin 1 0.0156419
ADAR adenosine deaminase, RNA-specific 0.015616
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0155273
ZFHX4 zinc finger homeobox 4 0.0155205
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0151835
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0149003
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0147386
SCLT1 sodium channel and clathrin linker 1 0.0147105
USP34 ubiquitin specific peptidase 34 0.014709
NFIB nuclear factor I/B 0.0146735
MIPOL1 mirror-image polydactyly 1 0.0146026
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0142731
FRYL FRY-like 0.0139973
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0139908
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0139323
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0138953
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0138554
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0138068
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0137928
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0136297
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0135778
HDAC8 histone deacetylase 8 0.0135502
ZC3H12B zinc finger CCCH-type containing 12B 0.0135404
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0135262
FMNL2 formin-like 2 0.0132505
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0130836
CCSER1 coiled-coil serine-rich protein 1 0.0130031
KIF1B kinesin family member 1B 0.0129236
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0128479
PARD3B par-3 family cell polarity regulator beta 0.0127475
WWC2 WW and C2 domain containing 2 0.012741
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0127307
ZFAND3 zinc finger, AN1-type domain 3 0.0126697
DNAH14 dynein, axonemal, heavy chain 14 0.0126507

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.169188
PTMA prothymosin, alpha -0.106329
RPS6 ribosomal protein S6 -0.106325
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0958173
RPS8 ribosomal protein S8 -0.0902761
ACTG1 actin gamma 1 -0.089096
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0758549
RPLP1 ribosomal protein, large, P1 -0.0735042
RPL37A ribosomal protein L37a -0.0731194
RPS12 ribosomal protein S12 -0.0698244
RPL11 ribosomal protein L11 -0.0696081
TPT1 tumor protein, translationally-controlled 1 -0.0688595
RPS24 ribosomal protein S24 -0.0660981
TMSB10 thymosin beta 10 -0.0653798
RPL31 ribosomal protein L31 -0.0618821
RPL26 ribosomal protein L26 -0.0614783
RPL34 ribosomal protein L34 -0.060796
RPS3 ribosomal protein S3 -0.0590924
RPS11 ribosomal protein S11 -0.0582905
RPS29 ribosomal protein S29 -0.0582855
RPL23 ribosomal protein L23 -0.0572892
RPS27A ribosomal protein S27a -0.0572696
RPL35A ribosomal protein L35a -0.0551575
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0549234
RPS5 ribosomal protein S5 -0.0545918
RPL13A ribosomal protein L13a -0.0526553
RPS21 ribosomal protein S21 -0.0519205
RPLP2 ribosomal protein, large, P2 -0.0506378
RPL12 ribosomal protein L12 -0.049859
RPL9 ribosomal protein L9 -0.0476902
RPS13 ribosomal protein S13 -0.0472411
RPS19 ribosomal protein S19 -0.0466111
RPL5 ribosomal protein L5 -0.0455143
HMGA1 high mobility group AT-hook 1 -0.0452869
RPLP0 ribosomal protein, large, P0 -0.0447008
RPL7A ribosomal protein L7a -0.0443566
RPS23 ribosomal protein S23 -0.0439487
RPS25 ribosomal protein S25 -0.0431491
RPL38 ribosomal protein L38 -0.0431083
RPL28 ribosomal protein L28 -0.0430046
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0411237
RPS16 ribosomal protein S16 -0.0406284
GNAS GNAS complex locus -0.0404681
RACK1 receptor for activated C kinase 1 -0.0402172
RPL19 ribosomal protein L19 -0.0398943
RPS17 ribosomal protein S17 -0.0384039
RPL30 ribosomal protein L30 -0.0376326
VIM vimentin -0.0376237
NAP1L1 nucleosome assembly protein 1-like 1 -0.037385
RPL37 ribosomal protein L37 -0.0368987
EIF1 eukaryotic translation initiation factor 1 -0.0367022
SOX4 SRY (sex determining region Y)-box 4 -0.0356251
RPL36 ribosomal protein L36 -0.034725
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0346828
RPL27A ribosomal protein L27a -0.0343708
FTL ferritin, light polypeptide -0.0341263
RCC1 regulator of chromosome condensation 1 -0.0316351
RPS14 ribosomal protein S14 -0.0314885
GOLGA4 golgin A4 -0.0307367
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0307338
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0303879
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0298751
RPS4X ribosomal protein S4, X-linked -0.029434
RPL32 ribosomal protein L32 -0.0285046
RPS27 ribosomal protein S27 -0.0284041
RPL36A ribosomal protein L36a -0.028392
RPS10 ribosomal protein S10 -0.0278683
KPNB1 karyopherin (importin) beta 1 -0.0275929
RPS20 ribosomal protein S20 -0.0275217
RPL8 ribosomal protein L8 -0.0274265
RPL35 ribosomal protein L35 -0.0274138
EGR1 early growth response 1 -0.0272156
LOC112694756 uncharaterized LOC112694756 -0.0267745
IARS1 isoleucyl-tRNA synthetase 1 -0.0267391
HMGB1 high mobility group box 1 -0.0262252
TPM4 tropomyosin 4 -0.0257143
LMAN1 lectin, mannose-binding, 1 -0.0253879
RPS15 ribosomal protein S15 -0.0253805
RPS28 ribosomal protein S28 -0.025379
NUP58 nucleoporin 58 -0.0252484
S100A9 S100 calcium binding protein A9 -0.0250724
MYL12B myosin, light chain 12B, regulatory -0.0248458
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0246406
CANX calnexin -0.0245732
WDR45B WD repeat domain 45B -0.0245675
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0242883
NACA nascent polypeptide-associated complex alpha subunit -0.0242063
RAN RAN, member RAS oncogene family -0.024134
EIF5B eukaryotic translation initiation factor 5B -0.0240529
DEK DEK proto-oncogene -0.0238894
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0237295
RPL10A ribosomal protein L10a -0.0235598
RPS2 ribosomal protein S2 -0.0230126
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0224539
SEPTIN7 septin 7 -0.021877
GARS1 glycyl-tRNA synthetase 1 -0.0217547
RPL15 ribosomal protein L15 -0.0216006
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0215474
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0215204
AKAP9 A kinase (PRKA) anchor protein 9 -0.0211958