APTO-253_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the APTO-253_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.162116
GCLC glutamate-cysteine ligase, catalytic subunit 0.105763
MACC1 metastasis associated in colon cancer 1 0.097774
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0772287
SMAD3 SMAD family member 3 0.0667826
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0650571
MYO1E myosin IE 0.0628728
RNF213 ring finger protein 213 0.0608658
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0599457
EPSTI1 epithelial stromal interaction 1 (breast) 0.0597035
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0585457
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0534364
EXT1 exostosin glycosyltransferase 1 0.0529083
ANXA2 annexin A2 0.0479717
AKAP13 A kinase (PRKA) anchor protein 13 0.0457541
KLF6 Kruppel-like factor 6 0.0454301
ZSWIM6 zinc finger, SWIM-type containing 6 0.0421449
TRIM2 tripartite motif containing 2 0.0415474
MCU mitochondrial calcium uniporter 0.0408099
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0401133
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.038032
INTS6 integrator complex subunit 6 0.0380061
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0377532
VCL vinculin 0.0374181
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0354538
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0353386
ARHGAP26 Rho GTPase activating protein 26 0.035025
GMDS GDP-mannose 4,6-dehydratase 0.0339025
RSAD2 radical S-adenosyl methionine domain containing 2 0.0336591
EPS8 epidermal growth factor receptor pathway substrate 8 0.03174
TXNRD1 thioredoxin reductase 1 0.0310071
H1-0 H1.0 linker histone 0.0305563
EREG epiregulin 0.0299829
DUSP10 dual specificity phosphatase 10 0.0298034
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0297464
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0296689
SPAG9 sperm associated antigen 9 0.0294215
RIGI RNA sensor RIG-I 0.0292727
AREG amphiregulin 0.0291304
TM4SF19 transmembrane 4 L six family member 19 0.0291118
DSPP dentin sialophosphoprotein 0.0286847
TJP1 tight junction protein 1 0.0284773
HKDC1 hexokinase domain containing 1 0.0279274
KYNU kynureninase 0.0277768
ABHD2 abhydrolase domain containing 2 0.0272964
MX2 MX dynamin-like GTPase 2 0.0272438
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0270931
VMP1 vacuole membrane protein 1 0.0264653
ANKRD10 ankyrin repeat domain 10 0.0256294
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.025398
SPATA13 spermatogenesis associated 13 0.024992
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.024471
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0242998
SHB Src homology 2 domain containing adaptor protein B 0.0242843
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.0241333
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 0.0240039
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0239886
POF1B premature ovarian failure, 1B 0.0239273
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0237526
ALCAM activated leukocyte cell adhesion molecule 0.0235777
ETV6 ets variant 6 0.0229172
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0224877
EFNB2 ephrin-B2 0.0224637
MSI2 musashi RNA-binding protein 2 0.0222571
CTNND1 catenin (cadherin-associated protein), delta 1 0.0221472
SP100 SP100 nuclear antigen 0.022089
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0218816
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0215442
LURAP1L leucine rich adaptor protein 1-like 0.0211012
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0209015
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0202523
NCEH1 neutral cholesterol ester hydrolase 1 0.0201421
EZR ezrin 0.0201058
PLSCR2 phospholipid scramblase 2 0.020027
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0191732
MACF1 microtubule-actin crosslinking factor 1 0.0190477
TMEM65 transmembrane protein 65 0.0189934
BAIAP2L1 BAI1-associated protein 2-like 1 0.0188819
PDLIM5 PDZ and LIM domain 5 0.018748
PRKCA protein kinase C, alpha 0.0181868
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.0180492
PPARG peroxisome proliferator-activated receptor gamma 0.0176593
FNIP1 folliculin interacting protein 1 0.0175745
NQO1 NAD(P)H dehydrogenase, quinone 1 0.017461
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0172478
LOC102724023 ES1 protein homolog, mitochondrial 0.0171584
IGF1R insulin-like growth factor 1 receptor 0.0170729
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0169936
MAP7 microtubule-associated protein 7 0.0169757
MEIS2 Meis homeobox 2 0.0168855
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0168238
LAMA4 laminin, alpha 4 0.016621
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0163697
IQGAP1 IQ motif containing GTPase activating protein 1 0.0163681
ITGA6 integrin, alpha 6 0.0162993
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0162172
ABLIM1 actin binding LIM protein 1 0.0162022
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0159392
USP53 ubiquitin specific peptidase 53 0.0156406
KIAA1217 KIAA1217 0.0155105

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.114984
B2M beta-2-microglobulin -0.0725695
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0591659
LCN2 lipocalin 2 -0.0573608
LYZ lysozyme -0.0565806
RPL35A ribosomal protein L35a -0.0557738
ZMYND8 zinc finger, MYND-type containing 8 -0.05483
RPS6 ribosomal protein S6 -0.0470094
FTL ferritin, light polypeptide -0.0469835
HLA-B major histocompatibility complex, class I, B -0.0460064
EIF1 eukaryotic translation initiation factor 1 -0.044492
RPL11 ribosomal protein L11 -0.0356947
HLA-A major histocompatibility complex, class I, A -0.0349535
RPS29 ribosomal protein S29 -0.0339299
RPS27 ribosomal protein S27 -0.0331086
PTMA prothymosin, alpha -0.0330033
PKM pyruvate kinase, muscle -0.0323267
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0313304
RPL23 ribosomal protein L23 -0.030588
TMSB10 thymosin beta 10 -0.0302306
CSTB cystatin B (stefin B) -0.0293292
RPS13 ribosomal protein S13 -0.0288059
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0283985
NDRG1 N-myc downstream regulated 1 -0.0278798
RPS8 ribosomal protein S8 -0.0274355
IFI27 interferon, alpha-inducible protein 27 -0.0266797
RPL31 ribosomal protein L31 -0.0259972
RPS27A ribosomal protein S27a -0.0257074
ANKRD11 ankyrin repeat domain 11 -0.0254893
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0253508
FNDC3B fibronectin type III domain containing 3B -0.0252637
MT2A metallothionein 2A -0.0251391
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0250202
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0244166
S100P S100 calcium binding protein P -0.0238576
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0237946
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0235777
FTH1 ferritin, heavy polypeptide 1 -0.0231874
RAB6A RAB6A, member RAS oncogene family -0.0231588
TXNIP thioredoxin interacting protein -0.023153
RPS25 ribosomal protein S25 -0.0229794
TSC22D1 TSC22 domain family, member 1 -0.0228173
SLC38A1 solute carrier family 38, member 1 -0.0227718
SFTPA2 surfactant protein A2 -0.0226877
TPI1 triosephosphate isomerase 1 -0.022253
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0221703
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0216741
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0213404
RPS23 ribosomal protein S23 -0.0212407
RPL7L1 ribosomal protein L7-like 1 -0.0212267
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0211245
RPL19 ribosomal protein L19 -0.0210833
UBC ubiquitin C -0.0209531
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0209288
RPL7 ribosomal protein L7 -0.0208409
IFI6 interferon, alpha-inducible protein 6 -0.020789
PGK1 phosphoglycerate kinase 1 -0.0206175
RPS12 ribosomal protein S12 -0.0203007
RPL37A ribosomal protein L37a -0.020281
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0199294
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0195999
PHF3 PHD finger protein 3 -0.0195763
HELZ helicase with zinc finger -0.0195492
RPS20 ribosomal protein S20 -0.0193345
RPS24 ribosomal protein S24 -0.0192475
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.019157
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0190285
CANX calnexin -0.019009
EGR1 early growth response 1 -0.0189662
POTEF POTE ankyrin domain family, member F -0.0188301
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.018719
S100A9 S100 calcium binding protein A9 -0.0186496
SCAF11 SR-related CTD-associated factor 11 -0.0186026
RPL34 ribosomal protein L34 -0.0185419
CTSD cathepsin D -0.0184931
KPNB1 karyopherin (importin) beta 1 -0.0184785
WSB1 WD repeat and SOCS box containing 1 -0.0184189
ZNRF3 zinc and ring finger 3 -0.018307
RPS19 ribosomal protein S19 -0.0180241
VEGFA vascular endothelial growth factor A -0.0179897
RPL9 ribosomal protein L9 -0.0179532
RPS16 ribosomal protein S16 -0.0177745
RPS3 ribosomal protein S3 -0.0177686
SBF2 SET binding factor 2 -0.0176884
SAP18 Sin3A-associated protein, 18kDa -0.0176713
VDAC1 voltage-dependent anion channel 1 -0.0176443
RPLP1 ribosomal protein, large, P1 -0.0175843
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0175524
PRRC2B proline-rich coiled-coil 2B -0.0174636
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0173329
KTN1 kinectin 1 (kinesin receptor) -0.0173148
NCOR2 nuclear receptor corepressor 2 -0.0170725
LOC112694756 uncharaterized LOC112694756 -0.0170497
SAMD12 sterile alpha motif domain containing 12 -0.0169898
RPL38 ribosomal protein L38 -0.0168286
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0167916
ZFAND3 zinc finger, AN1-type domain 3 -0.0165829
BICRAL BICRA like chromatin remodeling complex associated protein -0.0165046
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0164677
RPLP2 ribosomal protein, large, P2 -0.0162804