APTO-253_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the APTO-253_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.474648
FTL ferritin, light polypeptide 0.154199
MT2A metallothionein 2A 0.138336
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.125146
VIM vimentin 0.12147
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0882313
ENO1 enolase 1, (alpha) 0.0873948
PTMA prothymosin, alpha 0.085153
B2M beta-2-microglobulin 0.0754652
STC1 stanniocalcin 1 0.0700272
MKI67 marker of proliferation Ki-67 0.0672195
KYNU kynureninase 0.064824
TPM4 tropomyosin 4 0.0618054
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0596012
RPS6 ribosomal protein S6 0.0531494
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0520051
CALR calreticulin 0.0471118
CENPF centromere protein F, 350/400kDa 0.0469056
TMSB10 thymosin beta 10 0.0423741
EIF1 eukaryotic translation initiation factor 1 0.0417078
TXNRD1 thioredoxin reductase 1 0.041456
AKAP12 A kinase (PRKA) anchor protein 12 0.0411537
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0406245
RPS8 ribosomal protein S8 0.0397491
PKM pyruvate kinase, muscle 0.03949
FTH1 ferritin, heavy polypeptide 1 0.0386243
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.038269
CD44 CD44 molecule (Indian blood group) 0.037036
TPI1 triosephosphate isomerase 1 0.0358926
ANKRD11 ankyrin repeat domain 11 0.0341446
RPLP1 ribosomal protein, large, P1 0.0340596
CXCL8 chemokine (C-X-C motif) ligand 8 0.0323272
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0320779
MT1X metallothionein 1X 0.0316446
SMC4 structural maintenance of chromosomes 4 0.0313738
RPL23 ribosomal protein L23 0.0309731
RACK1 receptor for activated C kinase 1 0.0309088
RPL35A ribosomal protein L35a 0.0303738
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0300015
CANX calnexin 0.0298589
PDIA3 protein disulfide isomerase family A, member 3 0.0291257
TXNIP thioredoxin interacting protein 0.0291216
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.0286143
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0285706
EGR1 early growth response 1 0.0284824
RPL34 ribosomal protein L34 0.0280747
SEPTIN7 septin 7 0.027518
LGALS1 lectin, galactoside-binding, soluble, 1 0.0271644
LAMB1 laminin, beta 1 0.0270127
CBX3 chromobox homolog 3 0.0270088
S100A10 S100 calcium binding protein A10 0.0269613
RPL12 ribosomal protein L12 0.0266955
S100A6 S100 calcium binding protein A6 0.0264542
KPNB1 karyopherin (importin) beta 1 0.0257127
TIMP1 TIMP metallopeptidase inhibitor 1 0.0252829
S100A9 S100 calcium binding protein A9 0.0251744
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0245847
RPLP0 ribosomal protein, large, P0 0.0242915
TUBA1B tubulin, alpha 1b 0.0238945
RPS2 ribosomal protein S2 0.0234378
RPS13 ribosomal protein S13 0.0227655
PRR11 proline rich 11 0.0225103
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0221977
RPL28 ribosomal protein L28 0.0220904
SEC61G Sec61 gamma subunit 0.0219748
ANTXR2 anthrax toxin receptor 2 0.0218497
ATF4 activating transcription factor 4 0.0217133
MAP1B microtubule-associated protein 1B 0.0213657
EEF2 eukaryotic translation elongation factor 2 0.0210229
RPL37A ribosomal protein L37a 0.0208889
DGKD diacylglycerol kinase, delta 130kDa 0.0207757
RPS11 ribosomal protein S11 0.0205737
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0205344
RPL32 ribosomal protein L32 0.0204759
RPL19 ribosomal protein L19 0.020301
PDIA4 protein disulfide isomerase family A, member 4 0.020245
NFE2L2 nuclear factor, erythroid 2-like 2 0.0201087
RPL7 ribosomal protein L7 0.0201074
YBX3 Y box binding protein 3 0.020084
CD99 CD99 molecule 0.020033
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0200259
RPS25 ribosomal protein S25 0.0199613
COG5 component of oligomeric golgi complex 5 0.0199238
INHBA inhibin, beta A 0.0198785
HLA-B major histocompatibility complex, class I, B 0.0197563
RPL36 ribosomal protein L36 0.0197491
YBX1 Y box binding protein 1 0.0196951
GOLGB1 golgin B1 0.0195741
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0194146
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0193508
SFTPA2 surfactant protein A2 0.0192361
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 0.0190896
SCAF11 SR-related CTD-associated factor 11 0.0190083
RPS14 ribosomal protein S14 0.0186631
UBC ubiquitin C 0.0182288
MTPN myotrophin 0.0180893
RPS4X ribosomal protein S4, X-linked 0.0180088
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0179743
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0178431
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0177068

decreased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 -0.179399
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.161452
GRB10 growth factor receptor-bound protein 10 -0.159371
IGFBP3 insulin-like growth factor binding protein 3 -0.138378
FN1 fibronectin 1 -0.0853756
EGFR epidermal growth factor receptor -0.0775596
DST dystonin -0.076055
SDK1 sidekick cell adhesion molecule 1 -0.0756666
TRIO trio Rho guanine nucleotide exchange factor -0.0684691
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0646937
NALF1 NALCN channel auxiliary factor 1 -0.0615106
COL5A1 collagen, type V, alpha 1 -0.0569333
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0541745
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0499736
TNS3 tensin 3 -0.048822
PDE4D phosphodiesterase 4D, cAMP-specific -0.0476529
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0463779
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.045809
ZBTB20 zinc finger and BTB domain containing 20 -0.0451676
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0444115
SPAG9 sperm associated antigen 9 -0.0443428
RIGI RNA sensor RIG-I -0.0430123
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.038083
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0375491
AUTS2 autism susceptibility candidate 2 -0.0341776
ZNF804A zinc finger protein 804A -0.0338557
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0334137
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0333703
CADM1 cell adhesion molecule 1 -0.0323949
TENM3 teneurin transmembrane protein 3 -0.032358
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.032162
TENT5A terminal nucleotidyltransferase 5A -0.0321463
GLS2 glutaminase 2 (liver, mitochondrial) -0.0320722
PSD3 pleckstrin and Sec7 domain containing 3 -0.0311
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0296616
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0294897
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0292395
NAV2 neuron navigator 2 -0.0286493
SOX5 SRY (sex determining region Y)-box 5 -0.0282064
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0278653
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0276894
CHD9 chromodomain helicase DNA binding protein 9 -0.0259527
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0258764
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0254487
SAMD9 sterile alpha motif domain containing 9 -0.0254265
PRSS23 protease, serine, 23 -0.0248284
DENND1A DENN/MADD domain containing 1A -0.0246962
INTS6 integrator complex subunit 6 -0.0245862
LOXL2 lysyl oxidase-like 2 -0.0239056
PRELID2 PRELI domain containing 2 -0.0238117
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0235221
TNNC1 troponin C type 1 (slow) -0.0229931
KDM4B lysine (K)-specific demethylase 4B -0.0227393
PLCB4 phospholipase C, beta 4 -0.0226153
NAV3 neuron navigator 3 -0.0220863
KCTD16 potassium channel tetramerization domain containing 16 -0.0214161
WSB1 WD repeat and SOCS box containing 1 -0.0211021
WARS1 tryptophanyl-tRNA synthetase 1 -0.0207652
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0206983
ZNF638 zinc finger protein 638 -0.0205607
TAS2R14 taste receptor, type 2, member 14 -0.020336
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0202494
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0202167
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0202087
ANK2 ankyrin 2, neuronal -0.0202039
FNIP1 folliculin interacting protein 1 -0.0201284
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0200845
IFIH1 interferon induced with helicase C domain 1 -0.0200646
HDAC9 histone deacetylase 9 -0.0199035
MMP12 matrix metallopeptidase 12 -0.0198231
HSPG2 heparan sulfate proteoglycan 2 -0.0194598
PARD3 par-3 family cell polarity regulator -0.0193337
MYOF myoferlin -0.0192793
KDM3B lysine (K)-specific demethylase 3B -0.0192698
RPTOR regulatory associated protein of MTOR, complex 1 -0.0191773
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0191182
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0190965
GLCCI1 glucocorticoid induced 1 -0.0190276
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.018962
RNF213 ring finger protein 213 -0.0183738
SUN1 Sad1 and UNC84 domain containing 1 -0.0183384
AEBP2 AE binding protein 2 -0.0181887
LRRC23 leucine rich repeat containing 23 -0.0177795
CTIF CBP80/20-dependent translation initiation factor -0.0177112
FER fer (fps/fes related) tyrosine kinase -0.0173154
AFAP1 actin filament associated protein 1 -0.0173118
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) -0.0173073
FUS FUS RNA binding protein -0.0171725
SH3RF3 SH3 domain containing ring finger 3 -0.0170978
PHEX phosphate regulating endopeptidase homolog, X-linked -0.0170463
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -0.0168163
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0168022
SNX14 sorting nexin 14 -0.0167591
PLAGL1 pleiomorphic adenoma gene-like 1 -0.0166818
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0165226
SYT1 synaptotagmin I -0.0163542
LPP LIM domain containing preferred translocation partner in lipoma -0.016255
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase -0.0160962
COMMD10 COMM domain containing 10 -0.0160889
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0160515