| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | APTO-253 perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the APTO-253_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.164999 |
| INTS6 | integrator complex subunit 6 | 0.0495773 |
| MKI67 | marker of proliferation Ki-67 | 0.0332917 |
| WWOX | WW domain containing oxidoreductase | 0.0330658 |
| VCL | vinculin | 0.0314479 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0266967 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0257866 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0256312 |
| LRRC23 | leucine rich repeat containing 23 | 0.0239936 |
| H1-0 | H1.0 linker histone | 0.0225611 |
| FHIT | fragile histidine triad | 0.0221583 |
| HOMER1 | homer scaffolding protein 1 | 0.021961 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0215903 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0215389 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0206124 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.0203789 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0200804 |
| MACROD2 | MACRO domain containing 2 | 0.018435 |
| RRM2 | ribonucleotide reductase M2 | 0.0183443 |
| ADD3 | adducin 3 (gamma) | 0.0182456 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0177431 |
| EGR1 | early growth response 1 | 0.0177036 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0175124 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.017081 |
| AEBP2 | AE binding protein 2 | 0.0170442 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0159715 |
| FAT1 | FAT atypical cadherin 1 | 0.0159359 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0158699 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0157228 |
| GPC5 | glypican 5 | 0.0152745 |
| NFIA | nuclear factor I/A | 0.0151097 |
| KDM3B | lysine (K)-specific demethylase 3B | 0.0148246 |
| SCAPER | S-phase cyclin A-associated protein in the ER | 0.0146686 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0146249 |
| CBX5 | chromobox homolog 5 | 0.014606 |
| CENPF | centromere protein F, 350/400kDa | 0.014392 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0143395 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0142479 |
| H1-4 | H1.4 linker histone, cluster member | 0.0142131 |
| BRD2 | bromodomain containing 2 | 0.0141909 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0139718 |
| DSPP | dentin sialophosphoprotein | 0.0135451 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0134945 |
| HELLS | helicase, lymphoid-specific | 0.0134773 |
| CCDC146 | coiled-coil domain containing 146 | 0.0133491 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0132768 |
| GPHN | gephyrin | 0.012972 |
| EHBP1 | EH domain binding protein 1 | 0.0128568 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0127692 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.01256 |
| TOB2 | transducer of ERBB2, 2 | 0.0124521 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0122718 |
| PATJ | PATJ crumbs cell polarity complex component | 0.012261 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0122123 |
| MSI2 | musashi RNA-binding protein 2 | 0.0120816 |
| GLCCI1 | glucocorticoid induced 1 | 0.011995 |
| WWC2 | WW and C2 domain containing 2 | 0.0119625 |
| CFAP44 | cilia and flagella associated protein 44 | 0.0116782 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0116557 |
| INO80 | INO80 complex subunit | 0.0116434 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0115756 |
| POLN | polymerase (DNA directed) nu | 0.0114166 |
| TGFB1 | transforming growth factor, beta 1 | 0.0112775 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0112106 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0111902 |
| SUMF1 | sulfatase modifying factor 1 | 0.0110951 |
| HMGB1 | high mobility group box 1 | 0.0110033 |
| MYO1E | myosin IE | 0.0109772 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0109634 |
| GCH1 | GTP cyclohydrolase 1 | 0.0109468 |
| RGS6 | regulator of G-protein signaling 6 | 0.0109453 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0109278 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0108859 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0107894 |
| MORC4 | MORC family CW-type zinc finger 4 | 0.0107582 |
| TRIM72 | tripartite motif containing 72, E3 ubiquitin protein ligase | 0.0107217 |
| FTO | fat mass and obesity associated | 0.0106267 |
| KLHL29 | kelch-like family member 29 | 0.0105813 |
| ATF3 | activating transcription factor 3 | 0.0105273 |
| FUS | FUS RNA binding protein | 0.0105222 |
| FAM222A | family with sequence similarity 222, member A | 0.0104355 |
| H1-2 | H1.2 linker histone, cluster member | 0.0103428 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0103317 |
| PCM1 | pericentriolar material 1 | 0.0102807 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0102776 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0102299 |
| TXNDC16 | thioredoxin domain containing 16 | 0.0100939 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0100575 |
| BZW2 | basic leucine zipper and W2 domains 2 | 0.0100014 |
| IL6ST | interleukin 6 signal transducer | 0.00997554 |
| SNRNP70 | small nuclear ribonucleoprotein 70kDa (U1) | 0.00995402 |
| PRKCA | protein kinase C, alpha | 0.00991933 |
| TACC1 | transforming, acidic coiled-coil containing protein 1 | 0.00990289 |
| KAZN | kazrin, periplakin interacting protein | 0.00990206 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.00986691 |
| MPHOSPH8 | M-phase phosphoprotein 8 | 0.00983599 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.00976728 |
| MEIS2 | Meis homeobox 2 | 0.00970346 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.00967482 |
| CADPS | Ca++-dependent secretion activator | 0.00958769 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.211517 |
| AHNAK | AHNAK nucleoprotein | -0.111806 |
| NDRG1 | N-myc downstream regulated 1 | -0.0912096 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0863723 |
| TPM4 | tropomyosin 4 | -0.0824996 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0767081 |
| TMSB10 | thymosin beta 10 | -0.0715519 |
| MT2A | metallothionein 2A | -0.0707929 |
| UBC | ubiquitin C | -0.0603778 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0551692 |
| LOC112694756 | uncharaterized LOC112694756 | -0.055142 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0546267 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0503553 |
| PCBP2 | poly(rC) binding protein 2 | -0.0473586 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0466208 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0455229 |
| RPS27A | ribosomal protein S27a | -0.0435693 |
| HMGA1 | high mobility group AT-hook 1 | -0.0415003 |
| RPS3 | ribosomal protein S3 | -0.0414726 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0411868 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0409115 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0385451 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0383719 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0381931 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0370164 |
| SDC4 | syndecan 4 | -0.0365945 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0350024 |
| S100A10 | S100 calcium binding protein A10 | -0.0332242 |
| LDHA | lactate dehydrogenase A | -0.0331174 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0328158 |
| RPL11 | ribosomal protein L11 | -0.032733 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0327288 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0323418 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0322618 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0319621 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0312739 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0306197 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0303472 |
| NF1 | neurofibromin 1 | -0.0303113 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0301495 |
| ARF4 | ADP-ribosylation factor 4 | -0.0300827 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0296965 |
| FTL | ferritin, light polypeptide | -0.0294513 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.029377 |
| GOLGA4 | golgin A4 | -0.0291013 |
| ANXA2 | annexin A2 | -0.0289146 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0288638 |
| GLG1 | golgi glycoprotein 1 | -0.0283757 |
| RPS25 | ribosomal protein S25 | -0.0280882 |
| CDCP1 | CUB domain containing protein 1 | -0.0280498 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0279587 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0277408 |
| ENO1 | enolase 1, (alpha) | -0.0274236 |
| S100A6 | S100 calcium binding protein A6 | -0.0273354 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0267549 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0263502 |
| OGA | O-GlcNAcase | -0.0261644 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0259099 |
| RPS12 | ribosomal protein S12 | -0.0256423 |
| CANX | calnexin | -0.0255852 |
| COPA | coatomer protein complex, subunit alpha | -0.025578 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0254199 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0253758 |
| MCL1 | myeloid cell leukemia 1 | -0.0251546 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0246331 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0245698 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0243871 |
| TBC1D22A | TBC1 domain family, member 22A | -0.024219 |
| FLNB | filamin B, beta | -0.0240468 |
| RPL26 | ribosomal protein L26 | -0.0236213 |
| SRP54 | signal recognition particle 54kDa | -0.0236196 |
| RPS19 | ribosomal protein S19 | -0.0235065 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0234288 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0232463 |
| SUCO | SUN domain containing ossification factor | -0.0230464 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0229724 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.022958 |
| ZNF654 | zinc finger protein 654 | -0.0229369 |
| VMP1 | vacuole membrane protein 1 | -0.0227673 |
| CD2AP | CD2-associated protein | -0.0227316 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0227091 |
| SETD5 | SET domain containing 5 | -0.0223401 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0221613 |
| TMEM41B | transmembrane protein 41B | -0.0221494 |
| EPN2 | epsin 2 | -0.0220657 |
| KRT18 | keratin 18, type I | -0.0220568 |
| ZNF207 | zinc finger protein 207 | -0.0220517 |
| RPL30 | ribosomal protein L30 | -0.0218889 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0218451 |
| RPS13 | ribosomal protein S13 | -0.0216049 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0213258 |
| RPL12 | ribosomal protein L12 | -0.0212852 |
| RPS23 | ribosomal protein S23 | -0.0212526 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.02125 |
| RRBP1 | ribosome binding protein 1 | -0.0209681 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0208929 |
| HMGA2 | high mobility group AT-hook 2 | -0.0207637 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0205735 |
| RPS8 | ribosomal protein S8 | -0.0205233 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0204727 |
