| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | APTO-253 perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the APTO-253_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.146798 |
| PRELID2 | PRELI domain containing 2 | 0.0768894 |
| MACROD2 | MACRO domain containing 2 | 0.0689914 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0665506 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0631384 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0541595 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0500821 |
| RAD51B | RAD51 paralog B | 0.050033 |
| MKI67 | marker of proliferation Ki-67 | 0.0469714 |
| DIAPH3 | diaphanous-related formin 3 | 0.0414891 |
| FHIT | fragile histidine triad | 0.0413659 |
| WWOX | WW domain containing oxidoreductase | 0.0382218 |
| MT2A | metallothionein 2A | 0.0381998 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0362369 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0353267 |
| VCL | vinculin | 0.0352524 |
| SVIL | supervillin | 0.0344201 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0333108 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | 0.0330584 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0328752 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0322245 |
| ATXN1 | ataxin 1 | 0.0320985 |
| BPTF | bromodomain PHD finger transcription factor | 0.03195 |
| EGR1 | early growth response 1 | 0.0317236 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0313496 |
| ITGB8 | integrin, beta 8 | 0.0303672 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0300809 |
| TXNRD1 | thioredoxin reductase 1 | 0.0288774 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0287129 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | 0.0287109 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0280947 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0278365 |
| CBX5 | chromobox homolog 5 | 0.0269819 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.025926 |
| NFIB | nuclear factor I/B | 0.0254155 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0249949 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0248087 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0246038 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0244411 |
| ASPH | aspartate beta-hydroxylase | 0.024155 |
| RPS19 | ribosomal protein S19 | 0.0229367 |
| POTEF | POTE ankyrin domain family, member F | 0.0228628 |
| RUNX1 | runt-related transcription factor 1 | 0.0227314 |
| NSRP1 | nuclear speckle splicing regulatory protein 1 | 0.0226536 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0223365 |
| MT1X | metallothionein 1X | 0.0220072 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0219221 |
| CENPF | centromere protein F, 350/400kDa | 0.0218447 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0217387 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0211722 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0211402 |
| UBXN4 | UBX domain protein 4 | 0.0209372 |
| SMYD3 | SET and MYND domain containing 3 | 0.0208405 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0197462 |
| TJP1 | tight junction protein 1 | 0.0193733 |
| MYO9A | myosin IXA | 0.0191414 |
| SCAPER | S-phase cyclin A-associated protein in the ER | 0.0189783 |
| CEP128 | centrosomal protein 128kDa | 0.0187635 |
| ANLN | anillin, actin binding protein | 0.0186789 |
| TPI1 | triosephosphate isomerase 1 | 0.0185105 |
| CBX3 | chromobox homolog 3 | 0.0185001 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.018446 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0182544 |
| ZNF652 | zinc finger protein 652 | 0.0181231 |
| EXOC4 | exocyst complex component 4 | 0.018081 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0180336 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0180128 |
| PFN1 | profilin 1 | 0.0177562 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0176251 |
| BBX | bobby sox homolog (Drosophila) | 0.01739 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0171772 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0171647 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0171347 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0167948 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0167404 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0166424 |
| SPAG16 | sperm associated antigen 16 | 0.016543 |
| PCED1B | PC-esterase domain containing 1B | 0.0165368 |
| ZRANB3 | zinc finger, RAN-binding domain containing 3 | 0.0157177 |
| STS | steroid sulfatase (microsomal), isozyme S | 0.0155779 |
| ATG7 | autophagy related 7 | 0.0155521 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0155435 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0155384 |
| CFAP44 | cilia and flagella associated protein 44 | 0.0154455 |
| SUMF1 | sulfatase modifying factor 1 | 0.0154142 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0153921 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0151951 |
| HELLS | helicase, lymphoid-specific | 0.0151718 |
| METTL15 | methyltransferase like 15 | 0.0151202 |
| KIAA1328 | KIAA1328 | 0.0150905 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.0150491 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0150419 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0149969 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 0.0149954 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0149875 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0149015 |
| RNF213 | ring finger protein 213 | 0.0148285 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0147653 |
| BCL2L1 | BCL2-like 1 | 0.0146035 |
| PAX8 | paired box 8 | 0.0145635 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.139281 |
| APP | amyloid beta (A4) precursor protein | -0.087263 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0744623 |
| AHNAK | AHNAK nucleoprotein | -0.0710409 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0651969 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0635912 |
| LAMB3 | laminin, beta 3 | -0.0598929 |
| ANXA2 | annexin A2 | -0.0557347 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0543564 |
| FLNB | filamin B, beta | -0.0498958 |
| TMSB4X | thymosin beta 4, X-linked | -0.049414 |
| PTMA | prothymosin, alpha | -0.0494018 |
| KRT7 | keratin 7, type II | -0.047848 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0468891 |
| RPS27A | ribosomal protein S27a | -0.0467151 |
| MATR3 | matrin 3 | -0.0462841 |
| ZNF292 | zinc finger protein 292 | -0.0459755 |
| GOLGA4 | golgin A4 | -0.0449618 |
| RLF | rearranged L-myc fusion | -0.0449582 |
| UBC | ubiquitin C | -0.0443495 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0442518 |
| FNBP1L | formin binding protein 1-like | -0.0438955 |
| CANX | calnexin | -0.0426692 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0418674 |
| UPP1 | uridine phosphorylase 1 | -0.0415801 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0405421 |
| ACTG1 | actin gamma 1 | -0.0403525 |
| SBF2 | SET binding factor 2 | -0.0400357 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0394148 |
| HELZ | helicase with zinc finger | -0.039304 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0370337 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0356982 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.035651 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0354347 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0346454 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0342133 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0339524 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0332589 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.032909 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0328461 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0326059 |
| EMP1 | epithelial membrane protein 1 | -0.0325822 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0323816 |
| RPS8 | ribosomal protein S8 | -0.0321433 |
| OGA | O-GlcNAcase | -0.0320388 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0318058 |
| CLINT1 | clathrin interactor 1 | -0.0316517 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.031523 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0310586 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0309972 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0303883 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0302773 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.030211 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0298445 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0293885 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0293821 |
| RNF145 | ring finger protein 145 | -0.0292336 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0291922 |
| RACK1 | receptor for activated C kinase 1 | -0.0289784 |
| CALR | calreticulin | -0.0289708 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.0289217 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0289038 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0288887 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.028511 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0284109 |
| ORC4 | origin recognition complex, subunit 4 | -0.0283103 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0280691 |
| AFDN | afadin, adherens junction formation factor | -0.0280538 |
| USP3 | ubiquitin specific peptidase 3 | -0.0280232 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0276039 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.027603 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | -0.0275934 |
| RYBP | RING1 and YY1 binding protein | -0.0271496 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0270588 |
| JMJD1C | jumonji domain containing 1C | -0.0270564 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0270115 |
| SLMAP | sarcolemma associated protein | -0.0268885 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0268088 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0267553 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0266306 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.026626 |
| NCKAP1 | NCK-associated protein 1 | -0.0264981 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0263977 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0263889 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | -0.0263651 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0263503 |
| RPS3 | ribosomal protein S3 | -0.0262148 |
| SQSTM1 | sequestosome 1 | -0.0260402 |
| QKI | QKI, KH domain containing, RNA binding | -0.0259734 |
| RYK | receptor-like tyrosine kinase | -0.0259692 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0259655 |
| RPL12 | ribosomal protein L12 | -0.0258023 |
| MED13 | mediator complex subunit 13 | -0.0253765 |
| HDLBP | high density lipoprotein binding protein | -0.0251453 |
| RPL23 | ribosomal protein L23 | -0.0249998 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | -0.0249917 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | -0.0247767 |
| TFG | TRK-fused gene | -0.0246367 |
| ANKRD28 | ankyrin repeat domain 28 | -0.024411 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0243485 |
