APTO-253_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the APTO-253_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.096726
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0902058
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0583167
ENO1 enolase 1, (alpha) 0.0491686
RPS6 ribosomal protein S6 0.042944
CENPF centromere protein F, 350/400kDa 0.0381693
RPL12 ribosomal protein L12 0.0333865
RPS8 ribosomal protein S8 0.0333182
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0328018
ZNF292 zinc finger protein 292 0.030661
RPS12 ribosomal protein S12 0.0287989
STC1 stanniocalcin 1 0.0276231
TIMP1 TIMP metallopeptidase inhibitor 1 0.0265346
FAM13A family with sequence similarity 13, member A 0.0228946
ANGPTL4 angiopoietin-like 4 0.0207149
RPL11 ribosomal protein L11 0.0206464
RPL37A ribosomal protein L37a 0.020488
YBX3 Y box binding protein 3 0.0193129
RPS3 ribosomal protein S3 0.0192252
EIF3A eukaryotic translation initiation factor 3, subunit A 0.018917
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0183803
G0S2 G0/G1 switch 2 0.0177511
MIMS1 mitochondrial inner membrane scaffold 1 0.017528
HILPDA hypoxia inducible lipid droplet-associated 0.017265
FTH1 ferritin, heavy polypeptide 1 0.0172502
KTN1 kinectin 1 (kinesin receptor) 0.016835
IL1B interleukin 1, beta 0.0166906
KIF5B kinesin family member 5B 0.0164362
RPL26 ribosomal protein L26 0.0161818
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0158248
FAM162A family with sequence similarity 162, member A 0.015664
AMPD3 adenosine monophosphate deaminase 3 0.0156596
TPI1 triosephosphate isomerase 1 0.0156194
FOSL1 FOS-like antigen 1 0.0155695
RNMT RNA (guanine-7-) methyltransferase 0.0154972
BTG1 B-cell translocation gene 1, anti-proliferative 0.0150639
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0148541
DDIT4 DNA-damage-inducible transcript 4 0.0148475
RPL30 ribosomal protein L30 0.0148416
KCMF1 potassium channel modulatory factor 1 0.0141683
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0140038
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0138847
IRS2 insulin receptor substrate 2 0.0132688
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0130806
PNISR PNN-interacting serine/arginine-rich protein 0.0129802
ARRDC3 arrestin domain containing 3 0.0128398
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0128192
RPL9 ribosomal protein L9 0.0126768
RPL8 ribosomal protein L8 0.0126219
PFN1 profilin 1 0.0125807
CLEC1B C-type lectin domain family 1, member B 0.012573
NAP1L1 nucleosome assembly protein 1-like 1 0.0123033
EIF1 eukaryotic translation initiation factor 1 0.0121083
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0121047
RPS17 ribosomal protein S17 0.012057
LDHA lactate dehydrogenase A 0.0120252
B2M beta-2-microglobulin 0.0119814
SET SET nuclear proto-oncogene 0.0119555
RPL28 ribosomal protein L28 0.0118949
NUP58 nucleoporin 58 0.0115335
SFPQ splicing factor proline/glutamine-rich 0.0114743
SFXN1 sideroflexin 1 0.0114634
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0113688
FGFR1 fibroblast growth factor receptor 1 0.0113274
RPS2 ribosomal protein S2 0.0113051
EZR ezrin 0.0112742
RPS19 ribosomal protein S19 0.0112449
RPL13A ribosomal protein L13a 0.0111485
OGA O-GlcNAcase 0.0110178
RPLP2 ribosomal protein, large, P2 0.0109976
RPL7A ribosomal protein L7a 0.0109309
NPTN neuroplastin 0.0108953
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0107377
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0107012
RPS10 ribosomal protein S10 0.0106893
RPL37 ribosomal protein L37 0.0106685
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0106459
SYAP1 synapse associated protein 1 0.0105932
RNF145 ring finger protein 145 0.010504
TPT1 tumor protein, translationally-controlled 1 0.0104408
DOT1L DOT1-like histone H3K79 methyltransferase 0.0103999
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0102749
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0101909
GOLGA4 golgin A4 0.0101321
RPL5 ribosomal protein L5 0.0101249
PLAUR plasminogen activator, urokinase receptor 0.0101097
NGLY1 N-glycanase 1 0.0101089
CDCP1 CUB domain containing protein 1 0.0100159
TMF1 TATA element modulatory factor 1 0.010009
RPL27 ribosomal protein L27 0.00998866
PKM pyruvate kinase, muscle 0.00995522
TRA2B transformer 2 beta homolog (Drosophila) 0.00988341
RPL7 ribosomal protein L7 0.00983107
TMSB4X thymosin beta 4, X-linked 0.00976795
BBX bobby sox homolog (Drosophila) 0.00972501
H3-3B H3.3 histone B 0.00967858
CDCA2 cell division cycle associated 2 0.00967672
TPR translocated promoter region, nuclear basket protein 0.009656
SPRED1 sprouty-related, EVH1 domain containing 1 0.0096447
SKP1 S-phase kinase-associated protein 1 0.00964081

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.284103
HMGA2 high mobility group AT-hook 2 -0.192447
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.127443
EXT1 exostosin glycosyltransferase 1 -0.120069
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0963272
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0946055
COL5A1 collagen, type V, alpha 1 -0.0925917
CDH13 cadherin 13 -0.0780366
EGR1 early growth response 1 -0.0729962
MYO10 myosin X -0.0721427
LOX lysyl oxidase -0.0704937
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0664696
COL6A3 collagen, type VI, alpha 3 -0.065803
IGF2 insulin-like growth factor 2 -0.0649159
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0632548
VCL vinculin -0.0624265
COL6A1 collagen, type VI, alpha 1 -0.0599036
TENM2 teneurin transmembrane protein 2 -0.0579793
NAV1 neuron navigator 1 -0.0572733
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0562546
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0554208
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0544631
FNDC3B fibronectin type III domain containing 3B -0.0531512
TMSB10 thymosin beta 10 -0.0522444
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.051036
AHNAK AHNAK nucleoprotein -0.0506352
RAI14 retinoic acid induced 14 -0.0501659
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0479939
TRIO trio Rho guanine nucleotide exchange factor -0.0478084
EGFR epidermal growth factor receptor -0.0458007
ZFAND3 zinc finger, AN1-type domain 3 -0.0439497
USP34 ubiquitin specific peptidase 34 -0.0435168
NALF1 NALCN channel auxiliary factor 1 -0.0415903
OSMR oncostatin M receptor -0.0414862
NF1 neurofibromin 1 -0.0402354
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0400884
VIM vimentin -0.0398173
DST dystonin -0.0396067
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0392645
MAP4 microtubule-associated protein 4 -0.0389912
SEC31A SEC31 homolog A (S. cerevisiae) -0.0389736
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0387247
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0377202
CLTC clathrin, heavy chain (Hc) -0.037498
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0374693
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0370292
SEPTIN9 septin 9 -0.036633
IGF1R insulin-like growth factor 1 receptor -0.03551
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0354083
LPP LIM domain containing preferred translocation partner in lipoma -0.0349001
FMN1 formin 1 -0.0344159
ACTG1 actin gamma 1 -0.0340792
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0339315
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0333169
MBD5 methyl-CpG binding domain protein 5 -0.0333168
TAOK1 TAO kinase 1 -0.0331884
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0328662
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0327961
VMP1 vacuole membrane protein 1 -0.0326789
COPA coatomer protein complex, subunit alpha -0.0326224
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0307129
PDLIM5 PDZ and LIM domain 5 -0.0300564
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0297575
COL6A2 collagen, type VI, alpha 2 -0.0296497
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0294542
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0292698
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0291301
SMYD3 SET and MYND domain containing 3 -0.0290662
MPRIP myosin phosphatase Rho interacting protein -0.0288851
CLMP CXADR-like membrane protein -0.0287936
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0287144
HDLBP high density lipoprotein binding protein -0.0286103
CLIC4 chloride intracellular channel 4 -0.0278973
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0277062
TAS2R14 taste receptor, type 2, member 14 -0.0276517
RAB1A RAB1A, member RAS oncogene family -0.0274951
MAML3 mastermind-like 3 (Drosophila) -0.0274637
ASPH aspartate beta-hydroxylase -0.0269444
RAD51B RAD51 paralog B -0.0267196
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0264216
CALU calumenin -0.0263923
RAP1B RAP1B, member of RAS oncogene family -0.0257794
CANX calnexin -0.0254809
PCBP3 poly(rC) binding protein 3 -0.0254127
ANXA2 annexin A2 -0.0253514
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -0.0251207
MORF4L2 mortality factor 4 like 2 -0.0249908
ZBTB38 zinc finger and BTB domain containing 38 -0.0249723
SAMD4A sterile alpha motif domain containing 4A -0.0249377
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0246078
RAB7A RAB7A, member RAS oncogene family -0.0244903
JARID2 jumonji, AT rich interactive domain 2 -0.0240755
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0240689
ZBTB20 zinc finger and BTB domain containing 20 -0.0238318
GLIS3 GLIS family zinc finger 3 -0.0237551
BICD1 bicaudal D homolog 1 (Drosophila) -0.023596
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0232241
ARHGAP22 Rho GTPase activating protein 22 -0.0231938
MAP1B microtubule-associated protein 1B -0.0230891
ARB2A ARB2 cotranscriptional regulator A -0.0230097