| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | APTO-253 perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the APTO-253_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.162805 |
| NDRG1 | N-myc downstream regulated 1 | 0.161912 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.136598 |
| COL1A1 | collagen, type I, alpha 1 | 0.0931216 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0873089 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.071774 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0559732 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0556651 |
| FTL | ferritin, light polypeptide | 0.0494503 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0427323 |
| CALD1 | caldesmon 1 | 0.0395564 |
| VEGFA | vascular endothelial growth factor A | 0.0378311 |
| PDE10A | phosphodiesterase 10A | 0.0354382 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0349581 |
| MYO10 | myosin X | 0.034095 |
| HDAC9 | histone deacetylase 9 | 0.0331717 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0324103 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.031786 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0316603 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0313027 |
| POTEF | POTE ankyrin domain family, member F | 0.031044 |
| MSN | moesin | 0.0301719 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0288302 |
| RPL35A | ribosomal protein L35a | 0.0274008 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0265276 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0264168 |
| ADAM12 | ADAM metallopeptidase domain 12 | 0.0261741 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0243201 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0228736 |
| MED13L | mediator complex subunit 13-like | 0.0222699 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0220295 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.0219071 |
| RUNX1 | runt-related transcription factor 1 | 0.0218116 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0214772 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0213603 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0209984 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0207816 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.020753 |
| EGFR | epidermal growth factor receptor | 0.0203689 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0202488 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0201729 |
| S100A9 | S100 calcium binding protein A9 | 0.0200564 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.019373 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0192733 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0187203 |
| RPL3 | ribosomal protein L3 | 0.0183056 |
| FAM219A | family with sequence similarity 219, member A | 0.0182316 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0182295 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0179288 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0175466 |
| CCNL1 | cyclin L1 | 0.0173004 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0172247 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0169 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0168817 |
| QKI | QKI, KH domain containing, RNA binding | 0.0167998 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0164891 |
| TXNRD1 | thioredoxin reductase 1 | 0.016351 |
| PTK2 | protein tyrosine kinase 2 | 0.0163103 |
| FOSL1 | FOS-like antigen 1 | 0.0161127 |
| RNF220 | ring finger protein 220 | 0.0160268 |
| TLE4 | transducin-like enhancer of split 4 | 0.0158342 |
| RAD51B | RAD51 paralog B | 0.015788 |
| PFN1 | profilin 1 | 0.0157665 |
| FTO | fat mass and obesity associated | 0.0157288 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0156542 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0154323 |
| TPM1 | tropomyosin 1 (alpha) | 0.0154199 |
| SETBP1 | SET binding protein 1 | 0.0152148 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0152077 |
| YAP1 | Yes-associated protein 1 | 0.015204 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.01517 |
| RPS19 | ribosomal protein S19 | 0.0151307 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0147882 |
| CUX1 | cut-like homeobox 1 | 0.0146616 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0144585 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0143798 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0143468 |
| CABIN1 | calcineurin binding protein 1 | 0.0142391 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0141099 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.014037 |
| ENO1 | enolase 1, (alpha) | 0.0139974 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0139951 |
| EXOC4 | exocyst complex component 4 | 0.0139854 |
| STC2 | stanniocalcin 2 | 0.0139012 |
| NOTCH2 | notch 2 | 0.0138597 |
| MRTFA | myocardin related transcription factor A | 0.0137324 |
| COL5A1 | collagen, type V, alpha 1 | 0.0136545 |
| PKM | pyruvate kinase, muscle | 0.0135849 |
| RPS14 | ribosomal protein S14 | 0.013583 |
| VEGFC | vascular endothelial growth factor C | 0.0135035 |
| ITGA8 | integrin, alpha 8 | 0.0134956 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0134798 |
| AHR | aryl hydrocarbon receptor | 0.0134424 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0134131 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | 0.0133298 |
| CCNY | cyclin Y | 0.0132478 |
| TNS1 | tensin 1 | 0.0132199 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0131667 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0130542 |
| CNTN5 | contactin 5 | 0.0129757 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.317241 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.261294 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.196048 |
| STC1 | stanniocalcin 1 | -0.14517 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.1432 |
| VIM | vimentin | -0.134903 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.132173 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.13021 |
| CDH13 | cadherin 13 | -0.123466 |
| COL1A2 | collagen, type I, alpha 2 | -0.100854 |
| CANX | calnexin | -0.0948649 |
| IER3 | immediate early response 3 | -0.0838201 |
| TPM4 | tropomyosin 4 | -0.0814424 |
| LOXL2 | lysyl oxidase-like 2 | -0.0698927 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0672398 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0637318 |
| CAVIN1 | caveolae associated protein 1 | -0.0604862 |
| RRBP1 | ribosome binding protein 1 | -0.0569467 |
| AHNAK | AHNAK nucleoprotein | -0.0565936 |
| VCAN | versican | -0.0510691 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0492272 |
| HMGA2 | high mobility group AT-hook 2 | -0.0478104 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0460526 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0447807 |
| CLMP | CXADR-like membrane protein | -0.0444706 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0443301 |
| SLC38A2 | solute carrier family 38, member 2 | -0.043432 |
| POSTN | periostin, osteoblast specific factor | -0.0422409 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0420193 |
| HDLBP | high density lipoprotein binding protein | -0.0412041 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0409867 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0408866 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0405598 |
| INHBA | inhibin, beta A | -0.0394322 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0391236 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0367495 |
| HLA-B | major histocompatibility complex, class I, B | -0.036705 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0363821 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0358952 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0356077 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0354009 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.034808 |
| MT2A | metallothionein 2A | -0.0347816 |
| CD44 | CD44 molecule (Indian blood group) | -0.0346152 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0340201 |
| DUSP6 | dual specificity phosphatase 6 | -0.0340149 |
| SQLE | squalene epoxidase | -0.03372 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0330571 |
| RND3 | Rho family GTPase 3 | -0.0329625 |
| RPS3 | ribosomal protein S3 | -0.032682 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0323246 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0322741 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0319921 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.03159 |
| RTN4 | reticulon 4 | -0.03139 |
| TMSB4X | thymosin beta 4, X-linked | -0.031321 |
| OSMR | oncostatin M receptor | -0.0310413 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0310389 |
| MAP4 | microtubule-associated protein 4 | -0.0309178 |
| HLA-E | major histocompatibility complex, class I, E | -0.0308089 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0304996 |
| PRELID2 | PRELI domain containing 2 | -0.0301427 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0293597 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0291471 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0285485 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0276757 |
| OGA | O-GlcNAcase | -0.0274482 |
| ANXA2 | annexin A2 | -0.0274447 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0268782 |
| RACK1 | receptor for activated C kinase 1 | -0.0265162 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0257816 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0255938 |
| HMGA1 | high mobility group AT-hook 1 | -0.025385 |
| PHF3 | PHD finger protein 3 | -0.0253669 |
| SRGN | serglycin | -0.0253609 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0250242 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0250226 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0248103 |
| TARS1 | threonyl-tRNA synthetase 1 | -0.0246565 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0246153 |
| CALU | calumenin | -0.0245181 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0244934 |
| ZFR | zinc finger RNA binding protein | -0.0242972 |
| NUMB | numb homolog (Drosophila) | -0.0241137 |
| KLF6 | Kruppel-like factor 6 | -0.0239541 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0238469 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0237038 |
| ARHGAP35 | Rho GTPase activating protein 35 | -0.0235031 |
| ATP13A3 | ATPase type 13A3 | -0.0232317 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0230702 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0228348 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.022589 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0225609 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0224731 |
| BBX | bobby sox homolog (Drosophila) | -0.022376 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0222759 |
| APP | amyloid beta (A4) precursor protein | -0.0221777 |
| DST | dystonin | -0.022163 |
| IL6ST | interleukin 6 signal transducer | -0.022159 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0221579 |
