| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | APTO-253 perturbation in HT-29 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the APTO-253_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.194374 |
| TXNRD1 | thioredoxin reductase 1 | 0.173366 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.147187 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.127899 |
| KRT18 | keratin 18, type I | 0.0952316 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0922269 |
| CD2AP | CD2-associated protein | 0.0688964 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0678888 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0634646 |
| AHNAK | AHNAK nucleoprotein | 0.0625946 |
| TJP1 | tight junction protein 1 | 0.0601281 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0581254 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0566025 |
| KRT8 | keratin 8, type II | 0.0559438 |
| SMAD3 | SMAD family member 3 | 0.0553701 |
| KLF6 | Kruppel-like factor 6 | 0.0538949 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0531905 |
| PDZD8 | PDZ domain containing 8 | 0.050785 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0502684 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0493815 |
| EXPH5 | exophilin 5 | 0.0491729 |
| RND3 | Rho family GTPase 3 | 0.0480732 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0478841 |
| MYH14 | myosin, heavy chain 14, non-muscle | 0.0459106 |
| RAD21 | RAD21 homolog (S. pombe) | 0.045225 |
| KRT19 | keratin 19, type I | 0.0451048 |
| FAT1 | FAT atypical cadherin 1 | 0.0449472 |
| S100A10 | S100 calcium binding protein A10 | 0.0448848 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0442913 |
| MYO5B | myosin VB | 0.0441787 |
| FOXO1 | forkhead box O1 | 0.0440762 |
| ABHD2 | abhydrolase domain containing 2 | 0.0440328 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0438535 |
| DST | dystonin | 0.0433599 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0432973 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.042439 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0423384 |
| FHL2 | four and a half LIM domains 2 | 0.041804 |
| PLK2 | polo-like kinase 2 | 0.0408368 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0402813 |
| MYO1E | myosin IE | 0.0393716 |
| TMEM123 | transmembrane protein 123 | 0.0389693 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0388991 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0383409 |
| ETV6 | ets variant 6 | 0.037577 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0368835 |
| SGMS2 | sphingomyelin synthase 2 | 0.0368331 |
| LDHA | lactate dehydrogenase A | 0.035467 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0352741 |
| EREG | epiregulin | 0.03509 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0345407 |
| RNF213 | ring finger protein 213 | 0.0342196 |
| KRT20 | keratin 20, type I | 0.0333851 |
| CLIC5 | chloride intracellular channel 5 | 0.0332084 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0329009 |
| MKI67 | marker of proliferation Ki-67 | 0.0326479 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0326434 |
| AREG | amphiregulin | 0.0322467 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0320694 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0319245 |
| PGK1 | phosphoglycerate kinase 1 | 0.0315076 |
| PGCKA1 | PDCD10 and GCKIII kinases associated 1 | 0.0314897 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0302483 |
| UGT1A6 | UDP glucuronosyltransferase 1 family, polypeptide A6 | 0.0302149 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0296529 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0295816 |
| BCL2L1 | BCL2-like 1 | 0.0295787 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0293005 |
| TM4SF4 | transmembrane 4 L six family member 4 | 0.0282802 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.028126 |
| CENPF | centromere protein F, 350/400kDa | 0.0277961 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0275702 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0274829 |
| EZR | ezrin | 0.0273454 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0267484 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.0264675 |
| SPTLC2 | serine palmitoyltransferase, long chain base subunit 2 | 0.0264079 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0263345 |
| DPP4 | dipeptidyl-peptidase 4 | 0.0260542 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.025995 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.025367 |
| SHROOM3 | shroom family member 3 | 0.025208 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0250193 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0242091 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0240964 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0238283 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0237827 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0235785 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.023564 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0233455 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0232944 |
| LYZ | lysozyme | 0.0230634 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0229896 |
| ENO1 | enolase 1, (alpha) | 0.0229638 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0228351 |
| EHF | ets homologous factor | 0.0227867 |
| MYOF | myoferlin | 0.0227307 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0226814 |
| CLMN | calmin (calponin-like, transmembrane) | 0.0224547 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0223971 |
| Symbol | Name | Standardized Value |
|---|---|---|
| INTS6 | integrator complex subunit 6 | -0.0984861 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.091398 |
| NDRG1 | N-myc downstream regulated 1 | -0.0861854 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0818694 |
| RPS3 | ribosomal protein S3 | -0.06573 |
| RPL37A | ribosomal protein L37a | -0.0564209 |
| EGR1 | early growth response 1 | -0.0558276 |
| FRY | furry homolog (Drosophila) | -0.0556718 |
| SLC45A4 | solute carrier family 45, member 4 | -0.0555999 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0551303 |
| MCL1 | myeloid cell leukemia 1 | -0.0533887 |
| RPL13A | ribosomal protein L13a | -0.0527951 |
| RPS12 | ribosomal protein S12 | -0.0480681 |
| RPL31 | ribosomal protein L31 | -0.0480042 |
| RPLP2 | ribosomal protein, large, P2 | -0.0459414 |
| ANXA2 | annexin A2 | -0.04577 |
| RPS6 | ribosomal protein S6 | -0.0447359 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | -0.0423547 |
| ACTN4 | actinin, alpha 4 | -0.0407394 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0380046 |
| B2M | beta-2-microglobulin | -0.0373083 |
| S100P | S100 calcium binding protein P | -0.0362213 |
| RPL11 | ribosomal protein L11 | -0.035833 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0353333 |
| RPS25 | ribosomal protein S25 | -0.0348667 |
| ASPH | aspartate beta-hydroxylase | -0.0343848 |
| RPS8 | ribosomal protein S8 | -0.0328841 |
| ACTG1 | actin gamma 1 | -0.0325732 |
| NIBAN2 | niban apoptosis regulator 2 | -0.0317566 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0310021 |
| RPS27A | ribosomal protein S27a | -0.0306651 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0305548 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.029687 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0286501 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0285567 |
| RPS16 | ribosomal protein S16 | -0.0282743 |
| RPL26 | ribosomal protein L26 | -0.0277586 |
| SBF2 | SET binding factor 2 | -0.0276843 |
| RPL9 | ribosomal protein L9 | -0.027368 |
| RPS29 | ribosomal protein S29 | -0.0263791 |
| RPL28 | ribosomal protein L28 | -0.0258938 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0256522 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -0.0253125 |
| RPS13 | ribosomal protein S13 | -0.0248203 |
| TMEM45B | transmembrane protein 45B | -0.0244837 |
| RPS19 | ribosomal protein S19 | -0.0239426 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0238482 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0236227 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0233452 |
| RPL36A | ribosomal protein L36a | -0.0231238 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0223379 |
| PSPC1 | paraspeckle component 1 | -0.0222316 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0222048 |
| RPL37 | ribosomal protein L37 | -0.0218956 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0217048 |
| SQSTM1 | sequestosome 1 | -0.0216415 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0215525 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0214814 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0214572 |
| RBM47 | RNA binding motif protein 47 | -0.021262 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0212337 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0210585 |
| VEGFA | vascular endothelial growth factor A | -0.0206155 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0203713 |
| TUFT1 | tuftelin 1 | -0.0199602 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0199266 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0196944 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0196017 |
| LASP1 | LIM and SH3 protein 1 | -0.0195195 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0195105 |
| DUSP5 | dual specificity phosphatase 5 | -0.0194461 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0192529 |
| ATF4 | activating transcription factor 4 | -0.019139 |
| JUP | junction plakoglobin | -0.0190546 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0188147 |
| RPL7A | ribosomal protein L7a | -0.0186969 |
| CREB3L1 | cAMP responsive element binding protein 3-like 1 | -0.0186858 |
| SETX | senataxin | -0.0185956 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0185419 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0185334 |
| RPS11 | ribosomal protein S11 | -0.0184187 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0183721 |
| RPL38 | ribosomal protein L38 | -0.0178335 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | -0.0177477 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0176093 |
| RPS10 | ribosomal protein S10 | -0.0174152 |
| RPS27 | ribosomal protein S27 | -0.0173095 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0172764 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | -0.0170975 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0170703 |
| LRRC23 | leucine rich repeat containing 23 | -0.0170242 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0169903 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0168719 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.0167543 |
| UBAP2 | ubiquitin associated protein 2 | -0.0166389 |
| PRELID2 | PRELI domain containing 2 | -0.0166007 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -0.0164261 |
| LAMB3 | laminin, beta 3 | -0.0164042 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | -0.0163884 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0163696 |
