APTO-253_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the APTO-253_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.150433
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0997572
SAMD4A sterile alpha motif domain containing 4A 0.0855471
DSPP dentin sialophosphoprotein 0.0689557
VCL vinculin 0.0620322
LRMDA leucine rich melanocyte differentiation associated 0.0611419
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0606677
SVIL supervillin 0.0595499
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0549665
FNDC3B fibronectin type III domain containing 3B 0.0545826
FN1 fibronectin 1 0.0504117
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0462258
EXT1 exostosin glycosyltransferase 1 0.0457507
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0457442
TXNRD1 thioredoxin reductase 1 0.0394181
DST dystonin 0.0394016
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0376849
PAWR PRKC, apoptosis, WT1, regulator 0.0355131
KYNU kynureninase 0.0348152
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0344427
ITGAV integrin, alpha V 0.0319258
ZBTB20 zinc finger and BTB domain containing 20 0.0302512
GPC6 glypican 6 0.0301767
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.028283
ENO1 enolase 1, (alpha) 0.0282391
PTCHD4 patched domain containing 4 0.0281867
PALLD palladin, cytoskeletal associated protein 0.026888
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.025764
TRIO trio Rho guanine nucleotide exchange factor 0.0257358
RUNX1 runt-related transcription factor 1 0.0249621
ATXN1 ataxin 1 0.0244897
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0238392
ZNF644 zinc finger protein 644 0.0231784
CTNND1 catenin (cadherin-associated protein), delta 1 0.0227433
PTPRM protein tyrosine phosphatase, receptor type, M 0.0226036
JMJD1C jumonji domain containing 1C 0.0222689
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0222258
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0222004
GCLC glutamate-cysteine ligase, catalytic subunit 0.021846
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0214924
PDLIM5 PDZ and LIM domain 5 0.0214829
NRIP1 nuclear receptor interacting protein 1 0.0209386
TBC1D22A TBC1 domain family, member 22A 0.02092
MALRD1 MAM and LDL receptor class A domain containing 1 0.0208129
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0207825
FILIP1L filamin A interacting protein 1-like 0.0207133
LPP LIM domain containing preferred translocation partner in lipoma 0.0203764
DTNA dystrobrevin, alpha 0.0200099
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0198638
NPAS2 neuronal PAS domain protein 2 0.0197751
AHR aryl hydrocarbon receptor 0.0197262
RASA2 RAS p21 protein activator 2 0.0195236
GLIS3 GLIS family zinc finger 3 0.0191672
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0190933
FOXP1 forkhead box P1 0.0190917
FAM107B family with sequence similarity 107, member B 0.0190424
MBNL2 muscleblind-like splicing regulator 2 0.0189209
LMCD1 LIM and cysteine-rich domains 1 0.0186055
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0184212
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0183667
MYO1E myosin IE 0.0183238
ADAM9 ADAM metallopeptidase domain 9 0.0181172
KIF21A kinesin family member 21A 0.0178824
H1-0 H1.0 linker histone 0.0178721
DIAPH1 diaphanous-related formin 1 0.0174911
FNIP1 folliculin interacting protein 1 0.0174837
ANKRD12 ankyrin repeat domain 12 0.0174619
AFDN afadin, adherens junction formation factor 0.0170597
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0168976
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0167826
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.016764
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0166685
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0166337
TXNIP thioredoxin interacting protein 0.0164776
PRRC2C proline-rich coiled-coil 2C 0.0161569
RAD51B RAD51 paralog B 0.0161538
MBD5 methyl-CpG binding domain protein 5 0.0159399
RIGI RNA sensor RIG-I 0.0158632
ARHGAP9 Rho GTPase activating protein 9 0.0157893
MYO5B myosin VB 0.0157237
TLE4 transducin-like enhancer of split 4 0.01566
CRY1 cryptochrome circadian clock 1 0.0156132
PNRC1 proline-rich nuclear receptor coactivator 1 0.0155081
CEMIP2 cell migration inducing hyaluronidase 2 0.0153109
ZFAND3 zinc finger, AN1-type domain 3 0.0152614
MRTFA myocardin related transcription factor A 0.0152045
RNF213 ring finger protein 213 0.0151936
ENKUR enkurin, TRPC channel interacting protein 0.0151357
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0150258
KIAA1217 KIAA1217 0.0149613
GRB10 growth factor receptor-bound protein 10 0.0148363
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0148183
PLXDC2 plexin domain containing 2 0.0146362
KDM4C lysine (K)-specific demethylase 4C 0.0145419
CADM1 cell adhesion molecule 1 0.0143652
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0143274
ZSWIM6 zinc finger, SWIM-type containing 6 0.0142946
GLIPR1 GLI pathogenesis-related 1 0.0142791
USP47 ubiquitin specific peptidase 47 0.0141732
MCU mitochondrial calcium uniporter 0.0141654

decreased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.211755
APOA2 apolipoprotein A-II -0.209032
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.195935
TIMP1 TIMP metallopeptidase inhibitor 1 -0.151086
AKAP12 A kinase (PRKA) anchor protein 12 -0.148682
MT2A metallothionein 2A -0.132693
TPT1 tumor protein, translationally-controlled 1 -0.098271
IGFBP1 insulin-like growth factor binding protein 1 -0.0818226
TM4SF1 transmembrane 4 L six family member 1 -0.0695292
RPL37A ribosomal protein L37a -0.0693958
HMGA1 high mobility group AT-hook 1 -0.0679768
RPS6 ribosomal protein S6 -0.060153
APOB apolipoprotein B -0.0552369
SLC38A2 solute carrier family 38, member 2 -0.0519773
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0519196
RPS27A ribosomal protein S27a -0.0492093
RPL11 ribosomal protein L11 -0.0482115
RPLP1 ribosomal protein, large, P1 -0.045108
RPS29 ribosomal protein S29 -0.043547
IER3 immediate early response 3 -0.0421279
CTSB cathepsin B -0.0420591
GPC3 glypican 3 -0.0417676
FTL ferritin, light polypeptide -0.0413158
GMDS GDP-mannose 4,6-dehydratase -0.0407603
TMSB10 thymosin beta 10 -0.039881
RPS8 ribosomal protein S8 -0.0397827
RPL35A ribosomal protein L35a -0.038648
RPS24 ribosomal protein S24 -0.037725
RPS3 ribosomal protein S3 -0.0366551
RPLP0 ribosomal protein, large, P0 -0.0364866
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.034854
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 -0.0330014
NHSL1 NHS-like 1 -0.0319366
RPS12 ribosomal protein S12 -0.0317599
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.031749
RPLP2 ribosomal protein, large, P2 -0.0317016
RPS23 ribosomal protein S23 -0.0313803
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0310801
RPL37 ribosomal protein L37 -0.0310298
RPL31 ribosomal protein L31 -0.0303183
EML4 echinoderm microtubule associated protein like 4 -0.0295125
LYZ lysozyme -0.028342
RPL9 ribosomal protein L9 -0.0268742
APOE apolipoprotein E -0.0264253
RPL26 ribosomal protein L26 -0.0259701
RPL38 ribosomal protein L38 -0.0252546
RPL12 ribosomal protein L12 -0.0251443
RACK1 receptor for activated C kinase 1 -0.024755
RPL34 ribosomal protein L34 -0.0247266
RPS19 ribosomal protein S19 -0.0241717
ITGA1 integrin, alpha 1 -0.0237231
RAI14 retinoic acid induced 14 -0.0233979
RPS5 ribosomal protein S5 -0.0231366
RPL13A ribosomal protein L13a -0.0230667
FBF1 Fas (TNFRSF6) binding factor 1 -0.0224701
SLC38A1 solute carrier family 38, member 1 -0.022329
RPL28 ribosomal protein L28 -0.0223126
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0222691
SDC4 syndecan 4 -0.0222335
RPS25 ribosomal protein S25 -0.0220407
RPL30 ribosomal protein L30 -0.0219334
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.0218898
IGFBP3 insulin-like growth factor binding protein 3 -0.0218584
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0218491
CNKSR3 CNKSR family member 3 -0.0216584
APOA1 apolipoprotein A-I -0.0215588
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0214733
RPS17 ribosomal protein S17 -0.0214283
RPS20 ribosomal protein S20 -0.0213835
RPS13 ribosomal protein S13 -0.0213394
RPL10A ribosomal protein L10a -0.0213258
AMBP alpha-1-microglobulin/bikunin precursor -0.020992
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0207097
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0204254
GDF15 growth differentiation factor 15 -0.0201396
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0199805
EIF1 eukaryotic translation initiation factor 1 -0.0197677
HPCAL1 hippocalcin-like 1 -0.019766
RPS16 ribosomal protein S16 -0.0197015
ACTG1 actin gamma 1 -0.0197001
MCL1 myeloid cell leukemia 1 -0.01934
FRMD5 FERM domain containing 5 -0.0192792
RPL23 ribosomal protein L23 -0.0190763
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0190017
B2M beta-2-microglobulin -0.0188959
RPL36A ribosomal protein L36a -0.0185093
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0182367
PTMA prothymosin, alpha -0.0179809
GNAS GNAS complex locus -0.01765
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0173607
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0171049
RPL7 ribosomal protein L7 -0.0170801
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0170128
NAP1L1 nucleosome assembly protein 1-like 1 -0.0168586
FERMT1 fermitin family member 1 -0.0168207
TRIM26 tripartite motif containing 26 -0.0164615
NPR2 natriuretic peptide receptor 2 -0.0163516
RPL36 ribosomal protein L36 -0.016288
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0162086
SELENOP selenoprotein P -0.0162014