APTO-253_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in Hs 766T cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the APTO-253_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.212609
TIMP3 TIMP metallopeptidase inhibitor 3 0.187811
LMO7 LIM domain 7 0.175164
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.167921
PDE4D phosphodiesterase 4D, cAMP-specific 0.162895
DPYD dihydropyrimidine dehydrogenase 0.135046
PDLIM5 PDZ and LIM domain 5 0.115463
SULF1 sulfatase 1 0.087495
PALLD palladin, cytoskeletal associated protein 0.0810511
ALCAM activated leukocyte cell adhesion molecule 0.0779405
MECOM MDS1 and EVI1 complex locus 0.0661211
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0578483
FOXP1 forkhead box P1 0.0578377
AOPEP aminopeptidase O (putative) 0.0572761
EXT1 exostosin glycosyltransferase 1 0.0545204
DOK5 docking protein 5 0.0544772
KLF5 Kruppel-like factor 5 (intestinal) 0.0534883
TRIO trio Rho guanine nucleotide exchange factor 0.0532044
RASAL2 RAS protein activator like 2 0.0523825
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0518685
TSC22D1 TSC22 domain family, member 1 0.0516898
EXOC4 exocyst complex component 4 0.0514324
FOXO1 forkhead box O1 0.051096
NEK7 NIMA-related kinase 7 0.0496672
MYOF myoferlin 0.0489456
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0484571
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0462299
CNTNAP3 contactin associated protein-like 3 0.0448986
RAD51B RAD51 paralog B 0.0446653
DST dystonin 0.0418071
MBNL1 muscleblind-like splicing regulator 1 0.0417997
AHNAK AHNAK nucleoprotein 0.0406979
PTK2 protein tyrosine kinase 2 0.039459
MAML2 mastermind-like 2 (Drosophila) 0.0389984
PICALM phosphatidylinositol binding clathrin assembly protein 0.038642
SMYD3 SET and MYND domain containing 3 0.03782
MKI67 marker of proliferation Ki-67 0.0377539
OSMR oncostatin M receptor 0.0364906
RABGAP1L RAB GTPase activating protein 1-like 0.0362958
EFNA5 ephrin-A5 0.0361426
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0360065
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0357235
UTRN utrophin 0.0356741
TXNRD1 thioredoxin reductase 1 0.0356698
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0350134
CD44 CD44 molecule (Indian blood group) 0.0346514
RAI14 retinoic acid induced 14 0.0343569
MEIS2 Meis homeobox 2 0.0341659
MTSS1 metastasis suppressor 1 0.0340809
MYH9 myosin, heavy chain 9, non-muscle 0.0335639
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.033549
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0335112
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.033367
HDAC9 histone deacetylase 9 0.033152
PRELID2 PRELI domain containing 2 0.0327269
ANO1 anoctamin 1, calcium activated chloride channel 0.0324109
PARP14 poly (ADP-ribose) polymerase family, member 14 0.031764
DGKH diacylglycerol kinase, eta 0.0316256
FLNB filamin B, beta 0.0310376
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0309307
BCAR3 breast cancer anti-estrogen resistance 3 0.0306703
DOCK5 dedicator of cytokinesis 5 0.0306289
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0305213
PSD3 pleckstrin and Sec7 domain containing 3 0.0303916
ITGB8 integrin, beta 8 0.0301614
IFI44L interferon-induced protein 44-like 0.0300587
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0299485
KIAA1671 KIAA1671 0.0299404
NRG1 neuregulin 1 0.0298749
FN1 fibronectin 1 0.0297478
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0294588
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0292684
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0288424
TXNIP thioredoxin interacting protein 0.0288328
RIGI RNA sensor RIG-I 0.0284982
CDK17 cyclin-dependent kinase 17 0.0283565
MBNL2 muscleblind-like splicing regulator 2 0.0280448
PRSS23 protease, serine, 23 0.0279483
PLCE1 phospholipase C, epsilon 1 0.0277262
ACTN4 actinin, alpha 4 0.0276295
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.0276045
HSPG2 heparan sulfate proteoglycan 2 0.0269659
ZMYND8 zinc finger, MYND-type containing 8 0.0269517
TENM4 teneurin transmembrane protein 4 0.0268756
TNS3 tensin 3 0.0268553
TTC28 tetratricopeptide repeat domain 28 0.0268108
BLCAP bladder cancer associated protein 0.0266826
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0263855
FAF1 Fas (TNFRSF6) associated factor 1 0.0262156
EGFR epidermal growth factor receptor 0.0260567
ZSWIM6 zinc finger, SWIM-type containing 6 0.0255405
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0251085
PTPRB protein tyrosine phosphatase, receptor type, B 0.0250519
ABI3BP ABI family, member 3 (NESH) binding protein 0.0249347
VCL vinculin 0.0249279
INTS6 integrator complex subunit 6 0.0249239
SOX5 SRY (sex determining region Y)-box 5 0.0243754
ANKRD12 ankyrin repeat domain 12 0.0242412
HMGA2 high mobility group AT-hook 2 0.0239248
OXSR1 oxidative stress responsive 1 0.0232527

decreased expression

Symbol Name Standardized Value
STC1 stanniocalcin 1 -0.145857
NDRG1 N-myc downstream regulated 1 -0.12716
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.113877
CLU clusterin -0.101467
MT2A metallothionein 2A -0.0735018
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0720303
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0668422
POTEF POTE ankyrin domain family, member F -0.0623703
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0618218
TPT1 tumor protein, translationally-controlled 1 -0.0618076
LAMC2 laminin, gamma 2 -0.0576493
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0572505
NAMPT nicotinamide phosphoribosyltransferase -0.0567239
KRT17 keratin 17, type I -0.0530237
ITGA6 integrin, alpha 6 -0.0520641
PTMA prothymosin, alpha -0.0479307
PODXL podocalyxin-like -0.0476399
S100A10 S100 calcium binding protein A10 -0.0474461
RPS13 ribosomal protein S13 -0.0472673
S100A2 S100 calcium binding protein A2 -0.046711
TMSB10 thymosin beta 10 -0.0466752
DSTN destrin (actin depolymerizing factor) -0.0443408
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0436932
GOLGA4 golgin A4 -0.04074
SQLE squalene epoxidase -0.0401982
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0398348
ANXA1 annexin A1 -0.0388403
CD99 CD99 molecule -0.0386474
MYO10 myosin X -0.0382038
SPAG9 sperm associated antigen 9 -0.0379928
EMP1 epithelial membrane protein 1 -0.037787
S100A6 S100 calcium binding protein A6 -0.0375925
KTN1 kinectin 1 (kinesin receptor) -0.0367192
RPL11 ribosomal protein L11 -0.0366023
OGA O-GlcNAcase -0.0365447
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0358185
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0358108
BHLHE40 basic helix-loop-helix family, member e40 -0.0354156
RPLP2 ribosomal protein, large, P2 -0.0350527
PDIA3 protein disulfide isomerase family A, member 3 -0.0349535
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0343791
KDM5B lysine (K)-specific demethylase 5B -0.0342412
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0341836
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0341182
ANXA2 annexin A2 -0.0339392
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0338827
RPS6 ribosomal protein S6 -0.0338314
FMNL2 formin-like 2 -0.0326649
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0322418
RIOK3 RIO kinase 3 -0.0316086
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0304083
MEF2A myocyte enhancer factor 2A -0.0302265
RLF rearranged L-myc fusion -0.0300976
CEMIP cell migration inducing protein, hyaluronan binding -0.0300681
WSB1 WD repeat and SOCS box containing 1 -0.0299782
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0296708
SUCO SUN domain containing ossification factor -0.0296407
KDM7A lysine (K)-specific demethylase 7A -0.0295562
MORF4L2 mortality factor 4 like 2 -0.0294111
RPL12 ribosomal protein L12 -0.0292799
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -0.0291461
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0286283
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0284915
HLA-E major histocompatibility complex, class I, E -0.0284338
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0272697
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0271329
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -0.0271017
NUP58 nucleoporin 58 -0.0269694
VDAC1 voltage-dependent anion channel 1 -0.0265802
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0264813
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.026424
NPEPPS aminopeptidase puromycin sensitive -0.0264221
RPS12 ribosomal protein S12 -0.0263829
FSCN1 fascin actin-bundling protein 1 -0.0263342
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0259827
COPB1 coatomer protein complex, subunit beta 1 -0.0259142
RPS25 ribosomal protein S25 -0.0258558
RPS23 ribosomal protein S23 -0.0258505
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.02565
FOSL1 FOS-like antigen 1 -0.0255859
CSTB cystatin B (stefin B) -0.0255839
KMT2E lysine (K)-specific methyltransferase 2E -0.0253755
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0251563
RPL23 ribosomal protein L23 -0.0250187
ADAM17 ADAM metallopeptidase domain 17 -0.0249322
TPM4 tropomyosin 4 -0.0246669
PNISR PNN-interacting serine/arginine-rich protein -0.0245321
KDM6A lysine (K)-specific demethylase 6A -0.0245292
RPS21 ribosomal protein S21 -0.0244916
ARRDC3 arrestin domain containing 3 -0.0244797
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.024159
BZW2 basic leucine zipper and W2 domains 2 -0.0240131
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.023996
EZR ezrin -0.0238019
RPS29 ribosomal protein S29 -0.023744
CSNK1E casein kinase 1, epsilon -0.0236082
SRP54 signal recognition particle 54kDa -0.0235729
MARCHF6 membrane associated ring-CH-type finger 6 -0.0234463
NRIP1 nuclear receptor interacting protein 1 -0.0234219
RACK1 receptor for activated C kinase 1 -0.0233509