APTO-253_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the APTO-253_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.171986
MT2A metallothionein 2A 0.171261
FTH1 ferritin, heavy polypeptide 1 0.125453
FTL ferritin, light polypeptide 0.118334
B2M beta-2-microglobulin 0.105856
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.098065
TXNRD1 thioredoxin reductase 1 0.0925511
HLA-B major histocompatibility complex, class I, B 0.0913092
MT1X metallothionein 1X 0.0742499
ENO1 enolase 1, (alpha) 0.0702811
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0671315
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0595081
CALR calreticulin 0.0447097
HLA-A major histocompatibility complex, class I, A 0.0430868
PDIA3 protein disulfide isomerase family A, member 3 0.0404239
IFI6 interferon, alpha-inducible protein 6 0.0394821
PFN1 profilin 1 0.0393335
UGCG UDP-glucose ceramide glucosyltransferase 0.0373685
PTMA prothymosin, alpha 0.0367914
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.032995
CENPF centromere protein F, 350/400kDa 0.032414
DEK DEK proto-oncogene 0.0322723
TMSB10 thymosin beta 10 0.0317263
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0314023
ERBIN erbb2 interacting protein 0.0297743
GOLGA4 golgin A4 0.0292238
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0290859
IFITM3 interferon induced transmembrane protein 3 0.0289004
BASP1 brain abundant, membrane attached signal protein 1 0.0285584
KPNB1 karyopherin (importin) beta 1 0.0278143
S100A10 S100 calcium binding protein A10 0.0277534
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0274217
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.027337
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0262379
TUBA1B tubulin, alpha 1b 0.0259836
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0255019
RHOBTB3 Rho-related BTB domain containing 3 0.0251724
KRT18 keratin 18, type I 0.024396
KRT7 keratin 7, type II 0.0241485
RPS8 ribosomal protein S8 0.0235783
RPS6 ribosomal protein S6 0.0234578
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0229594
KTN1 kinectin 1 (kinesin receptor) 0.0225785
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.022423
RPL35A ribosomal protein L35a 0.022163
KRT8 keratin 8, type II 0.0220412
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0217505
PA2G4 proliferation-associated 2G4, 38kDa 0.0215225
MKI67 marker of proliferation Ki-67 0.0214314
YBX1 Y box binding protein 1 0.0213111
HMGB1 high mobility group box 1 0.0209951
RPS19 ribosomal protein S19 0.0209406
TPI1 triosephosphate isomerase 1 0.0208484
SMC4 structural maintenance of chromosomes 4 0.020536
TPM3 tropomyosin 3 0.0202274
RPL23 ribosomal protein L23 0.0197234
SET SET nuclear proto-oncogene 0.0196908
NAMPT nicotinamide phosphoribosyltransferase 0.019679
NPPB natriuretic peptide B 0.019505
SERBP1 SERPINE1 mRNA binding protein 1 0.0190667
RPL19 ribosomal protein L19 0.0190294
RPL35 ribosomal protein L35 0.0190236
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0188423
ELL2 elongation factor, RNA polymerase II, 2 0.0183732
RPL12 ribosomal protein L12 0.0183259
LIMA1 LIM domain and actin binding 1 0.0181783
TUBB4B tubulin, beta 4B class IVb 0.0177046
IFITM1 interferon induced transmembrane protein 1 0.0176322
NEK7 NIMA-related kinase 7 0.0173542
ARHGAP29 Rho GTPase activating protein 29 0.0172845
SERF2 small EDRK-rich factor 2 0.0172478
PRRC2C proline-rich coiled-coil 2C 0.017117
LDHB lactate dehydrogenase B 0.0166793
MTDH metadherin 0.0165815
CBX3 chromobox homolog 3 0.0163951
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0163803
RPL32 ribosomal protein L32 0.0162718
ATP5F1E ATP synthase F1 subunit epsilon 0.01627
LOC112694756 uncharaterized LOC112694756 0.0162439
S100A9 S100 calcium binding protein A9 0.0161883
FAM162A family with sequence similarity 162, member A 0.0160954
STMN1 stathmin 1 0.0158533
TKT transketolase 0.0157196
PKM pyruvate kinase, muscle 0.0156137
SRRM2 serine/arginine repetitive matrix 2 0.0156007
FOSL1 FOS-like antigen 1 0.0155617
UBE2K ubiquitin-conjugating enzyme E2K 0.0152536
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0151993
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0150247
BSG basigin (Ok blood group) 0.0149477
VGLL3 vestigial-like family member 3 0.0148789
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0147505
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.014351
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.014269
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0142597
SMC1A structural maintenance of chromosomes 1A 0.0141825
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 0.0141144
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.0140764
TPX2 TPX2, microtubule-associated 0.0139595
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.0139062

decreased expression

Symbol Name Standardized Value
NALF1 NALCN channel auxiliary factor 1 -0.346357
FN1 fibronectin 1 -0.218026
TRIO trio Rho guanine nucleotide exchange factor -0.157554
ABI3BP ABI family, member 3 (NESH) binding protein -0.126577
EXT1 exostosin glycosyltransferase 1 -0.118196
PHACTR1 phosphatase and actin regulator 1 -0.101163
INTS6 integrator complex subunit 6 -0.081538
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0716646
AHNAK AHNAK nucleoprotein -0.0690932
LPP LIM domain containing preferred translocation partner in lipoma -0.0686612
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0659527
SDK1 sidekick cell adhesion molecule 1 -0.0620174
FLNB filamin B, beta -0.0594993
COL5A1 collagen, type V, alpha 1 -0.0590666
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.055995
RAI14 retinoic acid induced 14 -0.0555486
FNDC3B fibronectin type III domain containing 3B -0.0535621
PLCB4 phospholipase C, beta 4 -0.0526001
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0515883
IGFBP3 insulin-like growth factor binding protein 3 -0.050803
ASPH aspartate beta-hydroxylase -0.0492188
NAV2 neuron navigator 2 -0.0478497
RAD51B RAD51 paralog B -0.0465989
NDRG1 N-myc downstream regulated 1 -0.0458059
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0451462
DLG1 discs, large homolog 1 (Drosophila) -0.0450008
TNS3 tensin 3 -0.0448752
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0439119
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0428611
NABP1 nucleic acid binding protein 1 -0.0423289
AKAP12 A kinase (PRKA) anchor protein 12 -0.0419227
EGFR epidermal growth factor receptor -0.0419221
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0409834
GLIS3 GLIS family zinc finger 3 -0.0403011
TENM3 teneurin transmembrane protein 3 -0.0400805
FRMD6 FERM domain containing 6 -0.0400718
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0399597
PRELID2 PRELI domain containing 2 -0.0399435
DST dystonin -0.0388832
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0386183
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0383651
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0376752
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0375574
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0370073
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0369282
MYOF myoferlin -0.0360395
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0354722
PODXL podocalyxin-like -0.0353562
SBF2 SET binding factor 2 -0.0352334
SMYD3 SET and MYND domain containing 3 -0.0350745
FHIT fragile histidine triad -0.035027
TLE4 transducin-like enhancer of split 4 -0.0347603
ZBTB20 zinc finger and BTB domain containing 20 -0.0343798
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0342428
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0338395
LYPD6B LY6/PLAUR domain containing 6B -0.0335799
MMP12 matrix metallopeptidase 12 -0.0330705
NAV1 neuron navigator 1 -0.0329549
DIAPH3 diaphanous-related formin 3 -0.0328274
FLNA filamin A, alpha -0.03278
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0325911
PTPRM protein tyrosine phosphatase, receptor type, M -0.0322545
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.032077
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0318453
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -0.0317064
ATXN1 ataxin 1 -0.0316951
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.031694
CCBE1 collagen and calcium binding EGF domains 1 -0.0306565
MAML2 mastermind-like 2 (Drosophila) -0.0304539
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0302665
RUNX1 runt-related transcription factor 1 -0.0302628
SAMD12 sterile alpha motif domain containing 12 -0.0298585
ZNF804A zinc finger protein 804A -0.0296673
CUL4B cullin 4B -0.0285761
CAMTA1 calmodulin binding transcription activator 1 -0.0285169
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0283639
NSD2 nuclear receptor binding SET domain protein 2 -0.0280186
DTNA dystrobrevin, alpha -0.0276912
MYH9 myosin, heavy chain 9, non-muscle -0.0276802
FSTL1 follistatin-like 1 -0.0276316
WSB1 WD repeat and SOCS box containing 1 -0.0275236
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0274675
GLS2 glutaminase 2 (liver, mitochondrial) -0.0271191
LRMDA leucine rich melanocyte differentiation associated -0.0263249
EXOC4 exocyst complex component 4 -0.0257085
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0256789
DIAPH2 diaphanous-related formin 2 -0.0254835
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0254358
DENND1A DENN/MADD domain containing 1A -0.025339
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -0.0253099
RASAL2 RAS protein activator like 2 -0.025173
EGR1 early growth response 1 -0.025164
KALRN kalirin, RhoGEF kinase -0.0250356
NCOR2 nuclear receptor corepressor 2 -0.0249437
E2F3 E2F transcription factor 3 -0.024487
PTK2 protein tyrosine kinase 2 -0.0244221
FBXO11 F-box protein 11 -0.0243898
ASXL1 additional sex combs like transcriptional regulator 1 -0.0241323
MAP4 microtubule-associated protein 4 -0.0240447
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0239674