APTO-253_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the APTO-253_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 0.148554
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.121146
TMSB10 thymosin beta 10 0.114687
GMDS GDP-mannose 4,6-dehydratase 0.11296
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0979464
POTEF POTE ankyrin domain family, member F 0.0876172
LMO7 LIM domain 7 0.0764008
RPL35A ribosomal protein L35a 0.0744276
CEMIP cell migration inducing protein, hyaluronan binding 0.0730583
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0720529
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.069763
PTMA prothymosin, alpha 0.0670501
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0621499
NPSR1 neuropeptide S receptor 1 0.0576436
FAT1 FAT atypical cadherin 1 0.0555964
RPL23 ribosomal protein L23 0.0552859
FTL ferritin, light polypeptide 0.0546423
S100A10 S100 calcium binding protein A10 0.0521679
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0505075
ASPH aspartate beta-hydroxylase 0.0492883
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0485048
ITGA6 integrin, alpha 6 0.048047
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0477479
ANXA2 annexin A2 0.0473023
KRT18 keratin 18, type I 0.0450292
RPS6 ribosomal protein S6 0.0438041
PDIA3 protein disulfide isomerase family A, member 3 0.0437399
MAML2 mastermind-like 2 (Drosophila) 0.0430072
MYOF myoferlin 0.0417514
KRT8 keratin 8, type II 0.0399249
BCL2L1 BCL2-like 1 0.038883
RPLP1 ribosomal protein, large, P1 0.0378898
S100A6 S100 calcium binding protein A6 0.0377375
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0368431
DOCK5 dedicator of cytokinesis 5 0.0367559
ACTG1 actin gamma 1 0.0367036
FLNB filamin B, beta 0.0365949
CALR calreticulin 0.035668
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0343
ACTN4 actinin, alpha 4 0.0341239
AKAP13 A kinase (PRKA) anchor protein 13 0.0340301
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0337037
RPS25 ribosomal protein S25 0.0335867
GDA guanine deaminase 0.0333293
ANLN anillin, actin binding protein 0.0332802
HMGA1 high mobility group AT-hook 1 0.0332269
TPT1 tumor protein, translationally-controlled 1 0.0331105
RPS19 ribosomal protein S19 0.0318327
EZR ezrin 0.0317543
CLTC clathrin, heavy chain (Hc) 0.0317238
PDIA4 protein disulfide isomerase family A, member 4 0.0310392
ENO1 enolase 1, (alpha) 0.0309091
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0302997
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0297986
TPM4 tropomyosin 4 0.0287612
S100A9 S100 calcium binding protein A9 0.0284917
AGR2 anterior gradient 2 0.027577
SMAD3 SMAD family member 3 0.0270225
EMP1 epithelial membrane protein 1 0.0269857
DSTN destrin (actin depolymerizing factor) 0.0268453
EPS8 epidermal growth factor receptor pathway substrate 8 0.0268329
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0257791
SLTM SAFB-like, transcription modulator 0.0257747
RRM2 ribonucleotide reductase M2 0.0255364
ADAM9 ADAM metallopeptidase domain 9 0.0254833
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0254111
ZFAND3 zinc finger, AN1-type domain 3 0.0247428
SIK3 SIK family kinase 3 0.0245703
RPS14 ribosomal protein S14 0.0241947
ESYT2 extended synaptotagmin-like protein 2 0.0240397
UBASH3B ubiquitin associated and SH3 domain containing B 0.0239158
RPL9 ribosomal protein L9 0.0237796
RPS17 ribosomal protein S17 0.0237458
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0236004
S100A11 S100 calcium binding protein A11 0.0235744
RAB7A RAB7A, member RAS oncogene family 0.0234796
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0234695
KMT2C lysine (K)-specific methyltransferase 2C 0.0234428
RPL7A ribosomal protein L7a 0.023323
KRT19 keratin 19, type I 0.0232587
COBL cordon-bleu WH2 repeat protein 0.0228805
PDIA6 protein disulfide isomerase family A, member 6 0.0228529
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0227605
H1-0 H1.0 linker histone 0.022723
YAP1 Yes-associated protein 1 0.022696
PRRC2C proline-rich coiled-coil 2C 0.0225268
EFNA5 ephrin-A5 0.0223893
APLP2 amyloid beta (A4) precursor-like protein 2 0.0223718
RPS8 ribosomal protein S8 0.0223418
SREBF2 sterol regulatory element binding transcription factor 2 0.0222231
MCU mitochondrial calcium uniporter 0.0221725
DLC1 DLC1 Rho GTPase activating protein 0.0220673
EHBP1 EH domain binding protein 1 0.0219923
SMC1A structural maintenance of chromosomes 1A 0.0217858
TUBA1B tubulin, alpha 1b 0.0215744
FRMD5 FERM domain containing 5 0.0212008
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.0211271
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0210776
RPL19 ribosomal protein L19 0.0206977
NCEH1 neutral cholesterol ester hydrolase 1 0.0206896

decreased expression

Symbol Name Standardized Value
NUPR1 nuclear protein, transcriptional regulator, 1 -0.0428155
TMEM123 transmembrane protein 123 -0.0300667
FRY furry homolog (Drosophila) -0.0260398
ATF5 activating transcription factor 5 -0.0237482
VEGFA vascular endothelial growth factor A -0.0233102
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0231439
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0230235
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0222439
PHF3 PHD finger protein 3 -0.0216721
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0208651
AKAP9 A kinase (PRKA) anchor protein 9 -0.0201318
FAAH2 fatty acid amide hydrolase 2 -0.0198618
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0195106
SLC38A2 solute carrier family 38, member 2 -0.0177788
HLA-E major histocompatibility complex, class I, E -0.0177706
CLDN4 claudin 4 -0.0177389
IFI6 interferon, alpha-inducible protein 6 -0.0175648
KLF5 Kruppel-like factor 5 (intestinal) -0.0173485
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0171898
SQSTM1 sequestosome 1 -0.0162606
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0156955
CCDC146 coiled-coil domain containing 146 -0.0152266
FOXP1 forkhead box P1 -0.0151932
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0151512
XAF1 XIAP associated factor 1 -0.0149783
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0146594
RAB40B RAB40B, member RAS oncogene family -0.0139088
ALPK1 alpha-kinase 1 -0.0138179
CLINT1 clathrin interactor 1 -0.0137797
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0137065
GPX2 glutathione peroxidase 2 -0.0136878
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0134958
NCOA7 nuclear receptor coactivator 7 -0.0130156
NIPSNAP2 nipsnap homolog 2 -0.0125479
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0125457
TXNIP thioredoxin interacting protein -0.0125014
CALCOCO2 calcium binding and coiled-coil domain 2 -0.0122276
GOLGB1 golgin B1 -0.0121906
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0121576
APOL6 apolipoprotein L, 6 -0.0119565
DDIT3 DNA-damage-inducible transcript 3 -0.0118605
ZMYND8 zinc finger, MYND-type containing 8 -0.0118323
SLFN5 schlafen family member 5 -0.0115437
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0113795
CAPN5 calpain 5 -0.0110492
TMF1 TATA element modulatory factor 1 -0.0109952
POF1B premature ovarian failure, 1B -0.0108705
WASL Wiskott-Aldrich syndrome-like -0.0106134
ZBTB20 zinc finger and BTB domain containing 20 -0.0106012
PRKN parkin RBR E3 ubiquitin protein ligase -0.0105668
CDK19 cyclin-dependent kinase 19 -0.0105601
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0104154
SAMD12 sterile alpha motif domain containing 12 -0.0103872
GCC2 GRIP and coiled-coil domain containing 2 -0.0103028
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.00988448
BCAS3 breast carcinoma amplified sequence 3 -0.00987882
DDIT4 DNA-damage-inducible transcript 4 -0.00978132
FAM114A1 family with sequence similarity 114, member A1 -0.00964263
PTPRF protein tyrosine phosphatase, receptor type, F -0.0095487
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.00949457
JUN jun proto-oncogene -0.00945174
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.00943394
PATJ PATJ crumbs cell polarity complex component -0.00918297
FOS FBJ murine osteosarcoma viral oncogene homolog -0.00917418
KLHL24 kelch-like family member 24 -0.00894433
AUH AU RNA binding protein/enoyl-CoA hydratase -0.00890582
RNF24 ring finger protein 24 -0.00887646
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.00883621
PYGB phosphorylase, glycogen; brain -0.00882354
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) -0.00879919
ALDOC aldolase C, fructose-bisphosphate -0.00876607
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0087222
TRIM56 tripartite motif containing 56 -0.00856168
RAD51B RAD51 paralog B -0.00848238
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.00842699
ATXN7L1 ataxin 7-like 1 -0.00840025
NARS1 asparaginyl-tRNA synthetase 1 -0.00836049
SEC62 SEC62 homolog (S. cerevisiae) -0.0083291
PIWIL4 piwi-like RNA-mediated gene silencing 4 -0.00831932
TCEA1 transcription elongation factor A (SII), 1 -0.00822382
SERINC5 serine incorporator 5 -0.00819641
N4BP2L2 NEDD4 binding protein 2-like 2 -0.00816713
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -0.00815152
SCAPER S-phase cyclin A-associated protein in the ER -0.00811693
URI1 URI1, prefoldin-like chaperone -0.00803917
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -0.00802194
IQGAP2 IQ motif containing GTPase activating protein 2 -0.00797326
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B -0.00794219
ETV6 ets variant 6 -0.00792054
PLSCR1 phospholipid scramblase 1 -0.00791621
ZNF292 zinc finger protein 292 -0.00788253
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 -0.0078074
EXOC4 exocyst complex component 4 -0.00779748
SDCBP2 syndecan binding protein (syntenin) 2 -0.00778249
SP100 SP100 nuclear antigen -0.00777784
ARCN1 archain 1 -0.0077776
NCOA1 nuclear receptor coactivator 1 -0.00775893
ZNF217 zinc finger protein 217 -0.00775439
IFITM1 interferon induced transmembrane protein 1 -0.00772444
ADAM28 ADAM metallopeptidase domain 28 -0.00769876