APTO-253_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the APTO-253_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MSN moesin 0.0576644
POTEF POTE ankyrin domain family, member F 0.0565421
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0416861
SMAD3 SMAD family member 3 0.0413964
EEF2 eukaryotic translation elongation factor 2 0.0398815
NALF1 NALCN channel auxiliary factor 1 0.0346041
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0335392
PCBP2 poly(rC) binding protein 2 0.0316573
PKM pyruvate kinase, muscle 0.0313869
RPL3 ribosomal protein L3 0.0303399
NDRG1 N-myc downstream regulated 1 0.0298759
TXNIP thioredoxin interacting protein 0.028092
MYH9 myosin, heavy chain 9, non-muscle 0.0268786
DPYD dihydropyrimidine dehydrogenase 0.0259057
FTL ferritin, light polypeptide 0.0256705
CD44 CD44 molecule (Indian blood group) 0.0245817
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0245256
LPP LIM domain containing preferred translocation partner in lipoma 0.0242548
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0241086
NLGN1 neuroligin 1 0.0235733
CCN2 cellular communication network factor 2 0.0234558
MCL1 myeloid cell leukemia 1 0.0229494
MAP1B microtubule-associated protein 1B 0.0223461
MAML2 mastermind-like 2 (Drosophila) 0.0222039
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0220907
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0219402
TMPRSS15 transmembrane protease, serine 15 0.0213837
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0211869
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.021091
FLNA filamin A, alpha 0.0203615
EGR1 early growth response 1 0.019282
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0187495
PCDH11X protocadherin 11 X-linked 0.018703
ETV6 ets variant 6 0.018442
ZSWIM6 zinc finger, SWIM-type containing 6 0.0183789
FRMD6 FERM domain containing 6 0.0177749
RPL21 ribosomal protein L21 0.0177048
ATXN1 ataxin 1 0.0174112
NEGR1 neuronal growth regulator 1 0.0171038
ARL15 ADP-ribosylation factor-like 15 0.017026
PTPRG protein tyrosine phosphatase, receptor type, G 0.0168803
FGF5 fibroblast growth factor 5 0.0166977
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0165732
DISC1 disrupted in schizophrenia 1 0.0163909
NCOR2 nuclear receptor corepressor 2 0.0162061
NOTCH2 notch 2 0.0161596
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0159398
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0159013
FOSL1 FOS-like antigen 1 0.0157855
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0155884
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0152146
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0149591
EIF4B eukaryotic translation initiation factor 4B 0.0145129
GLIS3 GLIS family zinc finger 3 0.0144557
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0143903
EXOC6B exocyst complex component 6B 0.0143264
APLP2 amyloid beta (A4) precursor-like protein 2 0.0142337
BRD2 bromodomain containing 2 0.0139995
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0138635
FNDC3B fibronectin type III domain containing 3B 0.0138351
FTH1 ferritin, heavy polypeptide 1 0.0136896
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0131416
HSPA8 heat shock 70kDa protein 8 0.0131139
KLF12 Kruppel-like factor 12 0.0131078
RIMS2 regulating synaptic membrane exocytosis 2 0.0129516
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.012936
PTBP3 polypyrimidine tract binding protein 3 0.0129314
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0127618
KMT2D lysine (K)-specific methyltransferase 2D 0.0127171
CEP112 centrosomal protein 112kDa 0.0125212
EIF5 eukaryotic translation initiation factor 5 0.0125201
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0124375
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0124292
AXL AXL receptor tyrosine kinase 0.0123488
CNTLN centlein, centrosomal protein 0.0122809
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0118165
ADGRB3 adhesion G protein-coupled receptor B3 0.0118138
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0117747
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0117715
PARVA parvin, alpha 0.0116525
ALCAM activated leukocyte cell adhesion molecule 0.0116207
ITGA6 integrin, alpha 6 0.011527
RABGAP1L RAB GTPase activating protein 1-like 0.0115129
WWOX WW domain containing oxidoreductase 0.0114535
LINGO2 leucine rich repeat and Ig domain containing 2 0.0114372
ASXL2 additional sex combs like transcriptional regulator 2 0.0113814
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0112323
TPM3 tropomyosin 3 0.0111956
ANTXR1 anthrax toxin receptor 1 0.0110895
TRAPPC9 trafficking protein particle complex 9 0.0110502
NRP2 neuropilin 2 0.0109674
FBXL17 F-box and leucine-rich repeat protein 17 0.010944
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0109258
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0109117
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0108587
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0108555
STAU2 staufen double-stranded RNA binding protein 2 0.0107377
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0105871
BDNF brain-derived neurotrophic factor 0.0105826
PAX3 paired box 3 0.010526

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.306761
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.253989
DTNA dystrobrevin, alpha -0.22079
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.186393
AKAP12 A kinase (PRKA) anchor protein 12 -0.133922
TPT1 tumor protein, translationally-controlled 1 -0.128298
TMSB10 thymosin beta 10 -0.12104
PHACTR1 phosphatase and actin regulator 1 -0.111143
RPS6 ribosomal protein S6 -0.111027
LSAMP limbic system-associated membrane protein -0.109344
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0935245
PTMA prothymosin, alpha -0.0932987
EFNA5 ephrin-A5 -0.078824
EXT1 exostosin glycosyltransferase 1 -0.0775895
NAP1L1 nucleosome assembly protein 1-like 1 -0.0727531
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0670369
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0651906
PGK1 phosphoglycerate kinase 1 -0.0642998
RPL23 ribosomal protein L23 -0.0634346
EIF1 eukaryotic translation initiation factor 1 -0.0613109
RPL37A ribosomal protein L37a -0.0600198
RPLP1 ribosomal protein, large, P1 -0.0579013
KDM3A lysine (K)-specific demethylase 3A -0.0563557
CDH13 cadherin 13 -0.0560309
RPL12 ribosomal protein L12 -0.0558611
RPL35A ribosomal protein L35a -0.0551186
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0538513
RPS8 ribosomal protein S8 -0.0536242
RPS24 ribosomal protein S24 -0.0534983
ACTG1 actin gamma 1 -0.0532644
CAVIN1 caveolae associated protein 1 -0.0531852
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0530735
WSB1 WD repeat and SOCS box containing 1 -0.0529968
C2CD2 C2 calcium-dependent domain containing 2 -0.0525185
CANX calnexin -0.0518571
MMP12 matrix metallopeptidase 12 -0.0503497
AHNAK AHNAK nucleoprotein -0.0498845
RAB1A RAB1A, member RAS oncogene family -0.0497866
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0492913
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0486238
RPS19 ribosomal protein S19 -0.0479447
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0473937
ELL2 elongation factor, RNA polymerase II, 2 -0.0453442
RPS13 ribosomal protein S13 -0.0437268
RPL34 ribosomal protein L34 -0.0423922
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0423518
PTK2 protein tyrosine kinase 2 -0.0421033
RPL31 ribosomal protein L31 -0.0410763
RPL26 ribosomal protein L26 -0.0409847
RPL38 ribosomal protein L38 -0.0406159
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.040496
FGFR1 fibroblast growth factor receptor 1 -0.0404855
LMAN1 lectin, mannose-binding, 1 -0.0403996
BIRC6 baculoviral IAP repeat containing 6 -0.0403522
ANXA2 annexin A2 -0.0401976
TM4SF1 transmembrane 4 L six family member 1 -0.0392928
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0382882
DSCAM Down syndrome cell adhesion molecule -0.0365675
CSTB cystatin B (stefin B) -0.0358226
ENKUR enkurin, TRPC channel interacting protein -0.0356324
GNAS GNAS complex locus -0.0355921
KIAA1217 KIAA1217 -0.0355112
GOLGA4 golgin A4 -0.0351666
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0346991
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0344852
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0343898
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0340409
SAMD3 sterile alpha motif domain containing 3 -0.0336307
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0335445
WDR45B WD repeat domain 45B -0.0335412
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0333718
RPS3 ribosomal protein S3 -0.0332115
ZNF804A zinc finger protein 804A -0.0330599
TAS2R14 taste receptor, type 2, member 14 -0.0328128
CFAP251 cilia and flagella associated protein 251 -0.0327546
RPL11 ribosomal protein L11 -0.0325972
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0322318
MACF1 microtubule-actin crosslinking factor 1 -0.0319355
BZW1 basic leucine zipper and W2 domains 1 -0.0318736
PBX3 pre-B-cell leukemia homeobox 3 -0.0316843
TPM4 tropomyosin 4 -0.0315326
RPL13A ribosomal protein L13a -0.0309711
RPLP2 ribosomal protein, large, P2 -0.0309272
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0308565
RPS25 ribosomal protein S25 -0.0306316
CALU calumenin -0.0305855
SPAG9 sperm associated antigen 9 -0.0302337
RPL19 ribosomal protein L19 -0.0298545
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0295605
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0295603
KMT2C lysine (K)-specific methyltransferase 2C -0.0294659
RPL5 ribosomal protein L5 -0.0294519
RPS27A ribosomal protein S27a -0.0293756
FN1 fibronectin 1 -0.0293575
VDAC1 voltage-dependent anion channel 1 -0.0291118
PRKCE protein kinase C, epsilon -0.0290133
NIPBL Nipped-B homolog (Drosophila) -0.0289614
SEPTIN7 septin 7 -0.028656
RAD21 RAD21 homolog (S. pombe) -0.0284972
MXI1 MAX interactor 1, dimerization protein -0.0283453