| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | APTO-253 perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the APTO-253_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | 0.210788 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.16051 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.154758 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.121185 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.118098 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.116862 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0985908 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0906685 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0771251 |
| AREG | amphiregulin | 0.0747367 |
| TXNIP | thioredoxin interacting protein | 0.0688309 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0608485 |
| RPS6 | ribosomal protein S6 | 0.0584619 |
| RNF145 | ring finger protein 145 | 0.0529022 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0489126 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0443258 |
| GOLGA4 | golgin A4 | 0.0393099 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0387797 |
| CENPF | centromere protein F, 350/400kDa | 0.0377904 |
| B2M | beta-2-microglobulin | 0.0371153 |
| RPL3 | ribosomal protein L3 | 0.0338064 |
| EREG | epiregulin | 0.0321873 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0320141 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0318961 |
| VEGFA | vascular endothelial growth factor A | 0.0308127 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0299357 |
| DSTN | destrin (actin depolymerizing factor) | 0.0295482 |
| RPS12 | ribosomal protein S12 | 0.0292923 |
| MUC13 | mucin 13, cell surface associated | 0.0291077 |
| YBX1 | Y box binding protein 1 | 0.0284777 |
| ENO1 | enolase 1, (alpha) | 0.028431 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0282743 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.027822 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0268036 |
| EPCAM | epithelial cell adhesion molecule | 0.0253308 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0252502 |
| WDR45B | WD repeat domain 45B | 0.0244753 |
| PCBP2 | poly(rC) binding protein 2 | 0.0242571 |
| FAM120A | family with sequence similarity 120A | 0.0239189 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0238209 |
| MYO1E | myosin IE | 0.0234007 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0226281 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0223254 |
| ANXA1 | annexin A1 | 0.0221337 |
| TPD52 | tumor protein D52 | 0.0217725 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0216393 |
| TFG | TRK-fused gene | 0.0215546 |
| UBC | ubiquitin C | 0.0214053 |
| LDHA | lactate dehydrogenase A | 0.0211493 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0211029 |
| TRIM2 | tripartite motif containing 2 | 0.0210409 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0208854 |
| RPS2 | ribosomal protein S2 | 0.0207686 |
| RPS8 | ribosomal protein S8 | 0.0206772 |
| BRD2 | bromodomain containing 2 | 0.0203888 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0203022 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0202909 |
| COPA | coatomer protein complex, subunit alpha | 0.0202878 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0200429 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.019857 |
| RPL21 | ribosomal protein L21 | 0.0196749 |
| PIGR | polymeric immunoglobulin receptor | 0.0194759 |
| PFN1 | profilin 1 | 0.019392 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.0193038 |
| CCNL1 | cyclin L1 | 0.018763 |
| ATF3 | activating transcription factor 3 | 0.0184846 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0181155 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0180164 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0178082 |
| ATF4 | activating transcription factor 4 | 0.0177876 |
| RPL8 | ribosomal protein L8 | 0.0175453 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0173078 |
| RPLP0 | ribosomal protein, large, P0 | 0.0172975 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0171777 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0171729 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0170431 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0169064 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0169012 |
| NOP58 | NOP58 ribonucleoprotein | 0.0168337 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0167489 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0166666 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0164987 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0164084 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0164041 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0163539 |
| CALR | calreticulin | 0.0162143 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0162019 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0161334 |
| TMF1 | TATA element modulatory factor 1 | 0.0158053 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0158018 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0157911 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0156915 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0155585 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.0155552 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.015526 |
| KLF6 | Kruppel-like factor 6 | 0.0154332 |
| YBX3 | Y box binding protein 3 | 0.0154238 |
| NUP58 | nucleoporin 58 | 0.0154019 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0153171 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0151381 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.145062 |
| NPSR1 | neuropeptide S receptor 1 | -0.136719 |
| ASPH | aspartate beta-hydroxylase | -0.104269 |
| ONECUT3 | one cut homeobox 3 | -0.102892 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.102353 |
| FLNB | filamin B, beta | -0.0933433 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0860107 |
| AHNAK | AHNAK nucleoprotein | -0.0836941 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0804082 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0769632 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0728059 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0687339 |
| SMYD3 | SET and MYND domain containing 3 | -0.0680445 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0671689 |
| PRELID2 | PRELI domain containing 2 | -0.066379 |
| TMSB10 | thymosin beta 10 | -0.0633124 |
| FAT1 | FAT atypical cadherin 1 | -0.062678 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0616113 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0577105 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0574652 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0557993 |
| LAMA4 | laminin, alpha 4 | -0.0553631 |
| ANXA2 | annexin A2 | -0.0542498 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0509145 |
| FHIT | fragile histidine triad | -0.0501681 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0488909 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0468777 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0465309 |
| DENND1A | DENN/MADD domain containing 1A | -0.0463821 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.046088 |
| DIAPH2 | diaphanous-related formin 2 | -0.0460489 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0456799 |
| RAD51B | RAD51 paralog B | -0.0456335 |
| VCL | vinculin | -0.0446971 |
| TNS4 | tensin 4 | -0.043499 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0426953 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0423976 |
| FERMT1 | fermitin family member 1 | -0.0419417 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0417517 |
| EGFR | epidermal growth factor receptor | -0.0417143 |
| RNF217 | ring finger protein 217 | -0.0415425 |
| RNF43 | ring finger protein 43 | -0.0412084 |
| ATXN1 | ataxin 1 | -0.0407331 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0406221 |
| EHBP1 | EH domain binding protein 1 | -0.040564 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0403535 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.0402056 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0401891 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0385266 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0384319 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0372357 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0369615 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.036502 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0364388 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0356834 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0353797 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0350159 |
| RPS24 | ribosomal protein S24 | -0.0347532 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0346967 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0344978 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0342345 |
| PATJ | PATJ crumbs cell polarity complex component | -0.034179 |
| TBC1D5 | TBC1 domain family, member 5 | -0.033723 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0333564 |
| EXOC4 | exocyst complex component 4 | -0.0333241 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0328572 |
| RIN2 | Ras and Rab interactor 2 | -0.0320367 |
| ACTN4 | actinin, alpha 4 | -0.0319177 |
| SBF2 | SET binding factor 2 | -0.0317832 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.031615 |
| IER3 | immediate early response 3 | -0.0313113 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.031218 |
| KRT8 | keratin 8, type II | -0.0311531 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0310517 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0309606 |
| ACTG1 | actin gamma 1 | -0.0307186 |
| RPL35A | ribosomal protein L35a | -0.0303468 |
| SAMD5 | sterile alpha motif domain containing 5 | -0.0302336 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0301388 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0301144 |
| ITGA6 | integrin, alpha 6 | -0.0300738 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.0297509 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0293607 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.029282 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0286444 |
| MSI2 | musashi RNA-binding protein 2 | -0.0281575 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0277141 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0275462 |
| PRSS3 | protease, serine, 3 | -0.0271609 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | -0.0268802 |
| RPL38 | ribosomal protein L38 | -0.0267083 |
| PTK2 | protein tyrosine kinase 2 | -0.0265691 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0254106 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0251792 |
| S100P | S100 calcium binding protein P | -0.0250394 |
| CDCP1 | CUB domain containing protein 1 | -0.0249987 |
| LAMC2 | laminin, gamma 2 | -0.0248721 |
| GPR39 | G protein-coupled receptor 39 | -0.0246549 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.024542 |
| TPM4 | tropomyosin 4 | -0.0243147 |
