APTO-253_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the APTO-253_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.101714
MYO1E myosin IE 0.078335
FRMD5 FERM domain containing 5 0.0684478
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0670044
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0522915
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0513861
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 0.0498889
ZSWIM6 zinc finger, SWIM-type containing 6 0.0492135
LOC105378220 macrophage receptor MARCO-like 0.0483792
OXSR1 oxidative stress responsive 1 0.0420772
EZR ezrin 0.0410764
KRT18 keratin 18, type I 0.0406386
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0399756
RIMKLB ribosomal modification protein rimK-like family member B 0.0375518
RPL3 ribosomal protein L3 0.0374891
CATSPERB catsper channel auxiliary subunit beta 0.0370588
HSPA8 heat shock 70kDa protein 8 0.0351596
MYO5B myosin VB 0.0337248
PDE4D phosphodiesterase 4D, cAMP-specific 0.0327576
MSI2 musashi RNA-binding protein 2 0.0306007
ITPRID2 ITPR interacting domain containing 2 0.0302804
ALCAM activated leukocyte cell adhesion molecule 0.0301427
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0299898
PDZD8 PDZ domain containing 8 0.0297983
MPRIP myosin phosphatase Rho interacting protein 0.0293013
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0285069
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0283971
INTS6 integrator complex subunit 6 0.0266798
MUC13 mucin 13, cell surface associated 0.0266592
SP100 SP100 nuclear antigen 0.026023
TRAPPC9 trafficking protein particle complex 9 0.0250018
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0249316
FBXO11 F-box protein 11 0.0245708
DSG2 desmoglein 2 0.0245614
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0243655
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0242955
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0241121
CTBP2 C-terminal binding protein 2 0.0238355
LGALS12 lectin, galactoside-binding, soluble, 12 0.0237611
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0235281
DST dystonin 0.0233035
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0227469
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0226795
LOC102724023 ES1 protein homolog, mitochondrial 0.0223927
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0222288
LMO7 LIM domain 7 0.021981
PELI1 pellino E3 ubiquitin protein ligase 1 0.0216787
DIAPH1 diaphanous-related formin 1 0.0209952
F3 coagulation factor III (thromboplastin, tissue factor) 0.020804
OSBPL8 oxysterol binding protein-like 8 0.0205051
FNIP1 folliculin interacting protein 1 0.0202112
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.020084
PKM pyruvate kinase, muscle 0.0200712
SLTM SAFB-like, transcription modulator 0.0198057
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.019794
PSD3 pleckstrin and Sec7 domain containing 3 0.0194134
FOXO3 forkhead box O3 0.0192806
PARD3B par-3 family cell polarity regulator beta 0.0189846
CLIC5 chloride intracellular channel 5 0.018953
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.0189352
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 0.0186571
NPSR1 neuropeptide S receptor 1 0.0186173
FMNL2 formin-like 2 0.0185718
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.018269
DOCK5 dedicator of cytokinesis 5 0.0180479
RNF213 ring finger protein 213 0.0176948
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0175666
APP amyloid beta (A4) precursor protein 0.0173714
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0170064
UBAP2 ubiquitin associated protein 2 0.0168703
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0168328
POTEF POTE ankyrin domain family, member F 0.016566
ENO1 enolase 1, (alpha) 0.0165511
MYH14 myosin, heavy chain 14, non-muscle 0.0165354
ESYT2 extended synaptotagmin-like protein 2 0.0164952
HSPH1 heat shock 105kDa/110kDa protein 1 0.0164887
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0164753
RASAL2 RAS protein activator like 2 0.0163237
CAV2 caveolin 2 0.0162923
FHIT fragile histidine triad 0.0159001
PALLD palladin, cytoskeletal associated protein 0.01586
CXCL8 chemokine (C-X-C motif) ligand 8 0.0158449
LPP LIM domain containing preferred translocation partner in lipoma 0.0157881
SGMS2 sphingomyelin synthase 2 0.0157808
L3MBTL4 l(3)mbt-like 4 (Drosophila) 0.0156597
EIF4A2 eukaryotic translation initiation factor 4A2 0.015587
RABGAP1L RAB GTPase activating protein 1-like 0.0155036
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0153653
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0153433
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0152903
NABP1 nucleic acid binding protein 1 0.01527
PLK2 polo-like kinase 2 0.0151965
SUMF1 sulfatase modifying factor 1 0.0151898
TXNIP thioredoxin interacting protein 0.0150217
GLS2 glutaminase 2 (liver, mitochondrial) 0.015008
OSBPL10 oxysterol binding protein-like 10 0.0149665
GMDS GDP-mannose 4,6-dehydratase 0.0147515
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 0.0147201
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0144196
WWOX WW domain containing oxidoreductase 0.0143647

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.148802
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.140663
EPS8 epidermal growth factor receptor pathway substrate 8 -0.135657
RPS6 ribosomal protein S6 -0.0816932
RPLP1 ribosomal protein, large, P1 -0.0770489
RPS12 ribosomal protein S12 -0.0726723
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0692586
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0640426
RPL37A ribosomal protein L37a -0.0635216
TMSB10 thymosin beta 10 -0.0618426
RPS8 ribosomal protein S8 -0.0618243
RPLP2 ribosomal protein, large, P2 -0.0602264
RPS3 ribosomal protein S3 -0.059583
GOLGA4 golgin A4 -0.0589952
RPS23 ribosomal protein S23 -0.0582874
GARS1 glycyl-tRNA synthetase 1 -0.0576096
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0574304
EIF1 eukaryotic translation initiation factor 1 -0.0573807
AKAP9 A kinase (PRKA) anchor protein 9 -0.0559106
RPL35A ribosomal protein L35a -0.055637
RPLP0 ribosomal protein, large, P0 -0.0548038
RPL11 ribosomal protein L11 -0.0544389
RPS13 ribosomal protein S13 -0.0542713
RPS29 ribosomal protein S29 -0.0540636
RPS19 ribosomal protein S19 -0.0506498
RPL13A ribosomal protein L13a -0.0487848
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0487203
RPL12 ribosomal protein L12 -0.0466371
BACE2 beta-site APP-cleaving enzyme 2 -0.0464639
RPS25 ribosomal protein S25 -0.0463424
MON2 MON2 homolog (S. cerevisiae) -0.0446267
RPL26 ribosomal protein L26 -0.0434576
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0428391
PLAC8 placenta-specific 8 -0.0428027
RPS27A ribosomal protein S27a -0.0427486
RPL31 ribosomal protein L31 -0.0417416
RPL9 ribosomal protein L9 -0.0411354
SHROOM3 shroom family member 3 -0.0407461
GDF15 growth differentiation factor 15 -0.0401961
RPL34 ribosomal protein L34 -0.040109
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0397516
PRELID2 PRELI domain containing 2 -0.0390934
PTMA prothymosin, alpha -0.038934
DSCAM Down syndrome cell adhesion molecule -0.0379281
ABHD17C abhydrolase domain containing 17C -0.0371767
ITGA6 integrin, alpha 6 -0.0370881
TTC3 tetratricopeptide repeat domain 3 -0.037028
RPL27A ribosomal protein L27a -0.0365291
ACTG1 actin gamma 1 -0.0362944
BTBD9 BTB (POZ) domain containing 9 -0.0361787
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0353143
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0351018
S100P S100 calcium binding protein P -0.0350493
PKP2 plakophilin 2 -0.0349521
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0344348
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0343508
RPL37 ribosomal protein L37 -0.0336201
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.032437
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0321834
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0321577
RPS21 ribosomal protein S21 -0.0319869
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -0.0314907
RPL5 ribosomal protein L5 -0.0313368
HLA-B major histocompatibility complex, class I, B -0.0308274
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0306689
NAP1L1 nucleosome assembly protein 1-like 1 -0.0304322
RPS16 ribosomal protein S16 -0.0303995
RPS27 ribosomal protein S27 -0.0299486
RPL23 ribosomal protein L23 -0.0295097
CALB1 calbindin 1, 28kDa -0.0294372
RPL19 ribosomal protein L19 -0.0293873
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.029321
RPS24 ribosomal protein S24 -0.0292732
MYO6 myosin VI -0.0291843
PTPRR protein tyrosine phosphatase, receptor type, R -0.0291631
RPL30 ribosomal protein L30 -0.0290861
RPS20 ribosomal protein S20 -0.0290028
CCPG1 cell cycle progression 1 -0.0289355
RPL36 ribosomal protein L36 -0.028867
SETD5 SET domain containing 5 -0.0285304
PRSS3 protease, serine, 3 -0.0284338
RPL38 ribosomal protein L38 -0.0283093
RACK1 receptor for activated C kinase 1 -0.0282729
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.0282603
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0280252
ANTXR2 anthrax toxin receptor 2 -0.027971
TXNRD1 thioredoxin reductase 1 -0.0277842
PNISR PNN-interacting serine/arginine-rich protein -0.0277824
RPS11 ribosomal protein S11 -0.0276268
ANKRD11 ankyrin repeat domain 11 -0.0275972
OGA O-GlcNAcase -0.0275464
HMGA1 high mobility group AT-hook 1 -0.0274243
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0272654
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0271162
PCDHB16 protocadherin beta 16 -0.0266969
GCC2 GRIP and coiled-coil domain containing 2 -0.0259425
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.025797
TMEM41B transmembrane protein 41B -0.0257818
FOXO1 forkhead box O1 -0.0256345
TRIM2 tripartite motif containing 2 -0.0253709