APTO-253_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the APTO-253_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PSD3 pleckstrin and Sec7 domain containing 3 0.103446
TP63 tumor protein p63 0.0795611
ZDHHC14 zinc finger, DHHC-type containing 14 0.0346488
TSC22D1 TSC22 domain family, member 1 0.0318995
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0312543
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0304473
FMNL2 formin-like 2 0.0297259
SP100 SP100 nuclear antigen 0.028607
BCAR3 breast cancer anti-estrogen resistance 3 0.02848
WWTR1 WW domain containing transcription regulator 1 0.0253033
RUNX1 runt-related transcription factor 1 0.0245079
PDE10A phosphodiesterase 10A 0.0237219
SDCCAG8 serologically defined colon cancer antigen 8 0.0233543
CAPRIN2 caprin family member 2 0.0227018
ZBTB38 zinc finger and BTB domain containing 38 0.0225184
NPAS2 neuronal PAS domain protein 2 0.020542
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0201299
NEK10 NIMA-related kinase 10 0.019957
HOMER1 homer scaffolding protein 1 0.0198039
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0186037
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0182917
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0173718
CFAP299 cilia and flagella associated protein 299 0.0164172
CFLAR CASP8 and FADD-like apoptosis regulator 0.0154469
DNAH14 dynein, axonemal, heavy chain 14 0.015106
PMP22 peripheral myelin protein 22 0.0148995
ZSWIM6 zinc finger, SWIM-type containing 6 0.0147071
DST dystonin 0.0144808
ANGPTL4 angiopoietin-like 4 0.0142067
BICD1 bicaudal D homolog 1 (Drosophila) 0.014006
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0137575
TGM2 transglutaminase 2 0.0136663
MACF1 microtubule-actin crosslinking factor 1 0.0131489
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0129106
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0127285
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0122242
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 0.0122012
DNER delta/notch-like EGF repeat containing 0.0121908
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0121084
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0121014
INTS6 integrator complex subunit 6 0.0120122
COL5A2 collagen, type V, alpha 2 0.0114416
EHBP1 EH domain binding protein 1 0.0113064
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0109438
MB21D2 Mab-21 domain containing 2 0.0109317
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0107801
RAD51B RAD51 paralog B 0.0107303
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.0106885
CMIP c-Maf inducing protein 0.0106012
RIGI RNA sensor RIG-I 0.0103582
PDGFC platelet derived growth factor C 0.0102779
LMNTD1 lamin tail domain containing 1 0.00961042
PARP14 poly (ADP-ribose) polymerase family, member 14 0.00934789
RPS27 ribosomal protein S27 0.00927849
CCDC190 coiled-coil domain containing 190 0.00917913
ZBTB20 zinc finger and BTB domain containing 20 0.00907417
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.00904005
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.00895932
DPYD dihydropyrimidine dehydrogenase 0.00883802
CACNG8 calcium channel, voltage-dependent, gamma subunit 8 0.00880254
SPATS2L spermatogenesis associated, serine-rich 2-like 0.00873519
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 0.00872528
SGK1 serum/glucocorticoid regulated kinase 1 0.00869721
MCTP1 multiple C2 domains, transmembrane 1 0.00862153
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0085342
VEGFC vascular endothelial growth factor C 0.00850377
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00831886
VMP1 vacuole membrane protein 1 0.00827281
NTSR1 neurotensin receptor 1 (high affinity) 0.00823085
PLSCR1 phospholipid scramblase 1 0.00819765
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.00807604
SGMS2 sphingomyelin synthase 2 0.00804386
RPL27 ribosomal protein L27 0.00793881
NCEH1 neutral cholesterol ester hydrolase 1 0.00787671
XAF1 XIAP associated factor 1 0.0078525
SLC39A10 solute carrier family 39 (zinc transporter), member 10 0.00783624
AEBP2 AE binding protein 2 0.00775783
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.00757061
CADM2 cell adhesion molecule 2 0.00740748
WDR27 WD repeat domain 27 0.00711488
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 0.0070644
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.00701138
BIRC3 baculoviral IAP repeat containing 3 0.00680352
RPS6 ribosomal protein S6 0.00671927
BBS9 Bardet-Biedl syndrome 9 0.00664563
GOLGB1 golgin B1 0.00661835
TRIM56 tripartite motif containing 56 0.00661753
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.00659116
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.00650765
LOC102724023 ES1 protein homolog, mitochondrial 0.00631214
HBEGF heparin-binding EGF-like growth factor 0.00630704
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.00627096
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.00619109
RCOR1 REST corepressor 1 0.00614613
TBCK TBC1 domain containing kinase 0.0060981
APOLD1 apolipoprotein L domain containing 1 0.00605126
ADARB1 adenosine deaminase, RNA-specific, B1 0.00601852
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.00597271
TRAPPC9 trafficking protein particle complex 9 0.00596454
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.00595882

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.22684
VIM vimentin -0.188238
TMSB10 thymosin beta 10 -0.107356
PTMA prothymosin, alpha -0.0908135
POTEF POTE ankyrin domain family, member F -0.085066
MT2A metallothionein 2A -0.0530372
UBC ubiquitin C -0.0473909
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0465125
LDHA lactate dehydrogenase A -0.045548
LOC112694756 uncharaterized LOC112694756 -0.0441837
HLA-B major histocompatibility complex, class I, B -0.0422259
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0417865
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0388612
PGK1 phosphoglycerate kinase 1 -0.0376167
FTL ferritin, light polypeptide -0.0369733
TMSB4X thymosin beta 4, X-linked -0.0341841
HMGA1 high mobility group AT-hook 1 -0.0341177
ACTG1 actin gamma 1 -0.0318612
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0317489
TM4SF1 transmembrane 4 L six family member 1 -0.0311316
EEF2 eukaryotic translation elongation factor 2 -0.0296972
SLC38A2 solute carrier family 38, member 2 -0.0296696
RPL35A ribosomal protein L35a -0.0292612
RBM25 RNA binding motif protein 25 -0.0287128
FLNB filamin B, beta -0.0272999
RPS24 ribosomal protein S24 -0.0261108
EGR1 early growth response 1 -0.0260821
TPT1 tumor protein, translationally-controlled 1 -0.025832
RAI1 retinoic acid induced 1 -0.0250062
ANKRD12 ankyrin repeat domain 12 -0.0226863
RTN4 reticulon 4 -0.0226831
TPI1 triosephosphate isomerase 1 -0.0223239
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0221963
SEPTIN7 septin 7 -0.0221323
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0220338
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0219173
RAB7A RAB7A, member RAS oncogene family -0.0218143
RPS27A ribosomal protein S27a -0.0218132
PRRC2C proline-rich coiled-coil 2C -0.0217143
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0213018
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0212127
CENPF centromere protein F, 350/400kDa -0.0211648
YBX1 Y box binding protein 1 -0.0211004
B2M beta-2-microglobulin -0.0210597
ENO2 enolase 2 (gamma, neuronal) -0.020875
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0207391
SBF2 SET binding factor 2 -0.0203093
TUBB tubulin, beta class I -0.020221
S100A6 S100 calcium binding protein A6 -0.0201071
ENO1 enolase 1, (alpha) -0.0200926
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.020012
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0199604
HLA-A major histocompatibility complex, class I, A -0.0199381
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0198984
TXNRD1 thioredoxin reductase 1 -0.0198662
DEK DEK proto-oncogene -0.0195761
KDM3A lysine (K)-specific demethylase 3A -0.0188508
WASF2 WAS protein family, member 2 -0.0186544
PKM pyruvate kinase, muscle -0.0186412
BIRC6 baculoviral IAP repeat containing 6 -0.0185092
CANX calnexin -0.0185033
VDAC1 voltage-dependent anion channel 1 -0.0183267
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0183195
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0180973
ADAM17 ADAM metallopeptidase domain 17 -0.0180618
GNAS GNAS complex locus -0.0180617
SPAG9 sperm associated antigen 9 -0.0179719
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0177906
TAPBP TAP binding protein (tapasin) -0.0177798
PCBP2 poly(rC) binding protein 2 -0.0177293
CALR calreticulin -0.0176992
OGA O-GlcNAcase -0.0176826
ADAM10 ADAM metallopeptidase domain 10 -0.0173586
NDRG1 N-myc downstream regulated 1 -0.0172666
ZNF292 zinc finger protein 292 -0.0164536
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0162929
PTPRF protein tyrosine phosphatase, receptor type, F -0.0161243
RPS3 ribosomal protein S3 -0.016045
PODXL podocalyxin-like -0.0158928
TMEM123 transmembrane protein 123 -0.0158113
KIAA1958 KIAA1958 -0.0156738
SDC4 syndecan 4 -0.0156282
ZNF148 zinc finger protein 148 -0.015501
JUN jun proto-oncogene -0.015439
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0152857
ECE1 endothelin converting enzyme 1 -0.0151548
SET SET nuclear proto-oncogene -0.0151005
GSK3B glycogen synthase kinase 3 beta -0.015066
GOLGA4 golgin A4 -0.015014
RPL11 ribosomal protein L11 -0.0149321
EIF1 eukaryotic translation initiation factor 1 -0.0149311
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0147452
YEATS2 YEATS domain containing 2 -0.0146836
RPL12 ribosomal protein L12 -0.0146388
WSB1 WD repeat and SOCS box containing 1 -0.014633
DOCK11 dedicator of cytokinesis 11 -0.0146209
PRDX1 peroxiredoxin 1 -0.0146154
ECPAS Ecm29 proteasome adaptor and scaffold -0.0145005
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0144193
BRWD1 bromodomain and WD repeat domain containing 1 -0.0142861