APTO-253_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the APTO-253_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.220533
GRAMD1B GRAM domain containing 1B 0.143762
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.101201
THSD4 thrombospondin, type I, domain containing 4 0.0881015
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0820695
LRP1B low density lipoprotein receptor-related protein 1B 0.0789314
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0743271
OSMR oncostatin M receptor 0.0723847
NAMPT nicotinamide phosphoribosyltransferase 0.0614855
PDE4D phosphodiesterase 4D, cAMP-specific 0.0585631
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0569523
GCLC glutamate-cysteine ligase, catalytic subunit 0.0568781
ELL2 elongation factor, RNA polymerase II, 2 0.0557504
CES1 carboxylesterase 1 0.0511229
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0476517
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0464243
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0448706
DOCK5 dedicator of cytokinesis 5 0.0446691
EFNA5 ephrin-A5 0.0435512
SLTM SAFB-like, transcription modulator 0.0430399
RNF213 ring finger protein 213 0.0430251
FTH1 ferritin, heavy polypeptide 1 0.0427251
FAM13A family with sequence similarity 13, member A 0.0424539
LAMA4 laminin, alpha 4 0.0416743
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0413468
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.040856
FNDC3B fibronectin type III domain containing 3B 0.0399665
PM20D1 peptidase M20 domain containing 1 0.0396373
MCL1 myeloid cell leukemia 1 0.0372597
PKM pyruvate kinase, muscle 0.0370002
CXCL8 chemokine (C-X-C motif) ligand 8 0.036686
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0356329
JMJD1C jumonji domain containing 1C 0.035278
BCAR3 breast cancer anti-estrogen resistance 3 0.0352105
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0347073
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0343365
SMAD3 SMAD family member 3 0.0341385
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0340988
TBC1D22A TBC1 domain family, member 22A 0.0331685
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0330838
SMYD3 SET and MYND domain containing 3 0.0320303
PTPRM protein tyrosine phosphatase, receptor type, M 0.0317085
GSK3B glycogen synthase kinase 3 beta 0.0309347
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0308007
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0294432
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0294287
CCSER1 coiled-coil serine-rich protein 1 0.0288836
TSC22D2 TSC22 domain family, member 2 0.0286878
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0284305
LGALS12 lectin, galactoside-binding, soluble, 12 0.0282248
FOXP1 forkhead box P1 0.027566
ADAM9 ADAM metallopeptidase domain 9 0.0268793
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0265409
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0265009
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0261452
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0260956
STK24 serine/threonine kinase 24 0.0249152
VMP1 vacuole membrane protein 1 0.024754
MYH9 myosin, heavy chain 9, non-muscle 0.024618
KYNU kynureninase 0.0243875
PCBP2 poly(rC) binding protein 2 0.0241137
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0240859
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0239138
CTNND1 catenin (cadherin-associated protein), delta 1 0.023735
ANKRD11 ankyrin repeat domain 11 0.0236492
TRIO trio Rho guanine nucleotide exchange factor 0.0235833
RTN4 reticulon 4 0.0234997
RAB10 RAB10, member RAS oncogene family 0.0234453
CEMIP cell migration inducing protein, hyaluronan binding 0.0231224
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0228734
RNF149 ring finger protein 149 0.0228402
BABAM2 BRISC and BRCA1 A complex member 2 0.0228387
MAP7 microtubule-associated protein 7 0.0227738
TBC1D5 TBC1 domain family, member 5 0.0226378
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0224752
RICTOR RPTOR independent companion of MTOR, complex 2 0.0222423
SYAP1 synapse associated protein 1 0.0221857
WDFY3 WD repeat and FYVE domain containing 3 0.0220671
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0213536
MYO1B myosin IB 0.0212381
DOCK1 dedicator of cytokinesis 1 0.0208073
MSN moesin 0.0208068
VEGFC vascular endothelial growth factor C 0.0206813
ZNF638 zinc finger protein 638 0.0204602
DIAPH1 diaphanous-related formin 1 0.0204345
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0203287
MED13L mediator complex subunit 13-like 0.0202716
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0201785
ERRFI1 ERBB receptor feedback inhibitor 1 0.0201397
ATP11A ATPase, class VI, type 11A 0.0199988
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0198695
IGFBP3 insulin-like growth factor binding protein 3 0.0198093
SRPK2 SRSF protein kinase 2 0.0195918
PDLIM5 PDZ and LIM domain 5 0.0195086
TES testin LIM domain protein 0.0195075
STRN3 striatin, calmodulin binding protein 3 0.0195046
TPD52 tumor protein D52 0.0194322
TJP1 tight junction protein 1 0.0194219
MACC1 metastasis associated in colon cancer 1 0.0193132
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0192783

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.12623
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.109782
TPT1 tumor protein, translationally-controlled 1 -0.0832414
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0795684
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0667266
INTS6 integrator complex subunit 6 -0.0645486
PTMA prothymosin, alpha -0.0461035
ACTG1 actin gamma 1 -0.0446761
BZW1 basic leucine zipper and W2 domains 1 -0.0446187
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0445122
S100A10 S100 calcium binding protein A10 -0.0441676
RPL37A ribosomal protein L37a -0.0417905
RPS24 ribosomal protein S24 -0.0394192
GOLGB1 golgin B1 -0.0389243
RPS3 ribosomal protein S3 -0.0382297
HDLBP high density lipoprotein binding protein -0.0376193
RPS8 ribosomal protein S8 -0.0362729
CANX calnexin -0.0353422
EIF1 eukaryotic translation initiation factor 1 -0.0323598
EGR1 early growth response 1 -0.0318992
AHNAK AHNAK nucleoprotein -0.0313861
KRT18 keratin 18, type I -0.0310259
RPL31 ribosomal protein L31 -0.0309891
RPL34 ribosomal protein L34 -0.0305547
RPS25 ribosomal protein S25 -0.0302268
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0299234
AGR2 anterior gradient 2 -0.0292949
SEC31A SEC31 homolog A (S. cerevisiae) -0.0280716
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0269428
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0261137
SQSTM1 sequestosome 1 -0.0250055
LAMB3 laminin, beta 3 -0.0249222
DSPP dentin sialophosphoprotein -0.0247143
IER3 immediate early response 3 -0.0236786
RPS6 ribosomal protein S6 -0.0232215
HOMER1 homer scaffolding protein 1 -0.0231783
GM2A GM2 ganglioside activator -0.0230299
BTG1 B-cell translocation gene 1, anti-proliferative -0.022702
RPL35A ribosomal protein L35a -0.0226076
RPLP1 ribosomal protein, large, P1 -0.0222567
RPL11 ribosomal protein L11 -0.0221596
HMGA1 high mobility group AT-hook 1 -0.022023
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0220027
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0218077
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0214636
ARF1 ADP-ribosylation factor 1 -0.0210141
RPL19 ribosomal protein L19 -0.0209002
RPLP0 ribosomal protein, large, P0 -0.0206367
RPS29 ribosomal protein S29 -0.0205992
GNAS GNAS complex locus -0.0205706
TTC3 tetratricopeptide repeat domain 3 -0.0205507
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0199966
FBXO11 F-box protein 11 -0.0198592
SPIRE1 spire-type actin nucleation factor 1 -0.0198084
RPL37 ribosomal protein L37 -0.0196885
TMEM184B transmembrane protein 184B -0.0195865
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0195854
RACK1 receptor for activated C kinase 1 -0.0194426
RAB1A RAB1A, member RAS oncogene family -0.0192652
AHNAK2 AHNAK nucleoprotein 2 -0.0190382
ADAM32 ADAM metallopeptidase domain 32 -0.0189206
SP100 SP100 nuclear antigen -0.0187314
TMSB10 thymosin beta 10 -0.0187118
ATF4 activating transcription factor 4 -0.0186076
LRRC23 leucine rich repeat containing 23 -0.0184565
MORF4L2 mortality factor 4 like 2 -0.0184242
HLA-B major histocompatibility complex, class I, B -0.0179023
RPS12 ribosomal protein S12 -0.017707
RPS27A ribosomal protein S27a -0.0177036
RPS23 ribosomal protein S23 -0.0175551
WASF2 WAS protein family, member 2 -0.0172037
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0170874
RPS16 ribosomal protein S16 -0.0169231
SRP72 signal recognition particle 72kDa -0.0169098
CSTB cystatin B (stefin B) -0.0168687
LDHA lactate dehydrogenase A -0.0168508
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.016738
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0166262
RSL1D1 ribosomal L1 domain containing 1 -0.0164052
RPL26 ribosomal protein L26 -0.0160759
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0160107
CAV1 caveolin 1, caveolae protein, 22kDa -0.015994
RPL38 ribosomal protein L38 -0.0159429
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0158713
RPL8 ribosomal protein L8 -0.0158678
PDIA5 protein disulfide isomerase family A, member 5 -0.0156768
ANXA2 annexin A2 -0.0156362
AKAP9 A kinase (PRKA) anchor protein 9 -0.0156361
H1-0 H1.0 linker histone -0.0155612
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0154656
S100P S100 calcium binding protein P -0.0154403
HM13 histocompatibility (minor) 13 -0.0153175
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0152711
RPL12 ribosomal protein L12 -0.0152475
ENSA endosulfine alpha -0.0152331
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0149956
SPDYA speedy/RINGO cell cycle regulator family member A -0.0149798
GOLGA4 golgin A4 -0.0149206
SEC61G Sec61 gamma subunit -0.0148914
CAMTA1 calmodulin binding transcription activator 1 -0.0148006