| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | APTO-253 perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the APTO-253_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FNDC3B | fibronectin type III domain containing 3B | 0.0769585 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0735503 |
| FN1 | fibronectin 1 | 0.0665479 |
| LOX | lysyl oxidase | 0.0590103 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0382119 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0379425 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0362966 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0352438 |
| AADAC | arylacetamide deacetylase | 0.035193 |
| IFI44L | interferon-induced protein 44-like | 0.0335786 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0333719 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0325637 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0323483 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0317999 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0317583 |
| CD44 | CD44 molecule (Indian blood group) | 0.0302996 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0296959 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0288124 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0286313 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0273206 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.026737 |
| MEF2A | myocyte enhancer factor 2A | 0.0260043 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.0241415 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.023358 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0230952 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0229325 |
| CLIC4 | chloride intracellular channel 4 | 0.0227632 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.022758 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0222266 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0222106 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0220418 |
| TNNC1 | troponin C type 1 (slow) | 0.0216998 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0216165 |
| H1-0 | H1.0 linker histone | 0.0210819 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0208127 |
| S100A6 | S100 calcium binding protein A6 | 0.020761 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | 0.0205763 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.020071 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0195636 |
| RAD51B | RAD51 paralog B | 0.019373 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0192168 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0190118 |
| TMSB10 | thymosin beta 10 | 0.0190067 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0189142 |
| GLIS3 | GLIS family zinc finger 3 | 0.0183374 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0172855 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0170777 |
| SP100 | SP100 nuclear antigen | 0.0170671 |
| TXNRD1 | thioredoxin reductase 1 | 0.0169755 |
| PLIN2 | perilipin 2 | 0.0167209 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0164262 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0162304 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | 0.0160698 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0160066 |
| FBN1 | fibrillin 1 | 0.0159011 |
| HDAC4 | histone deacetylase 4 | 0.015722 |
| PTMA | prothymosin, alpha | 0.0157209 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0155852 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0154555 |
| NTN4 | netrin 4 | 0.01538 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0152282 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0151563 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.0151065 |
| MYADM | myeloid-associated differentiation marker | 0.015061 |
| IL6ST | interleukin 6 signal transducer | 0.0148571 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.014808 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0145685 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0145451 |
| OXR1 | oxidation resistance 1 | 0.0143636 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | 0.0143276 |
| PRELID2 | PRELI domain containing 2 | 0.0143268 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.0143051 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.014292 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0141886 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.014148 |
| ASPH | aspartate beta-hydroxylase | 0.014092 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0140861 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0138937 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0138292 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0137421 |
| HAS2 | hyaluronan synthase 2 | 0.013683 |
| DCN | decorin | 0.0135763 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0135653 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0135235 |
| CCDC80 | coiled-coil domain containing 80 | 0.0131628 |
| MT1X | metallothionein 1X | 0.0131187 |
| C1R | complement component 1, r subcomponent | 0.012991 |
| TMOD3 | tropomodulin 3 (ubiquitous) | 0.0128697 |
| KYNU | kynureninase | 0.0128186 |
| SON | SON DNA binding protein | 0.0127957 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0127449 |
| RNF24 | ring finger protein 24 | 0.012528 |
| DST | dystonin | 0.0124965 |
| TXNIP | thioredoxin interacting protein | 0.0121505 |
| HM13 | histocompatibility (minor) 13 | 0.0120699 |
| KSR1 | kinase suppressor of ras 1 | 0.012003 |
| SUMF1 | sulfatase modifying factor 1 | 0.0119777 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0119762 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.01186 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.011846 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.127764 |
| VIM | vimentin | -0.0987162 |
| CDH13 | cadherin 13 | -0.0886731 |
| MT2A | metallothionein 2A | -0.0730555 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0713606 |
| NRP1 | neuropilin 1 | -0.0667037 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0650293 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0643073 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0615107 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0579803 |
| STC1 | stanniocalcin 1 | -0.0563323 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0554974 |
| RPS12 | ribosomal protein S12 | -0.0554163 |
| RPL37A | ribosomal protein L37a | -0.047051 |
| RPS29 | ribosomal protein S29 | -0.0459729 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0458808 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0444886 |
| RPS6 | ribosomal protein S6 | -0.0433558 |
| MTSS1 | metastasis suppressor 1 | -0.0424058 |
| CDCP1 | CUB domain containing protein 1 | -0.0396565 |
| RPS3 | ribosomal protein S3 | -0.0370712 |
| CLMP | CXADR-like membrane protein | -0.0363116 |
| HMGA2 | high mobility group AT-hook 2 | -0.0346997 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0342187 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0339991 |
| FTL | ferritin, light polypeptide | -0.0329461 |
| RPL31 | ribosomal protein L31 | -0.0328117 |
| RAI14 | retinoic acid induced 14 | -0.0323039 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.032199 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0316813 |
| JMJD1C | jumonji domain containing 1C | -0.0312406 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0311296 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0309652 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.030751 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0302757 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.030195 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.029819 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0297424 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.0296684 |
| FAM107B | family with sequence similarity 107, member B | -0.0293865 |
| RPS13 | ribosomal protein S13 | -0.0290907 |
| RBM39 | RNA binding motif protein 39 | -0.0286846 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | -0.0285392 |
| EGFR | epidermal growth factor receptor | -0.0285064 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0285035 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0281788 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.028141 |
| PARD3 | par-3 family cell polarity regulator | -0.0279768 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0279256 |
| RPS25 | ribosomal protein S25 | -0.0277598 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0277374 |
| SYT1 | synaptotagmin I | -0.0276274 |
| RPL35A | ribosomal protein L35a | -0.0272369 |
| SH3RF3 | SH3 domain containing ring finger 3 | -0.0272067 |
| RPL28 | ribosomal protein L28 | -0.0271919 |
| FMNL2 | formin-like 2 | -0.0271271 |
| SEPTIN9 | septin 9 | -0.026463 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0260063 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0251608 |
| RPL5 | ribosomal protein L5 | -0.0251241 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0248808 |
| RPS8 | ribosomal protein S8 | -0.0245728 |
| MECOM | MDS1 and EVI1 complex locus | -0.0245347 |
| PYGL | phosphorylase, glycogen, liver | -0.0242621 |
| RPL13A | ribosomal protein L13a | -0.0241172 |
| RPL38 | ribosomal protein L38 | -0.0240522 |
| RPL19 | ribosomal protein L19 | -0.0238078 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.0232998 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0231756 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0229995 |
| RACK1 | receptor for activated C kinase 1 | -0.0227207 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0224156 |
| SETD5 | SET domain containing 5 | -0.0223989 |
| BMERB1 | bMERB domain containing 1 | -0.0222254 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0213801 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0211714 |
| RUNX1 | runt-related transcription factor 1 | -0.021073 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0210554 |
| RPL37 | ribosomal protein L37 | -0.0209671 |
| RPS21 | ribosomal protein S21 | -0.0209034 |
| RPL11 | ribosomal protein L11 | -0.0207155 |
| RPL23 | ribosomal protein L23 | -0.0207064 |
| GLCCI1 | glucocorticoid induced 1 | -0.0206306 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0205148 |
| RIOK3 | RIO kinase 3 | -0.0203962 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0202836 |
| ANXA2 | annexin A2 | -0.0202026 |
| TBL1X | transducin (beta)-like 1X-linked | -0.0200818 |
| PRSS3 | protease, serine, 3 | -0.0198915 |
| RPL9 | ribosomal protein L9 | -0.0196209 |
| IL1B | interleukin 1, beta | -0.0195332 |
| DUSP5 | dual specificity phosphatase 5 | -0.0194712 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0194309 |
| PHIP | pleckstrin homology domain interacting protein | -0.0192626 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0191987 |
| ABCA6 | ATP-binding cassette, sub-family A (ABC1), member 6 | -0.0190946 |
| FOXO3 | forkhead box O3 | -0.0189957 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0186497 |
| HIP1 | huntingtin interacting protein 1 | -0.0186435 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | -0.0186364 |
