APTO-253_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the APTO-253_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.116659
PDE4D phosphodiesterase 4D, cAMP-specific 0.080476
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0789088
IGFBP3 insulin-like growth factor binding protein 3 0.0633764
SAMD4A sterile alpha motif domain containing 4A 0.0588016
HLA-B major histocompatibility complex, class I, B 0.0515519
SMOC1 SPARC related modular calcium binding 1 0.047815
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0431451
ARHGAP26 Rho GTPase activating protein 26 0.0366321
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0347196
HLA-A major histocompatibility complex, class I, A 0.033441
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0331927
RPS8 ribosomal protein S8 0.0312903
THSD4 thrombospondin, type I, domain containing 4 0.0312886
CMIP c-Maf inducing protein 0.0299343
KYNU kynureninase 0.0293367
BASP1 brain abundant, membrane attached signal protein 1 0.0289764
RPL35A ribosomal protein L35a 0.0286729
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0272508
RPL31 ribosomal protein L31 0.0271614
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0270589
SVIL supervillin 0.0270431
DOCK5 dedicator of cytokinesis 5 0.0265926
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0258371
NDRG1 N-myc downstream regulated 1 0.0256423
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0254916
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0253102
ZSWIM6 zinc finger, SWIM-type containing 6 0.0252593
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0249689
LOC102724023 ES1 protein homolog, mitochondrial 0.024412
DOCK4 dedicator of cytokinesis 4 0.0243189
IL6 interleukin 6 0.0241845
MYO1E myosin IE 0.0240322
PYGL phosphorylase, glycogen, liver 0.0237191
ATXN1 ataxin 1 0.0227472
GOLGB1 golgin B1 0.0223709
ALCAM activated leukocyte cell adhesion molecule 0.02208
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0217824
EGFR epidermal growth factor receptor 0.0215375
INTS6 integrator complex subunit 6 0.0213383
FTH1 ferritin, heavy polypeptide 1 0.0208106
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0206376
CCL5 chemokine (C-C motif) ligand 5 0.0187712
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0185553
MT1F metallothionein 1F 0.0183027
CUX1 cut-like homeobox 1 0.0182099
RAD51B RAD51 paralog B 0.0181752
FNDC3B fibronectin type III domain containing 3B 0.0180946
TPM1 tropomyosin 1 (alpha) 0.0180285
S100A6 S100 calcium binding protein A6 0.0177854
C15ORF48 chromosome 15 open reading frame 48 0.017281
EPAS1 endothelial PAS domain protein 1 0.0171146
IER3 immediate early response 3 0.0170812
VCL vinculin 0.0167956
ZBTB20 zinc finger and BTB domain containing 20 0.0167934
PTPRJ protein tyrosine phosphatase, receptor type, J 0.01643
ACTG1 actin gamma 1 0.0164113
TPT1 tumor protein, translationally-controlled 1 0.0163908
MAP7 microtubule-associated protein 7 0.0163127
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0162708
ANKRD12 ankyrin repeat domain 12 0.0162011
OSMR oncostatin M receptor 0.0160195
SOD2 superoxide dismutase 2, mitochondrial 0.0159722
DHRSX dehydrogenase/reductase (SDR family) X-linked 0.0158483
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0156219
ANGPTL4 angiopoietin-like 4 0.0155924
PCNX4 pecanex 4 0.0155485
NNMT nicotinamide N-methyltransferase 0.0153038
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.015056
CALD1 caldesmon 1 0.0148733
CD99 CD99 molecule 0.0146429
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0145911
RPL34 ribosomal protein L34 0.0145716
LOXL2 lysyl oxidase-like 2 0.0145312
CD44 CD44 molecule (Indian blood group) 0.014397
PDE10A phosphodiesterase 10A 0.0143632
LDHA lactate dehydrogenase A 0.0143477
IGFBP4 insulin-like growth factor binding protein 4 0.01427
RAB31 RAB31, member RAS oncogene family 0.0142417
PSEN1 presenilin 1 0.0138924
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0137998
RPS29 ribosomal protein S29 0.0136901
ASTN2 astrotactin 2 0.0136456
RPS27 ribosomal protein S27 0.0136157
RPS17 ribosomal protein S17 0.0135538
NF1 neurofibromin 1 0.0135058
FHIT fragile histidine triad 0.0134849
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0134664
NPAS2 neuronal PAS domain protein 2 0.0134039
NLK nemo-like kinase 0.0132211
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0131687
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0131606
USP36 ubiquitin specific peptidase 36 0.0131494
GLIS3 GLIS family zinc finger 3 0.0131006
LGALS1 lectin, galactoside-binding, soluble, 1 0.0130384
EHBP1 EH domain binding protein 1 0.0128448
TBCA tubulin folding cofactor A 0.0127656
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0127284
MED13 mediator complex subunit 13 0.01268
RPL37A ribosomal protein L37a 0.0125607

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.178943
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.113596
TXNRD1 thioredoxin reductase 1 -0.0939953
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0813029
TFPI2 tissue factor pathway inhibitor 2 -0.077376
RTN4 reticulon 4 -0.0653242
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0614959
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0583728
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0581138
TMSB10 thymosin beta 10 -0.0566758
FTL ferritin, light polypeptide -0.0520331
USP3 ubiquitin specific peptidase 3 -0.0502151
VIM vimentin -0.0481359
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.048122
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0471542
WDR43 WD repeat domain 43 -0.0464722
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.046459
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0461519
RBM39 RNA binding motif protein 39 -0.0449192
TPD52 tumor protein D52 -0.0443588
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0439861
RAD21 RAD21 homolog (S. pombe) -0.043288
YBX1 Y box binding protein 1 -0.0426158
RBM25 RNA binding motif protein 25 -0.0410881
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0407787
ZNF292 zinc finger protein 292 -0.0400273
CYRIB CYFIP related Rac1 interactor B -0.0395104
TPM3 tropomyosin 3 -0.0390246
MATR3 matrin 3 -0.0370201
TM4SF1 transmembrane 4 L six family member 1 -0.0368923
RPLP0 ribosomal protein, large, P0 -0.0366569
KIF5B kinesin family member 5B -0.036561
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0364641
ECT2 epithelial cell transforming 2 -0.0364297
YBX3 Y box binding protein 3 -0.0359279
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0358796
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0356339
ZFAND3 zinc finger, AN1-type domain 3 -0.0353147
ERBIN erbb2 interacting protein -0.0334616
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0332336
ANKRD28 ankyrin repeat domain 28 -0.0332191
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0331787
FGB fibrinogen beta chain -0.0328358
NAMPT nicotinamide phosphoribosyltransferase -0.0326836
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0323626
ENAH enabled homolog (Drosophila) -0.0322403
PAWR PRKC, apoptosis, WT1, regulator -0.0315868
PTMA prothymosin, alpha -0.0315247
CHN1 chimerin 1 -0.0312318
TMEM123 transmembrane protein 123 -0.0309103
SLC38A2 solute carrier family 38, member 2 -0.030263
TNPO1 transportin 1 -0.0297948
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0295975
PFDN2 prefoldin subunit 2 -0.0292729
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0291845
ADGRG6 adhesion G protein-coupled receptor G6 -0.0290078
CCNL1 cyclin L1 -0.0289542
GRAMD1B GRAM domain containing 1B -0.0288573
NUP58 nucleoporin 58 -0.0287636
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.028555
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0284396
MIS18BP1 MIS18 binding protein 1 -0.0282945
EIF3H eukaryotic translation initiation factor 3, subunit H -0.028119
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0280667
PDIA6 protein disulfide isomerase family A, member 6 -0.0278131
FNBP1L formin binding protein 1-like -0.0276616
NOP58 NOP58 ribonucleoprotein -0.0271896
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0267939
QKI QKI, KH domain containing, RNA binding -0.026776
MARCHF6 membrane associated ring-CH-type finger 6 -0.0266622
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0266591
RNF145 ring finger protein 145 -0.0259721
YME1L1 YME1-like 1 ATPase -0.025884
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0258469
APP amyloid beta (A4) precursor protein -0.0257997
MORF4L1 mortality factor 4 like 1 -0.0257844
VEZT vezatin, adherens junctions transmembrane protein -0.0257648
HMGA1 high mobility group AT-hook 1 -0.0257533
NCEH1 neutral cholesterol ester hydrolase 1 -0.0257528
CSDE1 cold shock domain containing E1, RNA-binding -0.0256074
PCBP2 poly(rC) binding protein 2 -0.0254437
EEF2 eukaryotic translation elongation factor 2 -0.0249181
SLC38A1 solute carrier family 38, member 1 -0.0248174
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0247598
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0247531
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0247312
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0247156
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0245736
WBP11 WW domain binding protein 11 -0.024418
RHEB Ras homolog enriched in brain -0.0243609
ADAM9 ADAM metallopeptidase domain 9 -0.0243366
ANXA2 annexin A2 -0.0241973
RPL19 ribosomal protein L19 -0.0238864
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.023277
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 -0.0231634
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0231132
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0230937
TPX2 TPX2, microtubule-associated -0.0230263
NAP1L1 nucleosome assembly protein 1-like 1 -0.02295
TFG TRK-fused gene -0.0226892