APTO-253_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the APTO-253_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.072434
YBX3 Y box binding protein 3 0.0654127
GRAMD1B GRAM domain containing 1B 0.0553534
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0443373
RAD51B RAD51 paralog B 0.0426993
TXNRD1 thioredoxin reductase 1 0.0409003
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0396318
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.039451
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0380626
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0360775
VCL vinculin 0.0336999
RIMS2 regulating synaptic membrane exocytosis 2 0.0329429
WWOX WW domain containing oxidoreductase 0.032101
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0299792
OSMR oncostatin M receptor 0.0297328
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.028871
STAT1 signal transducer and activator of transcription 1, 91kDa 0.027597
IGF1R insulin-like growth factor 1 receptor 0.0267033
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0261546
ZSWIM6 zinc finger, SWIM-type containing 6 0.0258743
BIRC2 baculoviral IAP repeat containing 2 0.0257551
PDE10A phosphodiesterase 10A 0.0255767
ELL2 elongation factor, RNA polymerase II, 2 0.0242949
FNDC3B fibronectin type III domain containing 3B 0.0234564
THSD4 thrombospondin, type I, domain containing 4 0.0232866
CALD1 caldesmon 1 0.0226799
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0218362
PDLIM5 PDZ and LIM domain 5 0.0214038
DST dystonin 0.0213949
ERRFI1 ERBB receptor feedback inhibitor 1 0.0209393
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0203306
TAS2R14 taste receptor, type 2, member 14 0.0194955
YAP1 Yes-associated protein 1 0.0189036
EXOC4 exocyst complex component 4 0.0188764
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0188514
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0183713
SSH2 slingshot protein phosphatase 2 0.0178782
ADGRG6 adhesion G protein-coupled receptor G6 0.0178256
JMJD1C jumonji domain containing 1C 0.0168947
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.015973
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.015802
VMP1 vacuole membrane protein 1 0.0155506
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0152163
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0147539
NCOA7 nuclear receptor coactivator 7 0.0147426
FAF1 Fas (TNFRSF6) associated factor 1 0.0146869
BIRC3 baculoviral IAP repeat containing 3 0.0145289
SAMHD1 SAM domain and HD domain 1 0.0144619
LPP LIM domain containing preferred translocation partner in lipoma 0.0144581
RIGI RNA sensor RIG-I 0.0143042
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0141314
HOMER1 homer scaffolding protein 1 0.0140963
PRKCE protein kinase C, epsilon 0.0138777
FOXP1 forkhead box P1 0.013774
BNC2 basonuclin 2 0.0136773
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0136517
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0135711
EFNA5 ephrin-A5 0.0133971
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0132367
SNAP25 synaptosomal-associated protein, 25kDa 0.013148
KLF6 Kruppel-like factor 6 0.0131214
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0130055
DNAH14 dynein, axonemal, heavy chain 14 0.0129964
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0129795
TPM4 tropomyosin 4 0.0129768
HMGA2 high mobility group AT-hook 2 0.012806
PDE4B phosphodiesterase 4B, cAMP-specific 0.0127823
MIPOL1 mirror-image polydactyly 1 0.0126401
ATXN1 ataxin 1 0.0125362
MAP7 microtubule-associated protein 7 0.0125338
FHIT fragile histidine triad 0.0124878
SRSF6 serine/arginine-rich splicing factor 6 0.012361
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0121577
SON SON DNA binding protein 0.0119226
BBS9 Bardet-Biedl syndrome 9 0.0118852
IFIH1 interferon induced with helicase C domain 1 0.0118379
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0117144
KIAA1328 KIAA1328 0.0116955
PATJ PATJ crumbs cell polarity complex component 0.0116737
MACROD2 MACRO domain containing 2 0.011635
PRH1 proline-rich protein HaeIII subfamily 1 0.0114425
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0113813
RAB7A RAB7A, member RAS oncogene family 0.011242
ULK4 unc-51 like kinase 4 0.0112347
PHF20 PHD finger protein 20 0.0112048
DIAPH3 diaphanous-related formin 3 0.0111832
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0111448
H1-0 H1.0 linker histone 0.011121
COL5A2 collagen, type V, alpha 2 0.011064
ZFP36L1 ZFP36 ring finger protein-like 1 0.011038
PRELID2 PRELI domain containing 2 0.0109176
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0109038
NABP1 nucleic acid binding protein 1 0.0108792
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0108528
BCLAF1 BCL2-associated transcription factor 1 0.0107392
MSH2 mutS homolog 2 0.010648
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0106031
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0105701
CENPF centromere protein F, 350/400kDa 0.0105693
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0105025

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.205435
RPS3 ribosomal protein S3 -0.0945779
VIM vimentin -0.0906044
TFPI2 tissue factor pathway inhibitor 2 -0.0833274
RPL37A ribosomal protein L37a -0.0832939
TMSB10 thymosin beta 10 -0.0780729
RPS27A ribosomal protein S27a -0.0744995
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0737897
RPL37 ribosomal protein L37 -0.0716746
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0654184
RPS12 ribosomal protein S12 -0.0629441
RPS29 ribosomal protein S29 -0.0599613
UBC ubiquitin C -0.059547
RPS8 ribosomal protein S8 -0.0593109
RPS27 ribosomal protein S27 -0.0542911
TM4SF1 transmembrane 4 L six family member 1 -0.0540883
TPT1 tumor protein, translationally-controlled 1 -0.0503642
PTMA prothymosin, alpha -0.0494275
EIF1 eukaryotic translation initiation factor 1 -0.0478801
RPL31 ribosomal protein L31 -0.0463671
RPL26 ribosomal protein L26 -0.0455975
RPL11 ribosomal protein L11 -0.0434985
RPL12 ribosomal protein L12 -0.0408026
RPL35A ribosomal protein L35a -0.0404364
WSB1 WD repeat and SOCS box containing 1 -0.0397498
RPS10 ribosomal protein S10 -0.0391274
NAP1L1 nucleosome assembly protein 1-like 1 -0.038367
KTN1 kinectin 1 (kinesin receptor) -0.0380749
RPS13 ribosomal protein S13 -0.0379897
NTSR1 neurotensin receptor 1 (high affinity) -0.0374265
PCBP2 poly(rC) binding protein 2 -0.0371611
RPS21 ribosomal protein S21 -0.0363804
RPL36 ribosomal protein L36 -0.0361504
RPS17 ribosomal protein S17 -0.0360232
AKAP12 A kinase (PRKA) anchor protein 12 -0.0358449
MT2A metallothionein 2A -0.0356932
RPS6 ribosomal protein S6 -0.0354958
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0344277
RPLP2 ribosomal protein, large, P2 -0.034184
RPLP1 ribosomal protein, large, P1 -0.0336061
TPI1 triosephosphate isomerase 1 -0.0335892
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0324852
RPS25 ribosomal protein S25 -0.0322218
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0321428
RPL23 ribosomal protein L23 -0.0319222
RPL19 ribosomal protein L19 -0.031708
RPL13A ribosomal protein L13a -0.0314337
RPL28 ribosomal protein L28 -0.031392
RPL9 ribosomal protein L9 -0.0313778
RPS23 ribosomal protein S23 -0.0311913
EEF2 eukaryotic translation elongation factor 2 -0.0307648
MYL12B myosin, light chain 12B, regulatory -0.0304155
RTN4 reticulon 4 -0.0292833
TPM2 tropomyosin 2 (beta) -0.0290099
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0284305
RACK1 receptor for activated C kinase 1 -0.0282779
RPL38 ribosomal protein L38 -0.0277218
HLA-B major histocompatibility complex, class I, B -0.0266415
STC1 stanniocalcin 1 -0.0255841
RPS15 ribosomal protein S15 -0.0252719
FTL ferritin, light polypeptide -0.0249459
RPL36A ribosomal protein L36a -0.0247896
PGK1 phosphoglycerate kinase 1 -0.0245734
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0244977
MARCHF4 membrane associated ring-CH-type finger 4 -0.0244673
XPOT exportin, tRNA -0.0240118
RPS19 ribosomal protein S19 -0.023914
YBX1 Y box binding protein 1 -0.023661
RPL5 ribosomal protein L5 -0.0236599
RPL8 ribosomal protein L8 -0.0235587
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0233978
RPL34 ribosomal protein L34 -0.0233056
ENO1 enolase 1, (alpha) -0.0229937
ANKRD11 ankyrin repeat domain 11 -0.0229082
OGA O-GlcNAcase -0.0228344
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0228053
IER3 immediate early response 3 -0.0226326
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0224838
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0223931
CAVIN1 caveolae associated protein 1 -0.022294
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0220796
TLN1 talin 1 -0.0220461
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0219858
RPLP0 ribosomal protein, large, P0 -0.0218242
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0216227
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0212839
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0208332
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0207335
RPL30 ribosomal protein L30 -0.0206568
RPL15 ribosomal protein L15 -0.0204416
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0203462
FBXO11 F-box protein 11 -0.0200872
KDM2A lysine (K)-specific demethylase 2A -0.0198057
PTPRF protein tyrosine phosphatase, receptor type, F -0.0197788
ATP5F1B ATP synthase F1 subunit beta -0.0197774
RPS24 ribosomal protein S24 -0.0195255
MCL1 myeloid cell leukemia 1 -0.0195116
RPS11 ribosomal protein S11 -0.0193423
RPS16 ribosomal protein S16 -0.0192778
RPL27 ribosomal protein L27 -0.0192587