| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | APTO-253 perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the APTO-253_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.262673 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.188703 |
| POTEF | POTE ankyrin domain family, member F | 0.166439 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.141389 |
| TXNRD1 | thioredoxin reductase 1 | 0.14133 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.129156 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.115371 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.114759 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.113976 |
| TMSB10 | thymosin beta 10 | 0.106444 |
| S100A6 | S100 calcium binding protein A6 | 0.104207 |
| MT2A | metallothionein 2A | 0.102102 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0966915 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0922475 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0854641 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.083726 |
| PTMA | prothymosin, alpha | 0.0802003 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0764458 |
| ENO1 | enolase 1, (alpha) | 0.0736813 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0727961 |
| TXNIP | thioredoxin interacting protein | 0.0679565 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0646934 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0643138 |
| MAP1B | microtubule-associated protein 1B | 0.0570474 |
| RPLP1 | ribosomal protein, large, P1 | 0.0565913 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0565818 |
| SGMS2 | sphingomyelin synthase 2 | 0.0562274 |
| FN1 | fibronectin 1 | 0.0559754 |
| RPS19 | ribosomal protein S19 | 0.0539506 |
| S100A10 | S100 calcium binding protein A10 | 0.0533777 |
| RPL8 | ribosomal protein L8 | 0.0481799 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0461642 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.045435 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0452624 |
| RNF145 | ring finger protein 145 | 0.0423926 |
| RUNX1 | runt-related transcription factor 1 | 0.041735 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0414341 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0404965 |
| KRT7 | keratin 7, type II | 0.0402203 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0396975 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0395762 |
| RPLP0 | ribosomal protein, large, P0 | 0.0390879 |
| MSN | moesin | 0.0389046 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0378088 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.037571 |
| HMGA1 | high mobility group AT-hook 1 | 0.0373695 |
| S100A9 | S100 calcium binding protein A9 | 0.0373323 |
| CD44 | CD44 molecule (Indian blood group) | 0.037159 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0369155 |
| RPL32 | ribosomal protein L32 | 0.0368826 |
| KLF6 | Kruppel-like factor 6 | 0.0368158 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0360531 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0359485 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.03577 |
| EZR | ezrin | 0.0355759 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0354025 |
| LAMB3 | laminin, beta 3 | 0.0351808 |
| PARD3 | par-3 family cell polarity regulator | 0.034949 |
| DSG2 | desmoglein 2 | 0.0347238 |
| ANXA2 | annexin A2 | 0.0345184 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.0337851 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0333698 |
| RASAL2 | RAS protein activator like 2 | 0.0332386 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0327574 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0323803 |
| LDHA | lactate dehydrogenase A | 0.032038 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0314528 |
| GRAMD2B | GRAM domain containing 2B | 0.0313089 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0306137 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0301706 |
| NDRG1 | N-myc downstream regulated 1 | 0.0300168 |
| DST | dystonin | 0.0299955 |
| DUSP10 | dual specificity phosphatase 10 | 0.0297315 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0291849 |
| SEPTIN7 | septin 7 | 0.0288774 |
| CALR | calreticulin | 0.0286692 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0282821 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.028253 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.027813 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.027777 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0277288 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0276251 |
| IL6ST | interleukin 6 signal transducer | 0.0275245 |
| YBX1 | Y box binding protein 1 | 0.0275119 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0275032 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0273392 |
| GPX4 | glutathione peroxidase 4 | 0.0265318 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0262218 |
| TPD52 | tumor protein D52 | 0.0262205 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0262102 |
| ARRDC3 | arrestin domain containing 3 | 0.0260295 |
| VGLL3 | vestigial-like family member 3 | 0.0259529 |
| CCNI | cyclin I | 0.0258883 |
| BRD2 | bromodomain containing 2 | 0.0258602 |
| SH3RF2 | SH3 domain containing ring finger 2 | 0.0258341 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.025634 |
| OSMR | oncostatin M receptor | 0.0255883 |
| DSPP | dentin sialophosphoprotein | 0.0254531 |
| MYOF | myoferlin | 0.0251109 |
| UBC | ubiquitin C | 0.0251063 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.096784 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0924398 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0903785 |
| RAI14 | retinoic acid induced 14 | -0.0772962 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0715265 |
| LMO7 | LIM domain 7 | -0.0636367 |
| GOLGB1 | golgin B1 | -0.0636214 |
| TOP1 | topoisomerase (DNA) I | -0.0573267 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0519306 |
| SQSTM1 | sequestosome 1 | -0.0511349 |
| RPL37A | ribosomal protein L37a | -0.0475107 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0471054 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.046349 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.0453384 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0450576 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.044864 |
| RPS29 | ribosomal protein S29 | -0.0448553 |
| EGR1 | early growth response 1 | -0.0438509 |
| ASPH | aspartate beta-hydroxylase | -0.0428239 |
| RPS27A | ribosomal protein S27a | -0.0420313 |
| CSTB | cystatin B (stefin B) | -0.0415482 |
| RBM47 | RNA binding motif protein 47 | -0.0411975 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0404735 |
| PDLIM5 | PDZ and LIM domain 5 | -0.039936 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0394348 |
| NAV2 | neuron navigator 2 | -0.0373178 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.035301 |
| MORF4L2 | mortality factor 4 like 2 | -0.0346074 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0344749 |
| ARF4 | ADP-ribosylation factor 4 | -0.0344153 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0343159 |
| MSI2 | musashi RNA-binding protein 2 | -0.0341726 |
| FNBP4 | formin binding protein 4 | -0.0337289 |
| INTS6 | integrator complex subunit 6 | -0.033523 |
| FBXO34 | F-box protein 34 | -0.0334573 |
| CTBP2 | C-terminal binding protein 2 | -0.0334564 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0332858 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0329302 |
| UPP1 | uridine phosphorylase 1 | -0.0329059 |
| TMF1 | TATA element modulatory factor 1 | -0.0328834 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0326756 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0324366 |
| RPS3 | ribosomal protein S3 | -0.0322684 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0313848 |
| CANX | calnexin | -0.0309339 |
| SMAD3 | SMAD family member 3 | -0.0305291 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.030428 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0296628 |
| RPS12 | ribosomal protein S12 | -0.0295305 |
| CEP350 | centrosomal protein 350kDa | -0.0292522 |
| ZNF217 | zinc finger protein 217 | -0.0287999 |
| BBX | bobby sox homolog (Drosophila) | -0.0284767 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0282297 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.028167 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0281398 |
| HLA-A | major histocompatibility complex, class I, A | -0.0280669 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0278879 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | -0.0275347 |
| HLA-B | major histocompatibility complex, class I, B | -0.0271739 |
| TMEM165 | transmembrane protein 165 | -0.0269323 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | -0.0268344 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0264249 |
| FAM107B | family with sequence similarity 107, member B | -0.0262906 |
| PIK3CB | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta | -0.0260754 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0259126 |
| FTL | ferritin, light polypeptide | -0.0255303 |
| RSF1 | remodeling and spacing factor 1 | -0.0255228 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0253966 |
| ATOSA | atos homolog A | -0.0247104 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0245034 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0244882 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0243777 |
| TMEM263 | transmembrane protein 263 | -0.024354 |
| STC2 | stanniocalcin 2 | -0.0242203 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0242134 |
| PLEC | plectin | -0.0241602 |
| ANO10 | anoctamin 10 | -0.0241346 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0238675 |
| RPS13 | ribosomal protein S13 | -0.0238549 |
| PLSCR1 | phospholipid scramblase 1 | -0.0237147 |
| EXOC4 | exocyst complex component 4 | -0.023629 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0234506 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.023323 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0233146 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0232952 |
| USP34 | ubiquitin specific peptidase 34 | -0.0232795 |
| LRRC23 | leucine rich repeat containing 23 | -0.0231464 |
| CRABP2 | cellular retinoic acid binding protein 2 | -0.0231356 |
| GLRX | glutaredoxin (thioltransferase) | -0.0231053 |
| NECTIN4 | nectin cell adhesion molecule 4 | -0.023095 |
| PDXK | pyridoxal (pyridoxine, vitamin B6) kinase | -0.0230764 |
| TUT7 | terminal uridylyl transferase 7 | -0.0230629 |
| MCL1 | myeloid cell leukemia 1 | -0.0229724 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | -0.022917 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0228935 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0228013 |
| FBXW11 | F-box and WD repeat domain containing 11 | -0.02275 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.02267 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0224713 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0224341 |
