APTO-253_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the APTO-253_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.137616
KYNU kynureninase 0.0968123
PM20D1 peptidase M20 domain containing 1 0.0875894
PDLIM5 PDZ and LIM domain 5 0.0721016
COL8A1 collagen, type VIII, alpha 1 0.0688121
COL5A2 collagen, type V, alpha 2 0.0663412
TXNRD1 thioredoxin reductase 1 0.0627949
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.047946
AGTPBP1 ATP/GTP binding protein 1 0.0455612
P3H2 prolyl 3-hydroxylase 2 0.0428895
BASP1 brain abundant, membrane attached signal protein 1 0.0404059
CENPF centromere protein F, 350/400kDa 0.0374235
FTH1 ferritin, heavy polypeptide 1 0.0322397
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0299909
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0284507
CD109 CD109 molecule 0.0278438
MAP7 microtubule-associated protein 7 0.0271022
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0270701
FTL ferritin, light polypeptide 0.0270346
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0270302
SH3KBP1 SH3-domain kinase binding protein 1 0.026805
EXT1 exostosin glycosyltransferase 1 0.0262362
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0253486
INHBA inhibin, beta A 0.0252232
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0225596
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0223158
IRS2 insulin receptor substrate 2 0.0221664
TGFBR1 transforming growth factor, beta receptor 1 0.0221545
MKI67 marker of proliferation Ki-67 0.0220071
NT5C2 5'-nucleotidase, cytosolic II 0.0217549
MYOF myoferlin 0.0214974
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0205922
ZEB2 zinc finger E-box binding homeobox 2 0.019094
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0179251
RPL3 ribosomal protein L3 0.0178205
PRELID2 PRELI domain containing 2 0.0171373
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0170624
OXSR1 oxidative stress responsive 1 0.0167715
PTMA prothymosin, alpha 0.0167251
WWOX WW domain containing oxidoreductase 0.0165863
RPS4X ribosomal protein S4, X-linked 0.0165446
LSAMP limbic system-associated membrane protein 0.016222
EZR ezrin 0.0162111
NFX1 nuclear transcription factor, X-box binding 1 0.0160251
TENM2 teneurin transmembrane protein 2 0.0159183
MGST1 microsomal glutathione S-transferase 1 0.015827
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0155699
SMOC1 SPARC related modular calcium binding 1 0.015418
SAMD4A sterile alpha motif domain containing 4A 0.0152579
LGALS3 lectin, galactoside-binding, soluble, 3 0.0150237
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0147683
EEF2 eukaryotic translation elongation factor 2 0.0147353
HSPA8 heat shock 70kDa protein 8 0.0143192
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0141702
NEK7 NIMA-related kinase 7 0.0141683
MALT1 MALT1 paracaspase 0.0139936
POTEF POTE ankyrin domain family, member F 0.0137259
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0136028
CTIF CBP80/20-dependent translation initiation factor 0.0134899
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0133118
NTN4 netrin 4 0.0132256
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0131556
SFPQ splicing factor proline/glutamine-rich 0.013005
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0129779
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0129289
PCDH15 protocadherin-related 15 0.0128023
RPS2 ribosomal protein S2 0.0127452
PCBP2 poly(rC) binding protein 2 0.0125773
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0123777
ASTN2 astrotactin 2 0.0121503
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0121206
LOC102724023 ES1 protein homolog, mitochondrial 0.0119145
UGCG UDP-glucose ceramide glucosyltransferase 0.0118823
RPL23 ribosomal protein L23 0.0117709
ALPK2 alpha-kinase 2 0.0117323
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0116875
FBXL7 F-box and leucine-rich repeat protein 7 0.0116732
SLF1 SMC5-SMC6 complex localization factor 1 0.0115805
VMP1 vacuole membrane protein 1 0.0113269
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0111477
ANLN anillin, actin binding protein 0.0109571
DIAPH3 diaphanous-related formin 3 0.0106955
ELL2 elongation factor, RNA polymerase II, 2 0.0106454
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0104229
NRIP1 nuclear receptor interacting protein 1 0.0104046
MACROD2 MACRO domain containing 2 0.010394
MFF mitochondrial fission factor 0.0102394
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0101999
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0100826
IQGAP1 IQ motif containing GTPase activating protein 1 0.009894
RPLP1 ribosomal protein, large, P1 0.00989261
FAM168A family with sequence similarity 168, member A 0.00983221
PRR5L proline rich 5 like 0.00979788
TXNIP thioredoxin interacting protein 0.00978598
LMNA lamin A/C 0.0095892
FNIP1 folliculin interacting protein 1 0.00956585
TXN2 thioredoxin 2 0.00945779
TPM3 tropomyosin 3 0.00944779
CBX3 chromobox homolog 3 0.00943035
PRKN parkin RBR E3 ubiquitin protein ligase 0.0093605

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.235994
PSD3 pleckstrin and Sec7 domain containing 3 -0.16811
EFNA5 ephrin-A5 -0.135255
VIM vimentin -0.126184
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.108713
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0957374
MAML3 mastermind-like 3 (Drosophila) -0.0948647
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0913743
CDH13 cadherin 13 -0.0898038
PCBP3 poly(rC) binding protein 3 -0.0894663
DOCK4 dedicator of cytokinesis 4 -0.0887281
PDE4D phosphodiesterase 4D, cAMP-specific -0.0827414
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0818944
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0807386
TFPI2 tissue factor pathway inhibitor 2 -0.0796831
NPAS2 neuronal PAS domain protein 2 -0.0761943
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0722389
NRCAM neuronal cell adhesion molecule -0.0700834
NALF1 NALCN channel auxiliary factor 1 -0.0673662
IGFBP3 insulin-like growth factor binding protein 3 -0.0664794
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0636337
SMYD3 SET and MYND domain containing 3 -0.0627676
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0593211
CANX calnexin -0.059264
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0585938
TM4SF1 transmembrane 4 L six family member 1 -0.0566834
MCL1 myeloid cell leukemia 1 -0.0552291
TPT1 tumor protein, translationally-controlled 1 -0.0518747
STC1 stanniocalcin 1 -0.0516166
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0483212
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0481904
THSD4 thrombospondin, type I, domain containing 4 -0.04706
PYGL phosphorylase, glycogen, liver -0.0470099
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0464598
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0443381
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0438175
PGK1 phosphoglycerate kinase 1 -0.0424986
NCKAP5 NCK-associated protein 5 -0.04154
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0413139
ESM1 endothelial cell-specific molecule 1 -0.0411647
ADGRD1 adhesion G protein-coupled receptor D1 -0.0407556
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0387729
GLIS3 GLIS family zinc finger 3 -0.0376409
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0373365
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0364818
CTSL cathepsin L -0.0347249
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0345106
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0334649
RPL31 ribosomal protein L31 -0.0331771
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0331208
RPL37A ribosomal protein L37a -0.0329988
HLA-B major histocompatibility complex, class I, B -0.0324029
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0314714
PDE10A phosphodiesterase 10A -0.0308871
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0308061
MAML2 mastermind-like 2 (Drosophila) -0.0305371
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0297334
RPS3 ribosomal protein S3 -0.0292685
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0291178
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0290911
LAMB1 laminin, beta 1 -0.0290634
ZMYND8 zinc finger, MYND-type containing 8 -0.0286746
BZW1 basic leucine zipper and W2 domains 1 -0.0278646
SDCCAG8 serologically defined colon cancer antigen 8 -0.0277019
RTN1 reticulon 1 -0.0271336
WSB1 WD repeat and SOCS box containing 1 -0.0267418
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0265625
MACF1 microtubule-actin crosslinking factor 1 -0.0257643
PTPRD protein tyrosine phosphatase, receptor type, D -0.0254493
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0254068
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.02512
RPS24 ribosomal protein S24 -0.0246815
DOCK5 dedicator of cytokinesis 5 -0.0244885
HLA-A major histocompatibility complex, class I, A -0.0241943
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0241132
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0240934
BCAS3 breast carcinoma amplified sequence 3 -0.0240139
FRMD4B FERM domain containing 4B -0.0238473
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0238225
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0235685
S100A6 S100 calcium binding protein A6 -0.0234992
ASPH aspartate beta-hydroxylase -0.0233411
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0231647
TBC1D19 TBC1 domain family, member 19 -0.0231624
ADGRB3 adhesion G protein-coupled receptor B3 -0.0231532
PDE4B phosphodiesterase 4B, cAMP-specific -0.023114
COL4A6 collagen, type IV, alpha 6 -0.0230036
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0226509
NHSL1 NHS-like 1 -0.0224464
PBX1 pre-B-cell leukemia homeobox 1 -0.0221634
SCN3A sodium channel, voltage gated, type III alpha subunit -0.0220337
NTSR1 neurotensin receptor 1 (high affinity) -0.0220124
RGS2 regulator of G-protein signaling 2 -0.0219027
FOXC1 forkhead box C1 -0.0218766
WARS1 tryptophanyl-tRNA synthetase 1 -0.0217471
CAPN2 calpain 2, (m/II) large subunit -0.0215916
HDAC8 histone deacetylase 8 -0.0215002
RPS16 ribosomal protein S16 -0.0214643
COL4A5 collagen, type IV, alpha 5 -0.0214224
RPS29 ribosomal protein S29 -0.0213634