APTO-253_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

184 genes differentially expressed following the APTO-253_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.182307
EXT1 exostosin glycosyltransferase 1 0.162635
CADM2 cell adhesion molecule 2 0.0724955
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.067757
PRKG1 protein kinase, cGMP-dependent, type I 0.0658683
ZBTB20 zinc finger and BTB domain containing 20 0.0615027
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0614872
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0613406
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0609864
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0600192
NALF1 NALCN channel auxiliary factor 1 0.0594562
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0588729
PEG10 paternally expressed 10 0.0562124
DST dystonin 0.0530466
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0523623
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0517834
JMJD1C jumonji domain containing 1C 0.0504167
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0502374
DNER delta/notch-like EGF repeat containing 0.0484656
RORA RAR-related orphan receptor A 0.0483938
ZSWIM6 zinc finger, SWIM-type containing 6 0.0453275
ARHGAP29 Rho GTPase activating protein 29 0.0446976
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0439493
AKAP9 A kinase (PRKA) anchor protein 9 0.0438695
MED13 mediator complex subunit 13 0.0438409
NDRG1 N-myc downstream regulated 1 0.0426046
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.041122
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0397438
PTK2 protein tyrosine kinase 2 0.0396377
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0390905
RAB2A RAB2A, member RAS oncogene family 0.0389953
PDE10A phosphodiesterase 10A 0.0389474
SLC38A2 solute carrier family 38, member 2 0.0388146
ARRDC3 arrestin domain containing 3 0.038393
GPC6 glypican 6 0.0361235
IGFBP3 insulin-like growth factor binding protein 3 0.0333787
RPL37 ribosomal protein L37 0.0318076
VCL vinculin 0.0317536
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0309663
GOLGB1 golgin B1 0.0307249
EIF1 eukaryotic translation initiation factor 1 0.0292783
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0292216
NCOR1 nuclear receptor corepressor 1 0.0291737
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0289297
LSAMP limbic system-associated membrane protein 0.0285873
TRIO trio Rho guanine nucleotide exchange factor 0.0279712
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0278208
XRN2 5'-3' exoribonuclease 2 0.0274382
GOLGA4 golgin A4 0.0273367
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0267258
SYT1 synaptotagmin I 0.0228828
SETD5 SET domain containing 5 0.0219142
MBNL1 muscleblind-like splicing regulator 1 0.0215877
TXNRD1 thioredoxin reductase 1 0.0215625
KMT2C lysine (K)-specific methyltransferase 2C 0.0213003
CANX calnexin 0.021213
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0207696
MYOF myoferlin 0.0206894
FLNB filamin B, beta 0.019262
PKM pyruvate kinase, muscle 0.0190997
RSL1D1 ribosomal L1 domain containing 1 0.0188197
PHF3 PHD finger protein 3 0.0181057
CDH13 cadherin 13 0.0179477
ANXA2 annexin A2 0.0171952
WAC WW domain containing adaptor with coiled-coil 0.0168193
RPL19 ribosomal protein L19 0.0166532
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0160656
RNF213 ring finger protein 213 0.0149693
RAD51B RAD51 paralog B 0.0148464
HMGA2 high mobility group AT-hook 2 0.01471
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0123856
PGK1 phosphoglycerate kinase 1 0.0120324
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0118707
FNDC3A fibronectin type III domain containing 3A 0.0117781
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0115647
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0112561
STAU1 staufen double-stranded RNA binding protein 1 0.0109024
ERRFI1 ERBB receptor feedback inhibitor 1 0.0105375
EIF5B eukaryotic translation initiation factor 5B 0.0103404
RPL15 ribosomal protein L15 0.0102455
TPM4 tropomyosin 4 0.00976038
ANKRD17 ankyrin repeat domain 17 0.00973069
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.00964473
PTPRK protein tyrosine phosphatase, receptor type, K 0.00804639
GLS2 glutaminase 2 (liver, mitochondrial) 0.00772062
RPL11 ribosomal protein L11 0.0071852
BBX bobby sox homolog (Drosophila) 0.0070955
RPL7A ribosomal protein L7a 0.00701619
PDE4D phosphodiesterase 4D, cAMP-specific 0.00690488
CD44 CD44 molecule (Indian blood group) 0.0066733
ASPH aspartate beta-hydroxylase 0.0061214
NPAS2 neuronal PAS domain protein 2 0.00602251
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.00550917
GMDS GDP-mannose 4,6-dehydratase 0.00450267
MED13L mediator complex subunit 13-like 0.00281985
CXCL8 chemokine (C-X-C motif) ligand 8 0.00259609
RPS8 ribosomal protein S8 0.0020832
SMYD3 SET and MYND domain containing 3 0.00177695
PARD3 par-3 family cell polarity regulator 0.00147754
SPAG9 sperm associated antigen 9 2.58986E-4

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.132045
TMSB10 thymosin beta 10 -0.108666
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0952919
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.079655
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0785815
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0742316
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0707509
MT2A metallothionein 2A -0.0682172
FNDC3B fibronectin type III domain containing 3B -0.0662923
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0660181
LPP LIM domain containing preferred translocation partner in lipoma -0.0636335
RPLP2 ribosomal protein, large, P2 -0.0635813
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0631314
ITGA6 integrin, alpha 6 -0.0620856
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0613069
DSCAM Down syndrome cell adhesion molecule -0.0605227
FN1 fibronectin 1 -0.0601429
PTMA prothymosin, alpha -0.0596706
SLTM SAFB-like, transcription modulator -0.0593652
MYO10 myosin X -0.0570548
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0567551
RPLP1 ribosomal protein, large, P1 -0.0556094
B2M beta-2-microglobulin -0.055483
THSD4 thrombospondin, type I, domain containing 4 -0.051006
PRKCA protein kinase C, alpha -0.048232
MACF1 microtubule-actin crosslinking factor 1 -0.0480686
RPS6 ribosomal protein S6 -0.0469005
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0461804
ELL2 elongation factor, RNA polymerase II, 2 -0.0450961
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0431894
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0426192
ANKRD12 ankyrin repeat domain 12 -0.0413835
NIPBL Nipped-B homolog (Drosophila) -0.0399794
VIM vimentin -0.0391762
MCL1 myeloid cell leukemia 1 -0.0359645
LRP1B low density lipoprotein receptor-related protein 1B -0.033815
ENO1 enolase 1, (alpha) -0.0330282
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0328476
AKAP12 A kinase (PRKA) anchor protein 12 -0.0320327
RPL37A ribosomal protein L37a -0.0317537
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0315644
RTN4 reticulon 4 -0.0313051
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0311402
ACTG1 actin gamma 1 -0.0311075
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0294602
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0259448
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0255406
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.023758
SVIL supervillin -0.0226227
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0218116
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0206706
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0204168
NKD1 naked cuticle homolog 1 (Drosophila) -0.020148
FTL ferritin, light polypeptide -0.0170124
TTC3 tetratricopeptide repeat domain 3 -0.0152057
ATP11A ATPase, class VI, type 11A -0.0145343
TPT1 tumor protein, translationally-controlled 1 -0.0144961
LMO7 LIM domain 7 -0.0137503
RPL35A ribosomal protein L35a -0.0134214
STC1 stanniocalcin 1 -0.0132411
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0127725
ATXN1 ataxin 1 -0.012224
HPCAL1 hippocalcin-like 1 -0.0118099
RPS16 ribosomal protein S16 -0.0112254
ZFAND3 zinc finger, AN1-type domain 3 -0.0108757
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0103957
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0100684
ZNF292 zinc finger protein 292 -0.00965607
RPS12 ribosomal protein S12 -0.00915815
SBF2 SET binding factor 2 -0.00892041
RPLP0 ribosomal protein, large, P0 -0.00855032
KTN1 kinectin 1 (kinesin receptor) -0.00833147
MAML3 mastermind-like 3 (Drosophila) -0.00802598
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.00633896
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.00568465
RPS3 ribosomal protein S3 -0.00561781
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.00535468
RACK1 receptor for activated C kinase 1 -0.00471502
PSD3 pleckstrin and Sec7 domain containing 3 -0.00416793
NF1 neurofibromin 1 -0.00390666
MYO1E myosin IE -0.00310498
EEF2 eukaryotic translation elongation factor 2 -0.00295169
RPL12 ribosomal protein L12 -0.00194959
RASA2 RAS p21 protein activator 2 -8.82901E-4