APTO-253_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the APTO-253_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0977147
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.081238
PHIP pleckstrin homology domain interacting protein 0.0742914
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0561565
PGAP1 post-GPI attachment to proteins 1 0.052535
TSC22D2 TSC22 domain family, member 2 0.0518788
SAMD4A sterile alpha motif domain containing 4A 0.0512463
ADGRL3 adhesion G protein-coupled receptor L3 0.0505734
RASAL2 RAS protein activator like 2 0.0502941
FNDC3B fibronectin type III domain containing 3B 0.0499778
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0490261
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.0465093
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0460254
H1-0 H1.0 linker histone 0.0449079
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0431518
STRN3 striatin, calmodulin binding protein 3 0.0423552
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.042014
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0411844
TENM3 teneurin transmembrane protein 3 0.0398303
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0389771
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0381922
COL11A1 collagen, type XI, alpha 1 0.0365144
N4BP2L2 NEDD4 binding protein 2-like 2 0.0364856
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0362696
PICALM phosphatidylinositol binding clathrin assembly protein 0.035976
NEBL nebulette 0.0359532
FBXO11 F-box protein 11 0.0358247
PCLO piccolo presynaptic cytomatrix protein 0.0358157
CHD1 chromodomain helicase DNA binding protein 1 0.0354521
WAC WW domain containing adaptor with coiled-coil 0.0346758
ATXN2 ataxin 2 0.0343384
ADAM9 ADAM metallopeptidase domain 9 0.0343144
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0342862
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0341426
LRRC4C leucine rich repeat containing 4C 0.0341321
MBD5 methyl-CpG binding domain protein 5 0.0332576
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.0329992
AKAP9 A kinase (PRKA) anchor protein 9 0.0327381
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.0326738
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0326314
WWC2 WW and C2 domain containing 2 0.0320283
ZNF638 zinc finger protein 638 0.0318984
ADGRV1 adhesion G protein-coupled receptor V1 0.0318057
LYST lysosomal trafficking regulator 0.0316315
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0307196
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0300359
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0299442
SNX6 sorting nexin 6 0.0293855
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0288019
TENM2 teneurin transmembrane protein 2 0.0283978
UTRN utrophin 0.028253
TRPS1 trichorhinophalangeal syndrome I 0.0281084
SLC44A5 solute carrier family 44, member 5 0.0277651
PLS3 plastin 3 0.0272419
MRPS30 mitochondrial ribosomal protein S30 0.0269789
LHFPL6 LHFPL tetraspan subfamily member 6 0.0265521
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0264164
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0257824
ZMYM2 zinc finger, MYM-type 2 0.0253965
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0253429
NCOA2 nuclear receptor coactivator 2 0.0250558
TRIO trio Rho guanine nucleotide exchange factor 0.0241977
RREB1 ras responsive element binding protein 1 0.0239631
ATXN1 ataxin 1 0.0237123
RABGAP1L RAB GTPase activating protein 1-like 0.0237113
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0237053
MAML2 mastermind-like 2 (Drosophila) 0.023545
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0234589
PLPP1 phospholipid phosphatase 1 0.0234437
SRRM1 serine/arginine repetitive matrix 1 0.0234238
SOX5 SRY (sex determining region Y)-box 5 0.0231595
SETD5 SET domain containing 5 0.0227771
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0227754
PRR16 proline rich 16 0.0226356
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.022612
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0225888
PRRC2C proline-rich coiled-coil 2C 0.0223953
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0223118
SLK STE20-like kinase 0.0222972
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase 0.0220774
KMT2A lysine (K)-specific methyltransferase 2A 0.0219884
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0218347
PRTG protogenin 0.0217027
TLK2 tousled-like kinase 2 0.0216822
ADGRL2 adhesion G protein-coupled receptor L2 0.0216551
TCF12 transcription factor 12 0.0214392
PDIA6 protein disulfide isomerase family A, member 6 0.0213636
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.02131
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0208886
ZC3H15 zinc finger CCCH-type containing 15 0.0208673
NFIB nuclear factor I/B 0.0208196
METAP2 methionyl aminopeptidase 2 0.0206448
ATF7IP activating transcription factor 7 interacting protein 0.0206154
TMOD3 tropomodulin 3 (ubiquitous) 0.0205602
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0204225
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0204103
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0203264
KDM6A lysine (K)-specific demethylase 6A 0.0203091
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.020305
CFL2 cofilin 2 (muscle) 0.0201211

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.190441
RPS16 ribosomal protein S16 -0.123945
TMSB10 thymosin beta 10 -0.102285
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0944138
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0867223
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0848453
RPLP1 ribosomal protein, large, P1 -0.0788247
RPS27A ribosomal protein S27a -0.07075
ACTG1 actin gamma 1 -0.0686139
RPS8 ribosomal protein S8 -0.0678098
RPS6 ribosomal protein S6 -0.0646454
TPT1 tumor protein, translationally-controlled 1 -0.0638194
RPL26 ribosomal protein L26 -0.0620403
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0598974
RPL35A ribosomal protein L35a -0.0572538
COL3A1 collagen, type III, alpha 1 -0.0572356
PTMA prothymosin, alpha -0.0557247
UPP1 uridine phosphorylase 1 -0.0508725
RPS19 ribosomal protein S19 -0.0498975
RPL37 ribosomal protein L37 -0.0496239
RPL23 ribosomal protein L23 -0.0495666
RPL5 ribosomal protein L5 -0.0494839
ATP5F1B ATP synthase F1 subunit beta -0.0485751
RPL37A ribosomal protein L37a -0.0479
RPL19 ribosomal protein L19 -0.0473039
AHNAK AHNAK nucleoprotein -0.0465221
RPS12 ribosomal protein S12 -0.0458812
TMSB4X thymosin beta 4, X-linked -0.0457812
RPL7 ribosomal protein L7 -0.0437792
ANXA2 annexin A2 -0.0414802
EIF1 eukaryotic translation initiation factor 1 -0.0410154
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0404023
RPL12 ribosomal protein L12 -0.0392875
RPS25 ribosomal protein S25 -0.0392679
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0382933
MDK midkine (neurite growth-promoting factor 2) -0.0379028
RPLP2 ribosomal protein, large, P2 -0.0369052
RPS13 ribosomal protein S13 -0.0364927
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0361579
OLA1 Obg-like ATPase 1 -0.0357531
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0352329
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0349365
TPR translocated promoter region, nuclear basket protein -0.0346872
UBB ubiquitin B -0.0338575
MKI67 marker of proliferation Ki-67 -0.0336178
RPL31 ribosomal protein L31 -0.0332273
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0328377
CAVIN1 caveolae associated protein 1 -0.0321068
FAF1 Fas (TNFRSF6) associated factor 1 -0.0317382
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0314648
HNRNPL heterogeneous nuclear ribonucleoprotein L -0.0310638
HMGB2 high mobility group box 2 -0.0309525
RPL11 ribosomal protein L11 -0.0306656
ZEB2 zinc finger E-box binding homeobox 2 -0.0306302
ACTN4 actinin, alpha 4 -0.0302101
S100A10 S100 calcium binding protein A10 -0.0302019
RPS20 ribosomal protein S20 -0.0297172
MYL12B myosin, light chain 12B, regulatory -0.0291916
RPS29 ribosomal protein S29 -0.0289389
RPS10 ribosomal protein S10 -0.0286502
ANKRD33B ankyrin repeat domain 33B -0.0284638
COL5A2 collagen, type V, alpha 2 -0.0284339
SERBP1 SERPINE1 mRNA binding protein 1 -0.0283309
RPS21 ribosomal protein S21 -0.0283273
FOXP2 forkhead box P2 -0.0281372
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.0279106
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0278871
DSTN destrin (actin depolymerizing factor) -0.027887
SRP72 signal recognition particle 72kDa -0.0275449
OAZ1 ornithine decarboxylase antizyme 1 -0.0274534
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0273469
RPS4X ribosomal protein S4, X-linked -0.0273247
RPS2 ribosomal protein S2 -0.0270783
HMGB1 high mobility group box 1 -0.0268718
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0267754
RPS24 ribosomal protein S24 -0.0263285
RPLP0 ribosomal protein, large, P0 -0.0262765
RPL9 ribosomal protein L9 -0.0262582
NACA nascent polypeptide-associated complex alpha subunit -0.0261884
RPL30 ribosomal protein L30 -0.0260471
GNAS GNAS complex locus -0.0255506
FTL ferritin, light polypeptide -0.0254056
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0254012
RPL28 ribosomal protein L28 -0.0251663
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0251209
YBX1 Y box binding protein 1 -0.0246339
RPL7A ribosomal protein L7a -0.0245776
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0244343
MDN1 MDN1, midasin homolog (yeast) -0.0242852
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0241782
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0240226
CALR calreticulin -0.023796
RPS17 ribosomal protein S17 -0.0237031
SQSTM1 sequestosome 1 -0.0234798
POMP proteasome maturation protein -0.023287
RPL38 ribosomal protein L38 -0.0231861
APP amyloid beta (A4) precursor protein -0.0229702
SLC38A1 solute carrier family 38, member 1 -0.0229543
RPL36 ribosomal protein L36 -0.022497
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0224307