| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | APTO-253 perturbation in PANC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the APTO-253_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VCL | vinculin | 0.113181 |
| CENPF | centromere protein F, 350/400kDa | 0.0623819 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0494349 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.045722 |
| ZFP36 | ZFP36 ring finger protein | 0.0427759 |
| MKI67 | marker of proliferation Ki-67 | 0.0419328 |
| PLEKHG2 | pleckstrin homology domain containing, family G (with RhoGef domain) member 2 | 0.040395 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0374587 |
| EGR1 | early growth response 1 | 0.0364214 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0338293 |
| FBL | fibrillarin | 0.0312069 |
| ENO1 | enolase 1, (alpha) | 0.0303305 |
| VMP1 | vacuole membrane protein 1 | 0.0269282 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0255636 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0250599 |
| MAP1B | microtubule-associated protein 1B | 0.024357 |
| SAMD4B | sterile alpha motif domain containing 4B | 0.0243313 |
| WEE1 | WEE1 G2 checkpoint kinase | 0.0240977 |
| PFN1 | profilin 1 | 0.0240006 |
| SESN2 | sestrin 2 | 0.0239947 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.022274 |
| FHL2 | four and a half LIM domains 2 | 0.0219936 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0217387 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0216634 |
| GOLT1A | golgi transport 1A | 0.0199106 |
| RPL3 | ribosomal protein L3 | 0.0195558 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0195274 |
| FOSL1 | FOS-like antigen 1 | 0.0193494 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0188123 |
| RPL21 | ribosomal protein L21 | 0.018176 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0178578 |
| ATF6 | activating transcription factor 6 | 0.017599 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0170305 |
| CBX3 | chromobox homolog 3 | 0.0164904 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.016417 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0161522 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0158766 |
| PAF1 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 0.0156891 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0154189 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0153677 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0153264 |
| MYADM | myeloid-associated differentiation marker | 0.0147098 |
| EIF3K | eukaryotic translation initiation factor 3, subunit K | 0.0142198 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0141439 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0140985 |
| TUBA1B | tubulin, alpha 1b | 0.0140704 |
| RPS2 | ribosomal protein S2 | 0.0140421 |
| TIMM50 | translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) | 0.01392 |
| DSTN | destrin (actin depolymerizing factor) | 0.0137482 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | 0.0136516 |
| KLF6 | Kruppel-like factor 6 | 0.013558 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0133233 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0132898 |
| HDGF | hepatoma-derived growth factor | 0.0131732 |
| MYPN | myopalladin | 0.0131513 |
| CKAP2 | cytoskeleton associated protein 2 | 0.0130996 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0130558 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0129156 |
| KIF4A | kinesin family member 4A | 0.0129003 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0125208 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0124768 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0122549 |
| TGOLN2 | trans-golgi network protein 2 | 0.0119596 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0118362 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0117626 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0117579 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.011756 |
| TPX2 | TPX2, microtubule-associated | 0.0117093 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.0117071 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0116257 |
| KAT6B | K(lysine) acetyltransferase 6B | 0.0114385 |
| POTEF | POTE ankyrin domain family, member F | 0.0113213 |
| YBX3 | Y box binding protein 3 | 0.0111377 |
| LRP11 | low density lipoprotein receptor-related protein 11 | 0.0111351 |
| DEK | DEK proto-oncogene | 0.0110883 |
| HSPE1 | heat shock 10kDa protein 1 | 0.011035 |
| FLOT1 | flotillin 1 | 0.0110133 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.0109257 |
| RPL32 | ribosomal protein L32 | 0.0109116 |
| DDX18 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 | 0.0106961 |
| PRR13 | proline rich 13 | 0.0105643 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0103709 |
| TXNRD1 | thioredoxin reductase 1 | 0.0103073 |
| RPL7 | ribosomal protein L7 | 0.0102119 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.010195 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0101506 |
| IL6ST | interleukin 6 signal transducer | 0.0101462 |
| RAD23A | RAD23 homolog A (S. cerevisiae) | 0.0100763 |
| ATF3 | activating transcription factor 3 | 0.0100537 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0100347 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0100289 |
| STMN1 | stathmin 1 | 0.0100206 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0100093 |
| MRTFA | myocardin related transcription factor A | 0.00991898 |
| DNAJC8 | DnaJ (Hsp40) homolog, subfamily C, member 8 | 0.00990054 |
| SET | SET nuclear proto-oncogene | 0.00981801 |
| FAU | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | 0.0098051 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.00978525 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.00975859 |
| CCT2 | chaperonin containing TCP1, subunit 2 (beta) | 0.00960318 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.1861 |
| AHNAK | AHNAK nucleoprotein | -0.18578 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.185215 |
| VIM | vimentin | -0.18437 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.165118 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.146089 |
| SMAD3 | SMAD family member 3 | -0.101268 |
| FMNL2 | formin-like 2 | -0.09315 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0909545 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.087148 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0858439 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0808517 |
| MYOF | myoferlin | -0.0799472 |
| HMGA2 | high mobility group AT-hook 2 | -0.076252 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0760873 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0758948 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0754834 |
| SEPTIN9 | septin 9 | -0.0739867 |
| RPS16 | ribosomal protein S16 | -0.0720095 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0707225 |
| NAV2 | neuron navigator 2 | -0.0699057 |
| DST | dystonin | -0.0689498 |
| SPAG9 | sperm associated antigen 9 | -0.0669361 |
| PTK2 | protein tyrosine kinase 2 | -0.063066 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0558097 |
| PDE10A | phosphodiesterase 10A | -0.0555082 |
| NHSL1 | NHS-like 1 | -0.0536584 |
| OGA | O-GlcNAcase | -0.052111 |
| ATG7 | autophagy related 7 | -0.0511504 |
| CTBP2 | C-terminal binding protein 2 | -0.0510161 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0505824 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0495787 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.049288 |
| ASPH | aspartate beta-hydroxylase | -0.048027 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0477662 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0474176 |
| ACTN4 | actinin, alpha 4 | -0.0468111 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.046412 |
| AFAP1 | actin filament associated protein 1 | -0.0461673 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0451808 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0442351 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0441473 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.044114 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0430842 |
| TNS3 | tensin 3 | -0.0422153 |
| NF1 | neurofibromin 1 | -0.0420014 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0410055 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | -0.0399802 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0397789 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.039758 |
| CMIP | c-Maf inducing protein | -0.0386484 |
| CANX | calnexin | -0.0380833 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0375616 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0375543 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0372766 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0371834 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | -0.0367409 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0367403 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0366672 |
| EFNA5 | ephrin-A5 | -0.0362871 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0362705 |
| MORF4L2 | mortality factor 4 like 2 | -0.0362176 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0361184 |
| AFDN | afadin, adherens junction formation factor | -0.0359742 |
| APP | amyloid beta (A4) precursor protein | -0.035873 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0357086 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0355625 |
| EGFR | epidermal growth factor receptor | -0.0344735 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0332642 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0329728 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0327454 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.0323233 |
| SBF2 | SET binding factor 2 | -0.032159 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0319021 |
| ACTG1 | actin gamma 1 | -0.0318877 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0313898 |
| MYO10 | myosin X | -0.0313358 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0312834 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0307698 |
| SNX14 | sorting nexin 14 | -0.030491 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0304326 |
| PRSS23 | protease, serine, 23 | -0.0303813 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.030179 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0297795 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0297262 |
| RASA3 | RAS p21 protein activator 3 | -0.029601 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0294637 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.029068 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0290346 |
| ATM | ATM serine/threonine kinase | -0.0285469 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0281464 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0281422 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0278936 |
| RPL11 | ribosomal protein L11 | -0.0277674 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0277482 |
| COL18A1 | collagen, type XVIII, alpha 1 | -0.0276928 |
| CAVIN1 | caveolae associated protein 1 | -0.0276135 |
| HMGA1 | high mobility group AT-hook 1 | -0.0271371 |
| RPL37A | ribosomal protein L37a | -0.0271311 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0270284 |
