APTO-253_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description APTO-253 perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the APTO-253_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0486862
ZSWIM6 zinc finger, SWIM-type containing 6 0.0346328
WWC1 WW and C2 domain containing 1 0.0321429
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0306011
PCLO piccolo presynaptic cytomatrix protein 0.0290576
THBS1 thrombospondin 1 0.027746
DIAPH3 diaphanous-related formin 3 0.0276567
ARHGAP26 Rho GTPase activating protein 26 0.0265108
SMC4 structural maintenance of chromosomes 4 0.0262303
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0236259
CCNL1 cyclin L1 0.0235055
FAM3C family with sequence similarity 3, member C 0.0223096
MKI67 marker of proliferation Ki-67 0.0207446
VMP1 vacuole membrane protein 1 0.0202374
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0198938
NRIP1 nuclear receptor interacting protein 1 0.019705
SIK3 SIK family kinase 3 0.0196816
CENPF centromere protein F, 350/400kDa 0.0193919
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0188901
NFIB nuclear factor I/B 0.0188883
INTS6 integrator complex subunit 6 0.0177522
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0174137
TSC22D2 TSC22 domain family, member 2 0.0173963
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0164591
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0161966
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0159232
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0158417
OSBPL3 oxysterol binding protein-like 3 0.0157003
ARL15 ADP-ribosylation factor-like 15 0.015432
PCBP2 poly(rC) binding protein 2 0.0153862
NCEH1 neutral cholesterol ester hydrolase 1 0.0150132
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.014951
KDM6A lysine (K)-specific demethylase 6A 0.0148969
GPHN gephyrin 0.0147876
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0146749
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0141903
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.014011
ECT2 epithelial cell transforming 2 0.0136212
ADAM9 ADAM metallopeptidase domain 9 0.0136084
APLP2 amyloid beta (A4) precursor-like protein 2 0.0133904
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0132976
TRA2B transformer 2 beta homolog (Drosophila) 0.0129627
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0128657
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0127124
KRT17 keratin 17, type I 0.0126887
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0125563
RPL3 ribosomal protein L3 0.0121094
COBL cordon-bleu WH2 repeat protein 0.0120954
FRMD5 FERM domain containing 5 0.0119929
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0119426
GOLGA4 golgin A4 0.0118753
WDR43 WD repeat domain 43 0.0118613
SMOC1 SPARC related modular calcium binding 1 0.0116298
SFPQ splicing factor proline/glutamine-rich 0.0115658
FOSL1 FOS-like antigen 1 0.0113439
AHR aryl hydrocarbon receptor 0.0112606
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.0111911
MAPK8 mitogen-activated protein kinase 8 0.0111503
FXR1 fragile X mental retardation, autosomal homolog 1 0.0111283
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0110925
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0110308
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0109756
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0108462
ANLN anillin, actin binding protein 0.0107726
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0107559
ARHGAP29 Rho GTPase activating protein 29 0.0105989
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0104975
TXNRD1 thioredoxin reductase 1 0.0104488
LATS2 large tumor suppressor kinase 2 0.0103967
IRS2 insulin receptor substrate 2 0.0102706
WDPCP WD repeat containing planar cell polarity effector 0.0100461
RASAL2 RAS protein activator like 2 0.00999607
TGFB2 transforming growth factor, beta 2 0.00980354
TJP1 tight junction protein 1 0.00976224
CD46 CD46 molecule, complement regulatory protein 0.00972127
KIF18A kinesin family member 18A 0.00970264
TRIO trio Rho guanine nucleotide exchange factor 0.00959772
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.00953569
IL6ST interleukin 6 signal transducer 0.00952313
MYH9 myosin, heavy chain 9, non-muscle 0.00948104
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.00941234
ELOVL5 ELOVL fatty acid elongase 5 0.00940177
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.00939359
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.00937412
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.00930069
METTL15 methyltransferase like 15 0.00927822
PICALM phosphatidylinositol binding clathrin assembly protein 0.0092244
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.00911048
PDIA6 protein disulfide isomerase family A, member 6 0.00888167
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.00884911
ANKRD33B ankyrin repeat domain 33B 0.00878527
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.00877957
RB1 retinoblastoma 1 0.00875998
RBM26 RNA binding motif protein 26 0.00873517
LRPPRC leucine-rich pentatricopeptide repeat containing 0.00872127
CEP128 centrosomal protein 128kDa 0.00870182
PCCA propionyl CoA carboxylase, alpha polypeptide 0.00866562
CABIN1 calcineurin binding protein 1 0.00864593
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.008641
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0086128

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.207371
LAMB3 laminin, beta 3 -0.126416
LAMA4 laminin, alpha 4 -0.103605
EMP1 epithelial membrane protein 1 -0.0996746
TMSB4X thymosin beta 4, X-linked -0.0975432
LMO7 LIM domain 7 -0.0917509
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0895262
ACTG1 actin gamma 1 -0.088398
HMGA1 high mobility group AT-hook 1 -0.0854599
HLA-B major histocompatibility complex, class I, B -0.0837454
TPM4 tropomyosin 4 -0.080171
RPL35A ribosomal protein L35a -0.0778379
ANXA2 annexin A2 -0.0745732
TMSB10 thymosin beta 10 -0.071736
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.071373
PTMA prothymosin, alpha -0.0651458
IGFBP3 insulin-like growth factor binding protein 3 -0.0651024
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0645326
LAMC2 laminin, gamma 2 -0.0639889
F3 coagulation factor III (thromboplastin, tissue factor) -0.0616818
CD44 CD44 molecule (Indian blood group) -0.0608849
KRT19 keratin 19, type I -0.0595474
RPS6 ribosomal protein S6 -0.0593048
HLA-E major histocompatibility complex, class I, E -0.058878
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0579085
RPL37A ribosomal protein L37a -0.0524432
AHNAK AHNAK nucleoprotein -0.0495466
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.048913
RPS8 ribosomal protein S8 -0.0479137
RPL37 ribosomal protein L37 -0.0471874
FN1 fibronectin 1 -0.0471847
RPL31 ribosomal protein L31 -0.046478
RPS29 ribosomal protein S29 -0.0459469
SACK1A scaffolding CK1 anchoring protein A -0.0449656
ARHGAP5 Rho GTPase activating protein 5 -0.04337
G0S2 G0/G1 switch 2 -0.0429407
RPS27A ribosomal protein S27a -0.0423692
WSB1 WD repeat and SOCS box containing 1 -0.0408306
RPLP1 ribosomal protein, large, P1 -0.0404951
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.039523
DSG2 desmoglein 2 -0.0393802
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0393745
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0390196
RPS25 ribosomal protein S25 -0.0386792
EIF1 eukaryotic translation initiation factor 1 -0.0385974
RPL12 ribosomal protein L12 -0.0385896
NPEPPS aminopeptidase puromycin sensitive -0.0385129
RPL23 ribosomal protein L23 -0.0384986
RACK1 receptor for activated C kinase 1 -0.0378507
WFDC2 WAP four-disulfide core domain 2 -0.0376554
S100A6 S100 calcium binding protein A6 -0.0374524
RPS3 ribosomal protein S3 -0.0371002
HLA-A major histocompatibility complex, class I, A -0.0367295
NDRG1 N-myc downstream regulated 1 -0.036719
ASPH aspartate beta-hydroxylase -0.0363594
MT2A metallothionein 2A -0.0359406
RPS19 ribosomal protein S19 -0.0357663
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0357215
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0355128
MAML2 mastermind-like 2 (Drosophila) -0.0354221
RPS13 ribosomal protein S13 -0.0353976
RPS24 ribosomal protein S24 -0.0352977
SYT14 synaptotagmin XIV -0.0352854
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0346193
KRT7 keratin 7, type II -0.0340179
PLAU plasminogen activator, urokinase -0.0339671
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0333763
CD2AP CD2-associated protein -0.0323643
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0321561
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0320625
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0320089
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0317781
PGK1 phosphoglycerate kinase 1 -0.0317114
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0313735
SQSTM1 sequestosome 1 -0.0311662
KLF5 Kruppel-like factor 5 (intestinal) -0.0311526
RPL34 ribosomal protein L34 -0.0311354
KPNB1 karyopherin (importin) beta 1 -0.0311048
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0310796
B2M beta-2-microglobulin -0.0310338
RPL36A ribosomal protein L36a -0.0308876
MEF2A myocyte enhancer factor 2A -0.0307178
HLA-C major histocompatibility complex, class I, C -0.030531
PLSCR1 phospholipid scramblase 1 -0.0302298
MACF1 microtubule-actin crosslinking factor 1 -0.0299713
RPS21 ribosomal protein S21 -0.0298196
FTL ferritin, light polypeptide -0.0293485
EGFR epidermal growth factor receptor -0.0293286
RPL26 ribosomal protein L26 -0.0292756
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0287794
SOX4 SRY (sex determining region Y)-box 4 -0.0286917
SULF2 sulfatase 2 -0.0286393
HMGA2 high mobility group AT-hook 2 -0.0282935
RPL19 ribosomal protein L19 -0.0282326
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.027873
SVIL supervillin -0.0276597
RPL38 ribosomal protein L38 -0.0273079
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0270564
MYO6 myosin VI -0.0267941
CD9 CD9 molecule -0.0264561